SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOF_B_HQEB200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 TYR A  14
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.26A 3zofB-1uscA:
33.1		 3zofB-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.42A 3zofB-1uscA:
33.1		 3zofB-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		5 TYR A  17
VAL A  38
TRP A  39
ARG A  58
HIS A 131
 None
FMN  A1179 (-4.0A)
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.12A 3zofB-1uscA:
33.1		 3zofB-1uscA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 452
VAL A 418
ARG A  34
HIS A  35
 None
 1.40A 3zofB-2bvgA:
0.0		 3zofB-2bvgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6q MACROCYPIN 1A

(Macrolepiota
procera) 		no annotation 4 VAL A 150
TRP A 133
ARG A 160
HIS A 121
 None
 1.45A 3zofB-3h6qA:
0.0		 3zofB-3h6qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 236
VAL A 180
TRP A 179
HIS A  12
 None
 1.27A 3zofB-3ip3A:
0.0		 3zofB-3ip3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 251
VAL A 262
ARG A 135
HIS A 194
 None
 1.36A 3zofB-3zjkA:
0.0		 3zofB-3zjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zog FMN-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01613
(Flavin_Reduct) 		4 TYR A   8
TRP A  30
ARG A  49
HIS A 124
 None
A2Q  A 200 ( 3.3A)
FMN  A 173 ( 3.5A)
A2Q  A 200 ( 3.8A)
 0.45A 3zofB-3zogA:
23.9		 3zofB-3zogA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 TYR A  41
VAL A  50
TRP A 154
HIS A 272
 2A1  A 403 (-4.3A)
None
2A1  A 403 (-4.6A)
None
 1.32A 3zofB-4xf5A:
0.0		 3zofB-4xf5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 TYR A1057
VAL A1035
ARG A1086
HIS A1066
 None
 1.21A 3zofB-5h42A:
0.0		 3zofB-5h42A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 TYR A 257
VAL A 269
ARG A 135
HIS A 194
 None
 1.33A 3zofB-5ns8A:
0.0		 3zofB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 4 TYR A 176
VAL A  54
ARG A  61
HIS A  41
 None
 1.37A 3zofB-5vrcA:
undetectable		 3zofB-5vrcA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 4 TYR A 264
VAL A 277
ARG A 141
HIS A 200
 None
 1.33A 3zofB-5xgzA:
undetectable		 3zofB-5xgzA:
18.50