SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOF_A_HQEA200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.44A 3zofA-1uscA:
33.3		 3zofA-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		5 TYR A  17
VAL A  38
TRP A  39
ARG A  58
HIS A 131
 None
FMN  A1179 (-4.0A)
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.16A 3zofA-1uscA:
33.3		 3zofA-1uscA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 236
VAL A 180
TRP A 179
HIS A  12
 None
 1.29A 3zofA-3ip3A:
0.0		 3zofA-3ip3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 251
VAL A 262
ARG A 135
HIS A 194
 None
 1.41A 3zofA-3zjkA:
0.0		 3zofA-3zjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zog FMN-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01613
(Flavin_Reduct) 		4 TYR A   8
TRP A  30
ARG A  49
HIS A 124
 None
A2Q  A 200 ( 3.3A)
FMN  A 173 ( 3.5A)
A2Q  A 200 ( 3.8A)
 0.47A 3zofA-3zogA:
24.1		 3zofA-3zogA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 TYR A  96
VAL A 114
ARG A 122
HIS A 155
 None
KCX  A  66 ( 3.6A)
None
None
 1.45A 3zofA-4gn2A:
0.0		 3zofA-4gn2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		4 TYR A 289
VAL A  98
ARG A 184
HIS A 180
 None
 1.42A 3zofA-4j5iA:
0.0		 3zofA-4j5iA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 TYR A  41
VAL A  50
TRP A 154
HIS A 272
 2A1  A 403 (-4.3A)
None
2A1  A 403 (-4.6A)
None
 1.35A 3zofA-4xf5A:
0.0		 3zofA-4xf5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		4 TYR A 303
VAL A 107
ARG A 198
HIS A 194
 None
EPE  A 403 (-4.2A)
None
None
 1.36A 3zofA-4y0eA:
0.0		 3zofA-4y0eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 TYR A1057
VAL A1035
ARG A1086
HIS A1066
 None
 1.24A 3zofA-5h42A:
0.0		 3zofA-5h42A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 TYR A 257
VAL A 269
ARG A 135
HIS A 194
 None
 1.37A 3zofA-5ns8A:
undetectable		 3zofA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrc BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 4 TYR A 176
VAL A  54
ARG A  61
HIS A  41
 None
 1.31A 3zofA-5vrcA:
undetectable		 3zofA-5vrcA:
14.84