SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOD_A_HQEA1173_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA
FORMATE
DEHYDROGENASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF13247
(Fer4_11) 		4 TYR A 938
HIS B  38
ARG A 222
HIS A 937
 None
None
MGD  A1002 (-4.0A)
MGD  A1002 (-4.5A)
 1.31A 3zodA-1h0hA:
0.0		 3zodA-1h0hA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 TYR A  57
ARG A 178
HIS A  30
HIS A  56
 None
 1.19A 3zodA-1j5sA:
undetectable		 3zodA-1j5sA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		4 HIS A 280
ASP A 288
TRP A 289
HIS A 493
 None
 0.99A 3zodA-1jy1A:
0.0		 3zodA-1jy1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1020
ASP A 165
HIS A 161
HIS A1028
 CU  A1050 (-3.2A)
None
CU  A1051 (-3.3A)
None
 1.50A 3zodA-1kcwA:
0.0		 3zodA-1kcwA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 TYR A 428
ASP A 291
HIS A 297
HIS A 289
 MPD  A 802 ( 4.4A)
None
None
None
 1.41A 3zodA-1kwgA:
0.0		 3zodA-1kwgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 TYR A 106
ASP A 179
ARG A 182
HIS A  79
 None
 1.46A 3zodA-1nyqA:
0.0		 3zodA-1nyqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 HIS A  48
ASP A  83
HIS A 120
HIS A  80
 ZN  A 201 ( 3.2A)
ZN  A 202 (-2.1A)
ZN  A 201 ( 3.2A)
ZN  A 202 (-3.0A)
 1.42A 3zodA-1p1vA:
0.0		 3zodA-1p1vA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pkr PLASMINOGEN

(Homo sapiens) 		PF00051
(Kringle) 		4 TYR A  74
ASP A  57
TRP A  62
ARG A  34
 None
 1.39A 3zodA-1pkrA:
undetectable		 3zodA-1pkrA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.26A 3zodA-1uscA:
24.1		 3zodA-1uscA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 TYR A  17
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.51A 3zodA-1uscA:
24.1		 3zodA-1uscA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 TYR 1 659
ASP 1 623
ARG 1 676
HIS 1 506
 None
 1.30A 3zodA-1y791:
undetectable		 3zodA-1y791:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		4 HIS A  67
ASP A 137
ARG A 147
HIS A 124
 ZN  A 172 ( 3.1A)
None
None
CU  A 171 (-3.2A)
 1.24A 3zodA-2e47A:
undetectable		 3zodA-2e47A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		4 TYR A 211
HIS A 215
ASP A 125
HIS A  18
 None
 1.43A 3zodA-2e67A:
undetectable		 3zodA-2e67A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwr DNA-BINDING RESPONSE
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 TYR A 185
ASP A 101
TRP A 183
HIS A 197
 None
 1.38A 3zodA-2gwrA:
undetectable		 3zodA-2gwrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 TYR X 207
ASP X 259
ARG X 124
HIS X 291
 None
 1.38A 3zodA-2odtX:
undetectable		 3zodA-2odtX:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 HIS A 307
ASP A 198
HIS A  41
HIS A 252
 None
 1.37A 3zodA-2q01A:
undetectable		 3zodA-2q01A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 TYR A  66
ARG A 196
HIS A  39
HIS A  65
 None
 1.15A 3zodA-2q01A:
undetectable		 3zodA-2q01A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 TYR A 223
ASP A 138
ARG A 292
HIS A 131
 None
 1.24A 3zodA-2rgwA:
undetectable		 3zodA-2rgwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 777
ARG A 870
HIS A 843
HIS A 755
 None
 1.50A 3zodA-2y8nA:
undetectable		 3zodA-2y8nA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 HIS A  75
ASP A  14
ARG A 134
HIS A 250
 None
None
SO4  A1289 (-3.9A)
None
 1.18A 3zodA-2yb4A:
undetectable		 3zodA-2yb4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 TYR A 555
ASP A 416
HIS A 311
HIS A 563
 MAW  A1003 (-4.9A)
None
LGU  A1002 ( 3.9A)
None
 1.27A 3zodA-3aflA:
undetectable		 3zodA-3aflA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 TYR A 124
ASP A 280
ARG A 437
HIS A 206
 None
 1.15A 3zodA-3ayxA:
undetectable		 3zodA-3ayxA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ble CITRAMALATE SYNTHASE
FROM LEPTOSPIRA
INTERROGANS

(Leptospira
interrogans) 		PF00682
(HMGL-like) 		4 ASP A 147
ARG A 240
HIS A 209
HIS A 111
 None
None
ZN  A1003 ( 3.4A)
None
 1.40A 3zodA-3bleA:
undetectable		 3zodA-3bleA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 HIS A 217
ASP A  83
HIS A 251
HIS A  82
 ZN  A 601 (-3.5A)
None
None
None
 1.33A 3zodA-3c9fA:
undetectable		 3zodA-3c9fA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		4 ASP A 142
ARG A 235
HIS A 204
HIS A 106
 None
 1.39A 3zodA-3eegA:
undetectable		 3zodA-3eegA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		4 HIS A 202
ASP A   9
ARG A  13
HIS A  97
 None
 1.19A 3zodA-3eegA:
undetectable		 3zodA-3eegA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 ASP X 141
ARG X 234
HIS X 203
HIS X 105
 None
 1.46A 3zodA-3ewbX:
undetectable		 3zodA-3ewbX:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7s UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Pseudomonas
putida) 		PF13474
(SnoaL_3) 		4 TYR A  53
ASP A  40
TRP A 124
HIS A  56
 None
UNL  A 142 (-3.1A)
UNL  A 142 ( 4.4A)
None
 1.30A 3zodA-3f7sA:
undetectable		 3zodA-3f7sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 TYR A  48
ARG A 170
HIS A  26
HIS A  49
 None
FIX  A 428 (-2.9A)
ZN  A 430 ( 3.3A)
FIX  A 428 ( 4.1A)
 1.48A 3zodA-3hkaA:
undetectable		 3zodA-3hkaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 TYR A  50
ARG A 170
HIS A  26
HIS A  49
 FIX  A 428 ( 4.5A)
FIX  A 428 (-2.9A)
ZN  A 430 ( 3.3A)
FIX  A 428 ( 4.1A)
 1.27A 3zodA-3hkaA:
undetectable		 3zodA-3hkaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 TYR A 159
HIS A 400
ASP A  29
HIS A 141
 None
ZN  A 452 (-3.3A)
None
ZN  A 453 (-3.3A)
 1.46A 3zodA-3ie1A:
undetectable		 3zodA-3ie1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 TYR A  71
HIS A 187
ARG A 218
HIS A  24
 PO4  A 335 (-3.8A)
ZN  A 334 ( 3.2A)
None
ZN  A 333 ( 3.3A)
 1.28A 3zodA-3pnzA:
undetectable		 3zodA-3pnzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL

(Saccharophagus
degradans) 		PF04616
(Glyco_hydro_43) 		4 HIS A 264
ASP A  52
HIS A 206
HIS A 333
 GLA  A 375 (-4.0A)
None
None
None
 1.20A 3zodA-3r4zA:
undetectable		 3zodA-3r4zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ASP A 144
ARG A 237
HIS A 206
HIS A 108
 None
None
MN  A 365 (-3.4A)
None
 1.40A 3zodA-3rmjA:
undetectable		 3zodA-3rmjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sng NUCLEASE

(Solanum
lycopersicum) 		PF02265
(S1-P1_nuclease) 		4 HIS A 157
ARG A  73
HIS A 147
HIS A 182
 SO4  A 601 ( 3.2A)
SO4  A 601 (-2.7A)
ZN  A 402 (-3.2A)
None
 1.22A 3zodA-3sngA:
undetectable		 3zodA-3sngA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		4 ASP A 289
ARG A 220
HIS A 263
HIS A  94
 UNX  A 608 ( 2.4A)
None
None
UNX  A 608 ( 3.4A)
 1.28A 3zodA-3t8lA:
undetectable		 3zodA-3t8lA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ASP A 361
ARG A 358
HIS A 418
HIS A 225
 None
 1.34A 3zodA-3ttfA:
undetectable		 3zodA-3ttfA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uam CHITIN BINDING
DOMAIN

(Burkholderia
pseudomallei) 		PF03067
(LPMO_10) 		4 ASP A  96
TRP A 101
ARG A 141
HIS A 100
 None
 1.23A 3zodA-3uamA:
undetectable		 3zodA-3uamA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 TYR A  84
ASP A 140
HIS A 143
HIS A  88
 None
 1.39A 3zodA-3zgjA:
undetectable		 3zodA-3zgjA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zog FMN-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01613
(Flavin_Reduct) 		7 TYR A   8
HIS A  -7
ASP A  29
TRP A  30
ARG A  49
HIS A 124
HIS A 155
 None
A2Q  A 200 (-4.2A)
FMN  A 173 (-3.3A)
A2Q  A 200 ( 3.3A)
FMN  A 173 ( 3.5A)
A2Q  A 200 ( 3.8A)
FMN  A 173 (-3.6A)
 0.11A 3zodA-3zogA:
34.3		 3zodA-3zogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 TYR A  25
HIS A  74
HIS A 368
HIS A 161
 None
ZN  A1557 (-3.0A)
None
None
 1.42A 3zodA-3zq4A:
undetectable		 3zodA-3zq4A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		4 HIS A 302
ASP A  90
HIS A 244
HIS A 371
 None
EDO  A1404 ( 4.3A)
EDO  A1404 ( 3.5A)
None
 1.22A 3zodA-4ak5A:
undetectable		 3zodA-4ak5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6v EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 3

(Mus musculus) 		PF01652
(IF4E) 		4 TRP A 161
ARG A  95
HIS A 194
HIS A  88
 None
 1.29A 3zodA-4b6vA:
undetectable		 3zodA-4b6vA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 TYR A  94
ARG A 218
HIS A  19
HIS A  95
 None
 1.44A 3zodA-4jcmA:
undetectable		 3zodA-4jcmA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 HIS A 151
ASP A 179
ARG A 300
HIS A 186
 None
 1.43A 3zodA-4jw1A:
undetectable		 3zodA-4jw1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 TYR A 241
ASP A  29
HIS A 211
HIS A  99
 None
CA  A 400 ( 4.5A)
None
None
 1.25A 3zodA-4kpnA:
undetectable		 3zodA-4kpnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		4 TYR A  64
ASP A  91
ARG A  89
HIS A  55
 None
 1.33A 3zodA-4kvoA:
undetectable		 3zodA-4kvoA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		4 HIS A  62
ASP A 132
ARG A 142
HIS A 119
 ZN  A 202 ( 3.2A)
None
None
CU  A 201 (-3.2A)
 1.42A 3zodA-4ojaA:
undetectable		 3zodA-4ojaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 TYR A 225
ASP A  80
HIS A  57
HIS A 229
 None
 1.47A 3zodA-4p2bA:
undetectable		 3zodA-4p2bA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 HIS A 842
ASP A 872
ARG A 787
HIS A 875
 None
 1.35A 3zodA-4pj3A:
undetectable		 3zodA-4pj3A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 TYR A 255
ASP A 253
ARG A   8
HIS A 265
 FAD  A 301 (-3.5A)
None
None
ZN  A 302 ( 3.4A)
 1.27A 3zodA-4yhbA:
undetectable		 3zodA-4yhbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 HIS C 224
ASP C 253
ARG C 341
HIS C 277
 NI  C 601 (-4.7A)
None
None
NI  C 601 (-4.6A)
 1.49A 3zodA-4z42C:
undetectable		 3zodA-4z42C:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 TYR A 346
ARG A 214
HIS A 274
HIS A 339
 None
 1.05A 3zodA-4zq8A:
undetectable		 3zodA-4zq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 TYR A  47
ASP A 123
HIS A  73
HIS A  53
 None
 1.24A 3zodA-4zrsA:
undetectable		 3zodA-4zrsA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 TYR A 352
HIS A 213
HIS A 366
HIS A 340
 None
ZN  A 402 (-3.4A)
ZN  A 401 (-3.7A)
None
 1.35A 3zodA-5gneA:
undetectable		 3zodA-5gneA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		4 TYR A  54
HIS A 355
ASP A  51
HIS A 249
 None
 1.39A 3zodA-5j5uA:
undetectable		 3zodA-5j5uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 ASP C 171
ARG C 157
HIS C 154
HIS A 251
 None
 1.42A 3zodA-5k0uC:
undetectable		 3zodA-5k0uC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		4 ASP A  11
ARG A  33
HIS A  46
HIS A  25
 None
 1.39A 3zodA-5kqwA:
undetectable		 3zodA-5kqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 TYR A 263
HIS A  14
HIS A 107
HIS A 198
 None
ZN  A1002 (-3.2A)
ZN  A1001 ( 3.1A)
None
 1.38A 3zodA-5lewA:
undetectable		 3zodA-5lewA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		4 HIS A  23
ASP A  52
HIS A 171
HIS A  53
 PO4  A 503 ( 4.2A)
None
PO4  A 503 (-4.5A)
ACY  A 506 (-4.1A)
 1.35A 3zodA-5lmcA:
undetectable		 3zodA-5lmcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 ASP A 191
ARG A 316
HIS A 309
HIS A 268
 FE  A 401 (-2.4A)
ARG  A 403 (-3.7A)
None
FE  A 401 ( 3.2A)
 1.06A 3zodA-5lunA:
undetectable		 3zodA-5lunA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		4 HIS A 302
ASP A  90
HIS A 244
HIS A 371
 GAL  A 501 (-3.9A)
AAL  A 502 ( 3.7A)
AAL  A 502 (-3.3A)
None
 1.24A 3zodA-5ta9A:
undetectable		 3zodA-5ta9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 TRP A 426
ARG A 205
HIS A 430
HIS A 414
 None
 1.38A 3zodA-5wu7A:
undetectable		 3zodA-5wu7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 TYR A 586
HIS A 208
TRP A 179
HIS A 180
 None
 1.06A 3zodA-5yy3A:
undetectable		 3zodA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 TYR A2010
ASP A2645
ARG A2730
HIS A2647
 None
 1.43A 3zodA-6fb3A:
undetectable		 3zodA-6fb3A:
17.71