SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOA_A_ACRA1587_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 ARG A 337
PHE A 338
PRO A 339
 None
 0.81A 3zoaB-1c7tA:
10.2		 3zoaB-1c7tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		3 ARG A 342
PHE A 391
PRO A 392
 None
 0.50A 3zoaB-1e0tA:
9.4		 3zoaB-1e0tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 ARG A 369
PHE A 370
PRO A 371
 None
 0.86A 3zoaB-1hjvA:
5.9		 3zoaB-1hjvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 ARG A 185
PHE A  78
PRO A  79
 DEB  A 420 ( 4.6A)
None
None
 0.63A 3zoaB-1jioA:
undetectable		 3zoaB-1jioA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		3 ARG A 133
PHE A 447
PRO A 446
 None
 0.83A 3zoaB-1jmyA:
undetectable		 3zoaB-1jmyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B

(Escherichia
coli) 		PF02527
(GidB) 		3 ARG A  68
PHE A 133
PRO A 155
 None
 0.89A 3zoaB-1jsxA:
undetectable		 3zoaB-1jsxA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		3 ARG A 366
PHE A 420
PRO A 421
 None
 0.73A 3zoaB-1k9xA:
undetectable		 3zoaB-1k9xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		3 ARG A 116
PHE A  14
PRO A  15
 None
 0.48A 3zoaB-1oy5A:
undetectable		 3zoaB-1oy5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		3 ARG A 114
PHE A   9
PRO A  10
 None
 0.77A 3zoaB-1p9pA:
undetectable		 3zoaB-1p9pA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ARG A 304
PHE A 305
PRO A 306
 None
 0.78A 3zoaB-1r0lA:
undetectable		 3zoaB-1r0lA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ARG A  81
PHE A  86
PRO A  88
 None
MLA  A 432 (-4.9A)
MLA  A 432 (-4.3A)
 0.77A 3zoaB-1s1fA:
undetectable		 3zoaB-1s1fA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seh DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Escherichia
coli) 		PF00692
(dUTPase) 		3 ARG A  13
PHE A  18
PRO A  19
 None
 0.65A 3zoaB-1sehA:
undetectable		 3zoaB-1sehA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		3 ARG A 315
PHE A 316
PRO A 317
 None
 0.87A 3zoaB-1ua7A:
21.1		 3zoaB-1ua7A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ARG A 472
PHE A 471
PRO A 486
 None
 0.77A 3zoaB-1ut9A:
undetectable		 3zoaB-1ut9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaj HYPOTHETICAL PROTEIN
PH0010

(Pyrococcus
horikoshii) 		PF01871
(AMMECR1) 		3 ARG A  92
PHE A  93
PRO A  94
 None
 0.58A 3zoaB-1vajA:
undetectable		 3zoaB-1vajA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		3 ARG A 101
PHE A 102
PRO A 103
 None
 0.58A 3zoaB-1wscA:
undetectable		 3zoaB-1wscA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		3 ARG A 144
PHE A 145
PRO A 146
 None
 0.35A 3zoaB-1z45A:
undetectable		 3zoaB-1z45A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq7 HYPOTHETICAL PROTEIN
MM0484

(Methanosarcina
mazei) 		PF01871
(AMMECR1) 		3 ARG A  87
PHE A  88
PRO A  89
 None
 0.64A 3zoaB-1zq7A:
undetectable		 3zoaB-1zq7A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		3 ARG 1  56
PHE 1 368
PRO 1 369
 None
 0.87A 3zoaB-2bpa1:
undetectable		 3zoaB-2bpa1:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		3 ARG A 187
PHE A 391
PRO A 388
 ICT  A 501 (-3.6A)
ICT  A 501 (-4.5A)
None
 0.87A 3zoaB-2csgA:
undetectable		 3zoaB-2csgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 ARG A 221
PHE A 223
PRO A 224
 None
 0.80A 3zoaB-2cvzA:
undetectable		 3zoaB-2cvzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Thermus
thermophilus) 		PF01451
(LMWPc) 		3 ARG A 101
PHE A 102
PRO A 103
 None
 0.88A 3zoaB-2cwdA:
undetectable		 3zoaB-2cwdA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		3 ARG A 156
PHE A 157
PRO A 158
 None
 0.85A 3zoaB-2g5dA:
undetectable		 3zoaB-2g5dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 ARG A 166
PHE A 167
PRO A 168
 None
 0.79A 3zoaB-2gjxA:
12.0		 3zoaB-2gjxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 3 ARG I 166
PHE I 167
PRO I 168
 None
 0.81A 3zoaB-2gk1I:
12.3		 3zoaB-2gk1I:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naf PEPTIDYL-TRNA
HYDROLASE

(Mycolicibacterium
smegmatis) 		PF01195
(Pept_tRNA_hydro) 		3 ARG A  21
PHE A 149
PRO A 146
 None
 0.81A 3zoaB-2nafA:
undetectable		 3zoaB-2nafA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		3 ARG A 432
PHE A  13
PRO A  14
 None
 0.44A 3zoaB-2q01A:
undetectable		 3zoaB-2q01A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		3 ARG A 159
PHE A 166
PRO A 167
 None
 0.71A 3zoaB-2qa1A:
undetectable		 3zoaB-2qa1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 ARG A 159
PHE A 166
PRO A 167
 None
 0.80A 3zoaB-2qa2A:
undetectable		 3zoaB-2qa2A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		3 ARG A 172
PHE A 162
PRO A 165
 None
 0.70A 3zoaB-2qiwA:
5.9		 3zoaB-2qiwA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbj OB TCR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG D  59
PHE D  61
PRO D  62
 None
 0.74A 3zoaB-2wbjD:
undetectable		 3zoaB-2wbjD:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		3 ARG A 432
PHE A 433
PRO A 434
 None
 0.53A 3zoaB-2xssA:
undetectable		 3zoaB-2xssA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		3 ARG B 424
PHE B 403
PRO B 404
 None
 0.58A 3zoaB-2xwuB:
undetectable		 3zoaB-2xwuB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		3 ARG A 223
PHE A 224
PRO A 225
 None
 0.75A 3zoaB-2yocA:
16.6		 3zoaB-2yocA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		3 ARG A 115
PHE A 116
PRO A 117
 None
 0.86A 3zoaB-2yysA:
undetectable		 3zoaB-2yysA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2i PEPTIDYL-TRNA
HYDROLASE

(Mycobacterium
tuberculosis) 		PF01195
(Pept_tRNA_hydro) 		3 ARG A  21
PHE A 149
PRO A 146
 None
 0.68A 3zoaB-2z2iA:
undetectable		 3zoaB-2z2iA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 ARG A 289
PHE A 290
PRO A 291
 None
 0.45A 3zoaB-3agrA:
undetectable		 3zoaB-3agrA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245

(Nitrosomonas
europaea) 		PF17131
(LolA_like) 		3 ARG A  48
PHE A  49
PRO A  50
 None
 0.81A 3zoaB-3buuA:
undetectable		 3zoaB-3buuA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 ARG A 571
PHE A 572
PRO A 573
 ACY  A 817 (-4.0A)
ACY  A 817 ( 4.4A)
None
 0.72A 3zoaB-3cf4A:
undetectable		 3zoaB-3cf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		3 ARG A   6
PHE A   7
PRO A   8
 None
 0.65A 3zoaB-3dmpA:
undetectable		 3zoaB-3dmpA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK

(Escherichia
coli) 		PF00106
(adh_short) 		3 ARG A 202
PHE A 206
PRO A 207
 NAP  A 300 (-4.8A)
None
None
 0.53A 3zoaB-3f1kA:
undetectable		 3zoaB-3f1kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		3 ARG A 241
PHE A 242
PRO A 243
 None
 0.47A 3zoaB-3h2bA:
undetectable		 3zoaB-3h2bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		3 ARG A 358
PHE A 427
PRO A 428
 None
 0.89A 3zoaB-3hoaA:
undetectable		 3zoaB-3hoaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 3 ARG A 239
PHE A 240
PRO A 241
 None
 0.52A 3zoaB-3hwpA:
undetectable		 3zoaB-3hwpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		3 ARG A 339
PHE A 340
PRO A 341
 None
 0.89A 3zoaB-3i4jA:
undetectable		 3zoaB-3i4jA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		3 ARG A 203
PHE A 207
PRO A 208
 EOH  A 257 (-3.3A)
ACT  A 256 ( 4.9A)
None
 0.62A 3zoaB-3iahA:
undetectable		 3zoaB-3iahA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128

(Homo sapiens) 		PF02225
(PA) 		3 ARG A 122
PHE A 148
PRO A 149
 None
 0.71A 3zoaB-3icuA:
undetectable		 3zoaB-3icuA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A  76
PHE A 494
PRO A 495
 None
 0.86A 3zoaB-3jq1A:
undetectable		 3zoaB-3jq1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		3 ARG A 113
PHE A   9
PRO A  10
 None
 0.82A 3zoaB-3knuA:
undetectable		 3zoaB-3knuA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld3 INORGANIC
PYROPHOSPHATASE

(Anaplasma
phagocytophilum) 		PF00719
(Pyrophosphatase) 		3 ARG A  77
PHE A  78
PRO A  79
 None
 0.58A 3zoaB-3ld3A:
undetectable		 3zoaB-3ld3A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		3 ARG A 432
PHE A 433
PRO A 434
 None
 0.54A 3zoaB-3lfvA:
undetectable		 3zoaB-3lfvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lo0 INORGANIC
PYROPHOSPHATASE

(Ehrlichia
chaffeensis) 		PF00719
(Pyrophosphatase) 		3 ARG A  77
PHE A  78
PRO A  79
 None
 0.61A 3zoaB-3lo0A:
undetectable		 3zoaB-3lo0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oui EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		3 ARG A 312
PHE A 346
PRO A 347
 None
 0.79A 3zoaB-3ouiA:
3.0		 3zoaB-3ouiA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 ARG A  51
PHE A  48
PRO A  49
 None
 0.81A 3zoaB-3pvcA:
undetectable		 3zoaB-3pvcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		3 ARG A 185
PHE A 182
PRO A 183
 None
 0.87A 3zoaB-3rreA:
undetectable		 3zoaB-3rreA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		3 ARG A   9
PHE A  10
PRO A  11
 None
 0.74A 3zoaB-3s6dA:
7.1		 3zoaB-3s6dA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqz DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Coxiella
burnetii) 		PF00692
(dUTPase) 		3 ARG A  13
PHE A  18
PRO A  19
 None
 0.62A 3zoaB-3tqzA:
undetectable		 3zoaB-3tqzA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 ARG A 291
PHE A 292
PRO A 293
 None
 0.38A 3zoaB-3ufbA:
undetectable		 3zoaB-3ufbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		3 ARG A  11
PHE A  12
PRO A  13
 None
 0.88A 3zoaB-3utoA:
undetectable		 3zoaB-3utoA:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 534
PHE A 535
PRO A 536
 None
 0.24A 3zoaB-3zo9A:
62.6		 3zoaB-3zo9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		3 ARG A 104
PHE A 129
PRO A 130
 None
 0.67A 3zoaB-4df3A:
undetectable		 3zoaB-4df3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		3 ARG A 342
PHE A 349
PRO A 350
 None
 0.51A 3zoaB-4fvaA:
undetectable		 3zoaB-4fvaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		3 ARG A 342
PHE A 349
PRO A 350
 None
 0.42A 3zoaB-4gewA:
undetectable		 3zoaB-4gewA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5

(Saccharomyces
cerevisiae) 		PF09084
(NMT1) 		3 ARG A  73
PHE A  75
PRO A  76
 None
 0.89A 3zoaB-4h65A:
undetectable		 3zoaB-4h65A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hri HETEROCYST
DIFFERENTIATION
CONTROL PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 3 ARG B 165
PHE B 106
PRO B 107
 None
 0.89A 3zoaB-4hriB:
undetectable		 3zoaB-4hriB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		3 ARG A 162
PHE A 169
PRO A 170
 None
 0.86A 3zoaB-4k2xA:
undetectable		 3zoaB-4k2xA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		3 ARG A 173
PHE A 180
PRO A 181
 None
 0.85A 3zoaB-4k5rA:
undetectable		 3zoaB-4k5rA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		3 ARG A 369
PHE A 358
PRO A 359
 None
 0.78A 3zoaB-4kg7A:
undetectable		 3zoaB-4kg7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		3 ARG A 137
PHE A 138
PRO A 139
 None
 0.39A 3zoaB-4lisA:
2.6		 3zoaB-4lisA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 536
PHE A 537
PRO A 538
 None
 0.39A 3zoaB-4lxfA:
58.9		 3zoaB-4lxfA:
80.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		3 ARG A 362
PHE A 351
PRO A 352
 None
 0.81A 3zoaB-4m1zA:
undetectable		 3zoaB-4m1zA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		3 ARG A 126
PHE A 116
PRO A 117
 None
 0.72A 3zoaB-4mf4A:
4.2		 3zoaB-4mf4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		3 ARG A 339
PHE A 342
PRO A 343
 None
 0.51A 3zoaB-4o5pA:
undetectable		 3zoaB-4o5pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		3 ARG A 150
PHE A 235
PRO A 236
 DHB  A 401 (-2.8A)
DHB  A 401 (-4.5A)
None
 0.87A 3zoaB-4pafA:
undetectable		 3zoaB-4pafA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		3 ARG A 306
PHE A 115
PRO A 114
 None
 0.84A 3zoaB-4pddA:
undetectable		 3zoaB-4pddA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 3 ARG A 320
PHE A 323
PRO A 324
 None
 0.81A 3zoaB-4rxxA:
undetectable		 3zoaB-4rxxA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 ARG A 195
PHE A 169
PRO A 166
 None
 0.63A 3zoaB-4upiA:
undetectable		 3zoaB-4upiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		3 ARG A 159
PHE A 166
PRO A 167
 None
 0.70A 3zoaB-4x4jA:
undetectable		 3zoaB-4x4jA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbz EVDO1

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		3 ARG A 271
PHE A 277
PRO A 275
 None
 0.87A 3zoaB-4xbzA:
undetectable		 3zoaB-4xbzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		3 ARG A 114
PHE A   9
PRO A  10
 None
 0.73A 3zoaB-4ypwA:
undetectable		 3zoaB-4ypwA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 ARG A 434
PHE A 476
PRO A 477
 None
 0.81A 3zoaB-4zadA:
undetectable		 3zoaB-4zadA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 ARG 3 214
PHE 3 215
PRO 3 216
 None
 0.81A 3zoaB-5aca3:
undetectable		 3zoaB-5aca3:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		3 ARG X 167
PHE X 296
PRO X 298
 None
 0.87A 3zoaB-5evyX:
undetectable		 3zoaB-5evyX:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		3 ARG A 324
PHE A 350
PRO A 351
 None
 0.52A 3zoaB-5ftfA:
undetectable		 3zoaB-5ftfA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 ARG A  30
PHE A  31
PRO A  79
 None
 0.87A 3zoaB-5gu6A:
undetectable		 3zoaB-5gu6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		3 ARG A 321
PHE A 322
PRO A 323
 None
 0.26A 3zoaB-5gvvA:
undetectable		 3zoaB-5gvvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyq SPIKE GLYCOPROTEIN

(Rousettus bat
coronavirus
HKU9) 		PF09408
(Spike_rec_bind) 		3 ARG A 120
PHE A 121
PRO A 122
 None
 0.82A 3zoaB-5gyqA:
undetectable		 3zoaB-5gyqA:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 3 ARG A 512
PHE A 513
PRO A 514
 None
 0.11A 3zoaB-5h2tA:
62.4		 3zoaB-5h2tA:
71.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		3 ARG A 230
PHE A 177
PRO A 176
 None
 0.87A 3zoaB-5hsiA:
undetectable		 3zoaB-5hsiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isv RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00583
(Acetyltransf_1) 		3 ARG A 105
PHE A  25
PRO A  26
 None
 0.87A 3zoaB-5isvA:
undetectable		 3zoaB-5isvA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		3 ARG A  78
PHE A  79
PRO A  80
 None
 0.64A 3zoaB-5iuyA:
undetectable		 3zoaB-5iuyA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 3 ARG B 243
PHE B 244
PRO B 245
 None
 0.89A 3zoaB-5n5nB:
2.0		 3zoaB-5n5nB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ARG A1132
PHE A1133
PRO A1134
 None
 0.73A 3zoaB-5tuyA:
undetectable		 3zoaB-5tuyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uds LACTATE RACEMIZATION
OPERON PROTEIN LARE

(Lactobacillus
plantarum) 		PF02540
(NAD_synthase) 		3 ARG A 259
PHE A 258
PRO A 225
 PO4  A 503 (-2.9A)
None
None
 0.72A 3zoaB-5udsA:
undetectable		 3zoaB-5udsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ARG A1220
PHE A1221
PRO A1222
 None
 0.82A 3zoaB-5vsdA:
undetectable		 3zoaB-5vsdA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 3 ARG A 168
PHE A 178
PRO A 179
 None
 0.83A 3zoaB-5w1eA:
undetectable		 3zoaB-5w1eA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3x DISEASE RESISTANCE
PROTEIN RRS1

(Arabidopsis
thaliana) 		PF03106
(WRKY) 		3 ARG B1227
PHE B1228
PRO B1229
 None
 0.54A 3zoaB-5w3xB:
undetectable		 3zoaB-5w3xB:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 119
PHE A  13
PRO A  14
 None
 0.69A 3zoaB-5wyrA:
undetectable		 3zoaB-5wyrA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 3 ARG A 158
PHE A 165
PRO A 166
 CL  A 504 (-4.0A)
None
None
 0.85A 3zoaB-6brdA:
undetectable		 3zoaB-6brdA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 3 ARG A 158
PHE A 165
PRO A 166
 None
 0.75A 3zoaB-6c7sA:
undetectable		 3zoaB-6c7sA:
8.90