SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZOA_A_ACRA1587_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 TRP A 659
ASN A 536
TYR A 676
PHE A 669
TYR A 670
 None
 1.07A 3zoaA-1md7A:
0.0		 3zoaA-1md7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzx PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		no annotation 5 MET A 134
THR A 184
TYR A 182
PHE A 142
TYR A 126
 None
 1.45A 3zoaA-3fzxA:
0.1		 3zoaA-3fzxA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		6 TRP A 476
ASN A 479
MET A 480
THR A 555
PHE A 577
TYR A 578
 None
 0.83A 3zoaA-3zo9A:
64.5		 3zoaA-3zo9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		9 TRP A 476
MET A 480
GLU A 553
MET A 554
THR A 555
TYR A 557
PHE A 577
TYR A 578
TRP A 579
 None
 0.24A 3zoaA-3zo9A:
64.5		 3zoaA-3zo9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		6 MET A 488
GLU A 555
THR A 557
PHE A 579
TYR A 580
TRP A 581
 None
 0.34A 3zoaA-4lxfA:
57.7		 3zoaA-4lxfA:
80.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 6 TRP A 463
MET A 467
GLU A 531
PHE A 555
TYR A 556
TRP A 557
 None
 0.30A 3zoaA-5h2tA:
63.8		 3zoaA-5h2tA:
71.29