SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZNC_A_BZ1A500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42) 		5 GLN A 184
VAL A 256
PHE A 210
LEU A 288
THR A 287
 None
 1.45A 3zncA-1dmlA:
undetectable		 3zncA-1dmlA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.24A 3zncA-1jd0A:
32.7		 3zncA-1jd0A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 1.48A 3zncA-1jd0A:
32.7		 3zncA-1jd0A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
 0.93A 3zncA-1jd0A:
32.7		 3zncA-1jd0A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
 1.45A 3zncA-1jd0A:
32.7		 3zncA-1jd0A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 GLN A  69
HIS A  92
HIS A  94
HIS A 111
THR A 177
THR A 178
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 0.97A 3zncA-1kopA:
26.4		 3zncA-1kopA:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		9 GLN A  90
HIS A  92
HIS A  94
HIS A 111
VAL A 113
LEU A 176
THR A 177
THR A 178
TRP A 187
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 0.49A 3zncA-1kopA:
26.4		 3zncA-1kopA:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A 111
LEU A 176
THR A 177
THR A 178
TRP A 187
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 1.48A 3zncA-1kopA:
26.4		 3zncA-1kopA:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  67
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
 None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 0.94A 3zncA-1rj6A:
33.6		 3zncA-1rj6A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.37A 3zncA-1rj6A:
33.6		 3zncA-1rj6A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 601 (-3.3A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 1.48A 3zncA-1rj6A:
33.6		 3zncA-1rj6A:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		5 HIS A 256
VAL A 207
PHE A 270
LEU A 223
THR A 240
 None
 1.44A 3zncA-1umiA:
undetectable		 3zncA-1umiA:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  67
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
 1.15A 3zncA-1urtA:
29.2		 3zncA-1urtA:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
 0.46A 3zncA-1urtA:
29.2		 3zncA-1urtA:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 1.47A 3zncA-1urtA:
29.2		 3zncA-1urtA:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
 0.79A 3zncA-1urtA:
29.2		 3zncA-1urtA:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
 1.39A 3zncA-1urtA:
29.2		 3zncA-1urtA:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		9 GLN A 113
HIS A 115
HIS A 117
HIS A 135
VAL A 137
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.39A 3zncA-1y7wA:
23.3		 3zncA-1y7wA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e32 F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF00646
(F-box)
PF04300
(FBA) 		5 HIS A 256
VAL A 207
PHE A 270
LEU A 223
THR A 240
 None
 1.47A 3zncA-2e32A:
undetectable		 3zncA-2e32A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		5 HIS A   9
HIS A 154
HIS A   7
LEU A  94
THR A 122
 MN  A 402 (-3.5A)
MN  A 402 (-3.3A)
MN  A 402 (-3.3A)
None
None
 1.40A 3zncA-2f6kA:
undetectable		 3zncA-2f6kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		5 HIS A  88
PHE A 246
LEU A  98
THR A  95
THR A  94
 PO4  A 501 ( 4.9A)
None
None
None
None
 1.28A 3zncA-2hekA:
undetectable		 3zncA-2hekA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.45A 3zncA-2it4A:
30.5		 3zncA-2it4A:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		5 VAL A 544
PHE A 533
LEU A 270
THR A 267
THR A 266
 None
None
None
BME  A1621 (-3.6A)
BME  A1621 (-4.1A)
 1.25A 3zncA-2jlsA:
undetectable		 3zncA-2jlsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
 0.34A 3zncA-2w2jA:
32.1		 3zncA-2w2jA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		5 VAL A 544
PHE A 533
LEU A 270
THR A 267
THR A 266
 None
 1.18A 3zncA-2whxA:
undetectable		 3zncA-2whxA:
16.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
PHE A 141
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
None
None
ZN  A   1 ( 4.7A)
None
None
 0.40A 3zncA-2zncA:
43.5		 3zncA-2zncA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 141
LEU A 198
THR A 199
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
None
ZN  A   1 ( 4.7A)
 1.45A 3zncA-2zncA:
43.5		 3zncA-2zncA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 0.82A 3zncA-2zncA:
43.5		 3zncA-2zncA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
 1.38A 3zncA-2zncA:
43.5		 3zncA-2zncA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 115
HIS A 163
HIS A 165
HIS A 182
THR A 260
THR A 261
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
ZN  A 378 ( 4.5A)
None
 0.91A 3zncA-3b1bA:
23.2		 3zncA-3b1bA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		9 GLN A 161
HIS A 163
HIS A 165
HIS A 182
VAL A 184
LEU A 259
THR A 260
THR A 261
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
None
ZN  A 378 ( 4.5A)
None
None
 0.46A 3zncA-3b1bA:
23.2		 3zncA-3b1bA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 161
HIS A 163
HIS A 182
VAL A 184
PHE A 199
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.1A)
None
None
None
 0.83A 3zncA-3b1bA:
23.2		 3zncA-3b1bA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 165
HIS A  42
THR A 261
THR A 260
TRP A  40
 ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
 1.43A 3zncA-3b1bA:
23.2		 3zncA-3b1bA:
23.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  93
HIS A  95
HIS A  97
HIS A 120
VAL A 122
LEU A 199
THR A 200
TRP A 210
 4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.75A 3zncA-3da2A:
31.2		 3zncA-3da2A:
32.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		5 VAL A 197
PHE A  24
LEU A  20
THR A  73
THR A  74
 None
 1.42A 3zncA-3ddjA:
undetectable		 3zncA-3ddjA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhx METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Escherichia
coli) 		PF09383
(NIL) 		5 HIS A  88
VAL A  90
PHE A  28
LEU A  38
THR A  41
 None
None
None
IOD  A 263 ( 4.3A)
None
 1.48A 3zncA-3dhxA:
undetectable		 3zncA-3dhxA:
14.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A 109
HIS A 111
HIS A 113
HIS A 138
VAL A 140
LEU A 219
THR A 220
TRP A 230
 None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
 0.74A 3zncA-3fe4A:
30.5		 3zncA-3fe4A:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 111
HIS A 113
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
 1.20A 3zncA-3fe4A:
30.5		 3zncA-3fe4A:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 138
HIS A 113
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.2A)
MG  A 901 (-3.4A)
None
None
None
 1.47A 3zncA-3fe4A:
30.5		 3zncA-3fe4A:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 138
HIS A 126
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.2A)
None
None
None
None
 1.48A 3zncA-3fe4A:
30.5		 3zncA-3fe4A:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8r PUTATIVE PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIA COMPONENT

(Streptococcus
mutans) 		PF02255
(PTS_IIA) 		5 HIS A  82
PHE A  28
LEU A  89
THR A  86
THR A  85
 None
 1.46A 3zncA-3l8rA:
undetectable		 3zncA-3l8rA:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
 None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 0.95A 3zncA-3ml5A:
31.7		 3zncA-3ml5A:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.47A 3zncA-3ml5A:
31.7		 3zncA-3ml5A:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  94
VAL A 121
PHE A 131
THR A 200
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.5A)
 1.40A 3zncA-3ml5A:
31.7		 3zncA-3ml5A:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 GLN A 102
HIS A 123
HIS A 125
HIS A 142
THR A 215
THR A 216
 None
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
 0.96A 3zncA-3q31A:
23.9		 3zncA-3q31A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		9 GLN A 121
HIS A 123
HIS A 125
HIS A 142
VAL A 144
LEU A 214
THR A 215
THR A 216
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 3.2A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 0.53A 3zncA-3q31A:
23.9		 3zncA-3q31A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 HIS A 125
VAL A 154
LEU A 214
THR A 215
THR A 216
 ZN  A   1 (-3.3A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
 0.90A 3zncA-3q31A:
23.9		 3zncA-3q31A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 HIS A 142
HIS A 125
VAL A 154
LEU A 214
THR A 216
 ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 (-2.8A)
 1.35A 3zncA-3q31A:
23.9		 3zncA-3q31A:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
THR A 198
THR A 199
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
ZN  A 261 ( 4.4A)
None
None
 0.49A 3zncA-3uyqA:
31.6		 3zncA-3uyqA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  94
HIS A  96
VAL A 121
THR A 198
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
ZN  A 261 ( 4.4A)
 1.32A 3zncA-3uyqA:
31.6		 3zncA-3uyqA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		5 GLN C2229
HIS C2260
PHE C2206
LEU C2280
THR C2276
 None
 1.44A 3zncA-4bgdC:
undetectable		 3zncA-4bgdC:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  89
HIS A  91
HIS A 108
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 0.95A 3zncA-4g7aA:
27.8		 3zncA-4g7aA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		9 GLN A  87
HIS A  89
HIS A  91
HIS A 108
VAL A 110
LEU A 173
THR A 174
THR A 175
TRP A 184
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.45A 3zncA-4g7aA:
27.8		 3zncA-4g7aA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 175
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
 1.06A 3zncA-4g7aA:
27.8		 3zncA-4g7aA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 GLN A 310
HIS A 260
VAL A 263
PHE A 262
THR A 251
 None
 1.49A 3zncA-4jcmA:
undetectable		 3zncA-4jcmA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		5 HIS A 212
VAL A 191
PHE A 110
LEU A 148
THR A 146
 None
 1.34A 3zncA-4limA:
undetectable		 3zncA-4limA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
None
None
 0.42A 3zncA-4qk3A:
31.0		 3zncA-4qk3A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  92
HIS A  94
VAL A 121
PHE A 131
THR A 200
 None
ZN  A 301 (-3.2A)
None
None
None
 1.41A 3zncA-4qk3A:
31.0		 3zncA-4qk3A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A 119
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 301 ( 4.4A)
None
None
 1.49A 3zncA-4qk3A:
31.0		 3zncA-4qk3A:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		9 GLN A 110
HIS A 112
HIS A 114
HIS A 131
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.47A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.48A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
 ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
 1.10A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 HIS A 114
HIS A 131
LEU A 197
THR A 198
THR A 199
TRP A 208
 ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.49A 3zncA-4uovA:
27.7		 3zncA-4uovA:
31.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wkw UNCHARACTERIZED
PROTEIN

(Mycobacterium
leprae) 		PF01323
(DSBA) 		5 HIS A 157
PHE A  42
LEU A  13
THR A 155
TRP A  14
 None
 1.45A 3zncA-4wkwA:
undetectable		 3zncA-4wkwA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  89
HIS A  91
HIS A 108
THR A 174
THR A 175
 None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 0.93A 3zncA-4x5sA:
27.4		 3zncA-4x5sA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		9 GLN A  87
HIS A  89
HIS A  91
HIS A 108
VAL A 110
LEU A 173
THR A 174
THR A 175
TRP A 184
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.47A 3zncA-4x5sA:
27.4		 3zncA-4x5sA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 175
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
 1.05A 3zncA-4x5sA:
27.4		 3zncA-4x5sA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 HIS A 110
HIS A 112
HIS A 129
VAL A 131
LEU A 190
THR A 191
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.1A)
None
None
ZN  A 301 (-4.3A)
None
 0.53A 3zncA-4xfwA:
24.9		 3zncA-4xfwA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 GLN A 138
HIS A 160
HIS A 162
HIS A 179
LEU A 253
THR A 254
THR A 255
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
 0.91A 3zncA-4xixA:
25.4		 3zncA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		9 GLN A 158
HIS A 160
HIS A 162
HIS A 179
VAL A 181
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.1A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 0.48A 3zncA-4xixA:
25.4		 3zncA-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 GLN A 143
HIS A 165
HIS A 167
HIS A 184
THR A 252
THR A 253
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.02A 3zncA-4xz5A:
27.3		 3zncA-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		9 GLN A 163
HIS A 165
HIS A 167
HIS A 184
VAL A 186
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 0.46A 3zncA-4xz5A:
27.3		 3zncA-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 167
HIS A 184
LEU A 251
THR A 252
THR A 253
TRP A 262
 ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.47A 3zncA-4xz5A:
27.3		 3zncA-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 167
VAL A 196
LEU A 251
THR A 252
THR A 253
 ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 0.88A 3zncA-4xz5A:
27.3		 3zncA-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 184
HIS A 167
VAL A 196
LEU A 251
THR A 252
 ZN  A 401 ( 3.1A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
 1.44A 3zncA-4xz5A:
27.3		 3zncA-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
 GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 0.93A 3zncA-5cjfA:
33.5		 3zncA-5cjfA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 0.44A 3zncA-5cjfA:
33.5		 3zncA-5cjfA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 0.91A 3zncA-5cjfA:
33.5		 3zncA-5cjfA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
 1.47A 3zncA-5cjfA:
33.5		 3zncA-5cjfA:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 0.25A 3zncA-5e5uA:
32.4		 3zncA-5e5uA:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 1.33A 3zncA-5e5uA:
32.4		 3zncA-5e5uA:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		9 GLN X  91
HIS X  93
HIS X  95
HIS X 118
VAL X 120
LEU X 196
THR X 197
THR X 198
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 (-3.1A)
None
None
ZN  X 301 ( 4.4A)
None
None
 0.51A 3zncA-5eztX:
31.6		 3zncA-5eztX:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 GLN X  91
HIS X  93
VAL X 120
PHE X 129
THR X 198
 None
ZN  X 301 (-3.2A)
None
None
None
 1.41A 3zncA-5eztX:
31.6		 3zncA-5eztX:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 GLN X  91
HIS X 121
VAL X  90
PHE X 129
LEU X 139
 None
 1.15A 3zncA-5eztX:
31.6		 3zncA-5eztX:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 HIS X 118
HIS X  95
VAL X 141
LEU X 196
THR X 198
 ZN  X 301 (-3.1A)
ZN  X 301 (-3.2A)
None
None
None
 1.43A 3zncA-5eztX:
31.6		 3zncA-5eztX:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsz KINESIN-LIKE PROTEIN
KIF19

(Mus musculus) 		PF00225
(Kinesin) 		5 HIS A 221
VAL A 223
PHE A 247
LEU A 307
THR A 304
 None
 1.34A 3zncA-5gszA:
undetectable		 3zncA-5gszA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		9 GLN A  94
HIS A  96
HIS A  98
HIS A 115
VAL A 117
LEU A 181
THR A 182
THR A 183
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
None
None
 0.55A 3zncA-5hpjA:
26.7		 3zncA-5hpjA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A 115
HIS A  98
VAL A 127
LEU A 181
THR A 183
 ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
None
None
None
 1.44A 3zncA-5hpjA:
26.7		 3zncA-5hpjA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.45A 3zncA-5jn9A:
40.0		 3zncA-5jn9A:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
 1.49A 3zncA-5jn9A:
40.0		 3zncA-5jn9A:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 200
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
 1.12A 3zncA-5jn9A:
40.0		 3zncA-5jn9A:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5i HTPA REDUCTASE

(Selaginella
moellendorffii) 		no annotation 5 HIS A 244
HIS A 227
VAL A 167
LEU A 183
THR A 181
 None
 1.47A 3zncA-5u5iA:
undetectable		 3zncA-5u5iA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 5 GLN A 446
PHE A 442
LEU A 453
THR A 449
THR A 452
 None
 1.40A 3zncA-6co7A:
undetectable		 3zncA-6co7A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 9 GLN A 115
HIS A 117
HIS A 119
HIS A 136
VAL A 138
LEU A 201
THR A 202
THR A 203
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 (-4.4A)
None
None
 0.46A 3zncA-6ekiA:
26.1		 3zncA-6ekiA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 HIS A 119
HIS A 136
LEU A 201
THR A 202
THR A 203
TRP A 212
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
None
 1.47A 3zncA-6ekiA:
26.1		 3zncA-6ekiA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.46A 3zncA-6fe1A:
32.3		 3zncA-6fe1A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
 1.02A 3zncA-6fe1A:
32.3		 3zncA-6fe1A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
 1.40A 3zncA-6fe1A:
32.3		 3zncA-6fe1A:
16.33