SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZJQ_A_NCAA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		4 TYR A 268
VAL A 266
PHE A 361
ILE A 377
 None
 0.93A 3zjqA-1b0zA:
undetectable		 3zjqA-1b0zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		4 VAL A 125
PHE A 355
VAL A  66
ILE A 290
 None
 0.93A 3zjqA-1dhsA:
0.0		 3zjqA-1dhsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		4 VAL A 128
PHE A 130
PHE A  30
ILE A  25
 None
 0.97A 3zjqA-1dl5A:
0.0		 3zjqA-1dl5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 VAL A 321
VAL A 309
PHE A 363
ILE A 240
 None
 0.93A 3zjqA-1ea6A:
0.0		 3zjqA-1ea6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzd FIBRINOGEN-420

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 VAL A 707
VAL A 736
PHE A 723
ILE A 656
 None
 0.95A 3zjqA-1fzdA:
undetectable		 3zjqA-1fzdA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		4 VAL 1 272
PHE 1  41
PHE 1 408
ILE 1  66
 None
 0.96A 3zjqA-1gff1:
undetectable		 3zjqA-1gff1:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 VAL B 456
PHE B 535
VAL B 493
ILE B 388
 None
 0.98A 3zjqA-1gh6B:
0.0		 3zjqA-1gh6B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 VAL A  56
VAL A  26
PHE A  29
ILE A  63
 None
 0.90A 3zjqA-1jqgA:
0.0		 3zjqA-1jqgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		4 PHE A 138
VAL A 129
PHE A 127
ILE A 113
 None
 0.90A 3zjqA-1ktwA:
undetectable		 3zjqA-1ktwA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi8 DNAB INTEIN

(Synechocystis
sp. PCC 6803) 		PF14890
(Intein_splicing) 		4 VAL A  48
PHE A  28
PHE A 145
ILE A   2
 None
 0.90A 3zjqA-1mi8A:
undetectable		 3zjqA-1mi8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 TYR A 337
VAL A 340
VAL A 470
PHE A 472
 None
 0.90A 3zjqA-1np7A:
undetectable		 3zjqA-1np7A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK

(Shigella
flexneri) 		PF03519
(Invas_SpaK) 		4 VAL A 102
PHE A  81
PHE A 115
ILE A  45
 None
 0.88A 3zjqA-1ry9A:
undetectable		 3zjqA-1ry9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 VAL A 292
VAL A 236
PHE A 234
ILE A 267
 None
 0.94A 3zjqA-1vm7A:
0.0		 3zjqA-1vm7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		4 VAL A  74
VAL A  37
PHE A  56
ILE A  21
 None
 0.98A 3zjqA-1wnhA:
undetectable		 3zjqA-1wnhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Thermotoga
maritima) 		PF01513
(NAD_kinase) 		4 TYR A  81
VAL A  68
PHE A  98
ILE A  22
 None
 0.98A 3zjqA-1yt5A:
undetectable		 3zjqA-1yt5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		5 TRP A 377
VAL A 370
PHE A 399
VAL A 388
PHE A 386
 None
 1.44A 3zjqA-1yw1A:
0.0		 3zjqA-1yw1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens) 		PF06907
(Latexin) 		4 VAL B  74
VAL B  37
PHE B  56
ILE B  21
 None
 0.89A 3zjqA-2bo9B:
undetectable		 3zjqA-2bo9B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		4 PHE 1  41
VAL 1 410
PHE 1 408
ILE 1  30
 None
 0.92A 3zjqA-2bpa1:
undetectable		 3zjqA-2bpa1:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpd APOBEC-1 STIMULATING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A 262
PHE A 251
VAL A 298
ILE A 265
 None
 0.81A 3zjqA-2cpdA:
undetectable		 3zjqA-2cpdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		4 TYR A 155
VAL A 152
PHE A 108
ILE A  91
 GOL  A 202 (-4.4A)
GOL  A 202 (-4.5A)
None
None
 0.79A 3zjqA-2d5iA:
undetectable		 3zjqA-2d5iA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0q THIOREDOXIN

(Sulfurisphaera
tokodaii) 		PF00085
(Thioredoxin) 		4 VAL A 109
VAL A  37
PHE A  86
ILE A 134
 None
 0.90A 3zjqA-2e0qA:
undetectable		 3zjqA-2e0qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		4 PHE A 120
VAL A 114
PHE A 112
ILE A  69
 None
 0.90A 3zjqA-2fbvA:
undetectable		 3zjqA-2fbvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE

(coryneform
bacterium) 		PF14832
(Tautomerase_3) 		4 VAL A   7
PHE A  43
VAL A  41
ILE A 100
 None
 0.97A 3zjqA-2flzA:
undetectable		 3zjqA-2flzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqp HYPOTHETICAL PROTEIN
BP2299

(Bordetella
pertussis) 		PF07883
(Cupin_2) 		4 TRP A  22
TYR A  39
VAL A  41
VAL A  74
 None
ACT  A 101 (-4.4A)
None
None
 0.96A 3zjqA-2fqpA:
undetectable		 3zjqA-2fqpA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 TYR A  34
VAL A   7
PHE A  47
ILE A  29
 None
 0.94A 3zjqA-2gz3A:
undetectable		 3zjqA-2gz3A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 PHE A 280
VAL A 295
PHE A 308
ILE A 388
 None
 0.98A 3zjqA-2hjhA:
undetectable		 3zjqA-2hjhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		4 VAL A 114
PHE A  92
PHE A  52
ILE A 108
 None
 0.97A 3zjqA-2hlsA:
undetectable		 3zjqA-2hlsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 VAL A  12
PHE A 106
VAL A  34
ILE A  22
 None
 0.94A 3zjqA-2jssA:
undetectable		 3zjqA-2jssA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kie INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF16726
(OCRL_clath_bd) 		4 VAL A 116
PHE A  67
VAL A  91
ILE A 103
 None
 0.93A 3zjqA-2kieA:
undetectable		 3zjqA-2kieA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kj8 PUTATIVE PROPHAGE
CPS-53 INTEGRASE

(Escherichia
coli) 		PF14659
(Phage_int_SAM_3) 		4 VAL A  58
PHE A  34
VAL A  81
PHE A  82
 None
 0.97A 3zjqA-2kj8A:
undetectable		 3zjqA-2kj8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwy BACTERIAL
INTEIN-LIKE DOMAIN

(Ruminiclostridium
thermocellum) 		PF07591
(PT-HINT) 		4 VAL A  99
VAL A  78
PHE A  70
ILE A  62
 None
 0.88A 3zjqA-2lwyA:
undetectable		 3zjqA-2lwyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5r GLUTAMYL-TRNA
SYNTHETASE 1

(Thermotoga
maritima) 		PF00749
(tRNA-synt_1c) 		4 VAL A 405
VAL A 419
PHE A 416
ILE A 451
 None
 0.95A 3zjqA-2o5rA:
undetectable		 3zjqA-2o5rA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2od4 HYPOTHETICAL PROTEIN

(uncultured
marine organism) 		no annotation 4 TYR A  58
VAL A  13
VAL A  38
ILE A  10
 EDO  A 103 ( 4.9A)
None
None
None
 0.98A 3zjqA-2od4A:
undetectable		 3zjqA-2od4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqt HYPOTHETICAL PROTEIN
SPY0176

(Streptococcus
pyogenes) 		PF00359
(PTS_EIIA_2) 		5 TYR A  58
VAL A  59
PHE A  91
VAL A  26
ILE A 119
 None
 1.43A 3zjqA-2oqtA:
undetectable		 3zjqA-2oqtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnm PROTEASE VP4

(Infectious
pancreatic
necrosis virus) 		PF01768
(Birna_VP4) 		4 TYR A 605
VAL A 589
PHE A 582
VAL A 642
 None
 0.94A 3zjqA-2pnmA:
undetectable		 3zjqA-2pnmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A  25
VAL A  56
PHE A  53
ILE A 128
 None
 0.95A 3zjqA-2pokA:
undetectable		 3zjqA-2pokA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 873
VAL A 827
PHE A 830
ILE A 842
 None
 0.96A 3zjqA-2qepA:
undetectable		 3zjqA-2qepA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 TYR A 358
VAL A 412
PHE A 410
ILE A 378
 None
 0.82A 3zjqA-2vpqA:
undetectable		 3zjqA-2vpqA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 VAL A 491
PHE A 470
VAL A 438
ILE A 480
 None
 0.95A 3zjqA-2wsuA:
undetectable		 3zjqA-2wsuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 VAL B 342
PHE B 354
VAL B 307
ILE B 184
 None
 0.98A 3zjqA-2xsjB:
undetectable		 3zjqA-2xsjB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 VAL A 533
VAL A 428
PHE A 497
ILE A 529
 None
 0.94A 3zjqA-2zciA:
undetectable		 3zjqA-2zciA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale) 		PF08282
(Hydrolase_3) 		4 TRP A  88
PHE A 166
VAL A  95
ILE A 147
 None
 0.87A 3zjqA-3daoA:
undetectable		 3zjqA-3daoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A 148
VAL A 152
VAL A   5
ILE A 252
 None
 0.88A 3zjqA-3gb4A:
undetectable		 3zjqA-3gb4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		4 VAL A 275
VAL A 324
PHE A 281
ILE A 298
 None
 0.95A 3zjqA-3hyvA:
undetectable		 3zjqA-3hyvA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		4 VAL A  32
PHE A  27
VAL A 395
ILE A  20
 None
 0.95A 3zjqA-3ik2A:
undetectable		 3zjqA-3ik2A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j6d PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		4 TRP A 206
VAL A 210
VAL A 186
PHE A 184
 None
 0.80A 3zjqA-3j6dA:
undetectable		 3zjqA-3j6dA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis;
Francisella
tularensis) 		PF05591
(T6SS_VipA)
PF05943
(VipB) 		4 VAL B 188
PHE B 146
VAL A  35
ILE B 243
 None
 0.99A 3zjqA-3j9oB:
undetectable		 3zjqA-3j9oB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lag UNCHARACTERIZED
PROTEIN RPA4178

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		4 TRP A  21
TYR A  38
VAL A  40
VAL A  74
 None
FMT  A 100 (-4.4A)
None
None
 0.97A 3zjqA-3lagA:
undetectable		 3zjqA-3lagA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 TYR A 114
VAL A 117
PHE A 133
ILE A  66
 None
 0.92A 3zjqA-3pt1A:
undetectable		 3zjqA-3pt1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TYR A 538
VAL A 541
PHE A 378
VAL A 512
 None
 0.90A 3zjqA-3v98A:
undetectable		 3zjqA-3v98A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 TRP A  43
PHE A 113
VAL A  27
PHE A  24
 None
 0.95A 3zjqA-3wfoA:
1.6		 3zjqA-3wfoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 TRP A  43
PHE A 113
VAL A  27
PHE A  24
 None
 0.91A 3zjqA-3wfpA:
undetectable		 3zjqA-3wfpA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 VAL A1115
PHE A1113
PHE A  22
ILE A  40
 None
 0.92A 3zjqA-3zgxA:
undetectable		 3zjqA-3zgxA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zh0 PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		6 TYR A  61
VAL A  64
PHE A  74
VAL A  89
PHE A  93
ILE A 149
 FMT  A 201 (-4.2A)
None
HEM  A 200 (-3.6A)
HEM  A 200 (-4.4A)
FMT  A 201 ( 4.3A)
HEM  A 200 (-4.3A)
 0.63A 3zjqA-3zh0A:
29.3		 3zjqA-3zh0A:
90.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zjl PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		6 TYR A  61
VAL A  64
PHE A  74
VAL A  89
PHE A  93
ILE A 149
 CYN  A 201 (-4.5A)
None
HEM  A 200 (-3.5A)
HEM  A 200 (-4.5A)
CYN  A 201 ( 4.5A)
HEM  A 200 ( 4.6A)
 0.71A 3zjqA-3zjlA:
34.0		 3zjqA-3zjlA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 TYR A 247
VAL A 243
VAL A 187
ILE A 288
 None
 0.98A 3zjqA-4a69A:
undetectable		 3zjqA-4a69A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 VAL A  85
PHE A  55
VAL A  67
ILE A 137
 None
 0.95A 3zjqA-4b97A:
undetectable		 3zjqA-4b97A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 VAL A 208
PHE A 206
VAL A 195
PHE A 275
ILE A 263
 None
 1.47A 3zjqA-4bfrA:
undetectable		 3zjqA-4bfrA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c79 SMOOTHENED

(Danio rerio) 		PF01392
(Fz) 		4 TYR A 108
VAL A 107
PHE A 144
ILE A 100
 None
 0.95A 3zjqA-4c79A:
undetectable		 3zjqA-4c79A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 TYR A 474
VAL A 664
PHE A 470
PHE A 491
ILE A 649
 None
 1.14A 3zjqA-4ccdA:
undetectable		 3zjqA-4ccdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chj IMC SUB-COMPARTMENT
PROTEIN ISP3

(Toxoplasma
gondii) 		no annotation 4 PHE A 131
VAL A 116
PHE A 118
ILE A  85
 None
 0.88A 3zjqA-4chjA:
undetectable		 3zjqA-4chjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		4 VAL A  58
PHE A 131
VAL A 119
ILE A  88
 None
 0.94A 3zjqA-4eiuA:
undetectable		 3zjqA-4eiuA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 VAL A 102
PHE A  81
VAL A  79
ILE A 247
 None
 0.99A 3zjqA-4eq9A:
undetectable		 3zjqA-4eq9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ese FMN-DEPENDENT
NADH-AZOREDUCTASE

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		4 TYR A 156
VAL A 153
PHE A 109
ILE A  92
 IMD  A 306 ( 4.3A)
IMD  A 306 ( 4.8A)
None
None
 0.80A 3zjqA-4eseA:
undetectable		 3zjqA-4eseA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		4 PHE A 337
VAL A 322
PHE A 301
ILE A 285
 None
None
None
EDO  A 510 (-4.6A)
 0.96A 3zjqA-4h09A:
undetectable		 3zjqA-4h09A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 VAL A 438
PHE A 657
VAL A 419
PHE A 420
ILE A 427
 None
 1.14A 3zjqA-4h1gA:
undetectable		 3zjqA-4h1gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		4 VAL A 283
VAL A 246
PHE A 241
ILE A 317
 MLY  A 310 ( 4.7A)
MLY  A 312 ( 4.2A)
None
None
 0.92A 3zjqA-4h3wA:
undetectable		 3zjqA-4h3wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hci CUPREDOXIN 1

(Bacillus
anthracis) 		PF13473
(Cupredoxin_1) 		4 VAL A 102
VAL A  90
PHE A  81
ILE A  59
 None
 0.92A 3zjqA-4hciA:
undetectable		 3zjqA-4hciA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he5 PEPTIDASE FAMILY U32

(Geobacillus
thermoleovorans) 		PF16325
(Peptidase_U32_C) 		4 VAL A 345
PHE A 371
VAL A 369
PHE A 363
 None
 0.97A 3zjqA-4he5A:
undetectable		 3zjqA-4he5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		4 VAL A 200
PHE A  90
VAL A 102
ILE A 132
 None
 0.94A 3zjqA-4ho4A:
undetectable		 3zjqA-4ho4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 PHE A 280
VAL A 295
PHE A 308
ILE A 388
 None
 0.90A 3zjqA-4iaoA:
undetectable		 3zjqA-4iaoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		4 TYR A 285
VAL A 255
VAL A 312
ILE A 271
 None
None
AMP  A 402 (-4.1A)
None
 0.94A 3zjqA-4ijnA:
undetectable		 3zjqA-4ijnA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C)
PF00125
(Histone) 		4 VAL D  47
PHE C  26
VAL D  69
ILE D  57
 None
 0.87A 3zjqA-4jjnD:
undetectable		 3zjqA-4jjnD:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF14262
(Cthe_2159) 		4 VAL A  99
PHE A  43
VAL A  63
ILE A 119
 None
 0.97A 3zjqA-4phbA:
undetectable		 3zjqA-4phbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pia AUTOLYSIN E

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase) 		4 TYR A 130
VAL A 126
PHE A 161
ILE A 190
 None
 0.90A 3zjqA-4piaA:
undetectable		 3zjqA-4piaA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		4 VAL A 358
PHE A 295
VAL A 381
ILE A  24
 None
 0.84A 3zjqA-4wxbA:
undetectable		 3zjqA-4wxbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Rattus
norvegicus) 		PF00083
(Sugar_tr) 		5 TYR A  33
PHE A  29
VAL A 175
PHE A 179
ILE A 193
 None
 1.46A 3zjqA-4ybqA:
undetectable		 3zjqA-4ybqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		4 VAL A 154
PHE A 207
VAL A 174
ILE A 168
 None
 0.91A 3zjqA-4ymgA:
undetectable		 3zjqA-4ymgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 VAL E 607
VAL E 702
PHE E 699
ILE E 662
 None
 0.97A 3zjqA-5c4gE:
undetectable		 3zjqA-5c4gE:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcp FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 VAL A1786
PHE A1747
VAL A1832
ILE A1807
 None
 0.82A 3zjqA-5dcpA:
undetectable		 3zjqA-5dcpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcp FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 VAL A1832
PHE A1814
VAL A1764
ILE A1751
 None
 0.86A 3zjqA-5dcpA:
undetectable		 3zjqA-5dcpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 TRP A 294
PHE A 275
VAL A 301
ILE A 318
 None
 0.99A 3zjqA-5gjvA:
undetectable		 3zjqA-5gjvA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		5 TYR B1161
VAL A  29
VAL A  23
PHE A  22
ILE A  44
 None
 1.34A 3zjqA-5h67B:
undetectable		 3zjqA-5h67B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02616
(SMC_ScpA) 		4 PHE C 237
VAL A  23
PHE A  22
ILE A  40
 None
 0.89A 3zjqA-5h67C:
undetectable		 3zjqA-5h67C:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 TYR A 292
VAL A 335
PHE A 214
ILE A 223
 None
 0.92A 3zjqA-5imyA:
undetectable		 3zjqA-5imyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6y ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		PF07691
(PA14) 		4 PHE A 162
VAL A 107
PHE A 105
ILE A 117
 None
 0.78A 3zjqA-5j6yA:
undetectable		 3zjqA-5j6yA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6y ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		PF07691
(PA14) 		4 VAL A 125
VAL A 161
PHE A 162
ILE A 115
 None
 0.88A 3zjqA-5j6yA:
undetectable		 3zjqA-5j6yA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		4 VAL A 528
PHE A 591
VAL A 443
ILE A 548
 None
 0.96A 3zjqA-5j7uA:
undetectable		 3zjqA-5j7uA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		4 TYR A 153
VAL A 151
PHE A 181
PHE A  82
 None
None
None
KCX  A  83 ( 4.9A)
 0.95A 3zjqA-5kzhA:
undetectable		 3zjqA-5kzhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		4 TYR A 130
VAL A 129
PHE A 166
ILE A 122
 None
 0.97A 3zjqA-5l7dA:
undetectable		 3zjqA-5l7dA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 4 TRP A 283
VAL A 210
PHE A 212
ILE A 276
 None
 0.82A 3zjqA-5oceA:
undetectable		 3zjqA-5oceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vey HISTONE H2B TYPE
1-J,HISTONE H2A TYPE
1-B/E

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 VAL A  20
PHE A 114
VAL A  42
ILE A  30
 None
 0.98A 3zjqA-5veyA:
undetectable		 3zjqA-5veyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		4 TYR A 155
VAL A 158
PHE A 186
VAL A 181
 None
 0.56A 3zjqA-5vmbA:
undetectable		 3zjqA-5vmbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 TYR A 940
VAL A 959
PHE A 953
ILE A 946
 None
 0.85A 3zjqA-5xvmA:
undetectable		 3zjqA-5xvmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 4 PHE A 289
VAL A 229
PHE A 228
ILE A 201
 None
 0.61A 3zjqA-5y4gA:
undetectable		 3zjqA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygk -

(-) 		no annotation 4 VAL A  45
PHE A 115
PHE A  36
ILE A 162
 None
 0.85A 3zjqA-5ygkA:
undetectable		 3zjqA-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1

(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		no annotation 4 VAL A 272
PHE A 218
VAL A 214
ILE A 286
 None
 0.99A 3zjqA-6ap1A:
undetectable		 3zjqA-6ap1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 4 TYR A 103
VAL A 102
PHE A 139
ILE A  95
 None
 0.95A 3zjqA-6d35A:
undetectable		 3zjqA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 4 VAL G 239
PHE G 200
VAL G 202
ILE G 218
 None
 0.94A 3zjqA-6d6qG:
undetectable		 3zjqA-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 4 VAL A 622
VAL A 717
PHE A 714
ILE A 677
 None
 0.85A 3zjqA-6gl3A:
undetectable		 3zjqA-6gl3A:
undetectable