SIMILAR PATTERNS OF AMINO ACIDS FOR 3ZBF_A_VGHA3000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
None
0.46A 3zbfA-1k9aA:
32.6
3zbfA-1k9aA:
28.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
5 ALA A 606
MET A 657
GLY A 660
ASP A 661
LEU A 731
None
0.30A 3zbfA-1lufA:
33.4
3zbfA-1lufA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
5 ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
None
0.48A 3zbfA-1u5qA:
25.6
3zbfA-1u5qA:
32.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 111
LEU A 143
MET A 162
GLY A 165
LEU A 212
None
0.46A 3zbfA-2ac5A:
20.1
3zbfA-2ac5A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  47
LEU A  78
LEU A  98
GLY A 104
LEU A 155
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
0.53A 3zbfA-2bujA:
25.2
3zbfA-2bujA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  47
LEU A  78
LEU A  98
LEU A 155
ASP A 166
STU  A1301 (-3.6A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.8A)
None
0.57A 3zbfA-2bujA:
25.2
3zbfA-2bujA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA X  37
MET X  85
GLY X  88
LEU X 137
ASP X 148
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
0.52A 3zbfA-2dq7X:
32.2
3zbfA-2dq7X:
39.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
6 ALA A  40
LEU A  95
MET A  96
ASP A  99
LEU A 144
ASP A 155
ADP  A 500 ( 3.7A)
ADP  A 500 ( 4.9A)
None
ADP  A 500 (-3.5A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 2.9A)
0.62A 3zbfA-2f9gA:
17.0
3zbfA-2f9gA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
5 ALA A  55
GLY A 110
LEU A 158
GLY A 168
ASP A 169
STU  A 400 (-3.2A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
None
STU  A 400 (-3.6A)
0.52A 3zbfA-2gcdA:
21.4
3zbfA-2gcdA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
0.68A 3zbfA-2h8hA:
29.1
3zbfA-2h8hA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
0.51A 3zbfA-2hckA:
29.1
3zbfA-2hckA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 251
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
0.54A 3zbfA-2hk5A:
26.1
3zbfA-2hk5A:
38.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
5 ALA A 452
LEU A 501
LEU A 553
GLY A 563
ASP A 564
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
0.45A 3zbfA-2j0jA:
33.2
3zbfA-2j0jA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 614
GLY A 669
ASP A 670
LEU A 785
GLY A 795
None
0.51A 3zbfA-2ogvA:
29.9
3zbfA-2ogvA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus)
PF00069
(Pkinase)
6 ALA A  46
LEU A 105
MET A 106
GLY A 109
LEU A 156
ASP A 167
ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
0.58A 3zbfA-2phkA:
24.3
3zbfA-2phkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus)
PF00069
(Pkinase)
6 LEU A  25
ALA A  46
LEU A 105
GLY A 109
LEU A 156
ASP A 167
ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
0.73A 3zbfA-2phkA:
24.3
3zbfA-2phkA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
0.47A 3zbfA-2pmiA:
23.2
3zbfA-2pmiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE


(Plasmodium
falciparum)
PF00069
(Pkinase)
5 ALA X  53
LEU X 101
MET X 120
LEU X 179
ASP X 190
HMD  X 400 (-3.5A)
HMD  X 400 (-4.2A)
None
HMD  X 400 (-4.7A)
HMD  X 400 (-3.7A)
0.38A 3zbfA-2pmoX:
18.5
3zbfA-2pmoX:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
0.42A 3zbfA-2qobA:
34.7
3zbfA-2qobA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ALA A 705
MET A 756
GLY A 759
THR A 763
LEU A 807
ASP A 818
None
0.41A 3zbfA-2r2pA:
29.4
3zbfA-2r2pA:
38.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 724
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
0.68A 3zbfA-2r4bA:
29.6
3zbfA-2r4bA:
38.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
6 ALA A 247
LEU A 301
LEU A 303
MET A 304
GLY A 307
LEU A 354
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
0.57A 3zbfA-2xk9A:
22.8
3zbfA-2xk9A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 226
ALA A 247
LEU A 301
LEU A 303
GLY A 307
LEU A 354
XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
0.72A 3zbfA-2xk9A:
22.8
3zbfA-2xk9A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  51
LEU A 109
MET A 110
GLY A 113
LEU A 160
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
0.33A 3zbfA-2y7jA:
25.6
3zbfA-2y7jA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  92
GLY A 147
ASP A 148
THR A 151
LEU A 194
ASP A 205
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
0.77A 3zbfA-2z7rA:
19.4
3zbfA-2z7rA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  68
ALA A  92
GLY A 147
ASP A 148
THR A 151
ASP A 205
STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
None
STU  A   1 ( 3.8A)
0.96A 3zbfA-2z7rA:
19.4
3zbfA-2z7rA:
26.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A1002
ALA A1028
LEU A1078
MET A1079
GLY A1082
ASP A1083
GLY A1149
ASP A1150
S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
S91  A   1 (-4.7A)
None
S91  A   1 (-3.3A)
S91  A   1 (-3.7A)
None
None
0.52A 3zbfA-2z8cA:
23.8
3zbfA-2z8cA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 LEU A 253
ALA A 273
MET A 322
GLY A 325
LEU A 374
ASP A 385
None
0.50A 3zbfA-2zv7A:
33.1
3zbfA-2zv7A:
38.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  19
ALA A  40
LEU A  93
LEU A  95
ASP A 161
4RB  A 401 ( 3.9A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 4.1A)
4RB  A 401 (-4.4A)
GOL  A 503 ( 3.1A)
0.42A 3zbfA-3bqrA:
23.3
3zbfA-3bqrA:
25.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A1108
LEU A1140
LEU A1157
MET A1160
GLY A1163
ASP A1164
CKK  A1500 (-3.2A)
CKK  A1500 (-4.8A)
CKK  A1500 (-4.7A)
None
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.7A)
0.53A 3zbfA-3c1xA:
30.6
3zbfA-3c1xA:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 220
MET A 269
GLY A 272
LEU A 321
ASP A 332
None
0.46A 3zbfA-3d7uA:
27.2
3zbfA-3d7uA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 455
LEU A 504
GLY A 508
LEU A 556
GLY A 566
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
None
0.52A 3zbfA-3fzpA:
25.8
3zbfA-3fzpA:
39.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 ALA A 665
MET A 716
GLY A 719
THR A 723
LEU A 767
ASP A 778
None
None
GOL  A 403 (-3.4A)
None
None
None
0.58A 3zbfA-3kulA:
35.0
3zbfA-3kulA:
38.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
5 ALA A 700
LEU A 745
LEU A 747
LEU A 804
ASP A 828
ADP  A2101 (-3.5A)
ADP  A2101 ( 4.4A)
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
0.47A 3zbfA-3lj0A:
24.3
3zbfA-3lj0A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A1031
LEU A1081
MET A1082
GLY A1085
ASP A1086
GLY A1152
None
None
None
None
None
CCX  A   1 (-3.6A)
0.39A 3zbfA-3lw0A:
30.6
3zbfA-3lw0A:
44.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A1005
ALA A1031
LEU A1081
MET A1082
GLY A1085
ASP A1086
None
0.40A 3zbfA-3lw0A:
30.6
3zbfA-3lw0A:
44.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
8 ALA A 213
LEU A 263
LEU A 265
MET A 266
GLY A 269
ASP A 270
LEU A 318
ASP A 329
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
0.61A 3zbfA-3nyoA:
23.8
3zbfA-3nyoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
8 LEU A 192
ALA A 213
LEU A 263
LEU A 265
MET A 266
GLY A 269
LEU A 318
ASP A 329
AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
0.68A 3zbfA-3nyoA:
23.8
3zbfA-3nyoA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A1112
LEU A1144
LEU A1161
MET A1164
GLY A1167
ASP A1168
ANP  A1358 ( 3.8A)
None
ANP  A1358 ( 4.1A)
None
None
ANP  A1358 (-4.1A)
0.51A 3zbfA-3plsA:
29.2
3zbfA-3plsA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 751
LEU A 800
MET A 801
GLY A 804
LEU A 852
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
0.41A 3zbfA-3pp0A:
31.7
3zbfA-3pp0A:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 800
MET A 801
GLY A 804
LEU A 852
ASP A 863
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
0.52A 3zbfA-3pp0A:
31.7
3zbfA-3pp0A:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 LEU A 295
ALA A 315
LEU A 347
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.71A 3zbfA-3ulzA:
23.4
3zbfA-3ulzA:
26.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 544
ALA A 570
GLY A 623
ASP A 624
GLY A 696
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.3A)
0.57A 3zbfA-3v5qA:
25.3
3zbfA-3v5qA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 544
ALA A 570
MET A 620
GLY A 623
ASP A 624
LEU A 686
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
0.52A 3zbfA-3v5qA:
25.3
3zbfA-3v5qA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 649
MET A 700
GLY A 703
LEU A 751
ASP A 762
None
0.39A 3zbfA-3zfxA:
35.6
3zbfA-3zfxA:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  59
ALA A  80
LEU A 130
LEU A 132
GLY A 193
ASP A 194
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
0.45A 3zbfA-4a4lA:
20.8
3zbfA-4a4lA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1


(Babesia
divergens)
PF02430
(AMA-1)
6 LEU A 167
MET A 278
GLY A 148
THR A 272
LEU A 147
GLY A 166
None
None
None
None
GOL  A1520 (-4.5A)
None
1.37A 3zbfA-4apmA:
undetectable
3zbfA-4apmA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 586
MET A 636
GLY A 639
ASP A 640
LEU A 699
ASP A 710
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
0.40A 3zbfA-4at3A:
31.6
3zbfA-4at3A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 560
ALA A 586
GLY A 639
ASP A 640
GLY A 709
ASP A 710
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-3.4A)
None
0.66A 3zbfA-4at3A:
31.6
3zbfA-4at3A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 560
ALA A 586
GLY A 639
ASP A 640
LEU A 699
ASP A 710
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
0.66A 3zbfA-4at3A:
31.6
3zbfA-4at3A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
0.38A 3zbfA-4aw5A:
28.9
3zbfA-4aw5A:
37.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  68
ALA A  89
LEU A 139
LEU A 141
GLY A 202
ASP A 203
9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
9ZP  A1333 (-3.8A)
9ZP  A1333 (-4.7A)
9ZP  A1333 ( 4.4A)
None
0.62A 3zbfA-4b6lA:
25.5
3zbfA-4b6lA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  82
LEU A 137
LEU A 139
MET A 140
ASP A 143
LEU A 189
GLY A 199
R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
0.74A 3zbfA-4b99A:
23.2
3zbfA-4b99A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A 137
LEU A 139
MET A 140
ASP A 143
LEU A 189
GLY A 199
ASP A 200
R4L  A1394 (-3.9A)
R4L  A1394 ( 4.9A)
None
R4L  A1394 ( 4.2A)
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
0.73A 3zbfA-4b99A:
23.2
3zbfA-4b99A:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 ALA A 588
LEU A 638
GLY A 642
ASP A 643
THR A 646
LEU A 690
ASP A 701
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
0.59A 3zbfA-4e93A:
35.0
3zbfA-4e93A:
35.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 515
ALA A 541
MET A 591
GLY A 594
ASP A 595
LEU A 656
GLY A 666
ASP A 667
None
0.54A 3zbfA-4f0iA:
31.7
3zbfA-4f0iA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 377
ALA A 400
GLY A 454
LEU A 501
ASP A 512
0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
0.43A 3zbfA-4f4pA:
27.8
3zbfA-4f4pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 LEU A 514
ALA A 538
MET A 596
GLY A 599
ASP A 600
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 (-4.5A)
0.93A 3zbfA-4feqA:
29.3
3zbfA-4feqA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 LEU A1122
ALA A1148
LEU A1196
LEU A1198
MET A1199
GLY A1202
ASP A1203
LEU A1256
GLY A1269
ASP A1270
0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
0.52A 3zbfA-4fodA:
25.7
3zbfA-4fodA:
46.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A  50
LEU A 102
GLY A 106
ASP A 107
LEU A 153
ASP A 164
STU  A 401 (-3.2A)
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-3.3A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
0.66A 3zbfA-4fr4A:
22.4
3zbfA-4fr4A:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 ALA A 880
GLY A 935
LEU A 983
GLY A 993
ASP A 994
IZA  A2001 (-3.4A)
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.5A)
0.41A 3zbfA-4gl9A:
30.4
3zbfA-4gl9A:
33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14604
(SH3_9)
6 LEU A 132
ALA A 156
LEU A 207
GLY A 211
LEU A 259
GLY A 269
None
0.58A 3zbfA-4hzsA:
28.6
3zbfA-4hzsA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  88
ALA A 109
LEU A 159
GLY A 222
ASP A 223
1C7  A 401 ( 4.4A)
1C7  A 401 (-3.2A)
1C7  A 401 (-4.0A)
None
None
0.56A 3zbfA-4i6fA:
24.4
3zbfA-4i6fA:
25.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 132
ALA A 156
LEU A 207
GLY A 211
LEU A 259
GLY A 269
ASP A 270
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
None
0.74A 3zbfA-4id7A:
32.4
3zbfA-4id7A:
38.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio)
PF00069
(Pkinase)
5 LEU A  45
ALA A  66
LEU A 116
GLY A 179
ASP A 180
None
0.56A 3zbfA-4j7bA:
24.8
3zbfA-4j7bA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN


(Toxoplasma
gondii)
PF14531
(Kinase-like)
6 LEU A 258
ALA A 279
ASP A 362
LEU A 416
GLY A 426
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
0.56A 3zbfA-4jrnA:
21.1
3zbfA-4jrnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  39
LEU A  73
LEU A  89
GLY A  95
LEU A 143
631  A 301 (-3.3A)
None
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
0.40A 3zbfA-4jxfA:
19.9
3zbfA-4jxfA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0.49A 3zbfA-4k11A:
29.1
3zbfA-4k11A:
29.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
5 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
0.41A 3zbfA-4lggA:
29.7
3zbfA-4lggA:
41.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS)
5 ALA A 218
LEU A 271
LEU A 273
MET A 274
ASP A 335
29X  A 702 (-3.1A)
29X  A 702 ( 4.7A)
29X  A 702 (-4.6A)
None
29X  A 702 (-4.4A)
0.48A 3zbfA-4mk0A:
23.5
3zbfA-4mk0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 928
GLY A 984
LEU A1030
GLY A1040
ASP A1041
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
0.53A 3zbfA-4oliA:
28.4
3zbfA-4oliA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  69
LEU A 124
MET A 125
ASP A 128
LEU A 173
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.8A)
None
EDO  A 413 (-2.9A)
38Z  A 418 (-4.4A)
0.55A 3zbfA-4qtbA:
23.3
3zbfA-4qtbA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
6 LEU A  14
ALA A  35
MET A  84
GLY A  87
LEU A 136
ASP A 147
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
0.51A 3zbfA-4ueuA:
33.3
3zbfA-4ueuA:
41.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus)
PF00069
(Pkinase)
PF00615
(RGS)
7 LEU A 193
ALA A 214
MET A 267
GLY A 270
ASP A 271
LEU A 321
ASP A 332
ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
None
0.79A 3zbfA-4wboA:
24.4
3zbfA-4wboA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 5 LEU B 267
ALA B 288
MET B 337
GLY B 340
LEU B 389
1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
0.30A 3zbfA-4xeyB:
32.7
3zbfA-4xeyB:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 616
ALA A 642
GLY A 697
ASP A 698
LEU A 818
P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
0.45A 3zbfA-4xufA:
30.5
3zbfA-4xufA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  82
LEU A 137
LEU A 139
MET A 140
ASP A 143
LEU A 189
GLY A 199
None
0.88A 3zbfA-4zslA:
22.6
3zbfA-4zslA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
6 ALA A  90
LEU A 146
MET A 147
ASP A 150
LEU A 196
ASP A 207
None
0.66A 3zbfA-5ci6A:
16.2
3zbfA-5ci6A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 275
LEU A 305
GLY A 331
LEU A 386
ASP A 397
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
STU  A 601 (-3.0A)
0.52A 3zbfA-5e8yA:
15.1
3zbfA-5e8yA:
26.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A1108
LEU A1140
LEU A1157
MET A1160
GLY A1163
ASP A1164
63K  A1401 (-3.5A)
None
63K  A1401 (-4.2A)
None
63K  A1401 (-3.6A)
63K  A1401 (-4.0A)
0.42A 3zbfA-5horA:
28.0
3zbfA-5horA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A1108
LEU A1140
MET A1160
GLY A1163
ASP A1164
ASP A1222
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.6A)
63K  A1401 (-4.0A)
None
0.50A 3zbfA-5horA:
28.0
3zbfA-5horA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 718
ALA A 743
LEU A 792
MET A 793
GLY A 796
LEU A 844
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
0.42A 3zbfA-5j9zA:
32.9
3zbfA-5j9zA:
33.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 417
LEU A 467
GLY A 471
ASP A 472
LEU A 518
GLY A 532
ASP A 533
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
0.65A 3zbfA-5jznA:
24.4
3zbfA-5jznA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 209
ALA A 228
LEU A 263
GLY A 289
LEU A 338
None
6UY  A 501 (-3.4A)
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
0.38A 3zbfA-5ko1A:
28.2
3zbfA-5ko1A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.48A 3zbfA-5lpyA:
24.5
3zbfA-5lpyA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
0.40A 3zbfA-5lpzA:
24.5
3zbfA-5lpzA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 593
ALA A 617
LEU A 671
MET A 674
GLY A 677
ASP A 678
THR A 681
ASP A 741
7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.7A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 ( 4.8A)
None
7AE  A1000 (-4.4A)
0.61A 3zbfA-5td2A:
30.4
3zbfA-5td2A:
40.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 542
ALA A 565
LEU A 620
MET A 623
GLY A 626
ASP A 627
ASP A 690
7YS  A9001 (-4.1A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.2A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.5A)
None
0.63A 3zbfA-5u6bA:
26.3
3zbfA-5u6bA:
38.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 ALA A 119
MET A 172
GLY A 175
ASP A 176
LEU A 221
ASP A 232
None
0.68A 3zbfA-5u7qA:
21.2
3zbfA-5u7qA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
6 ALA A 218
LEU A 271
LEU A 273
MET A 274
ASP A 278
ASP A 335
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
0.74A 3zbfA-5uuuA:
23.4
3zbfA-5uuuA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
6 ALA A 218
LEU A 273
MET A 274
ASP A 278
LEU A 324
ASP A 335
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
QRW  A 601 (-3.7A)
0.85A 3zbfA-5uuuA:
23.4
3zbfA-5uuuA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 5 ALA A  45
LEU A  79
MET A  98
GLY A 101
LEU A 153
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
0.50A 3zbfA-5w5jA:
24.1
3zbfA-5w5jA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4


(Mus musculus)
no annotation 6 ALA A  49
LEU A  82
MET A  99
GLY A 102
LEU A 150
ASP A 161
VX6  A 402 (-3.2A)
VX6  A 402 ( 4.8A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
0.52A 3zbfA-5wnmA:
29.0
3zbfA-5wnmA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 5 LEU A 891
ALA A 917
LEU A 947
GLY A 969
LEU A1017
ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
0.57A 3zbfA-5wnoA:
28.2
3zbfA-5wnoA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
no annotation 5 ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
0.31A 3zbfA-6c7yA:
29.8
3zbfA-6c7yA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1


(Homo sapiens)
no annotation 5 ALA A 155
LEU A 232
GLY A 236
LEU A 282
ASP A 293
H1N  A 501 (-3.4A)
H1N  A 501 (-4.3A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
H1N  A 501 (-3.5A)
0.43A 3zbfA-6ccfA:
12.9
3zbfA-6ccfA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 5 ALA A 192
LEU A 269
GLY A 273
LEU A 319
ASP A 330
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
0.50A 3zbfA-6cmjA:
24.2
3zbfA-6cmjA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 7 ALA A 217
LEU A 248
LEU A 266
MET A 267
GLY A 270
LEU A 319
GLY A 329
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
0.56A 3zbfA-6cz4A:
22.1
3zbfA-6cz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 6 LEU A 197
ALA A 217
LEU A 248
GLY A 270
LEU A 319
GLY A 329
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
0.78A 3zbfA-6cz4A:
22.1
3zbfA-6cz4A:
13.46