SIMILAR PATTERNS OF AMINO ACIDS FOR 3WZE_A_BAXA1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)

(Escherichia
coli) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 VAL A 244
VAL A 245
ILE A 216
ASP A 219
 None
 0.61A 3wzeA-1b0aA:
undetectable		 3wzeA-1b0aA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 189
LEU A 187
ILE A 128
ASP A 141
 None
 0.72A 3wzeA-1d6hA:
undetectable		 3wzeA-1d6hA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 110
LEU A 188
CYH A 199
ASP A 200
 None
 0.68A 3wzeA-1gngA:
20.8		 3wzeA-1gngA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 638
LEU A 731
ILE A 740
ASP A 742
 None
 0.59A 3wzeA-1lufA:
29.3		 3wzeA-1lufA:
34.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		4 VAL A 113
VAL A 114
LEU A 118
ASP A 139
 None
 0.68A 3wzeA-1lxyA:
undetectable		 3wzeA-1lxyA:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
ASP A 829
 None
 0.66A 3wzeA-1rjbA:
40.1		 3wzeA-1rjbA:
48.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 675
ILE A 827
CYH A 828
ASP A 829
PHE A 830
 None
 0.83A 3wzeA-1rjbA:
40.1		 3wzeA-1rjbA:
48.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		4 VAL A  21
CYH A 129
ILE A 188
PHE A  13
 None
 0.67A 3wzeA-1sawA:
undetectable		 3wzeA-1sawA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 654
CYH A 673
LEU A 799
ILE A 808
CYH A 809
ASP A 810
PHE A 811
 STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
None
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.41A 3wzeA-1t46A:
43.5		 3wzeA-1t46A:
53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 VAL A 157
ILE A 132
ASP A 134
PHE A 135
 None
None
MG  A1000 (-2.0A)
None
 0.67A 3wzeA-1w0hA:
undetectable		 3wzeA-1w0hA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbh 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T)
PF02037
(SAP) 		4 VAL A 157
ILE A 132
ASP A 134
PHE A 135
 None
None
MG  A1000 (-2.5A)
None
 0.59A 3wzeA-1zbhA:
undetectable		 3wzeA-1zbhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		5 VAL A 157
VAL A 156
ILE A 132
ASP A 134
PHE A 135
 None
None
None
MG  A1001 (-2.6A)
None
 1.19A 3wzeA-1zbuA:
undetectable		 3wzeA-1zbuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  67
VAL A  68
CYH A  87
LEU A 137
ILE A 146
 None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
None
 0.49A 3wzeA-1zltA:
20.7		 3wzeA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  67
VAL A  68
ILE A 146
ASP A 148
 None
HYM  A 400 (-4.8A)
None
HYM  A 400 (-3.9A)
 0.49A 3wzeA-1zltA:
20.7		 3wzeA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 142
LEU A 212
ILE A 224
CYH A 225
 None
 0.64A 3wzeA-2ac5A:
19.5		 3wzeA-2ac5A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ege UNCHARACTERIZED
PROTEIN KIAA1666

(Homo sapiens) 		PF07653
(SH3_2) 		4 VAL A  38
VAL A  39
LEU A  33
ILE A  11
 None
 0.66A 3wzeA-2egeA:
undetectable		 3wzeA-2egeA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		5 VAL A 189
VAL A 348
LEU A 373
ILE A 190
PHE A  70
 None
 1.50A 3wzeA-2gqfA:
undetectable		 3wzeA-2gqfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 177
ILE A 189
CYH A 190
ASP A 191
PHE A 192
 None
 1.06A 3wzeA-2hw6A:
11.6		 3wzeA-2hw6A:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 299
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 0.43A 3wzeA-2hz0A:
32.2		 3wzeA-2hz0A:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 301
LEU A 371
ASP A 382
PHE A 383
 None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.64A 3wzeA-2og8A:
31.2		 3wzeA-2og8A:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 301
LEU A 371
ILE A 380
ASP A 382
 None
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.3A)
 0.21A 3wzeA-2og8A:
31.2		 3wzeA-2og8A:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 647
CYH A 666
LEU A 785
ILE A 794
ASP A 796
 None
 0.63A 3wzeA-2ogvA:
39.6		 3wzeA-2ogvA:
50.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		4 VAL A  90
LEU A  88
ILE A  86
PHE A  77
 None
 0.67A 3wzeA-2p0oA:
undetectable		 3wzeA-2p0oA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 VAL A  80
VAL A  79
CYH A  76
ILE A 138
ASP A 157
 None
 1.44A 3wzeA-2vreA:
undetectable		 3wzeA-2vreA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL C 110
CYH C 132
LEU C 183
ILE C 192
 None
ANP  C   2 (-4.5A)
None
None
 0.28A 3wzeA-2wtkC:
21.8		 3wzeA-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 359
VAL A 360
CYH A 379
ILE A 461
 None
770  A 901 ( 4.7A)
770  A 901 (-3.9A)
None
 0.46A 3wzeA-2z2wA:
23.4		 3wzeA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 359
VAL A 360
ILE A 461
ASP A 463
 None
770  A 901 ( 4.7A)
None
770  A 901 (-3.8A)
 0.42A 3wzeA-2z2wA:
23.4		 3wzeA-2z2wA:
27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1059
VAL A1060
ILE A1148
ASP A1150
 None
 0.60A 3wzeA-2z8cA:
30.4		 3wzeA-2z8cA:
36.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE

(Desulfovibrio
alaskensis) 		PF09837
(DUF2064) 		5 VAL A 106
VAL A 105
ILE A   6
CYH A   5
ASP A  52
 None
 1.17A 3wzeA-3cgxA:
undetectable		 3wzeA-3cgxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		4 VAL A  37
ILE A  13
ASP A  15
PHE A  16
 None
None
MN  A 300 (-2.5A)
None
 0.65A 3wzeA-3cm5A:
undetectable		 3wzeA-3cm5A:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 694
VAL A 695
LEU A 765
ASP A 776
PHE A 777
 None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.42A 3wzeA-3dkoA:
32.6		 3wzeA-3dkoA:
33.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		4 VAL A  77
LEU A 158
CYH A 169
ASP A 170
 None
 0.70A 3wzeA-3e3pA:
19.1		 3wzeA-3e3pA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		5 VAL A 183
VAL A 184
CYH A 256
LEU A 241
ASP A 113
 None
None
None
None
ATP  A 407 ( 3.3A)
 1.45A 3wzeA-3fhxA:
undetectable		 3wzeA-3fhxA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3s GCN5-RELATED
N-ACETYLTRANSFERASE

(Streptococcus
suis) 		PF12746
(GNAT_acetyltran) 		5 VAL A 171
VAL A 170
CYH A 136
ILE A 164
ASP A 124
 None
 1.26A 3wzeA-3g3sA:
undetectable		 3wzeA-3g3sA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 891
VAL A 892
CYH A 912
LEU A1029
ILE A1038
CYH A1039
ASP A1040
PHE A1041
 None
8ST  A2001 ( 4.7A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
None
8ST  A2001 ( 3.7A)
 0.54A 3wzeA-3hngA:
43.3		 3wzeA-3hngA:
67.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 728
CYH A 748
LEU A 804
ILE A 826
 None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
None
 0.37A 3wzeA-3lj0A:
22.1		 3wzeA-3lj0A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
VAL A  79
CYH A 106
LEU A 156
 None
 0.27A 3wzeA-3mi9A:
2.7		 3wzeA-3mi9A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 246
VAL A 247
ILE A 327
ASP A 329
 None
None
None
AMP  A 577 (-4.0A)
 0.55A 3wzeA-3nyoA:
21.4		 3wzeA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 246
VAL A 247
LEU A 318
ILE A 327
 None
None
AMP  A 577 (-4.8A)
None
 0.64A 3wzeA-3nyoA:
21.4		 3wzeA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piw TYPE I INTERFERON 2

(Danio rerio) 		PF00143
(Interferon) 		4 VAL A 144
VAL A 145
LEU A 149
PHE A 125
 None
 0.60A 3wzeA-3piwA:
undetectable		 3wzeA-3piwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		4 VAL A  73
VAL A  74
CYH A  99
ILE A 164
 None
 0.64A 3wzeA-3qa8A:
17.4		 3wzeA-3qa8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 VAL A 114
VAL A 115
LEU A 188
CYH A 198
ASP A 199
 None
 0.78A 3wzeA-3rp9A:
19.2		 3wzeA-3rp9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		4 VAL A   8
ILE A  54
CYH A  55
ASP A  56
 None
 0.66A 3wzeA-3sy8A:
undetectable		 3wzeA-3sy8A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		4 VAL A 444
VAL A 445
CYH A 457
LEU A 449
 None
 0.64A 3wzeA-3tr5A:
undetectable		 3wzeA-3tr5A:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 601
LEU A 686
ILE A 695
ASP A 697
 None
0F4  A 902 (-4.5A)
0F4  A 902 (-4.6A)
None
 0.54A 3wzeA-3v5qA:
33.5		 3wzeA-3v5qA:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 898
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
ASP A1046
 None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-4.8A)
None
None
None
 0.51A 3wzeA-3vidA:
40.0		 3wzeA-3vidA:
85.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 189
LEU A 187
ILE A 128
ASP A 141
 VAL  A 189 ( 0.6A)
LEU  A 187 ( 0.5A)
ILE  A 128 ( 0.7A)
ASP  A 141 ( 0.6A)
 0.70A 3wzeA-3wd7A:
undetectable		 3wzeA-3wd7A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 898
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
 None
None
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
None
GOL  A1210 ( 3.3A)
 0.39A 3wzeA-3wzdA:
38.9		 3wzeA-3wzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  63
LEU A 132
CYH A 142
ASP A 143
 38R  A 350 ( 4.9A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
NA  A 353 ( 2.5A)
 0.62A 3wzeA-3zduA:
22.2		 3wzeA-3zduA:
27.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 536
VAL A 537
LEU A 622
ILE A 631
 None
 0.43A 3wzeA-3zzwA:
31.7		 3wzeA-3zzwA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 113
VAL A 114
CYH A 133
ILE A 192
 None
None
939  A1331 (-4.0A)
None
 0.48A 3wzeA-4a4lA:
16.6		 3wzeA-4a4lA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 113
VAL A 114
ILE A 192
ASP A 194
 None
None
None
939  A1331 (-3.1A)
 0.55A 3wzeA-4a4lA:
16.6		 3wzeA-4a4lA:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 898
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
ASP A1046
PHE A1047
 None
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
None
B49  A2000 ( 4.1A)
None
B49  A2000 (-4.0A)
 0.49A 3wzeA-4agdA:
44.7		 3wzeA-4agdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  64
CYH A  83
LEU A 133
CYH A 143
ASP A 144
 None
D15  A 500 (-4.3A)
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
D15  A 500 (-3.7A)
 0.62A 3wzeA-4aguA:
22.9		 3wzeA-4aguA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  64
LEU A 133
CYH A 143
ASP A 144
 TC0  A 500 (-4.7A)
TC0  A 500 (-4.3A)
TC0  A 500 ( 3.9A)
TC0  A 500 (-4.8A)
 0.68A 3wzeA-4bbmA:
21.0		 3wzeA-4bbmA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 VAL A  55
VAL A  54
ILE A  31
CYH A  30
ASP A 103
 None
 1.09A 3wzeA-4dqxA:
undetectable		 3wzeA-4dqxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  73
VAL A  74
ILE A 164
ASP A 166
 None
 0.55A 3wzeA-4e3cA:
17.9		 3wzeA-4e3cA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbv MYXOBACTERIAL
HEMAGGLUTININ

(Myxococcus
xanthus) 		no annotation 5 VAL A 235
VAL A 234
LEU A 237
ILE A 253
PHE A 262
 None
 0.98A 3wzeA-4fbvA:
undetectable		 3wzeA-4fbvA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 VAL A  99
VAL A 100
CYH A 119
ILE A 178
 None
 0.40A 3wzeA-4j7bA:
22.6		 3wzeA-4j7bA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 VAL A  99
VAL A 100
ILE A 178
ASP A 180
 None
 0.36A 3wzeA-4j7bA:
22.6		 3wzeA-4j7bA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  90
LEU A 163
ILE A 173
CYH A 174
ASP A 175
 None
1UL  A 501 (-4.3A)
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.2A)
 0.78A 3wzeA-4l52A:
19.7		 3wzeA-4l52A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  82
VAL A  83
CYH A 102
LEU A 153
 None
GOL  A 403 (-4.1A)
GOL  A 403 (-4.0A)
GOL  A 403 ( 4.4A)
 0.60A 3wzeA-4lg4A:
17.4		 3wzeA-4lg4A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 VAL A 415
VAL A 416
CYH A 435
LEU A 489
 None
 0.58A 3wzeA-4o1oA:
16.8		 3wzeA-4o1oA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  99
CYH A 126
LEU A 180
CYH A 190
ASP A 191
 None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
None
 0.94A 3wzeA-4o38A:
20.4		 3wzeA-4o38A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 LEU A 156
ILE A 165
CYH A 166
ASP A 167
 ANP  A 402 (-4.6A)
None
ANP  A 402 ( 4.3A)
ANP  A 402 ( 2.6A)
 0.71A 3wzeA-4qnyA:
21.8		 3wzeA-4qnyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 100
LEU A 173
ILE A 182
CYH A 183
ASP A 184
 None
38Z  A 418 (-4.4A)
None
38Z  A 418 ( 3.8A)
38Z  A 418 (-3.5A)
 0.62A 3wzeA-4qtbA:
21.5		 3wzeA-4qtbA:
26.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
ASP A 829
PHE A 830
 None
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.9A)
 0.42A 3wzeA-4rt7A:
32.1		 3wzeA-4rt7A:
40.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 246
VAL A 247
LEU A 318
ILE A 327
 None
None
SGV  A 601 (-4.9A)
None
 0.69A 3wzeA-4tnbA:
16.8		 3wzeA-4tnbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  92
CYH A 111
LEU A 162
ASP A 173
 None
6UI  A 700 (-4.2A)
6UI  A 700 (-4.2A)
None
 0.54A 3wzeA-4usfA:
18.0		 3wzeA-4usfA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 104
CYH A 129
LEU A 183
CYH A 193
ASP A 194
 None
KSA  A 405 (-4.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
ZN  A 403 ( 2.6A)
 0.68A 3wzeA-4wsqA:
22.9		 3wzeA-4wsqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhf NA-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NQRC

(Shewanella
oneidensis) 		PF04205
(FMN_bind) 		4 VAL A 166
VAL A 167
ASP A 182
PHE A 179
 None
 0.69A 3wzeA-4xhfA:
undetectable		 3wzeA-4xhfA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
ASP A 829
PHE A 830
 None
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
P30  A1001 (-4.8A)
None
P30  A1001 ( 4.1A)
 0.34A 3wzeA-4xufA:
39.2		 3wzeA-4xufA:
52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 247
VAL A 248
ILE A 328
ASP A 330
 None
None
None
AN2  A 601 (-3.0A)
 0.51A 3wzeA-4yhjA:
20.4		 3wzeA-4yhjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 247
VAL A 248
LEU A 319
ILE A 328
 None
 0.51A 3wzeA-4yhjA:
20.4		 3wzeA-4yhjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 625
CYH A 645
LEU A 695
ILE A 709
 NA  A1001 (-4.9A)
None
None
None
 0.30A 3wzeA-4z7gA:
20.2		 3wzeA-4z7gA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A 123
LEU A 196
ILE A 205
CYH A 206
 None
 0.27A 3wzeA-5ci6A:
20.4		 3wzeA-5ci6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  76
CYH A  95
LEU A 145
ILE A 163
 None
51W  A 401 (-3.9A)
51W  A 401 (-4.5A)
None
 0.53A 3wzeA-5ci7A:
23.6		 3wzeA-5ci7A:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL A 133
VAL A 134
LEU A 211
ILE A 220
 None
 0.66A 3wzeA-5dbxA:
20.1		 3wzeA-5dbxA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE

(Legionella
pneumophila) 		PF00156
(Pribosyltran) 		5 VAL A 103
VAL A 104
LEU A  56
ILE A  46
CYH A  47
 None
 1.40A 3wzeA-5esxA:
undetectable		 3wzeA-5esxA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 658
CYH A 677
LEU A 825
ILE A 834
CYH A 835
ASP A 836
PHE A 837
 748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-4.5A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.39A 3wzeA-5grnA:
33.2		 3wzeA-5grnA:
49.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 133
VAL A 134
LEU A 215
ASP A 226
 None
 0.69A 3wzeA-5gz8A:
18.5		 3wzeA-5gz8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  75
VAL A  76
LEU A 145
ILE A 154
ASP A 156
 65U  A 301 ( 4.3A)
65U  A 301 (-4.7A)
None
65U  A 301 (-4.1A)
65U  A 301 (-4.7A)
 0.62A 3wzeA-5hx6A:
22.5		 3wzeA-5hx6A:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 109
CYH A 133
LEU A 187
CYH A 197
ASP A 198
 None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.0A)
 0.63A 3wzeA-5i3oA:
22.7		 3wzeA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
LEU A 158
ILE A 171
ASP A 173
 None
6A7  A 401 (-4.8A)
None
FMT  A 403 ( 3.3A)
 0.70A 3wzeA-5idnA:
13.1		 3wzeA-5idnA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  98
ILE A 184
CYH A 185
ASP A 186
 None
 0.68A 3wzeA-5j0aA:
2.4		 3wzeA-5j0aA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL B 722
VAL B 723
ILE B 801
ASP B 803
 None
None
None
6U7  B1001 (-4.6A)
 0.61A 3wzeA-5kkrB:
19.6		 3wzeA-5kkrB:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 156
VAL A 157
LEU A 232
ILE A 539
 None
DMS  A 717 (-4.3A)
None
None
 0.54A 3wzeA-5myvA:
19.9		 3wzeA-5myvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 4 VAL A 527
LEU A 599
ILE A 611
ASP A 613
 None
 0.62A 3wzeA-5o0yA:
20.6		 3wzeA-5o0yA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		4 CYH A 114
LEU A 121
ILE A  95
PHE A 100
 None
 0.60A 3wzeA-5uibA:
undetectable		 3wzeA-5uibA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 272
VAL A 273
ILE A 378
ASP A 380
 PO4  A 503 (-4.6A)
8X7  A 501 ( 4.6A)
None
8X7  A 501 (-4.8A)
 0.36A 3wzeA-5vdkA:
22.5		 3wzeA-5vdkA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 VAL A 738
LEU A 810
ILE A 820
ASP A 822
 9E1  A1001 (-4.1A)
9E1  A1001 (-4.5A)
None
9E1  A1001 (-3.6A)
 0.66A 3wzeA-5vilA:
18.6		 3wzeA-5vilA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 4 VAL A 184
LEU A 182
ILE A 123
ASP A 136
 None
 0.70A 3wzeA-5w8qA:
undetectable		 3wzeA-5w8qA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 195
LEU A 193
ILE A 134
ASP A 147
 None
 0.62A 3wzeA-5wx4A:
undetectable		 3wzeA-5wx4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		4 VAL A 397
VAL A 398
LEU A  39
ILE A  48
 None
 0.69A 3wzeA-5wyaA:
undetectable		 3wzeA-5wyaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 VAL A 124
VAL A 125
LEU A 206
ILE A 215
 None
None
ANP  A1000 (-4.5A)
None
 0.63A 3wzeA-5xd6A:
22.7		 3wzeA-5xd6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 VAL A  82
VAL A  83
CYH A 102
LEU A 153
 None
None
ANP  A 501 (-4.2A)
ANP  A 501 (-4.6A)
 0.59A 3wzeA-6ao5A:
21.5		 3wzeA-6ao5A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 VAL A 248
VAL A 249
LEU A 319
ILE A 328
ASP A 330
 None
None
BI9  A 501 (-4.7A)
None
None
 0.61A 3wzeA-6bqlA:
22.1		 3wzeA-6bqlA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 VAL A 211
VAL A 212
LEU A 282
ILE A 291
ASP A 293
 None
H1N  A 501 (-4.9A)
H1N  A 501 (-4.8A)
None
H1N  A 501 (-3.5A)
 0.71A 3wzeA-6ccfA:
22.3		 3wzeA-6ccfA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 VAL A 248
VAL A 249
LEU A 319
ILE A 328
 None
None
F6J  A 501 (-4.5A)
None
 0.51A 3wzeA-6cmjA:
22.3		 3wzeA-6cmjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 VAL A 189
LEU A 187
ILE A 128
ASP A 141
 None
 0.70A 3wzeA-6co0A:
undetectable		 3wzeA-6co0A:
13.11