SIMILAR PATTERNS OF AMINO ACIDS FOR 3WZE_A_BAXA1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
LYS A  56
GLU A  74
LEU A  78
PHE A 111
HIS A 151
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
None
ANP  A 400 ( 4.3A)
None
 0.58A 3wzeA-1cm8A:
20.8		 3wzeA-1cm8A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
LYS A 222
GLU A 236
GLY A 272
LEU A 305
HIS A 312
 None
 0.62A 3wzeA-1k9aA:
31.9		 3wzeA-1k9aA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
VAL A 275
ALA A 288
GLU A 305
PHE A 336
GLY A 340
LEU A 373
HIS A 380
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
None
 0.44A 3wzeA-1opkA:
30.3		 3wzeA-1opkA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
PHE A 336
GLY A 340
HIS A 380
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
 0.54A 3wzeA-1opkA:
30.3		 3wzeA-1opkA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 219
ALA A 230
LYS A 232
GLU A 245
GLY A 286
LEU A 316
HIS A 331
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.6A)
None
None
 0.64A 3wzeA-1py5A:
25.7		 3wzeA-1py5A:
27.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 802
HIS A 809
 None
 0.60A 3wzeA-1rjbA:
40.1		 3wzeA-1rjbA:
48.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
LEU A 644
GLY A 676
LEU A 783
HIS A 790
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.5A)
 0.53A 3wzeA-1t46A:
43.5		 3wzeA-1t46A:
53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
LEU A 452
HIS A 459
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
None
None
 0.57A 3wzeA-1u59A:
31.1		 3wzeA-1u59A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 110
LEU A 142
HIS A 149
 None
 0.68A 3wzeA-1u5qA:
23.4		 3wzeA-1u5qA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 121
HIS A 128
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
None
 0.62A 3wzeA-1zltA:
20.7		 3wzeA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
None
GOL  A3001 (-3.5A)
None
None
None
None
None
 0.58A 3wzeA-2a2aA:
22.4		 3wzeA-2a2aA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
ALA A 184
LYS A 186
GLU A 201
LEU A 205
LEU A 274
HIS A 281
 None
 0.59A 3wzeA-2eu9A:
22.0		 3wzeA-2eu9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 205
HIS A 281
 None
 0.57A 3wzeA-2eu9A:
22.0		 3wzeA-2eu9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  59
LEU A  63
HIS A 135
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
 0.68A 3wzeA-2f9gA:
6.4		 3wzeA-2f9gA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
LYS A  42
GLU A  59
LEU A  63
LEU A 128
HIS A 135
 ADP  A 500 (-4.3A)
ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
None
None
 0.69A 3wzeA-2f9gA:
6.4		 3wzeA-2f9gA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  76
LEU A  80
GLY A 110
LEU A 142
HIS A 149
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
None
STU  A 400 (-3.4A)
None
None
 0.68A 3wzeA-2gcdA:
24.2		 3wzeA-2gcdA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
VAL A  63
ALA A  76
LEU A  98
GLY A 130
LEU A 161
HIS A 168
 None
 0.67A 3wzeA-2hw6A:
11.6		 3wzeA-2hw6A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
VAL A  63
ALA A  76
LYS A  78
LEU A  98
GLY A 130
HIS A 168
 None
 0.63A 3wzeA-2hw6A:
11.6		 3wzeA-2hw6A:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
ILE A 293
PHE A 317
GLY A 321
LEU A 354
HIS A 361
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.3A)
None
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
 0.79A 3wzeA-2hz0A:
32.2		 3wzeA-2hz0A:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLU A 633
GLY A 669
LEU A 769
HIS A 776
 None
 0.63A 3wzeA-2ogvA:
39.6		 3wzeA-2ogvA:
50.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
VAL A  33
ALA A  46
LYS A  48
LEU A  77
GLY A 109
HIS A 147
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
 0.51A 3wzeA-2phkA:
22.4		 3wzeA-2phkA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
VAL A 495
ALA A 515
GLU A 534
ILE A 541
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 None
 0.65A 3wzeA-2psqA:
34.9		 3wzeA-2psqA:
48.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
 0.65A 3wzeA-2w4kA:
22.4		 3wzeA-2w4kA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  71
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
None
 0.88A 3wzeA-2w4kA:
22.4		 3wzeA-2w4kA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
None
None
 0.51A 3wzeA-2xikA:
18.5		 3wzeA-2xikA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
None
None
 0.59A 3wzeA-2yabA:
22.4		 3wzeA-2yabA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  68
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
 0.48A 3wzeA-2yabA:
22.4		 3wzeA-2yabA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
LYS A  42
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
None
None
None
 0.72A 3wzeA-2yabA:
22.4		 3wzeA-2yabA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LYS A  94
PHE A 143
GLY A 147
LEU A 178
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
None
 0.47A 3wzeA-2z7rA:
21.6		 3wzeA-2z7rA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
VAL A1010
ALA A1028
GLU A1047
GLY A1082
LEU A1123
HIS A1130
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-3.3A)
None
None
 0.70A 3wzeA-2z8cA:
30.4		 3wzeA-2z8cA:
36.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
GLU A 534
ILE A 541
VAL A 564
LEU A 617
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
None
 0.57A 3wzeA-3b2tA:
25.5		 3wzeA-3b2tA:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ALA A 515
ILE A 541
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
None
 0.53A 3wzeA-3b2tA:
25.5		 3wzeA-3b2tA:
53.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  71
HIS A 137
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
None
None
 0.61A 3wzeA-3bqrA:
20.2		 3wzeA-3bqrA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  71
LEU A 130
HIS A 137
 4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
None
None
None
 0.65A 3wzeA-3bqrA:
20.2		 3wzeA-3bqrA:
27.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
ALA A 512
GLU A 531
ILE A 538
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 4.8A)
None
None
None
 0.74A 3wzeA-3c4fA:
33.8		 3wzeA-3c4fA:
55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
LYS A 222
GLU A 236
GLY A 272
LEU A 305
HIS A 312
 None
 0.62A 3wzeA-3d7uA:
26.1		 3wzeA-3d7uA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
ILE A 885
VAL A 909
GLY A 915
LEU A1013
HIS A1020
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
None
8ST  A2001 (-4.1A)
None
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.64A 3wzeA-3hngA:
43.3		 3wzeA-3hngA:
67.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
VAL A 689
ALA A 700
LYS A 702
LEU A 719
LEU A 788
HIS A 795
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
 0.66A 3wzeA-3lj0A:
22.1		 3wzeA-3lj0A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
ALA A  60
LEU A  84
GLY A 116
LEU A 149
HIS A 156
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
None
None
None
 0.55A 3wzeA-3lm5A:
23.8		 3wzeA-3lm5A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
LEU A 157
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
 0.58A 3wzeA-3mvjA:
14.0		 3wzeA-3mvjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
GLY A 165
LEU A 196
HIS A 203
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
None
 0.62A 3wzeA-3nuuA:
23.2		 3wzeA-3nuuA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
GLY A 269
LEU A 302
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
 0.64A 3wzeA-3nyoA:
21.4		 3wzeA-3nyoA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
VAL A 734
ALA A 751
LYS A 753
GLY A 804
LEU A 836
HIS A 843
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 ( 3.9A)
None
None
 0.63A 3wzeA-3pp0A:
29.9		 3wzeA-3pp0A:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
LYS A  86
LEU A 119
PHE A 146
LEU A 181
HIS A 188
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
None
 0.51A 3wzeA-3q5iA:
20.0		 3wzeA-3q5iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
LYS A  86
LEU A 119
PHE A 146
GLY A 150
LEU A 181
HIS A 188
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
None
None
 0.68A 3wzeA-3q5iA:
20.0		 3wzeA-3q5iA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
ALA A 512
GLU A 531
ILE A 538
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
None
None
 0.59A 3wzeA-3tt0A:
34.6		 3wzeA-3tt0A:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
ILE A 538
VAL A 561
LEU A 614
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
None
 0.65A 3wzeA-3tt0A:
34.6		 3wzeA-3tt0A:
46.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
PHE A 435
LEU A 470
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
None
 0.67A 3wzeA-3txoA:
13.6		 3wzeA-3txoA:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
None
 0.54A 3wzeA-3vidA:
40.0		 3wzeA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
None
4TT  A2001 (-4.5A)
 0.47A 3wzeA-3vidA:
40.0		 3wzeA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
None
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
None
None
 0.58A 3wzeA-3wzdA:
38.9		 3wzeA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.57A 3wzeA-3wzdA:
38.9		 3wzeA-3wzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
PHE A  81
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
None
 0.68A 3wzeA-3zduA:
22.2		 3wzeA-3zduA:
27.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
None
 0.57A 3wzeA-4agdA:
44.7		 3wzeA-4agdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
LEU A  85
PHE A 112
GLY A 116
HIS A 155
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
None
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
None
 0.64A 3wzeA-4bc6A:
13.8		 3wzeA-4bc6A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
LYS A 269
LEU A 292
GLY A 324
HIS A 362
 None
 0.57A 3wzeA-4c0tA:
22.4		 3wzeA-4c0tA:
15.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 653
LYS A 655
GLU A 672
LEU A 757
HIS A 764
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
 0.58A 3wzeA-4ckrA:
33.5		 3wzeA-4ckrA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
LEU A 126
HIS A 133
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 ( 4.6A)
None
None
 0.59A 3wzeA-4eutA:
19.7		 3wzeA-4eutA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.64A 3wzeA-4eutA:
19.7		 3wzeA-4eutA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
GLY A  92
LEU A 126
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
None
 0.49A 3wzeA-4euuA:
22.0		 3wzeA-4euuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
None
None
 0.56A 3wzeA-4euuA:
22.0		 3wzeA-4euuA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
LEU A 636
HIS A 643
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
 0.74A 3wzeA-4feqA:
22.5		 3wzeA-4feqA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
ALA A 880
LEU A 902
GLY A 935
LEU A 967
HIS A 974
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 (-3.3A)
None
None
 0.74A 3wzeA-4gl9A:
28.8		 3wzeA-4gl9A:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLY A 935
LEU A 967
HIS A 974
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
IZA  A2001 (-3.3A)
None
None
 0.61A 3wzeA-4gl9A:
28.8		 3wzeA-4gl9A:
33.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
VAL A 164
ALA A 177
LYS A 179
GLU A 198
LEU A 202
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
None
 0.62A 3wzeA-4gv1A:
21.2		 3wzeA-4gv1A:
26.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
LEU A 875
GLY A 908
LEU A 940
HIS A 947
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
None
None
 0.65A 3wzeA-4hviA:
30.5		 3wzeA-4hviA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
None
None
 0.50A 3wzeA-4jlcA:
18.2		 3wzeA-4jlcA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
ILE A 532
VAL A 555
GLY A 561
LEU A 608
HIS A 615
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
ACP  A 801 ( 4.6A)
None
None
 0.72A 3wzeA-4k33A:
26.6		 3wzeA-4k33A:
51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  50
ALA A  61
GLU A  77
LEU A  81
GLY A 110
LEU A 144
HIS A 154
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
None
None
 0.59A 3wzeA-4l52A:
19.7		 3wzeA-4l52A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LYS B  53
GLU B  70
GLY B 105
LEU B 135
HIS B 142
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
 0.75A 3wzeA-4o27B:
17.7		 3wzeA-4o27B:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
LEU A1014
HIS A1021
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
None
None
 0.76A 3wzeA-4oliA:
27.9		 3wzeA-4oliA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 802
HIS A 809
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
None
P30  A1001 ( 4.3A)
 0.29A 3wzeA-4rt7A:
32.1		 3wzeA-4rt7A:
40.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
LEU A 150
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
 0.64A 3wzeA-4wb7A:
14.3		 3wzeA-4wb7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 239
GLY A 270
LEU A 305
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
None
 0.68A 3wzeA-4wboA:
22.4		 3wzeA-4wboA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 473
ALA A 501
GLU A 520
ILE A 527
VAL A 550
LEU A 603
HIS A 610
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-4.7A)
None
None
 0.55A 3wzeA-4xcuA:
33.8		 3wzeA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 473
ALA A 501
GLU A 520
VAL A 550
GLY A 556
LEU A 603
HIS A 610
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
None
None
 0.53A 3wzeA-4xcuA:
33.8		 3wzeA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 802
HIS A 809
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.4A)
 0.55A 3wzeA-4xufA:
39.2		 3wzeA-4xufA:
52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
LYS A 490
GLU A 509
LEU A 513
LEU A 577
HIS A 586
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
None
None
 0.67A 3wzeA-4yffA:
18.7		 3wzeA-4yffA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 111
HIS A 149
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
None
 0.57A 3wzeA-4ysjA:
22.3		 3wzeA-4ysjA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
ILE A 538
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
None
None
 0.67A 3wzeA-5a46A:
34.7		 3wzeA-5a46A:
45.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
LYS A  54
LEU A  73
PHE A 107
GLY A 111
LEU A 144
HIS A 151
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.71A 3wzeA-5d7aA:
8.8		 3wzeA-5d7aA:
28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A 951
GLY A 984
LEU A1014
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
None
 0.70A 3wzeA-5f1zA:
28.6		 3wzeA-5f1zA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1014
HIS A1021
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
None
None
 0.53A 3wzeA-5f1zA:
28.6		 3wzeA-5f1zA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
LEU A 779
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
 0.60A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
 0.53A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
None
 0.70A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.68A 3wzeA-5fm2A:
33.1		 3wzeA-5fm2A:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
GLY A 680
LEU A 809
HIS A 816
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.45A 3wzeA-5grnA:
33.2		 3wzeA-5grnA:
49.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
HIS A 134
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
 0.71A 3wzeA-5hu3A:
22.9		 3wzeA-5hu3A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  61
PHE A  92
GLY A  96
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
None
 0.61A 3wzeA-5j5tA:
20.8		 3wzeA-5j5tA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 593
VAL A 601
ALA A 617
LYS A 619
PHE A 673
GLY A 677
LEU A 714
HIS A 721
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
None
None
 0.67A 3wzeA-5td2A:
29.4		 3wzeA-5td2A:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 794
HIS A 801
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
None
None
 0.57A 3wzeA-5vilA:
18.6		 3wzeA-5vilA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 10 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 929
PHE A 958
GLY A 962
LEU A 994
HIS A1001
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
None
None
 0.68A 3wzeA-6c7yA:
28.4		 3wzeA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
LEU A 865
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
None
 0.56A 3wzeA-6fekA:
32.6		 3wzeA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 8 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
None
None
 0.58A 3wzeA-6fekA:
32.6		 3wzeA-6fekA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
VAL A 177
ALA A 191
GLU A 208
LEU A 212
GLY A 247
LEU A 281
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
 0.72A 3wzeA-6fylA:
22.2		 3wzeA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
VAL A 177
ALA A 191
GLU A 208
LEU A 212
LEU A 281
HIS A 288
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
 0.67A 3wzeA-6fylA:
22.2		 3wzeA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
VAL A 177
ALA A 191
LYS A 193
LEU A 212
GLY A 247
LEU A 281
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
None
 0.71A 3wzeA-6fylA:
22.2		 3wzeA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
VAL A 177
ALA A 191
LYS A 193
LEU A 212
LEU A 281
HIS A 288
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
None
 0.60A 3wzeA-6fylA:
22.2		 3wzeA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
HIS A 286
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
 0.57A 3wzeA-6fyvA:
21.9		 3wzeA-6fyvA:
undetectable