SIMILAR PATTERNS OF AMINO ACIDS FOR 3WZD_A_LEVA1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8k PROTEIN
(NEUROTROPHIN-3)

(Homo sapiens) 		PF00243
(NGF) 		4 ILE A 102
VAL A  21
LEU A  19
ASP A 105
 None
 1.17A 3wzdA-1b8kA:
undetectable		 3wzdA-1b8kA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		4 ILE A 129
VAL A 176
LEU A 180
ASP A 160
 None
 1.06A 3wzdA-1f6yA:
undetectable		 3wzdA-1f6yA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A  89
VAL A  52
LEU A  46
ASP A  50
 None
 1.23A 3wzdA-1fq3A:
undetectable		 3wzdA-1fq3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  85
ILE A 100
VAL A 110
LEU A 188
 None
 0.59A 3wzdA-1gngA:
20.5		 3wzdA-1gngA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 430
VAL A 458
LEU A 528
ASP A 539
 None
 0.92A 3wzdA-1k2pA:
27.8		 3wzdA-1k2pA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 ILE A 172
VAL A 229
LEU A 206
ASP A 176
 None
 1.17A 3wzdA-1sjjA:
undetectable		 3wzdA-1sjjA:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 391
VAL A 419
LEU A 489
ASP A 500
 None
 0.95A 3wzdA-1snxA:
24.4		 3wzdA-1snxA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A 361
VAL A 433
LEU A 440
ASP A 345
 None
 1.16A 3wzdA-1u3dA:
undetectable		 3wzdA-1u3dA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 369
ILE A 389
LEU A 468
ASP A 479
 STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 1.13A 3wzdA-1u59A:
30.4		 3wzdA-1u59A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 369
VAL A 399
LEU A 468
ASP A 479
 STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.97A 3wzdA-1u59A:
30.4		 3wzdA-1u59A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unp RAC-ALPHA
SERINE/THREONINE
KINASE

(Homo sapiens) 		PF00169
(PH) 		4 ILE A   6
VAL A 106
LEU A 110
ASP A  32
 None
 1.08A 3wzdA-1unpA:
undetectable		 3wzdA-1unpA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A  32
VAL A  63
LEU A 132
ASP A 143
 None
 0.97A 3wzdA-1v0bA:
21.8		 3wzdA-1v0bA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 286
VAL A 312
LEU A 667
ASP A 290
 None
 1.16A 3wzdA-1z68A:
undetectable		 3wzdA-1z68A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  58
VAL A  68
LEU A 137
ASP A 148
 None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.90A 3wzdA-1zltA:
20.9		 3wzdA-1zltA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 627
VAL A 515
LEU A 612
ASP A 520
 None
 1.15A 3wzdA-2d3tA:
undetectable		 3wzdA-2d3tA:
18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE X  57
VAL X  67
LEU X 137
ASP X 148
 None
None
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.90A 3wzdA-2dq7X:
30.5		 3wzdA-2dq7X:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS X  39
ILE X  57
VAL X  67
LEU X 137
 STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.4A)
 0.81A 3wzdA-2dq7X:
30.5		 3wzdA-2dq7X:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 ILE A 103
VAL A 113
LEU A 182
ASP A 193
 None
 1.16A 3wzdA-2hakA:
14.6		 3wzdA-2hakA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LYS A  82
VAL A 113
LEU A 182
ASP A 193
 None
 1.02A 3wzdA-2hakA:
14.6		 3wzdA-2hakA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 LYS A 454
VAL A 484
LEU A 553
ASP A 564
 4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.91A 3wzdA-2j0jA:
32.6		 3wzdA-2j0jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		4 ILE A 390
VAL A  78
LEU A  74
ASP A 362
 None
 1.02A 3wzdA-2jepA:
undetectable		 3wzdA-2jepA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LYS A 234
ILE A 196
VAL A 186
LEU A 156
 None
 1.08A 3wzdA-2obvA:
undetectable		 3wzdA-2obvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzx GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		4 LYS A  65
ILE A 195
VAL A 191
LEU A 146
 CR8  A  64 ( 3.6A)
CR8  A  64 ( 3.6A)
None
None
 1.11A 3wzdA-2vzxA:
undetectable		 3wzdA-2vzxA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x18 RAC-GAMMA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00169
(PH) 		4 ILE A   6
VAL A 105
LEU A 109
ASP A  32
 None
 1.12A 3wzdA-2x18A:
undetectable		 3wzdA-2x18A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 123
ILE A 146
VAL A 156
ASP A 236
 STU  A 400 ( 4.3A)
None
None
STU  A 400 ( 3.8A)
 0.98A 3wzdA-3a62A:
21.4		 3wzdA-3a62A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djb HYDROLASE, HD FAMILY

(Bacillus
thuringiensis) 		PF01966
(HD) 		4 ILE A  97
VAL A  14
LEU A  18
ASP A  59
 None
None
None
MG  A 224 (-3.4A)
 1.21A 3wzdA-3djbA:
undetectable		 3wzdA-3djbA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 LYS A 665
ILE A 685
VAL A 695
LEU A 765
 IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
 0.59A 3wzdA-3dkoA:
32.0		 3wzdA-3dkoA:
33.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		4 LYS A  49
ILE A  64
VAL A  77
LEU A 158
 None
 0.79A 3wzdA-3e3pA:
19.4		 3wzdA-3e3pA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LYS A  85
VAL A 116
LEU A 185
ASP A 196
 None
 0.94A 3wzdA-3fe3A:
18.4		 3wzdA-3fe3A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 LYS A4014
ILE A4233
LEU A4062
ASP A4120
 None
 1.10A 3wzdA-3g1nA:
undetectable		 3wzdA-3g1nA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 861
ILE A 881
VAL A 892
LEU A1029
 8ST  A2001 (-4.0A)
None
8ST  A2001 ( 4.7A)
None
 0.84A 3wzdA-3hngA:
35.2		 3wzdA-3hngA:
67.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 744
VAL A 753
LEU A 822
ASP A 833
 None
None
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
 0.58A 3wzdA-3kexA:
27.3		 3wzdA-3kexA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  69
VAL A  79
LEU A 156
ASP A 167
 None
 1.00A 3wzdA-3mi9A:
22.3		 3wzdA-3mi9A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ILE A 237
VAL A 247
LEU A 318
ASP A 329
 None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 1.06A 3wzdA-3nyoA:
21.4		 3wzdA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 ILE A   6
VAL A 106
LEU A 110
ASP A  32
 ILE  A   6 ( 0.4A)
VAL  A 106 ( 0.6A)
LEU  A 110 ( 0.6A)
ASP  A  32 ( 0.6A)
 0.88A 3wzdA-3o96A:
19.5		 3wzdA-3o96A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  40
VAL A  72
LEU A 141
ASP A 152
 None
 0.85A 3wzdA-3oz6A:
21.3		 3wzdA-3oz6A:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 ILE A 599
VAL A 609
LEU A 683
ASP A 694
 None
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.90A 3wzdA-3ppzA:
27.9		 3wzdA-3ppzA:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
VAL A 609
LEU A 683
ASP A 694
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.97A 3wzdA-3ppzA:
27.9		 3wzdA-3ppzA:
32.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 ILE A 109
VAL A 135
LEU A 146
ASP A 192
 None
 1.18A 3wzdA-3qz4A:
undetectable		 3wzdA-3qz4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ILE A 244
VAL A 327
LEU A 325
ASP A 285
 None
 0.99A 3wzdA-3stjA:
undetectable		 3wzdA-3stjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  84
VAL A  94
LEU A 164
ASP A 175
 None
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.80A 3wzdA-4bc6A:
21.2		 3wzdA-4bc6A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  65
VAL A  94
LEU A 164
ASP A 175
 XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.74A 3wzdA-4bc6A:
21.2		 3wzdA-4bc6A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ILE A 708
VAL A 721
LEU A 789
ASP A 800
 None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 1.12A 3wzdA-4crsA:
15.7		 3wzdA-4crsA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LYS A 686
ILE A 708
VAL A 721
LEU A 789
 AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.92A 3wzdA-4crsA:
15.7		 3wzdA-4crsA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LYS A  40
VAL A  72
LEU A 141
ASP A 152
 None
 0.94A 3wzdA-4d28A:
20.8		 3wzdA-4d28A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 LYS A  66
ILE A  81
VAL A  91
ASP A 181
 None
 0.98A 3wzdA-4e7wA:
17.7		 3wzdA-4e7wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 ILE A 610
VAL A 620
LEU A 690
ASP A 701
 None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.80A 3wzdA-4e93A:
32.5		 3wzdA-4e93A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		4 LYS A1055
ILE A1081
VAL A1091
ASP A1177
 None
 1.17A 3wzdA-4f0gA:
26.7		 3wzdA-4f0gA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6a BH1408 PROTEIN

(Bacillus
halodurans) 		PF00583
(Acetyltransf_1) 		4 ILE A 109
VAL A  14
LEU A  40
ASP A  93
 None
 1.07A 3wzdA-4f6aA:
undetectable		 3wzdA-4f6aA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 ILE A  43
VAL A  47
LEU A  49
ASP A 118
 None
 1.23A 3wzdA-4fmfA:
undetectable		 3wzdA-4fmfA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A1170
VAL A1180
LEU A1256
ASP A1270
 None
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.72A 3wzdA-4fodA:
24.8		 3wzdA-4fodA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 901
VAL A 911
LEU A 983
ASP A 994
 None
None
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.86A 3wzdA-4gl9A:
28.2		 3wzdA-4gl9A:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 882
ILE A 901
VAL A 911
LEU A 983
 IZA  A2001 ( 4.7A)
None
None
IZA  A2001 ( 4.7A)
 0.74A 3wzdA-4gl9A:
28.2		 3wzdA-4gl9A:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 855
ILE A 874
LEU A 956
ASP A 967
 19S  A1201 (-3.5A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 1.12A 3wzdA-4hviA:
29.7		 3wzdA-4hviA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 855
ILE A 874
VAL A 884
LEU A 956
 19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.5A)
 0.58A 3wzdA-4hviA:
29.7		 3wzdA-4hviA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 436
ILE A 455
VAL A 465
LEU A 533
 None
None
None
B49  A 701 (-4.5A)
 0.91A 3wzdA-4ks8A:
23.1		 3wzdA-4ks8A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 436
VAL A 465
LEU A 533
ASP A 544
 None
None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.76A 3wzdA-4ks8A:
23.1		 3wzdA-4ks8A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  73
VAL A  83
LEU A 153
ASP A 164
 None
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 (-2.4A)
 0.95A 3wzdA-4lg4A:
19.6		 3wzdA-4lg4A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  56
VAL A  83
LEU A 153
ASP A 164
 GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 (-2.4A)
 0.89A 3wzdA-4lg4A:
19.6		 3wzdA-4lg4A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 345
ILE A 418
VAL A 239
LEU A 440
 None
 1.15A 3wzdA-4mv3A:
undetectable		 3wzdA-4mv3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 930
ILE A 950
LEU A1030
ASP A1041
 None
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 1.16A 3wzdA-4oliA:
27.7		 3wzdA-4oliA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LYS A  37
ILE A  55
VAL A  65
ASP A 147
 None
 1.18A 3wzdA-4ueuA:
30.8		 3wzdA-4ueuA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LYS A  37
ILE A  55
VAL A  65
LEU A 136
 None
None
None
ACP  A1264 ( 4.8A)
 0.79A 3wzdA-4ueuA:
30.8		 3wzdA-4ueuA:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LYS A 216
ILE A 238
VAL A 248
LEU A 321
ASP A 332
 None
None
None
ANW  A 601 (-4.9A)
None
 1.26A 3wzdA-4wboA:
22.3		 3wzdA-4wboA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  74
ILE A  93
VAL A 104
LEU A 183
 None
None
None
KSA  A 405 (-4.6A)
 1.03A 3wzdA-4wsqA:
22.4		 3wzdA-4wsqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		4 ILE A 369
VAL A 379
LEU A 447
ASP A 458
 None
None
None
ATP  A 601 ( 2.5A)
 0.74A 3wzdA-4xbrA:
17.9		 3wzdA-4xbrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		4 LYS A 350
ILE A 369
VAL A 379
ASP A 458
 ATP  A 601 (-2.8A)
None
None
ATP  A 601 ( 2.5A)
 1.04A 3wzdA-4xbrA:
17.9		 3wzdA-4xbrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 ILE A 238
VAL A 248
LEU A 319
ASP A 330
 None
None
None
AN2  A 601 (-3.0A)
 1.10A 3wzdA-4yhjA:
16.6		 3wzdA-4yhjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 LYS A 191
ILE A 152
VAL A 354
LEU A 339
 None
 1.23A 3wzdA-4zg7A:
undetectable		 3wzdA-4zg7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 LYS A 346
ILE A 339
VAL A 382
LEU A 358
 None
 1.23A 3wzdA-5b1qA:
undetectable		 3wzdA-5b1qA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 4 ILE A  59
VAL A 124
LEU A  25
ASP A  54
 None
 1.22A 3wzdA-5dmuA:
undetectable		 3wzdA-5dmuA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dy1 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 ILE A 176
VAL A 114
LEU A  70
ASP A  26
 None
 1.19A 3wzdA-5dy1A:
undetectable		 3wzdA-5dy1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 LYS A  85
ILE A 106
VAL A 116
LEU A 185
ASP A 196
 5RC  A4000 (-2.8A)
None
None
None
5RC  A4000 (-3.6A)
 1.17A 3wzdA-5es1A:
9.2		 3wzdA-5es1A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eui HBB PROTEIN

(Ochotona
princeps) 		PF00042
(Globin) 		4 LYS B   8
VAL B   1
LEU B  81
ASP B  79
 None
 1.06A 3wzdA-5euiB:
undetectable		 3wzdA-5euiB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF08276
(PAN_2) 		4 LYS A 326
ILE A 268
VAL A 277
ASP A 264
 None
 1.20A 3wzdA-5gyyA:
undetectable		 3wzdA-5gyyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 LYS A  37
ILE A 115
VAL A  80
ASP A  97
 None
 1.23A 3wzdA-5h7kA:
undetectable		 3wzdA-5h7kA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 ILE A  64
VAL A  74
LEU A 143
ASP A 157
 None
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 1.06A 3wzdA-5hu3A:
22.9		 3wzdA-5hu3A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  79
ILE A  98
VAL A 109
LEU A 187
 IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
 0.74A 3wzdA-5i3oA:
22.4		 3wzdA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  45
VAL A  74
LEU A 143
ASP A 154
 6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.94A 3wzdA-5j5tA:
21.3		 3wzdA-5j5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 LYS A 135
ILE A 138
VAL A 218
LEU A 126
 None
 1.06A 3wzdA-5ko5A:
undetectable		 3wzdA-5ko5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 121
VAL A 157
LEU A 232
ASP A 541
 SO4  A 702 (-3.3A)
DMS  A 717 (-4.3A)
None
DMS  A 717 (-4.3A)
 0.97A 3wzdA-5myvA:
19.6		 3wzdA-5myvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		4 ILE A 145
VAL A 163
LEU A  49
ASP A 139
 None
BU3  A 301 ( 4.6A)
BU3  A 301 ( 3.7A)
SAM  A 306 (-2.3A)
 1.01A 3wzdA-5n5dA:
undetectable		 3wzdA-5n5dA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 LYS A 196
VAL A 251
LEU A 344
ASP A 359
 None
None
None
MG  A 601 (-3.1A)
 0.81A 3wzdA-5oatA:
19.4		 3wzdA-5oatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		4 LYS A 512
ILE A 520
LEU A 392
ASP A 399
 None
 0.99A 3wzdA-5ulmA:
undetectable		 3wzdA-5ulmA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 4 ILE A 369
VAL A 379
LEU A 447
ASP A 458
 None
None
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 1.17A 3wzdA-5vefA:
22.3		 3wzdA-5vefA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5w NECTIN-1

(Sus scrofa) 		PF07686
(V-set) 		4 ILE B   7
VAL B  11
LEU B  13
ASP B  82
 None
 1.22A 3wzdA-5x5wB:
undetectable		 3wzdA-5x5wB:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 4 LYS A 227
VAL A 257
LEU A 326
ASP A 339
 None
 0.73A 3wzdA-5xzwA:
18.7		 3wzdA-5xzwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 ILE A 777
VAL A 787
LEU A 866
ASP A 877
 None
None
CJM  A1102 (-4.4A)
MG  A1101 (-2.5A)
 0.91A 3wzdA-6b3eA:
22.5		 3wzdA-6b3eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 LYS A 908
ILE A 928
LEU A1010
ASP A1021
 ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 1.17A 3wzdA-6c7yA:
27.8		 3wzdA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 LYS A 908
ILE A 928
VAL A 938
LEU A1010
 ADP  A1201 (-2.8A)
None
None
ADP  A1201 (-4.5A)
 0.83A 3wzdA-6c7yA:
27.8		 3wzdA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 ILE A 110
VAL A 120
LEU A 189
ASP A 200
 None
 1.22A 3wzdA-6c9dA:
21.0		 3wzdA-6c9dA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 LYS A  89
ILE A 110
VAL A 120
LEU A 189
 None
 1.00A 3wzdA-6c9dA:
21.0		 3wzdA-6c9dA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE

(Micromonospora
echinospora) 		no annotation 4 ILE A 177
VAL A 210
LEU A 316
ASP A 180
 None
 1.24A 3wzdA-6cboA:
undetectable		 3wzdA-6cboA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 LYS A 157
VAL A 212
LEU A 282
ASP A 293
 H1N  A 501 (-2.8A)
H1N  A 501 (-4.9A)
H1N  A 501 (-4.8A)
H1N  A 501 (-3.5A)
 1.10A 3wzdA-6ccfA:
6.3		 3wzdA-6ccfA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 LYS A 194
ILE A 239
VAL A 249
LEU A 319
ASP A 330
 F6J  A 501 (-2.9A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 1.09A 3wzdA-6cmjA:
22.4		 3wzdA-6cmjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 4 LYS D 211
ILE D 216
VAL D 231
ASP D 235
 None
 1.09A 3wzdA-6e29D:
undetectable		 3wzdA-6e29D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 ILE L 401
VAL L 137
LEU L 134
ASP L 261
 None
 1.15A 3wzdA-6ehsL:
undetectable		 3wzdA-6ehsL:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 4 LYS C 193
VAL C 247
LEU C 341
ASP C 357
 None
 0.95A 3wzdA-6eqiC:
19.3		 3wzdA-6eqiC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 LYS A 213
VAL A 246
LEU A 318
ASP A 329
 CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 1.01A 3wzdA-6f3dA:
23.3		 3wzdA-6f3dA:
15.19