SIMILAR PATTERNS OF AMINO ACIDS FOR 3WXO_A_NIZA804

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A 354
GLU A 380
ARG A  37
 None
 0.94A 3wxoA-1amuA:
0.0		 3wxoA-1amuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 ASN A 206
GLU A 209
ARG A 210
 None
 0.91A 3wxoA-1d0nA:
0.0		 3wxoA-1d0nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ASN A1078
GLU A1067
ARG A1069
 None
 0.99A 3wxoA-1f20A:
0.0		 3wxoA-1f20A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 ASN A 138
GLU A  22
ARG A  27
 None
 0.91A 3wxoA-1f82A:
0.0		 3wxoA-1f82A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glo CATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 ASN A 201
GLU A 121
ARG A 200
 None
 1.04A 3wxoA-1gloA:
undetectable		 3wxoA-1gloA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gme HEAT SHOCK PROTEIN
16.9B

(Triticum
aestivum) 		PF00011
(HSP20) 		3 ASN A   8
GLU A  37
ARG A 108
 None
 0.92A 3wxoA-1gmeA:
0.0		 3wxoA-1gmeA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 ASN A  82
GLU A  59
ARG A  95
 None
 0.70A 3wxoA-1inpA:
0.0		 3wxoA-1inpA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASN A 189
GLU A 148
ARG A 105
 None
 1.02A 3wxoA-1qgrA:
0.0		 3wxoA-1qgrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		3 ASN A  86
GLU A  83
ARG A  82
 None
 1.09A 3wxoA-1uf3A:
0.0		 3wxoA-1uf3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vki HYPOTHETICAL PROTEIN
ATU3699

(Agrobacterium
fabrum) 		PF04073
(tRNA_edit) 		3 ASN A  69
GLU A  67
ARG A  41
 None
 0.93A 3wxoA-1vkiA:
undetectable		 3wxoA-1vkiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wju NEDD8 ULTIMATE
BUSTER-1

(Homo sapiens) 		no annotation 3 ASN A  58
GLU A  57
ARG A  46
 None
 1.09A 3wxoA-1wjuA:
undetectable		 3wxoA-1wjuA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wq6 AML1-ETO

(Homo sapiens) 		PF08788
(NHR2) 		3 ASN A  59
GLU A  56
ARG A  55
 None
 1.01A 3wxoA-1wq6A:
undetectable		 3wxoA-1wq6A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		3 ASN A  86
GLU A  89
ARG A  93
 None
 0.80A 3wxoA-1x42A:
undetectable		 3wxoA-1x42A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		3 ASN A 133
GLU A 135
ARG A 164
 None
 0.96A 3wxoA-1xp8A:
undetectable		 3wxoA-1xp8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytq BETA CRYSTALLIN B2

(Homo sapiens) 		PF00030
(Crystall) 		3 ASN A  25
GLU A  24
ARG A  80
 None
 1.10A 3wxoA-1ytqA:
undetectable		 3wxoA-1ytqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		3 ASN X 160
GLU X 157
ARG X 156
 None
 0.80A 3wxoA-1zv4X:
undetectable		 3wxoA-1zv4X:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ASN A 132
GLU A 195
ARG A 131
 None
 1.09A 3wxoA-2ad1A:
undetectable		 3wxoA-2ad1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASN A1466
GLU A 845
ARG A 847
 None
 1.10A 3wxoA-2b39A:
1.5		 3wxoA-2b39A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASN A 149
GLU A 138
ARG A 140
 None
 1.00A 3wxoA-2dvlA:
undetectable		 3wxoA-2dvlA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		3 ASN A 250
GLU A 253
ARG A 254
 NGA  A 502 (-3.8A)
None
NGA  A 502 (-3.0A)
 0.90A 3wxoA-2gamA:
undetectable		 3wxoA-2gamA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		3 ASN A  61
GLU A  58
ARG A  57
 None
 0.89A 3wxoA-2gezA:
undetectable		 3wxoA-2gezA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		3 ASN A 179
GLU A 183
ARG A 375
 None
 1.09A 3wxoA-2gz6A:
undetectable		 3wxoA-2gz6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jli YOP PROTEINS
TRANSLOCATION
PROTEIN

(Yersinia pestis) 		PF01312
(Bac_export_2) 		3 ASN A 249
GLU A 252
ARG A 256
 None
 1.05A 3wxoA-2jliA:
undetectable		 3wxoA-2jliA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvq TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Escherichia
coli) 		PF00467
(KOW) 		3 ASN G 137
GLU G 179
ARG G 135
 None
 1.04A 3wxoA-2kvqG:
undetectable		 3wxoA-2kvqG:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzn DNA PRIMASE

(Staphylococcus
aureus) 		PF00772
(DnaB) 		3 ASN A 501
GLU A 473
ARG A 474
 None
 0.75A 3wxoA-2lznA:
undetectable		 3wxoA-2lznA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhj TPSB4 PROTEIN

(Pseudomonas
aeruginosa) 		PF08479
(POTRA_2) 		3 ASN A  30
GLU A  94
ARG A  31
 None
 1.11A 3wxoA-2mhjA:
undetectable		 3wxoA-2mhjA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2y MEIOSIS-EXPRESSED
GENE 1 PROTEIN

(Mus musculus) 		PF15163
(Meiosis_expr) 		3 ASN A  70
GLU A  74
ARG A  26
 None
 1.09A 3wxoA-2n2yA:
undetectable		 3wxoA-2n2yA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1

(Arabidopsis
thaliana) 		PF03759
(PRONE) 		3 ASN A 197
GLU A 338
ARG A 335
 None
 1.10A 3wxoA-2ntyA:
undetectable		 3wxoA-2ntyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3v INOSITOL-1-MONOPHOSP
HATASE

(Thermotoga
maritima) 		PF00459
(Inositol_P) 		3 ASN A1027
GLU A1040
ARG A1043
 None
 0.96A 3wxoA-2p3vA:
undetectable		 3wxoA-2p3vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 3 ASN A 162
GLU A 186
ARG A 160
 None
 1.10A 3wxoA-2p4oA:
undetectable		 3wxoA-2p4oA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ASN A 573
GLU A 576
ARG A 577
 None
 0.96A 3wxoA-2q1fA:
undetectable		 3wxoA-2q1fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 ASN A 553
GLU A 291
ARG A 290
 None
 1.09A 3wxoA-2rghA:
undetectable		 3wxoA-2rghA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		3 ASN A 445
GLU A  71
ARG A 246
 None
 0.95A 3wxoA-2ylzA:
undetectable		 3wxoA-2ylzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		3 ASN A 446
GLU A 544
ARG A 543
 None
 1.08A 3wxoA-2zpaA:
undetectable		 3wxoA-2zpaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 ASN A 538
GLU A 320
ARG A 327
 None
 1.01A 3wxoA-3bolA:
undetectable		 3wxoA-3bolA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		3 ASN A  40
GLU A  61
ARG A  20
 EDO  A 301 (-3.8A)
EDO  A 301 (-2.8A)
EDO  A 301 ( 4.6A)
 0.84A 3wxoA-3bwxA:
undetectable		 3wxoA-3bwxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		3 ASN A 232
GLU A 182
ARG A 115
 None
 1.00A 3wxoA-3d3aA:
undetectable		 3wxoA-3d3aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		3 ASN A 102
GLU A  91
ARG A 225
 None
K  A 306 ( 4.3A)
None
 1.07A 3wxoA-3e15A:
undetectable		 3wxoA-3e15A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 ASN A 532
GLU A 530
ARG A 531
 None
 0.90A 3wxoA-3eh1A:
1.0		 3wxoA-3eh1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fju CARBOXYPEPTIDASE A
INHIBITOR

(Ascaris suum) 		PF15270
(ACI44) 		3 ASN B  14
GLU B  16
ARG B   4
 None
 0.88A 3wxoA-3fjuB:
undetectable		 3wxoA-3fjuB:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		3 ASN A 382
GLU A 614
ARG A 384
 None
 0.82A 3wxoA-3htxA:
undetectable		 3wxoA-3htxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		3 ASN R 240
GLU R 241
ARG R 242
 None
 1.02A 3wxoA-3jb9R:
undetectable		 3wxoA-3jb9R:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 ASN F 615
GLU F  89
ARG F  86
 NAG  F1203 (-2.8A)
None
None
 0.78A 3wxoA-3jbrF:
undetectable		 3wxoA-3jbrF:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		3 ASN B 118
GLU B 181
ARG B 176
 None
 1.07A 3wxoA-3kydB:
undetectable		 3wxoA-3kydB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 ASN A 225
GLU A 175
ARG A 184
 None
 1.09A 3wxoA-3la4A:
undetectable		 3wxoA-3la4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		3 ASN A 104
GLU A 102
ARG A 103
 None
 1.08A 3wxoA-3ntvA:
undetectable		 3wxoA-3ntvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9h TUMOR SUSCEPTIBILITY
GENE 101 PROTEIN

(Homo sapiens) 		PF05743
(UEV) 		3 ASN A  27
GLU A  24
ARG A  23
 None
 0.84A 3wxoA-3p9hA:
undetectable		 3wxoA-3p9hA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ASN A  61
GLU A 543
ARG A 541
 None
 0.90A 3wxoA-3pocA:
undetectable		 3wxoA-3pocA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 ASN A 296
GLU A 216
ARG A 295
 None
 1.05A 3wxoA-3qt4A:
undetectable		 3wxoA-3qt4A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		3 ASN B 795
GLU B 792
ARG B 791
 None
 1.07A 3wxoA-3s4wB:
1.0		 3wxoA-3s4wB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqy SINGLE-STRANDED
DNA-BINDING PROTEIN

(Coxiella
burnetii) 		PF00436
(SSB) 		3 ASN A  34
GLU A  22
ARG A  24
 None
 0.85A 3wxoA-3tqyA:
undetectable		 3wxoA-3tqyA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ASN A  51
GLU A  58
ARG A  50
 None
None
ACT  A 708 (-3.3A)
 0.93A 3wxoA-3ve2A:
undetectable		 3wxoA-3ve2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A 298
GLU A 301
ARG A 302
 None
 1.02A 3wxoA-3vn9A:
0.4		 3wxoA-3vn9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		3 ASN A 133
GLU A 132
ARG A 141
 None
 1.09A 3wxoA-3vszA:
undetectable		 3wxoA-3vszA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 ASN A  48
GLU A 649
ARG A 633
 None
 0.91A 3wxoA-3wevA:
undetectable		 3wxoA-3wevA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		3 ASN A  63
GLU A 154
ARG A 146
 None
 1.02A 3wxoA-3zpxA:
undetectable		 3wxoA-3zpxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		3 ASN A 583
GLU A 533
ARG A 529
 None
 0.99A 3wxoA-4bv6A:
undetectable		 3wxoA-4bv6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		3 ASN B 107
GLU B  72
ARG B 106
 None
 1.08A 3wxoA-4ckeB:
undetectable		 3wxoA-4ckeB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ASN A 489
GLU A 490
ARG A 440
 FAD  A 501 (-4.4A)
None
FAD  A 501 (-3.9A)
 0.91A 3wxoA-4dnsA:
undetectable		 3wxoA-4dnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		3 ASN A 465
GLU A 175
ARG A 176
 None
None
UDP  A 501 (-4.1A)
 0.99A 3wxoA-4dshA:
undetectable		 3wxoA-4dshA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ASN A 712
GLU A 709
ARG A 632
 None
 0.82A 3wxoA-4etpA:
undetectable		 3wxoA-4etpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 ASN A  69
GLU A  71
ARG A 226
 None
 1.04A 3wxoA-4fsfA:
undetectable		 3wxoA-4fsfA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 ASN B 225
GLU B 175
ARG B 184
 None
 1.04A 3wxoA-4g7eB:
undetectable		 3wxoA-4g7eB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		3 ASN A 328
GLU A 332
ARG A 329
 None
 1.04A 3wxoA-4gniA:
undetectable		 3wxoA-4gniA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		3 ASN A  11
GLU A  97
ARG A 167
 None
 1.00A 3wxoA-4i8oA:
0.9		 3wxoA-4i8oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igu CG5036

(Drosophila
melanogaster) 		PF00615
(RGS) 		3 ASN A 101
GLU A  98
ARG A  97
 CL  A 203 (-3.6A)
None
CL  A 203 (-4.7A)
 0.88A 3wxoA-4iguA:
undetectable		 3wxoA-4iguA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		3 ASN A 308
GLU A 310
ARG A 374
 None
 0.89A 3wxoA-4ijmA:
undetectable		 3wxoA-4ijmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8

(Homo sapiens) 		PF00782
(DSPc) 		3 ASN A 214
GLU A 219
ARG A 252
 SO4  A 502 (-3.4A)
None
SO4  A 502 ( 3.7A)
 0.94A 3wxoA-4jmkA:
undetectable		 3wxoA-4jmkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASN A 838
GLU A1181
ARG A 836
 None
 0.96A 3wxoA-4lnvA:
undetectable		 3wxoA-4lnvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		3 ASN A 163
GLU A 135
ARG A 132
 None
 0.82A 3wxoA-4mhbA:
undetectable		 3wxoA-4mhbA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz9 SINGLE-STRANDED
DNA-BINDING PROTEIN

(Escherichia
coli) 		PF00436
(SSB) 		3 ASN A  31
GLU A  19
ARG A  21
 None
 1.02A 3wxoA-4mz9A:
undetectable		 3wxoA-4mz9A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		3 ASN A 212
GLU A 210
ARG A 172
 ORO  A 403 (-2.9A)
None
ORO  A 403 (-2.8A)
 1.09A 3wxoA-4nn3A:
undetectable		 3wxoA-4nn3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		3 ASN A  43
GLU A  98
ARG A 209
 None
 1.10A 3wxoA-4olqA:
undetectable		 3wxoA-4olqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		3 ASN A  60
GLU A  63
ARG A 143
 None
 0.81A 3wxoA-4pc4A:
undetectable		 3wxoA-4pc4A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASN A 463
GLU A 466
ARG A 467
 None
 0.97A 3wxoA-4pwnA:
undetectable		 3wxoA-4pwnA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		3 ASN A 103
GLU A 105
ARG A 109
 None
 1.01A 3wxoA-4qwvA:
undetectable		 3wxoA-4qwvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6k SOLUTE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF13416
(SBP_bac_8) 		3 ASN A 339
GLU A 341
ARG A 261
 None
 0.86A 3wxoA-4r6kA:
undetectable		 3wxoA-4r6kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		3 ASN A 210
GLU A 333
ARG A 294
 TRS  A 503 (-3.9A)
None
None
 1.09A 3wxoA-4r7fA:
undetectable		 3wxoA-4r7fA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rj9 C2 DOMAIN-CONTAINING
PROTEIN-LIKE

(Oryza sativa) 		PF00168
(C2) 		3 ASN A  85
GLU A  71
ARG A  69
 None
 1.06A 3wxoA-4rj9A:
undetectable		 3wxoA-4rj9A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN

(Legionella
pneumophila) 		PF14566
(PTPlike_phytase) 		3 ASN A  65
GLU A 258
ARG A 262
 CL  A 403 (-4.2A)
None
None
 0.90A 3wxoA-4tvvA:
undetectable		 3wxoA-4tvvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		3 ASN A 254
GLU A 265
ARG A 268
 None
 0.99A 3wxoA-4ufcA:
undetectable		 3wxoA-4ufcA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASN A 154
GLU A 428
ARG A 432
 None
 1.06A 3wxoA-4ypjA:
undetectable		 3wxoA-4ypjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz0 REPLICASE
POLYPROTEIN 1AB

(Avian
coronavirus) 		PF08715
(Viral_protease) 		3 ASN A  84
GLU A  95
ARG A  97
 None
 1.05A 3wxoA-5bz0A:
undetectable		 3wxoA-5bz0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		3 ASN B 333
GLU B 168
ARG B 158
 None
 1.04A 3wxoA-5ej1B:
undetectable		 3wxoA-5ej1B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 ASN F 615
GLU F  89
ARG F  86
 NAG  F1205 (-1.9A)
None
None
 0.90A 3wxoA-5gjwF:
0.5		 3wxoA-5gjwF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 ASN A 270
GLU A 273
ARG A 277
 None
 0.91A 3wxoA-5ikpA:
undetectable		 3wxoA-5ikpA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j69 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		3 ASN A 957
GLU A 856
ARG A 814
 None
 0.99A 3wxoA-5j69A:
undetectable		 3wxoA-5j69A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ASN A 250
GLU A 215
ARG A 217
 None
 1.07A 3wxoA-5k8fA:
undetectable		 3wxoA-5k8fA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k97 FLAP ENDONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ASN A  21
GLU A 206
ARG A  19
 None
 0.82A 3wxoA-5k97A:
0.3		 3wxoA-5k97A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 3 ASN E 132
GLU E 136
ARG E 133
 None
 1.07A 3wxoA-5n6yE:
undetectable		 3wxoA-5n6yE:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 3 ASN A   8
GLU A 429
ARG A 507
 None
 1.04A 3wxoA-5ndxA:
0.0		 3wxoA-5ndxA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 3 ASN A 853
GLU A 967
ARG A 963
 None
 0.98A 3wxoA-5nprA:
undetectable		 3wxoA-5nprA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 3 ASN A 370
GLU A 373
ARG A 374
 None
 1.07A 3wxoA-5ve8A:
undetectable		 3wxoA-5ve8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 ASN A 805
GLU A 924
ARG A 920
 None
 0.95A 3wxoA-6bf6A:
undetectable		 3wxoA-6bf6A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 3 ASN A 124
GLU A 110
ARG A 126
 None
 1.10A 3wxoA-6btgA:
undetectable		 3wxoA-6btgA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 3 ASN A 345
GLU A 346
ARG A 376
 None
 1.02A 3wxoA-6c0mA:
undetectable		 3wxoA-6c0mA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 3 ASN A  20
GLU A 174
ARG A 177
 None
 0.92A 3wxoA-6c2hA:
undetectable		 3wxoA-6c2hA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 3 ASN A  56
GLU A  54
ARG A  55
 None
UDP  A 501 (-4.9A)
None
 1.06A 3wxoA-6dusA:
undetectable		 3wxoA-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1

(Saccharomyces
cerevisiae) 		no annotation 3 ASN I 785
GLU I 731
ARG I 698
 None
 1.00A 3wxoA-6emkI:
undetectable		 3wxoA-6emkI:
7.32