SIMILAR PATTERNS OF AMINO ACIDS FOR 3WXO_A_NIZA803

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		4 ASP A 246
THR A 219
VAL A 231
SER A 216
 None
 1.32A 3wxoA-1alqA:
0.0		 3wxoA-1alqA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		4 ASP A 344
THR A 341
VAL A 292
SER A 261
 None
 1.13A 3wxoA-1g5gA:
0.0		 3wxoA-1g5gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		4 ASP A 507
THR A  89
VAL A 511
SER A  79
 None
 1.18A 3wxoA-1iokA:
0.0		 3wxoA-1iokA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASP A  78
THR A  63
VAL A 101
SER A  76
 None
 1.36A 3wxoA-1nr0A:
0.0		 3wxoA-1nr0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ASP A  85
THR A  68
VAL A 114
SER A  83
 None
 1.43A 3wxoA-1pguA:
0.0		 3wxoA-1pguA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ASP A  85
THR A  69
VAL A 114
SER A  83
 None
 1.32A 3wxoA-1pguA:
0.0		 3wxoA-1pguA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ASP A 274
THR A 278
VAL A 404
SER A 276
 None
 1.49A 3wxoA-1pw4A:
0.0		 3wxoA-1pw4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auk DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Escherichia
coli) 		no annotation 4 ASP A 180
THR A  90
VAL A 174
SER A  93
 None
 1.27A 3wxoA-2aukA:
0.0		 3wxoA-2aukA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ASP A  42
THR A 385
VAL A 228
SER A 315
 None
 1.50A 3wxoA-2bccA:
1.0		 3wxoA-2bccA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7x MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 4) 		PF00718
(Polyoma_coat) 		4 ASP A 268
THR A 279
VAL A 237
SER A 282
 None
 1.33A 3wxoA-3s7xA:
undetectable		 3wxoA-3s7xA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 ASP A 937
THR A1047
VAL A 944
SER A1045
 None
 1.44A 3wxoA-4bocA:
1.5		 3wxoA-4bocA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dou ADIPONECTIN

(Homo sapiens) 		PF00386
(C1q) 		4 ASP A 231
THR A 467
VAL A 483
SER A 456
 None
 1.10A 3wxoA-4douA:
undetectable		 3wxoA-4douA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dou ADIPONECTIN

(Homo sapiens) 		PF00386
(C1q) 		4 ASP A 372
THR A 185
VAL A 201
SER A 174
 None
 1.13A 3wxoA-4douA:
undetectable		 3wxoA-4douA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dou ADIPONECTIN

(Homo sapiens) 		PF00386
(C1q) 		4 ASP A 513
THR A 326
VAL A 342
SER A 315
 None
 1.16A 3wxoA-4douA:
undetectable		 3wxoA-4douA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Escherichia
coli) 		no annotation 4 ASP A 208
THR A 118
VAL A 202
SER A 121
 None
None
IOD  A 303 ( 4.2A)
NA  A 317 ( 4.2A)
 1.24A 3wxoA-4iqzA:
undetectable		 3wxoA-4iqzA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 174
THR A 178
VAL A 151
SER A 176
 None
 1.22A 3wxoA-4n5aA:
1.5		 3wxoA-4n5aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ASP A  45
THR A  49
VAL A  41
SER A  47
 None
 1.23A 3wxoA-4qbuA:
undetectable		 3wxoA-4qbuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASP A 469
THR A 404
VAL A 477
SER A 463
 None
 1.17A 3wxoA-4zlgA:
undetectable		 3wxoA-4zlgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 ASP A  79
THR A  75
VAL A  83
SER A 142
 None
None
None
7E8  A 402 ( 3.8A)
 0.80A 3wxoA-5bz3A:
0.1		 3wxoA-5bz3A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1e PECTINESTERASE

(Aspergillus
niger) 		PF01095
(Pectinesterase) 		4 ASP A  99
THR A  94
VAL A 101
SER A  30
 None
 1.19A 3wxoA-5c1eA:
undetectable		 3wxoA-5c1eA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 ASP A 218
THR A 223
VAL A 253
SER A 146
 None
None
PLP  A1441 (-4.2A)
None
 1.45A 3wxoA-5g4iA:
undetectable		 3wxoA-5g4iA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 ASP A 292
THR A 296
VAL A 420
SER A 392
 None
 1.37A 3wxoA-5khaA:
undetectable		 3wxoA-5khaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		4 ASP A  18
THR A 114
VAL A 171
SER A 117
 None
 1.37A 3wxoA-5lxvA:
undetectable		 3wxoA-5lxvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 4 ASP A 291
THR A 129
VAL A 320
SER A 127
 None
 1.39A 3wxoA-5tv1A:
undetectable		 3wxoA-5tv1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASP A 237
THR A 241
VAL A 164
SER A 156
 None
 1.47A 3wxoA-5vniA:
undetectable		 3wxoA-5vniA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 4 ASP A 281
THR A 268
VAL A 215
SER A 278
 None
 1.07A 3wxoA-6fhvA:
undetectable		 3wxoA-6fhvA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gui -

(-) 		no annotation 4 ASP A 100
THR A 102
VAL A  52
SER A  98
 None
 1.29A 3wxoA-6guiA:
undetectable		 3wxoA-6guiA:
undetectable