SIMILAR PATTERNS OF AMINO ACIDS FOR 3WXO_A_NIZA802_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 TRP A 573
LEU A 562
ILE A 561
GLY A 580
ILE A 578
 None
 1.17A 3wxoA-1bf5A:
0.0		 3wxoA-1bf5A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 TRP A  78
TRP A  79
LYS A 131
LEU A 288
ASN A 292
 None
 0.67A 3wxoA-1itkA:
60.5		 3wxoA-1itkA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 188
ASN A 135
GLY A 432
ILE A 433
 None
 0.83A 3wxoA-1itzA:
0.0		 3wxoA-1itzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 197
ASN A 150
GLY A 151
ILE A 159
 None
 0.80A 3wxoA-1iyxA:
0.0		 3wxoA-1iyxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 TRP A 263
ILE A 210
GLY A  13
ILE A  12
 None
 0.86A 3wxoA-1k27A:
0.0		 3wxoA-1k27A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 338
ILE A 367
ASN A 366
GLY A 381
 FAD  A 499 (-3.9A)
None
None
None
 0.87A 3wxoA-1k4qA:
0.0		 3wxoA-1k4qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5d CARBONYL
REDUCTASE/20BETA-HYD
ROXYSTEROID
DEHYDROGENASE

(Sus scrofa) 		PF00106
(adh_short) 		4 LEU A  72
ILE A  69
ASN A 119
GLY A 116
 None
 0.89A 3wxoA-1n5dA:
undetectable		 3wxoA-1n5dA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 169
ASN A 122
GLY A 420
ILE A 421
 None
 0.89A 3wxoA-1qgdA:
0.0		 3wxoA-1qgdA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 175
ASN A 122
GLY A 420
ILE A 421
 None
 0.81A 3wxoA-1qgdA:
0.0		 3wxoA-1qgdA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ILE B 184
ASN B 185
GLY B 149
ILE B 150
 None
 0.86A 3wxoA-1skyB:
0.0		 3wxoA-1skyB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 LEU A  71
ILE A  69
GLY A  19
ILE A  20
 None
 0.86A 3wxoA-1sqjA:
undetectable		 3wxoA-1sqjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3b THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Haemophilus
influenzae) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		4 LYS A  70
LEU A 173
GLY A  35
ILE A  36
 None
 0.82A 3wxoA-1t3bA:
undetectable		 3wxoA-1t3bA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A 245
ILE A 248
GLY A  18
ILE A  17
 None
 0.86A 3wxoA-1t5jA:
undetectable		 3wxoA-1t5jA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 171
ASN A 124
GLY A 427
ILE A 428
 None
 0.87A 3wxoA-1tkcA:
undetectable		 3wxoA-1tkcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 177
ASN A 124
GLY A 427
ILE A 428
 None
 0.83A 3wxoA-1tkcA:
undetectable		 3wxoA-1tkcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 LEU A 203
ILE A 206
GLY A 184
ILE A 186
 None
 0.89A 3wxoA-1uznA:
undetectable		 3wxoA-1uznA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5l ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
PDZ AND LIM DOMAIN 3

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A  80
ASN A   8
GLY A   7
ILE A  84
 None
 0.85A 3wxoA-1v5lA:
undetectable		 3wxoA-1v5lA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4n FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		4 LEU A  78
ILE A  81
GLY A  31
ILE A  30
 None
 0.90A 3wxoA-1x4nA:
undetectable		 3wxoA-1x4nA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x62 C-TERMINAL LIM
DOMAIN PROTEIN 1

(Homo sapiens) 		PF00412
(LIM) 		4 LEU A  15
ASN A  11
GLY A  10
ILE A   9
 None
 0.84A 3wxoA-1x62A:
undetectable		 3wxoA-1x62A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		4 LEU A 115
ILE A  87
GLY A 128
ILE A 127
 None
 0.71A 3wxoA-1xa0A:
undetectable		 3wxoA-1xa0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxr MANNOSE-BINDING
LECTIN

(Morus nigra) 		PF01419
(Jacalin) 		4 LEU A  89
ILE A 141
GLY A 156
ILE A 155
 None
 0.91A 3wxoA-1xxrA:
undetectable		 3wxoA-1xxrA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 LEU A  84
ILE A  89
GLY A  93
ILE A  70
 None
 0.84A 3wxoA-1yirA:
0.1		 3wxoA-1yirA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 TRP A 573
LEU A 562
ILE A 561
GLY A 580
ILE A 578
 None
 1.31A 3wxoA-1yvlA:
1.3		 3wxoA-1yvlA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 634
ILE A 633
GLY A 480
ILE A 648
 None
 0.87A 3wxoA-1zcjA:
undetectable		 3wxoA-1zcjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zip ADENYLATE KINASE

(Geobacillus
stearothermophilus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LEU A   5
ASN A   2
GLY A  80
ILE A  26
 None
 0.87A 3wxoA-1zipA:
undetectable		 3wxoA-1zipA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 LEU B 479
ILE B 473
ASN B 445
GLY B 444
 None
 0.86A 3wxoA-2afhB:
undetectable		 3wxoA-2afhB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		4 LEU A 122
ILE A 217
ASN A 216
GLY A 201
 None
 0.89A 3wxoA-2d6fA:
undetectable		 3wxoA-2d6fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		4 LEU A 450
ILE A 448
GLY A 474
ILE A 492
 None
 0.91A 3wxoA-2e0pA:
undetectable		 3wxoA-2e0pA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7a TUMOR NECROSIS
FACTOR

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A  93
ILE A  80
GLY A 153
ILE A 154
 None
 0.74A 3wxoA-2e7aA:
undetectable		 3wxoA-2e7aA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 LYS A  45
ILE A 173
GLY A 180
ILE A 183
 None
 0.74A 3wxoA-2eb0A:
undetectable		 3wxoA-2eb0A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		4 LEU A 126
ASN A 132
GLY A 133
ILE A 134
 None
 0.91A 3wxoA-2ewyA:
undetectable		 3wxoA-2ewyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		4 LEU A 117
ILE A 119
ASN A 139
ILE A 175
 None
 0.90A 3wxoA-2fywA:
undetectable		 3wxoA-2fywA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 LYS A 201
LEU A 267
ILE A 188
ASN A 189
ILE A 191
 None
 1.24A 3wxoA-2g1sA:
undetectable		 3wxoA-2g1sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 LEU A 197
ILE A 193
GLY A 314
ILE A 313
 None
 0.84A 3wxoA-2greA:
undetectable		 3wxoA-2greA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		4 LEU A 205
ILE A 208
GLY A 186
ILE A 188
 None
 0.80A 3wxoA-2hq1A:
undetectable		 3wxoA-2hq1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		4 LEU A 193
ILE A 152
ASN A 148
GLY A 113
 None
 0.88A 3wxoA-2iqtA:
undetectable		 3wxoA-2iqtA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 LEU A 506
ILE A 508
ASN A 510
ILE A 585
 None
 0.87A 3wxoA-2o1sA:
undetectable		 3wxoA-2o1sA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opu KHSRP PROTEIN

(Homo sapiens) 		PF00013
(KH_1) 		4 LEU A  83
ILE A  86
GLY A  36
ILE A  35
 None
 0.72A 3wxoA-2opuA:
undetectable		 3wxoA-2opuA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 LYS A  63
ILE A 118
ASN A 117
GLY A 114
 None
None
None
F6P  A 603 ( 3.7A)
 0.69A 3wxoA-2owzA:
undetectable		 3wxoA-2owzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 LEU A 112
ASN A 119
GLY A 120
ILE A 121
 None
ACT  A 306 (-3.2A)
None
None
 0.69A 3wxoA-2p4oA:
undetectable		 3wxoA-2p4oA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 LEU A 352
ILE A  28
GLY A 376
ILE A 373
 None
 0.90A 3wxoA-2p50A:
undetectable		 3wxoA-2p50A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		4 TRP A  96
LEU A 359
GLY A 295
ILE A 283
 None
 0.90A 3wxoA-2pyxA:
undetectable		 3wxoA-2pyxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		5 LEU A  97
ILE A 109
ASN A 149
GLY A 150
ILE A 132
 None
 1.32A 3wxoA-2qiwA:
undetectable		 3wxoA-2qiwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 LEU A 194
ILE A 197
GLY A 221
ILE A 223
 None
 0.75A 3wxoA-2r9hA:
0.6		 3wxoA-2r9hA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 LEU A 204
ILE A 207
GLY A 185
ILE A 187
 None
 0.90A 3wxoA-2uvdA:
undetectable		 3wxoA-2uvdA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A  69
ILE A  67
GLY A  32
ILE A 133
 None
 0.78A 3wxoA-2v41A:
undetectable		 3wxoA-2v41A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v65 L-LACTATE
DEHYDROGENASE A
CHAIN

(Champsocephalus
gunnari) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  45
ILE A 262
ASN A 295
GLY A 294
 None
 0.81A 3wxoA-2v65A:
undetectable		 3wxoA-2v65A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ILE A 433
ASN A 404
GLY A 403
ILE A 455
 TPP  A 601 (-4.0A)
None
None
None
 0.91A 3wxoA-2x7jA:
undetectable		 3wxoA-2x7jA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TRP A  97
LEU A 144
ILE A  76
GLY A  59
 None
 0.81A 3wxoA-2z23A:
undetectable		 3wxoA-2z23A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU B 428
ILE B 425
ASN B 467
ILE B 419
 None
 0.83A 3wxoA-3al0B:
undetectable		 3wxoA-3al0B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay8 GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A   6
ILE A  29
GLY A  26
ILE A  25
 None
None
GOL  A 217 ( 3.8A)
None
 0.84A 3wxoA-3ay8A:
undetectable		 3wxoA-3ay8A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqt UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF04994
(TfoX_C) 		4 LEU A   6
ILE A  12
ASN A  11
GLY A  60
 None
 0.79A 3wxoA-3bqtA:
undetectable		 3wxoA-3bqtA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 632
ILE A 617
ASN A 614
GLY A 649
ILE A 643
 None
 1.30A 3wxoA-3bwtA:
undetectable		 3wxoA-3bwtA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 TRP A 580
ILE A 568
GLY A 587
ILE A 585
 None
 0.81A 3wxoA-3cwgA:
undetectable		 3wxoA-3cwgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		4 LEU A 259
ILE A 234
GLY A 228
ILE A 227
 None
 0.90A 3wxoA-3d0qA:
undetectable		 3wxoA-3d0qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djw ORF99

(Acidianus
filamentous
virus 1) 		PF07118
(DUF1374) 		4 LEU A  10
ILE A  11
GLY A  43
ILE A  42
 None
 0.87A 3wxoA-3djwA:
undetectable		 3wxoA-3djwA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 383
ILE A 369
ASN A 368
GLY A 400
ILE A 399
 None
 1.46A 3wxoA-3e2sA:
undetectable		 3wxoA-3e2sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1x SERINE
ACETYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00132
(Hexapep) 		4 LEU A 126
ILE A 129
GLY A 200
ILE A 199
 None
 0.91A 3wxoA-3f1xA:
undetectable		 3wxoA-3f1xA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF02542
(YgbB) 		4 LEU A 122
ILE A 129
ASN A 130
ILE A  98
 None
 0.77A 3wxoA-3f6mA:
undetectable		 3wxoA-3f6mA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		4 TRP A 326
LEU A   9
ILE A 346
GLY A 334
 None
 0.91A 3wxoA-3fqdA:
undetectable		 3wxoA-3fqdA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftp 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 ILE A 209
ASN A 243
GLY A 187
ILE A 189
 None
 0.91A 3wxoA-3ftpA:
undetectable		 3wxoA-3ftpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 LEU A 205
ILE A 208
ASN A 242
GLY A 185
 None
None
None
PO4  A 249 (-4.8A)
 0.90A 3wxoA-3gk3A:
undetectable		 3wxoA-3gk3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 332
ILE A 302
GLY A 307
ILE A 308
 None
 0.82A 3wxoA-3l22A:
undetectable		 3wxoA-3l22A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 LEU B 198
ASN B 266
GLY B 265
ILE B 264
 SAM  B 301 (-4.1A)
None
None
None
 0.86A 3wxoA-3lcvB:
undetectable		 3wxoA-3lcvB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkx NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
TRANSCRIPTION FACTOR
BTF3

(Homo sapiens) 		PF01849
(NAC) 		4 LEU B  44
ILE B  43
GLY A  30
ILE A  31
 None
 0.85A 3wxoA-3lkxB:
undetectable		 3wxoA-3lkxB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A  86
ILE A   6
GLY A 101
ILE A 102
 None
 0.90A 3wxoA-3lm8A:
undetectable		 3wxoA-3lm8A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lup DEGV FAMILY PROTEIN

(Streptococcus
agalactiae) 		PF02645
(DegV) 		4 LEU A 110
ILE A 112
GLY A  86
ILE A   6
 None
 0.83A 3wxoA-3lupA:
undetectable		 3wxoA-3lupA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oad RENIN

(Homo sapiens) 		PF00026
(Asp) 		4 LEU B 272
ILE B 193
ASN B 194
ILE B 196
 None
 0.89A 3wxoA-3oadB:
undetectable		 3wxoA-3oadB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 LEU A 171
ASN A 197
GLY A 196
ILE A   9
 None
 0.88A 3wxoA-3oajA:
undetectable		 3wxoA-3oajA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		4 LEU A  91
ILE A  89
ASN A  87
GLY A  86
 None
 0.84A 3wxoA-3om5A:
undetectable		 3wxoA-3om5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ory FLAP ENDONUCLEASE 1

(Desulfurococcus
amylolyticus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A 338
ASN A 337
GLY A  76
ILE A  77
 None
 0.90A 3wxoA-3oryA:
undetectable		 3wxoA-3oryA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		5 LEU A 204
ILE A 207
ASN A 241
GLY A 185
ILE A 187
 None
 0.99A 3wxoA-3osuA:
undetectable		 3wxoA-3osuA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		4 TRP A  34
ILE A  82
ASN A  81
GLY A   9
 None
 0.82A 3wxoA-3r8eA:
undetectable		 3wxoA-3r8eA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 LEU M 276
ASN M 495
GLY M 494
ILE M 493
 None
 0.90A 3wxoA-3rkoM:
undetectable		 3wxoA-3rkoM:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		4 ILE A  69
ASN A  68
GLY A  67
ILE A  66
 None
 0.89A 3wxoA-3sl1A:
undetectable		 3wxoA-3sl1A:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 TRP A 123
LYS A 176
LEU A 342
ASN A 346
GLY A 351
 None
 1.09A 3wxoA-3ut2A:
60.5		 3wxoA-3ut2A:
51.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 TRP A 123
TRP A 124
LYS A 176
LEU A 342
GLY A 351
 None
 0.38A 3wxoA-3ut2A:
60.5		 3wxoA-3ut2A:
51.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A1718
ASN A1711
GLY A1710
ILE A1709
 None
 0.75A 3wxoA-3vkgA:
undetectable		 3wxoA-3vkgA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 LEU A 251
ILE A 250
GLY A  43
ILE A  42
 None
 0.88A 3wxoA-3wbkA:
undetectable		 3wxoA-3wbkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 102
ILE A 112
GLY A 214
ILE A 217
 None
None
PG4  A 404 (-3.4A)
CHU  A 403 (-4.0A)
 0.86A 3wxoA-3wigA:
undetectable		 3wxoA-3wigA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8v EXTRACELLULAR
PROTEIN 6

(Passalora fulva) 		PF01476
(LysM) 		4 LEU A  55
ILE A  57
GLY A  33
ILE A  34
 None
None
None
NDG  A1199 ( 4.6A)
 0.88A 3wxoA-4b8vA:
undetectable		 3wxoA-4b8vA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 LEU A 204
ILE A 207
ASN A 241
GLY A 185
ILE A 187
 None
 0.93A 3wxoA-4bo6A:
undetectable		 3wxoA-4bo6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 4 TRP A 386
LEU A 491
GLY A 512
ILE A 513
 None
 0.85A 3wxoA-4bwkA:
1.0		 3wxoA-4bwkA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 TRP A  90
TRP A  91
LYS A 143
LEU A 298
GLY A 307
 None
 0.40A 3wxoA-4c51A:
61.5		 3wxoA-4c51A:
54.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU B 185
ILE B 222
ASN B 223
GLY B 230
ILE B 233
 None
 1.12A 3wxoA-4c9bB:
undetectable		 3wxoA-4c9bB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 198
ASN A 151
GLY A 152
ILE A 160
 None
 0.80A 3wxoA-4ewjA:
undetectable		 3wxoA-4ewjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		4 LYS A 534
LEU A 543
GLY A 356
ILE A 355
 None
 0.88A 3wxoA-4finA:
undetectable		 3wxoA-4finA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		4 LEU A 137
ILE A 134
GLY A  91
ILE A 155
 None
 0.85A 3wxoA-4g1uA:
0.8		 3wxoA-4g1uA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Plasmodium
falciparum) 		PF00574
(CLP_protease) 		4 ILE A 115
ASN A 117
GLY A 120
ILE A 121
 None
 0.74A 3wxoA-4gm2A:
undetectable		 3wxoA-4gm2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 346
ILE A 350
GLY A 126
ILE A 127
 None
 0.86A 3wxoA-4h3vA:
undetectable		 3wxoA-4h3vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 159
ILE A 188
ASN A 221
GLY A 187
 None
 0.83A 3wxoA-4h4fA:
undetectable		 3wxoA-4h4fA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrv PUTATIVE LIPOPROTEIN
GNA1162

(Neisseria
meningitidis) 		PF05643
(DUF799) 		4 TRP A 146
LEU A 110
ILE A  38
GLY A  68
 None
 0.88A 3wxoA-4hrvA:
undetectable		 3wxoA-4hrvA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s VICK-LIKE PROTEIN
PUTATIVE HISTIDINE
KINASE COVS

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 LEU A 378
ILE A 379
GLY A 370
ILE A 371
 None
 0.86A 3wxoA-4i5sA:
undetectable		 3wxoA-4i5sA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes) 		PF13561
(adh_short_C2) 		4 LEU A 205
ILE A 208
GLY A 186
ILE A 188
 None
 0.85A 3wxoA-4jroA:
undetectable		 3wxoA-4jroA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08362
(TetR_C_3) 		4 TRP A 148
LEU A  91
ILE A  94
ILE A 145
 None
SO4  A 302 (-3.6A)
None
None
 0.91A 3wxoA-4jykA:
undetectable		 3wxoA-4jykA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6c ACETOACETYL-COA
REDUCTASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 LEU A 204
ILE A 207
ASN A 241
GLY A 184
 None
 0.90A 3wxoA-4k6cA:
undetectable		 3wxoA-4k6cA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		4 LEU A 234
ASN A 139
GLY A 182
ILE A 183
 None
 0.78A 3wxoA-4m87A:
undetectable		 3wxoA-4m87A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me4 METAL DEPENDENT
PHOSPHOHYDROLASE

(Persephonella
marina) 		PF01590
(GAF)
PF01966
(HD) 		4 LEU A  28
ILE A  43
GLY A 123
ILE A 122
 None
 0.88A 3wxoA-4me4A:
undetectable		 3wxoA-4me4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 383
ILE A 369
ASN A 368
GLY A 400
ILE A 399
 None
 1.45A 3wxoA-4o8aA:
undetectable		 3wxoA-4o8aA:
22.82