SIMILAR PATTERNS OF AMINO ACIDS FOR 3WSJ_A_MK1A201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b8x | PROTEIN (AML-1B) (Escherichiacoli) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 125ALA A 157ASP A 156LEU A 99ILE A 101 | None | 1.37A | 3wsjA-1b8xA:undetectable | 3wsjA-1b8xA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bg5 | FUSION PROTEIN OFALPHA-NA,K-ATPASEWITH GLUTATHIONES-TRANSFERASE (Rattusnorvegicus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 126ALA A 158ASP A 157LEU A 100ILE A 102 | None | 1.41A | 3wsjA-1bg5A:undetectable | 3wsjA-1bg5A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d9s | CYCLIN-DEPENDENTKINASE 4 INHIBITOR B (Mus musculus) |
PF12796(Ank_2) | 5 | LEU A 85ALA A 79ASP A 78LEU A 111ILE A 120 | None | 1.29A | 3wsjA-1d9sA:undetectable | 3wsjA-1d9sA:26.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fob | BETA-1,4-GALACTANASE (Aspergillusaculeatus) |
PF07745(Glyco_hydro_53) | 5 | LEU A 331ALA A 39ASP A 38VAL A 324ILE A 328 | None | 1.23A | 3wsjA-1fobA:0.0 | 3wsjA-1fobA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.4A)NoneA79 A 800 (-3.6A) | 0.78A | 3wsjA-1hvcA:8.9 | 3wsjA-1hvcA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.3A)NoneA79 A 800 (-3.8A) | 0.86A | 3wsjA-1hvcA:8.9 | 3wsjA-1hvcA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hyg | L-LACTATE/MALATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ALA A 107ASP A 135VAL A 143LEU A 133ILE A 118 | None | 1.37A | 3wsjA-1hygA:0.0 | 3wsjA-1hygA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1is7 | GTP CYCLOHYDROLASE I (Rattusnorvegicus) |
PF01227(GTP_cyclohydroI) | 5 | LEU A 154ALA A 183VAL A 193LEU A 222ILE A 184 | None | 1.43A | 3wsjA-1is7A:0.0 | 3wsjA-1is7A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iw8 | ACID PHOSPHATASE (Shimwelliablattae) |
PF01569(PAP2) | 5 | LEU A 55ALA A 64ASP A 67VAL A 184ILE A 185 | None | 1.21A | 3wsjA-1iw8A:undetectable | 3wsjA-1iw8A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l6r | HYPOTHETICAL PROTEINTA0175 (Thermoplasmaacidophilum) |
PF08282(Hydrolase_3) | 5 | ARG A 3ALA A 6VAL A 186LEU A 184ILE A 169 | None | 1.43A | 3wsjA-1l6rA:0.0 | 3wsjA-1l6rA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhs | PLASMA MEMBRANEATPASE (Neurosporacrassa) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 5 | ASP A 663ALA A 365VAL A 360LEU A 353ILE A 664 | None | 1.30A | 3wsjA-1mhsA:0.0 | 3wsjA-1mhsA:8.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mtp | SERINE PROTEINASEINHIBITOR (SERPIN),CHAIN ASERINE PROTEINASEINHIBITOR (SERPIN),CHAIN B (Thermobifidafusca) |
PF00079(Serpin)no annotation | 5 | LEU A 213ALA A 166ASP A 82VAL B 346LEU B 353 | None | 1.42A | 3wsjA-1mtpA:0.0 | 3wsjA-1mtpA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzn | DNA REPAIR ANDRECOMBINATIONPROTEIN RAD51 (Pyrococcusfuriosus) |
PF08423(Rad51)PF14520(HHH_5) | 5 | ARG A 312ASP A 267VAL A 279LEU A 235ILE A 133 | None | 1.07A | 3wsjA-1pznA:undetectable | 3wsjA-1pznA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5d | P450 EPOXIDASE (Sorangiumcellulosum) |
PF00067(p450) | 5 | ARG A 307LEU A 328ALA A 333ASP A 336ILE A 330 | HEM A 440 (-3.1A)NoneNoneNoneNone | 1.36A | 3wsjA-1q5dA:undetectable | 3wsjA-1q5dA:13.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29VAL A 32ILE A 84 | None | 0.51A | 3wsjA-1q9pA:7.9 | 3wsjA-1q9pA:33.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29ILE A 84 | None | 0.40A | 3wsjA-1sivA:12.4 | 3wsjA-1sivA:36.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8s | GLYCINE CLEAVAGESYSTEMTRANSCRIPTIONALREPRESSOR, PUTATIVE (Vibrio cholerae) |
PF13740(ACT_6) | 5 | LEU A 124ALA A 147VAL A 96LEU A 175ILE A 145 | None | 1.13A | 3wsjA-1u8sA:undetectable | 3wsjA-1u8sA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uuo | DIHYDROOROTATEDEHYDROGENASE (Rattus rattus) |
PF01180(DHO_dh) | 5 | LEU A 182ALA A 206ASP A 207VAL A 118ILE A 180 | None | 1.27A | 3wsjA-1uuoA:undetectable | 3wsjA-1uuoA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vr0 | PROBABLE2-PHOSPHOSULFOLACTATE PHOSPHATASE (Clostridiumacetobutylicum) |
PF04029(2-ph_phosp) | 5 | LEU A 67ALA A 65ASP A 64VAL A 46ILE A 99 | None | 1.42A | 3wsjA-1vr0A:undetectable | 3wsjA-1vr0A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xf1 | C5A PEPTIDASE (Streptococcuspyogenes) |
PF00082(Peptidase_S8)PF02225(PA)PF06280(fn3_5)PF13585(CHU_C) | 5 | LEU A 524ALA A 577ASP A 576VAL A 518ILE A 521 | None | 1.32A | 3wsjA-1xf1A:undetectable | 3wsjA-1xf1A:9.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yk3 | HYPOTHETICAL PROTEINRV1347C/MT1389 (Mycobacteriumtuberculosis) |
PF13523(Acetyltransf_8) | 5 | ARG A 163ALA A 111ASP A 114VAL A 28LEU A 24 | None | 1.22A | 3wsjA-1yk3A:undetectable | 3wsjA-1yk3A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yk3 | HYPOTHETICAL PROTEINRV1347C/MT1389 (Mycobacteriumtuberculosis) |
PF13523(Acetyltransf_8) | 5 | ARG A 163ASP A 126ALA A 111VAL A 28LEU A 24 | None | 1.39A | 3wsjA-1yk3A:undetectable | 3wsjA-1yk3A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yqd | SINAPYL ALCOHOLDEHYDROGENASE (Populustremuloides) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ARG A 348ASP A 331VAL A 353LEU A 357ILE A 351 | NAP A 500 (-3.1A)NoneNoneNoneNone | 1.35A | 3wsjA-1yqdA:undetectable | 3wsjA-1yqdA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2col | BIFUNCTIONALHEMOLYSIN-ADENYLATECYCLASE (Bordetellapertussis) |
PF03497(Anthrax_toxA) | 5 | LEU A 185ALA A 64ASP A 99VAL A 78ILE A 177 | None | 1.34A | 3wsjA-2colA:undetectable | 3wsjA-2colA:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3d | UTP--GLUCOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Escherichiacoli) |
PF00483(NTP_transferase) | 5 | LEU A 220ALA A 244ASP A 243TRP A 225ILE A 224 | None | 1.40A | 3wsjA-2e3dA:undetectable | 3wsjA-2e3dA:16.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29ILE A 89 | LP1 A 201 (-3.5A)NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-4.2A) | 0.49A | 3wsjA-2fmbA:11.0 | 3wsjA-2fmbA:31.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 81ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)NoneNoneLP1 A 201 (-4.2A) | 0.81A | 3wsjA-2fmbA:11.0 | 3wsjA-2fmbA:31.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jok | PUTATIVEG-NUCLEOTIDEEXCHANGE FACTOR (Burkholderiapseudomallei) |
PF07487(SopE_GEF) | 5 | LEU A 119ALA A 152ASP A 151VAL A 233LEU A 236 | None | 1.34A | 3wsjA-2jokA:undetectable | 3wsjA-2jokA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o52 | RAS-RELATED PROTEINRAB-4B (Homo sapiens) |
PF00071(Ras) | 5 | ALA A 106ASP A 105VAL A 116LEU A 86ILE A 114 | None | 1.43A | 3wsjA-2o52A:undetectable | 3wsjA-2o52A:16.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29ILE A 84 | AB1 A 501 ( 4.7A)NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 ( 4.2A) | 0.60A | 3wsjA-2rkfA:12.9 | 3wsjA-2rkfA:34.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 29LEU A 76ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)NoneAB1 A 501 ( 4.2A) | 0.72A | 3wsjA-2rkfA:12.9 | 3wsjA-2rkfA:34.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 6 | ARG A 10LEU A 35ASP A 37ALA A 40ASP A 41ILE A 108 | None | 0.86A | 3wsjA-2rspA:13.0 | 3wsjA-2rspA:29.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 5 | LEU A 194ASP A 231VAL A 255LEU A 247ILE A 227 | None | 1.18A | 3wsjA-2xh1A:undetectable | 3wsjA-2xh1A:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xua | 3-OXOADIPATEENOL-LACTONASE (Paraburkholderiaxenovorans) |
PF12146(Hydrolase_4) | 5 | ARG A 61LEU A 78ALA A 196ASP A 197ILE A 75 | None | 1.31A | 3wsjA-2xuaA:undetectable | 3wsjA-2xuaA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ybx | PHOSPHATIDYLINOSITOL-5-PHOSPHATE4-KINASE TYPE-2ALPHA (Homo sapiens) |
PF01504(PIP5K) | 5 | LEU A 52ASP A 109VAL A 45LEU A 116ILE A 49 | None | 1.44A | 3wsjA-2ybxA:undetectable | 3wsjA-2ybxA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yub | LIM DOMAIN KINASE 2 (Mus musculus) |
PF00595(PDZ) | 5 | LEU A 99ALA A 89ASP A 88LEU A 81ILE A 73 | None | 1.26A | 3wsjA-2yubA:undetectable | 3wsjA-2yubA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c0b | CONSERVED ARCHAEALPROTEIN Q6M145 (Methanococcusmaripaludis) |
PF01968(Hydantoinase_A) | 5 | LEU A 99ALA A 79VAL A 50LEU A 3ILE A 87 | None | 1.27A | 3wsjA-3c0bA:undetectable | 3wsjA-3c0bA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csw | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Thermotogamaritima) |
PF01063(Aminotran_4) | 5 | LEU A 34ALA A 77ASP A 78LEU A 2ILE A 86 | None | 1.29A | 3wsjA-3cswA:undetectable | 3wsjA-3cswA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d0q | PROTEIN CALG3 (Micromonosporaechinospora) |
PF06722(DUF1205) | 5 | LEU A 246ALA A 237VAL A 282LEU A 301ILE A 215 | None | 1.02A | 3wsjA-3d0qA:undetectable | 3wsjA-3d0qA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gay | FRUCTOSE-BISPHOSPHATE ALDOLASE (Giardiaintestinalis) |
PF01116(F_bP_aldolase) | 5 | ARG A 14LEU A 207ALA A 158ASP A 157ILE A 199 | None | 1.45A | 3wsjA-3gayA:undetectable | 3wsjA-3gayA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 5 | LEU A 312ALA A 322ASP A 323VAL A 34LEU A 331 | None | 1.16A | 3wsjA-3h4xA:undetectable | 3wsjA-3h4xA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js3 | 3-DEHYDROQUINATEDEHYDRATASE (Clostridioidesdifficile) |
PF01487(DHquinase_I) | 5 | LEU A 118ALA A 167ASP A 168VAL A 116ILE A 141 | None | 1.30A | 3wsjA-3js3A:undetectable | 3wsjA-3js3A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1d | 1,4-ALPHA-GLUCAN-BRANCHING ENZYME (Mycobacteriumtuberculosis) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 5 | LEU A 400VAL A 340LEU A 292TRP A 399ILE A 405 | None | 1.42A | 3wsjA-3k1dA:undetectable | 3wsjA-3k1dA:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l77 | SHORT-CHAIN ALCOHOLDEHYDROGENASE (Thermococcussibiricus) |
PF00106(adh_short) | 5 | LEU A 30ALA A 4VAL A 84LEU A 133ILE A 6 | None | 1.27A | 3wsjA-3l77A:undetectable | 3wsjA-3l77A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldg | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.472 (Streptococcusmutans) |
PF01170(UPF0020)PF02926(THUMP) | 5 | LEU A 257ASP A 200VAL A 285LEU A 287ILE A 259 | None | 1.38A | 3wsjA-3ldgA:undetectable | 3wsjA-3ldgA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mnf | PAC2 FAMILY PROTEIN (Streptomycesavermitilis) |
PF09754(PAC2) | 5 | ARG A 208LEU A 185ALA A 32VAL A 16LEU A 94 | None | 1.31A | 3wsjA-3mnfA:undetectable | 3wsjA-3mnfA:20.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76ILE A 84 | None | 0.81A | 3wsjA-3mwsA:13.1 | 3wsjA-3mwsA:35.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzl | PROTEIN TRANSPORTPROTEIN SEC31 (Saccharomycescerevisiae) |
PF12931(Sec16_C) | 5 | ARG B 571LEU B 588ALA B 599LEU B 615ILE B 596 | None | 1.44A | 3wsjA-3mzlB:undetectable | 3wsjA-3mzlB:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 5 | LEU A 77ASP A 122VAL A 115LEU A 134ILE A 96 | None CA A 404 ( 2.4A)NoneNoneNone | 1.02A | 3wsjA-3p4gA:undetectable | 3wsjA-3p4gA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8k | HYDROLASE,CARBON-NITROGENFAMILY (Staphylococcusaureus) |
PF00795(CN_hydrolase) | 5 | LEU A 70ALA A 80VAL A 98LEU A 104ILE A 67 | None | 1.45A | 3wsjA-3p8kA:undetectable | 3wsjA-3p8kA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 5 | LEU A 30ASP A 32ALA A 35VAL A 39LEU A 83 | None3TL A 126 (-2.4A)3TL A 126 ( 4.0A)NoneNone | 0.50A | 3wsjA-3slzA:10.3 | 3wsjA-3slzA:27.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76 | SO4 A 101 (-3.8A)017 A 201 (-2.6A)017 A 201 (-3.5A)017 A 201 (-3.5A)NoneNone | 1.10A | 3wsjA-3t3cA:12.6 | 3wsjA-3t3cA:34.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)017 A 201 (-3.5A)017 A 201 (-3.5A)NoneNone | 0.91A | 3wsjA-3t3cA:12.6 | 3wsjA-3t3cA:34.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | LEU A 189ALA A 259VAL A 294LEU A 332ILE A 257 | None | 1.01A | 3wsjA-3tmaA:undetectable | 3wsjA-3tmaA:15.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29LEU A 76ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)None017 A 201 (-4.7A) | 0.71A | 3wsjA-3ttpA:12.8 | 3wsjA-3ttpA:34.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tzt | GLYCOSYL TRANSFERASEFAMILY 8 (Anaerococcusprevotii) |
PF01501(Glyco_transf_8) | 5 | LEU A 94ALA A 4ASP A 3LEU A 160ILE A 101 | NoneEDO A 302 (-4.5A)EDO A 302 (-4.0A)NoneNone | 1.41A | 3wsjA-3tztA:undetectable | 3wsjA-3tztA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29 | NoneNone017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 (-3.2A) | 0.50A | 3wsjA-3u7sA:12.9 | 3wsjA-3u7sA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30 | NoneNone017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A) | 1.41A | 3wsjA-3u7sA:12.9 | 3wsjA-3u7sA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ALA A 28ASP A 29LEU A 76 | None017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)None | 0.60A | 3wsjA-3u7sA:12.9 | 3wsjA-3u7sA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w21 | PUTATIVEUNCHARACTERIZEDPROTEIN (Burkholderiaambifaria) |
no annotation | 5 | ARG A 11LEU A 9ALA A 26LEU A 237ILE A 38 | None | 1.06A | 3wsjA-3w21A:undetectable | 3wsjA-3w21A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wj7 | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF01370(Epimerase) | 5 | ARG A 322ALA A 328ASP A 186LEU A 197ILE A 329 | None | 1.46A | 3wsjA-3wj7A:undetectable | 3wsjA-3wj7A:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dbe | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Sulfolobussolfataricus) |
PF00215(OMPdecase) | 5 | LEU A 146ALA A 181ASP A 182VAL A 141ILE A 149 | None | 1.24A | 3wsjA-4dbeA:undetectable | 3wsjA-4dbeA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dia | 2-PYRONE-4,6-DICARBAXYLATE HYDROLASE (Sphingomonaspaucimobilis) |
PF04909(Amidohydro_2) | 5 | LEU A 289ALA A 30ASP A 29LEU A 282ILE A 244 | None | 1.39A | 3wsjA-4diaA:undetectable | 3wsjA-4diaA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkw | LARGE TERMINASEPROTEIN (Salmonellavirus P22) |
PF17289(Terminase_6C) | 5 | LEU A 333ALA A 463ASP A 321VAL A 347ILE A 331 | NoneNone MG A 501 (-2.6A)NoneNone | 0.96A | 3wsjA-4dkwA:undetectable | 3wsjA-4dkwA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnh | UNCHARACTERIZEDPROTEIN (Sinorhizobiummeliloti) |
PF06187(DUF993) | 5 | LEU A 105ALA A 114ASP A 113VAL A 79ILE A 116 | None | 1.43A | 3wsjA-4dnhA:undetectable | 3wsjA-4dnhA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dte | SERPIN PEPTIDASEINHIBITOR, CLADE E(NEXIN, PLASMINOGENACTIVATOR INHIBITORTYPE 1), MEMBER 1 (Danio rerio) |
PF00079(Serpin) | 5 | LEU A 287ALA A 41VAL A 309LEU A 155ILE A 290 | None | 1.37A | 3wsjA-4dteA:undetectable | 3wsjA-4dteA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4e | ATP-DEPENDENTPROTEASE SUBUNITHSLV (Escherichiacoli) |
PF00227(Proteasome) | 5 | LEU A 142ALA A 151VAL A 6LEU A 119ILE A 147 | None | 1.46A | 3wsjA-4g4eA:undetectable | 3wsjA-4g4eA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h9p | DEATHDOMAIN-ASSOCIATEDPROTEIN 6 (Homo sapiens) |
no annotation | 5 | LEU C 274ALA C 316ASP C 315VAL C 267ILE C 271 | None | 1.29A | 3wsjA-4h9pC:undetectable | 3wsjA-4h9pC:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jiw | PUTATIVEUNCHARACTERIZEDPROTEIN (Escherichiacoli) |
PF05488(PAAR_motif) | 5 | ARG D 56LEU D 43ALA D 37LEU D 34ILE D 22 | None | 1.41A | 3wsjA-4jiwD:undetectable | 3wsjA-4jiwD:27.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ARG A3723LEU A3760ALA A3714ASP A3712ILE A3781 | None | 1.41A | 3wsjA-4kc5A:undetectable | 3wsjA-4kc5A:8.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kc5 | RHIE PROTEIN (Paraburkholderiarhizoxinica) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A3760ALA A3714ASP A3712LEU A3901ILE A3781 | None | 1.31A | 3wsjA-4kc5A:undetectable | 3wsjA-4kc5A:8.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 5 | ARG A 248LEU A 279ALA A 265ASP A 266LEU A 156 | None | 1.44A | 3wsjA-4lglA:undetectable | 3wsjA-4lglA:10.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ASP A 25ALA A 28ILE A 84 | RIT A 500 (-3.2A)NoneRIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-4.3A) | 0.55A | 3wsjA-4njvA:12.8 | 3wsjA-4njvA:33.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)NoneNoneRIT A 500 (-4.3A) | 0.75A | 3wsjA-4njvA:12.8 | 3wsjA-4njvA:33.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6r | ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 5 | LEU A 414ALA A 403VAL A 288LEU A 391ILE A 255 | None | 1.12A | 3wsjA-4o6rA:undetectable | 3wsjA-4o6rA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ro1 | DIS3-LIKEEXONUCLEASE 2 (Schizosaccharomycespombe) |
no annotation | 5 | ARG B 562LEU B 460ALA B 481ASP B 482LEU B 518 | None | 1.35A | 3wsjA-4ro1B:undetectable | 3wsjA-4ro1B:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 5 | LEU A 215ASP A 177VAL A 189LEU A 162ILE A 218 | None | 1.04A | 3wsjA-4urjA:undetectable | 3wsjA-4urjA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wz9 | AGAP004809-PA (Anophelesgambiae) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | LEU A 856ALA A 844ASP A 804LEU A 806ILE A 845 | None | 1.14A | 3wsjA-4wz9A:undetectable | 3wsjA-4wz9A:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9e | DEOXYGUANOSINETRIPHOSPHATETRIPHOSPHOHYDROLASE (Escherichiacoli) |
PF01966(HD) | 5 | ARG A 87ALA A 266ASP A 269VAL A 76ILE A 80 | None | 1.20A | 3wsjA-4x9eA:undetectable | 3wsjA-4x9eA:13.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 8 | ARG A 10LEU A 30ASP A 32ALA A 35ASP A 36VAL A 39LEU A 91ILE A 100 | NoneNone4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)NoneNone4B1 A 201 (-4.8A) | 0.48A | 3wsjA-4ydfA:23.4 | 3wsjA-4ydfA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 8 | LEU A 30ASP A 32ALA A 35ASP A 36VAL A 39LEU A 91TRP A 98ILE A 100 | None4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)NoneNoneNone4B1 A 201 (-4.8A) | 0.29A | 3wsjA-4ydfA:23.4 | 3wsjA-4ydfA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | LEU A 177ALA A 32ASP A 33VAL A 168ILE A 175 | None | 0.96A | 3wsjA-5cwaA:undetectable | 3wsjA-5cwaA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwu | NUCLEOPORIN NUP188 (Chaetomiumthermophilum) |
no annotation | 5 | LEU A1550ALA A1557VAL A1519LEU A1515ILE A1554 | None | 1.45A | 3wsjA-5cwuA:undetectable | 3wsjA-5cwuA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn8 | GTPASE DER (Coxiellaburnetii) |
PF01926(MMR_HSR1)PF14714(KH_dom-like) | 5 | ARG A 388LEU A 385ALA A 383LEU A 411ILE A 393 | None | 1.43A | 3wsjA-5dn8A:undetectable | 3wsjA-5dn8A:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 5 | LEU B 688ALA B 674ASP B 676VAL B 647ILE B 649 | None | 1.46A | 3wsjA-5gztB:undetectable | 3wsjA-5gztB:7.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja1 | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | ARG A 151ALA A 55ASP A 56LEU A 140ILE A 149 | None | 1.11A | 3wsjA-5ja1A:undetectable | 3wsjA-5ja1A:7.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jqn | ALIPHATIC AMIDASE (Nesterenkoniasp. AN1) |
PF00795(CN_hydrolase) | 5 | LEU A 36ALA A 195VAL A 234LEU A 222ILE A 3 | None | 1.34A | 3wsjA-5jqnA:undetectable | 3wsjA-5jqnA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jx5 | GLUCANASE (Orpinomyces sp.Y102) |
PF01341(Glyco_hydro_6) | 5 | LEU A 347ALA A 291ASP A 290LEU A 272ILE A 308 | NoneNoneNH4 A 516 ( 2.7A)NoneNone | 1.39A | 3wsjA-5jx5A:undetectable | 3wsjA-5jx5A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nb3 | PHYCOERYTHRIN BETASUBUNIT,PHYCOERYTHRIN BETA SUBUNIT (Phormidiumrubidum) |
PF00502(Phycobilisome) | 5 | LEU M 108ASP M 104ALA M 100ASP M 99VAL M 91 | None | 1.45A | 3wsjA-5nb3M:undetectable | 3wsjA-5nb3M:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1q | N-ACETYLMURAMOYL-L-ALANINE AMIDASEDOMAIN-CONTAININGPROTEINSAOUHSC_02979 (Staphylococcusaureus) |
PF01832(Glucosaminidase)PF05257(CHAP) | 5 | LEU A 468ALA A 331ASP A 330LEU A 368ILE A 346 | None | 1.47A | 3wsjA-5t1qA:undetectable | 3wsjA-5t1qA:17.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29ILE A 84 | None | 0.63A | 3wsjA-5t2zA:12.3 | 3wsjA-5t2zA:33.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 29VAL A 32LEU A 76ILE A 84 | None | 0.85A | 3wsjA-5t2zA:12.3 | 3wsjA-5t2zA:33.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u30 | CRISPR-ASSOCIATEDENDONUCLEASE C2C1 (Alicyclobacillusacidoterrestris) |
no annotation | 5 | ASP A1080ALA A 907ASP A 902VAL A1100ILE A1085 | None | 1.46A | 3wsjA-5u30A:undetectable | 3wsjA-5u30A:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w57 | PERIPLASMIC SOLUTEBINDING PROTEIN (Paracoccusdenitrificans) |
PF01297(ZnuA) | 5 | LEU A 272ALA A 268VAL A 201LEU A 219ILE A 250 | None | 1.31A | 3wsjA-5w57A:undetectable | 3wsjA-5w57A:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8p | HOMOSERINEO-ACETYLTRANSFERASE (Mycobacteroidesabscessus) |
PF00561(Abhydrolase_1) | 5 | ARG A 238ASP A 327ALA A 184VAL A 351ILE A 324 | None | 1.28A | 3wsjA-5w8pA:undetectable | 3wsjA-5w8pA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wab | PUTATIVEBETA-GLUCOSIDASE (Bifidobacteriumadolescentis) |
no annotation | 5 | LEU A 152ASP A 232VAL A 229LEU A 247ILE A 196 | NoneGOL A 801 (-3.1A)NoneNoneNone | 1.23A | 3wsjA-5wabA:undetectable | 3wsjA-5wabA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xi0 | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE[NADH] (Aliivibriofischeri) |
no annotation | 5 | LEU A 124ASP A 133VAL A 213LEU A 214ILE A 125 | None | 1.42A | 3wsjA-5xi0A:undetectable | 3wsjA-5xi0A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bka | NITRONATEMONOOXYGENASE (Cyberlindneramrakii) |
no annotation | 5 | LEU A 184ASP A 185ASP A 163VAL A 144ILE A 166 | None | 1.46A | 3wsjA-6bkaA:undetectable | 3wsjA-6bkaA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 13LEU A 28ASP A 30ALA A 33ASP A 34 | NoneNone3TL A 201 (-3.5A)3TL A 201 (-4.0A)3TL A 201 (-3.9A) | 0.58A | 3wsjA-6fivA:12.0 | 3wsjA-6fivA:26.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 29ILE A 84 | NoneNoneNIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNone | 0.87A | 3wsjA-6upjA:12.1 | 3wsjA-6upjA:32.79 |