SIMILAR PATTERNS OF AMINO ACIDS FOR 3WRK_A_CAMA502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PHE A 464
GLY A 411
ILE A 469
VAL A 582
 None
 0.87A 3wrkA-1cb8A:
0.3		 3wrkA-1cb8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 PHE A 446
LEU A 404
GLY A 533
ILE A 456
 None
 0.78A 3wrkA-1kcwA:
0.0		 3wrkA-1kcwA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.88A 3wrkA-1kcxA:
undetectable		 3wrkA-1kcxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 241
GLY A 142
ILE A 112
VAL A  43
 None
 0.85A 3wrkA-1oypA:
0.0		 3wrkA-1oypA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfd TRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 PHE A 186
LEU A  66
GLY A 123
VAL A 159
 None
 0.89A 3wrkA-1tfdA:
undetectable		 3wrkA-1tfdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0j DNA REPLICATION
PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF01057
(Parvo_NS1) 		4 PHE A 316
LEU A 450
GLY A 339
ILE A 347
 None
None
ADP  A 491 (-3.3A)
None
 0.88A 3wrkA-1u0jA:
undetectable		 3wrkA-1u0jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 LEU A 102
GLY A  41
ILE A   6
VAL A  20
 None
 0.88A 3wrkA-1w2wA:
0.0		 3wrkA-1w2wA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yll CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF05962
(HutD) 		4 PHE A  53
LEU A 101
GLY A  70
ILE A  63
 None
 0.88A 3wrkA-1yllA:
0.0		 3wrkA-1yllA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yn9 POLYNUCLEOTIDE
5'-PHOSPHATASE

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00782
(DSPc) 		4 PHE A  24
GLY A  56
ILE A  48
VAL A  49
 None
 0.83A 3wrkA-1yn9A:
0.0		 3wrkA-1yn9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PHE A  81
GLY A  15
ILE A  72
VAL A  71
 None
NAP  A 900 (-3.2A)
None
None
 0.79A 3wrkA-1ys4A:
undetectable		 3wrkA-1ys4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 PHE A 427
GLY A 323
ILE A 357
VAL A 358
 None
 0.74A 3wrkA-2ftwA:
undetectable		 3wrkA-2ftwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		4 PHE A 253
GLY A  91
ILE A  88
VAL A  87
 None
 0.83A 3wrkA-2gzxA:
undetectable		 3wrkA-2gzxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM

(Mus musculus) 		PF16776
(INPP5B_PH) 		4 PHE A 126
LEU A  80
ILE A  24
VAL A  23
 None
 0.88A 3wrkA-2kigA:
undetectable		 3wrkA-2kigA:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
LEU A 244
GLY A 248
ILE A 395
VAL A 396
 CAM  A 502 (-4.6A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
None
None
 0.77A 3wrkA-2m56A:
56.4		 3wrkA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 330
GLY A 304
ILE A 291
VAL A 290
 LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 0.77A 3wrkA-2nvvA:
undetectable		 3wrkA-2nvvA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 PHE A 415
LEU A 395
GLY A 394
ILE A 405
VAL A 402
 None
 1.33A 3wrkA-2o0xA:
undetectable		 3wrkA-2o0xA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		4 LEU A 175
GLY A 145
ILE A 161
VAL A 157
 None
 0.77A 3wrkA-2qcvA:
undetectable		 3wrkA-2qcvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfl INOSITOL-1-MONOPHOSP
HATASE

(Escherichia
coli) 		PF00459
(Inositol_P) 		4 PHE A 230
GLY A 156
ILE A 171
VAL A 172
 None
 0.76A 3wrkA-2qflA:
undetectable		 3wrkA-2qflA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 PHE A   2
LEU A  84
GLY A  86
ILE A 102
 None
 0.85A 3wrkA-2qo4A:
undetectable		 3wrkA-2qo4A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		4 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.84A 3wrkA-2r09A:
undetectable		 3wrkA-2r09A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF14514
(TetR_C_9) 		4 PHE A 162
LEU A  81
ILE A 205
VAL A 202
 None
 0.89A 3wrkA-2rhaA:
undetectable		 3wrkA-2rhaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 PHE A 431
GLY A 186
ILE A 336
VAL A 337
 None
 0.79A 3wrkA-2veoA:
undetectable		 3wrkA-2veoA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		4 PHE A 396
GLY A 373
ILE A 365
VAL A 300
 None
 0.88A 3wrkA-2wn4A:
undetectable		 3wrkA-2wn4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xc7 PHOSPHORYLATED
ADAPTER RNA EXPORT
PROTEIN

(Homo sapiens) 		PF10258
(RNA_GG_bind) 		4 PHE A  70
GLY A  35
ILE A  15
VAL A  11
 None
 0.88A 3wrkA-2xc7A:
undetectable		 3wrkA-2xc7A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 LEU A 201
GLY A 205
ILE A 219
VAL A 218
 None
 0.75A 3wrkA-2y38A:
undetectable		 3wrkA-2y38A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		4 PHE A 302
LEU A 245
GLY A 317
VAL A 294
 None
 0.89A 3wrkA-3ajeA:
undetectable		 3wrkA-3ajeA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 PHE A 169
LEU A 297
GLY A 259
ILE A 128
 None
 0.76A 3wrkA-3blwA:
undetectable		 3wrkA-3blwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 PHE A 244
LEU A 276
GLY A 300
ILE A 238
 None
 0.75A 3wrkA-3cf4A:
undetectable		 3wrkA-3cf4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 PHE A 486
LEU A 476
ILE A 491
VAL A 263
 None
 0.88A 3wrkA-3d3kA:
undetectable		 3wrkA-3d3kA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4f DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Saccharomyces
cerevisiae) 		PF00692
(dUTPase) 		4 LEU A 117
GLY A  63
ILE A  53
VAL A  92
 None
None
None
UMP  A 200 (-3.6A)
 0.70A 3wrkA-3f4fA:
undetectable		 3wrkA-3f4fA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkv POLY [ADP-RIBOSE]
POLYMERASE 10

(Homo sapiens) 		PF00644
(PARP) 		4 LEU A 861
GLY A 901
ILE A 990
VAL A 918
 None
 0.68A 3wrkA-3hkvA:
undetectable		 3wrkA-3hkvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 PHE A 315
LEU A 356
ILE A 269
VAL A 268
 None
 0.83A 3wrkA-3htzA:
undetectable		 3wrkA-3htzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in6 FMN-BINDING PROTEIN

(Syntrophomonas
wolfei) 		no annotation 4 LEU A  34
GLY A  79
ILE A 136
VAL A 137
 None
None
MPD  A 149 (-4.4A)
None
 0.84A 3wrkA-3in6A:
undetectable		 3wrkA-3in6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		4 PHE A 125
LEU A 275
ILE A 156
VAL A 155
 None
 0.86A 3wrkA-3innA:
undetectable		 3wrkA-3innA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nostoc
punctiforme) 		PF00903
(Glyoxalase) 		4 PHE A 138
GLY A  42
ILE A 116
VAL A 115
 None
 0.74A 3wrkA-3kolA:
undetectable		 3wrkA-3kolA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 PHE A 198
GLY A 206
ILE A 259
VAL A 285
 None
 0.84A 3wrkA-3ldgA:
undetectable		 3wrkA-3ldgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 PHE A 186
LEU A  66
GLY A 123
VAL A 154
 None
 0.77A 3wrkA-3mc2A:
undetectable		 3wrkA-3mc2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 492
GLY A 488
ILE A 379
VAL A 380
 None
 0.58A 3wrkA-3ne5A:
0.8		 3wrkA-3ne5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 PHE A 314
LEU A 247
GLY A 246
ILE A 341
 None
 0.81A 3wrkA-3othA:
undetectable		 3wrkA-3othA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p48 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Saccharomyces
cerevisiae) 		PF00692
(dUTPase) 		4 LEU A 117
GLY A  63
ILE A  53
VAL A  92
 None
 0.73A 3wrkA-3p48A:
undetectable		 3wrkA-3p48A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A 213
GLY A 142
ILE A 206
VAL A 205
 None
 0.81A 3wrkA-3r7kA:
undetectable		 3wrkA-3r7kA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 PHE A 294
LEU A 310
GLY A 312
ILE A 317
 None
 0.79A 3wrkA-3rg1A:
undetectable		 3wrkA-3rg1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		4 LEU A  24
GLY A 235
ILE A 140
VAL A 183
 None
None
NDP  A 301 (-4.3A)
None
 0.86A 3wrkA-3sjuA:
undetectable		 3wrkA-3sjuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		4 PHE A 229
GLY A 223
ILE A 264
VAL A 265
 None
 0.88A 3wrkA-3sxpA:
undetectable		 3wrkA-3sxpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 PHE B 244
GLY B 221
ILE B 216
VAL B 162
 None
 0.74A 3wrkA-3u0jB:
0.8		 3wrkA-3u0jB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		4 LEU B  85
GLY B 148
ILE B  98
VAL B  97
 None
 0.87A 3wrkA-3u1jB:
undetectable		 3wrkA-3u1jB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 477
LEU A 464
GLY A 488
ILE A 479
VAL A 531
 None
 1.45A 3wrkA-3ui7A:
undetectable		 3wrkA-3ui7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		4 LEU A  46
GLY A 110
ILE A 145
VAL A 149
 None
 0.83A 3wrkA-3vc1A:
undetectable		 3wrkA-3vc1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens) 		PF12790
(T6SS-SciN) 		4 PHE A  41
LEU A 137
GLY A 120
ILE A  60
 None
 0.86A 3wrkA-4a1rA:
undetectable		 3wrkA-4a1rA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 PHE A  94
LEU A 118
GLY A 161
ILE A   5
 None
 0.87A 3wrkA-4ayjA:
undetectable		 3wrkA-4ayjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PHE A 373
GLY A  92
ILE A  59
VAL A 403
 None
 0.88A 3wrkA-4b90A:
undetectable		 3wrkA-4b90A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PHE A 373
GLY A  92
ILE A  59
VAL A 403
 None
 0.81A 3wrkA-4b92A:
undetectable		 3wrkA-4b92A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 LEU A 269
GLY A 281
ILE A 214
VAL A 213
 None
 0.89A 3wrkA-4bejA:
undetectable		 3wrkA-4bejA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 LEU A  25
GLY A 223
ILE A 139
VAL A 182
 None
 0.88A 3wrkA-4bo6A:
undetectable		 3wrkA-4bo6A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 LEU A 252
GLY A 256
ILE A 403
VAL A 404
 HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
None
GOL  A1419 (-3.5A)
 0.64A 3wrkA-4c9mA:
50.5		 3wrkA-4c9mA:
45.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.79A 3wrkA-4cnsA:
undetectable		 3wrkA-4cnsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.80A 3wrkA-4cntA:
undetectable		 3wrkA-4cntA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db5 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18

(Oryctolagus
cuniculus) 		no annotation 4 PHE A  90
GLY A 114
ILE A  37
VAL A  27
 None
 0.84A 3wrkA-4db5A:
undetectable		 3wrkA-4db5A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF00179
(UQ_con)
PF10275
(Peptidase_C65) 		4 LEU A1175
GLY A1097
ILE A1231
VAL A1257
 None
 0.89A 3wrkA-4ddiA:
undetectable		 3wrkA-4ddiA:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 PHE A  87
LEU A 250
GLY A 254
ILE A 401
VAL A 402
 None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
None
None
 0.62A 3wrkA-4dxyA:
53.9		 3wrkA-4dxyA:
46.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 PHE A 296
LEU A 348
ILE A 370
VAL A 369
 None
 0.83A 3wrkA-4eb5A:
undetectable		 3wrkA-4eb5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk7 PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 PHE A 440
GLY A 417
ILE A 409
VAL A 339
 None
 0.70A 3wrkA-4fk7A:
undetectable		 3wrkA-4fk7A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 PHE A 440
GLY A 417
ILE A 409
VAL A 339
 None
 0.74A 3wrkA-4fxqA:
1.0		 3wrkA-4fxqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4f TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18

(Otolemur
garnettii) 		no annotation 4 PHE A  90
GLY A 114
ILE A  37
VAL A  27
 None
 0.88A 3wrkA-4g4fA:
undetectable		 3wrkA-4g4fA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		4 PHE A 370
GLY A  89
ILE A  56
VAL A 400
 None
 0.88A 3wrkA-4gz7A:
undetectable		 3wrkA-4gz7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		4 LEU A 105
GLY A 100
ILE A  41
VAL A 464
 None
None
FAD  A 501 (-4.5A)
None
 0.67A 3wrkA-4i59A:
undetectable		 3wrkA-4i59A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		4 PHE A 339
LEU A  99
GLY A 308
VAL A 348
 None
 0.89A 3wrkA-4mfiA:
undetectable		 3wrkA-4mfiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		4 PHE A 298
GLY A 104
ILE A  24
VAL A  25
 None
 0.88A 3wrkA-4mynA:
undetectable		 3wrkA-4mynA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvt TRIOSEPHOSPHATE
ISOMERASE

(Brucella
melitensis) 		PF00121
(TIM) 		4 PHE A 244
LEU A   8
GLY A 231
VAL A 215
 None
 0.84A 3wrkA-4nvtA:
undetectable		 3wrkA-4nvtA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 LEU A 437
GLY A 358
ILE A 417
VAL A 376
 None
 0.88A 3wrkA-4oenA:
undetectable		 3wrkA-4oenA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 PHE A 104
LEU A  37
GLY A  36
ILE A 100
 None
 0.77A 3wrkA-4oetA:
undetectable		 3wrkA-4oetA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 PHE A 131
GLY A 177
ILE A 149
VAL A 189
 None
 0.80A 3wrkA-4p6vA:
undetectable		 3wrkA-4p6vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 PHE A 180
LEU A  61
GLY A 231
ILE A 205
VAL A 261
 None
 1.37A 3wrkA-4rvhA:
undetectable		 3wrkA-4rvhA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 PHE A 131
GLY A 177
ILE A 149
VAL A 189
 None
 0.78A 3wrkA-4u9oA:
undetectable		 3wrkA-4u9oA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 PHE A1529
LEU A1466
ILE A1516
VAL A1439
 None
 0.83A 3wrkA-4uwaA:
undetectable		 3wrkA-4uwaA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 148
GLY A 146
ILE A 323
VAL A 298
 None
 0.84A 3wrkA-4wojA:
undetectable		 3wrkA-4wojA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 PHE A 361
LEU A  66
GLY A  63
ILE A 293
 None
 0.86A 3wrkA-4xnuA:
0.6		 3wrkA-4xnuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 PHE A 110
LEU A 155
GLY A 135
ILE A 252
 None
 0.78A 3wrkA-5a0lA:
undetectable		 3wrkA-5a0lA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA
ATP SYNTHASE SUBUNIT
GAMMA CHAIN,
MITOCHONDRIAL

(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF00231
(ATP-synt) 		4 LEU G 292
GLY D 304
ILE D  47
VAL D  50
 None
 0.83A 3wrkA-5fl7G:
undetectable		 3wrkA-5fl7G:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmr INTRAFLAGELLAR
TRANSPORT PROTEIN
COMPONENT IFT52

(Chlamydomonas
reinhardtii) 		PF09822
(ABC_transp_aux) 		4 PHE A 249
LEU A  93
GLY A  66
ILE A  15
 None
 0.85A 3wrkA-5fmrA:
undetectable		 3wrkA-5fmrA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A 114
GLY A 110
ILE A  85
VAL A  84
 None
 0.86A 3wrkA-5h9dA:
0.8		 3wrkA-5h9dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 PHE A 774
LEU A 767
ILE A 814
VAL A 815
 None
 0.82A 3wrkA-5hdhA:
undetectable		 3wrkA-5hdhA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 324
GLY A 223
ILE A 200
VAL A 201
 None
 0.89A 3wrkA-5jjqA:
undetectable		 3wrkA-5jjqA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 PHE A 377
LEU A 290
GLY A 413
ILE A 376
 None
 0.87A 3wrkA-5kwaA:
undetectable		 3wrkA-5kwaA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10

(Homo sapiens) 		PF00644
(PARP) 		4 LEU A 861
GLY A 901
ILE A 990
VAL A 918
 None
 0.61A 3wrkA-5lx6A:
undetectable		 3wrkA-5lx6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		4 PHE A 352
LEU A 171
ILE A 384
VAL A 381
 None
 0.77A 3wrkA-5m28A:
undetectable		 3wrkA-5m28A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 4 PHE A 675
GLY A 725
ILE A 700
VAL A 701
 None
 0.88A 3wrkA-5o5aA:
undetectable		 3wrkA-5o5aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 118
LEU A  66
ILE A 144
VAL A 143
 None
 0.73A 3wrkA-5oqpA:
undetectable		 3wrkA-5oqpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 4 LEU A 404
GLY A 412
ILE A 336
VAL A 335
 None
 0.76A 3wrkA-5t3bA:
undetectable		 3wrkA-5t3bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 LEU A  35
GLY A 264
ILE A 241
VAL A 126
 None
 0.83A 3wrkA-5ugfA:
undetectable		 3wrkA-5ugfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 PHE A 380
GLY A  99
ILE A  66
VAL A 410
 None
 0.79A 3wrkA-5uqcA:
undetectable		 3wrkA-5uqcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 911
GLY A 909
ILE A 926
VAL A 927
 None
 0.79A 3wrkA-5vywA:
undetectable		 3wrkA-5vywA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		4 PHE A 170
GLY A 114
ILE A 133
VAL A 132
 None
 0.85A 3wrkA-5xgcA:
undetectable		 3wrkA-5xgcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 4 LEU A 323
GLY A 366
ILE A 150
VAL A 149
 None
 0.74A 3wrkA-5xwwA:
undetectable		 3wrkA-5xwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
US14

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2)
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 PHE d  50
GLY d  33
ILE d  48
VAL D  18
 None
 0.81A 3wrkA-5xxud:
undetectable		 3wrkA-5xxud:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 LEU A 415
GLY A 418
ILE A 350
VAL A 351
 None
 0.79A 3wrkA-5z06A:
1.8		 3wrkA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6baa ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 11

(Rattus
norvegicus) 		no annotation 4 PHE A 333
LEU A 251
ILE A 318
VAL A 319
 None
 0.83A 3wrkA-6baaA:
undetectable		 3wrkA-6baaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.84A 3wrkA-6bbpA:
undetectable		 3wrkA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8s LOGANIC ACID
O-METHYLTRANSFERASE

(Catharanthus
roseus) 		no annotation 4 PHE A 329
GLY A 182
ILE A 261
VAL A 256
 None
 0.88A 3wrkA-6c8sA:
undetectable		 3wrkA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgs CADHERIN-7

(Mus musculus) 		no annotation 5 PHE A 155
LEU A 205
GLY A 114
ILE A 164
VAL A 126
 None
 1.29A 3wrkA-6cgsA:
undetectable		 3wrkA-6cgsA:
undetectable