SIMILAR PATTERNS OF AMINO ACIDS FOR 3WRI_A_CAMA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLY A 484
THR A 453
ILE A 460
VAL A 456
 None
 0.89A 3wriA-1a3xA:
0.0		 3wriA-1a3xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3u TATA-BINDING PROTEIN

(Pyrococcus
woesei) 		PF00352
(TBP) 		4 LEU A 117
GLY A 136
ILE A 156
VAL A 157
 None
 0.89A 3wriA-1d3uA:
0.0		 3wriA-1d3uA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddm NUMB PROTEIN

(Drosophila
melanogaster) 		PF00640
(PID) 		4 LEU A 109
GLY A 176
ILE A 139
VAL A 140
 None
 0.89A 3wriA-1ddmA:
undetectable		 3wriA-1ddmA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 LEU A 139
GLY A 138
ILE A 251
VAL A 253
 None
 0.92A 3wriA-1dnvA:
undetectable		 3wriA-1dnvA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 172
THR A 176
ILE A 165
VAL A 192
 CAA  A 300 (-3.2A)
None
None
None
 0.86A 3wriA-1dubA:
0.0		 3wriA-1dubA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 GLY A 123
THR A 127
ILE A  75
VAL A  76
 None
 0.88A 3wriA-1h5qA:
undetectable		 3wriA-1h5qA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 241
GLY A 142
ILE A 112
VAL A  43
 None
 0.87A 3wriA-1oypA:
undetectable		 3wriA-1oypA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01634
(HisG) 		4 LEU E   4
THR E  22
ILE E 198
VAL E 197
 None
 0.90A 3wriA-1usyE:
undetectable		 3wriA-1usyE:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 LEU A 173
GLY A 168
THR A 129
ILE A 138
 None
 0.92A 3wriA-1venA:
1.6		 3wriA-1venA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 LEU A 415
GLY A 414
THR A 385
ILE A 394
 None
 0.83A 3wriA-1x3lA:
undetectable		 3wriA-1x3lA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  55
GLY A  60
ILE A  49
VAL A  75
 None
 0.84A 3wriA-1zh4A:
undetectable		 3wriA-1zh4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		4 GLY A 281
THR A 285
ILE A  27
VAL A  26
 None
 0.89A 3wriA-2fiqA:
undetectable		 3wriA-2fiqA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		4 GLY A 313
THR A 246
ILE A 266
VAL A 267
 None
 0.89A 3wriA-2ha9A:
undetectable		 3wriA-2ha9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 102
THR A 180
ILE A  42
VAL A  41
 None
 0.89A 3wriA-2hnlA:
undetectable		 3wriA-2hnlA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		4 LEU A  25
GLY A 224
ILE A 140
VAL A 183
 None
 0.85A 3wriA-2hq1A:
undetectable		 3wriA-2hq1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7h NITROREDUCTASE-LIKE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 LEU A 129
GLY A 163
THR A  89
ILE A  55
 None
 0.89A 3wriA-2i7hA:
undetectable		 3wriA-2i7hA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 LEU A 244
GLY A 248
THR A 252
ILE A 395
VAL A 396
 HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
None
 0.74A 3wriA-2m56A:
57.6		 3wriA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 GLY A  68
THR A  54
ILE A  65
VAL A  64
 None
 0.73A 3wriA-2m6kA:
undetectable		 3wriA-2m6kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		4 LEU A 426
GLY A 365
THR A 487
ILE A 368
 None
 0.87A 3wriA-2nrrA:
undetectable		 3wriA-2nrrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		4 LEU A 426
GLY A 365
THR A 487
ILE A 368
 None
 0.82A 3wriA-2nrxA:
undetectable		 3wriA-2nrxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 330
GLY A 304
ILE A 291
VAL A 290
 LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
 0.66A 3wriA-2nvvA:
undetectable		 3wriA-2nvvA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		4 LEU A 211
GLY A 163
ILE A 278
VAL A 277
 None
 0.83A 3wriA-2qksA:
undetectable		 3wriA-2qksA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		4 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.78A 3wriA-2r09A:
undetectable		 3wriA-2r09A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb7 PEPTIDASE,
M20/M25/M40 FAMILY

(Desulfovibrio
alaskensis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 313
GLY A 320
THR A 290
ILE A 170
VAL A 169
 None
 1.40A 3wriA-2rb7A:
undetectable		 3wriA-2rb7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 LEU A 226
GLY A 230
THR A 234
VAL A 381
 HEM  A1400 (-4.4A)
PG4  A1399 ( 3.2A)
HEM  A1400 (-3.7A)
None
 0.53A 3wriA-2xkrA:
45.2		 3wriA-2xkrA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 LEU A 201
GLY A 205
ILE A 219
VAL A 218
 None
 0.73A 3wriA-2y38A:
undetectable		 3wriA-2y38A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 LEU A 459
GLY A 464
ILE A 282
VAL A 281
 None
 0.87A 3wriA-3ayxA:
undetectable		 3wriA-3ayxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfy PUTATIVE LUXO
REPRESSOR PROTEIN

(Vibrio
parahaemolyticus) 		PF00072
(Response_reg) 		4 LEU A  56
GLY A  61
ILE A  50
VAL A  77
 None
 0.91A 3wriA-3cfyA:
undetectable		 3wriA-3cfyA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 171
GLY A 170
ILE A  85
VAL A  84
 None
 0.92A 3wriA-3coiA:
undetectable		 3wriA-3coiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 LEU A 316
GLY A 288
ILE A 223
VAL A 248
 None
 0.90A 3wriA-3cv3A:
undetectable		 3wriA-3cv3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989

(Ruegeria
pomeroyi) 		PF09347
(DUF1989) 		4 LEU A  83
GLY A 232
ILE A  70
VAL A 258
 None
 0.87A 3wriA-3di4A:
undetectable		 3wriA-3di4A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		5 LEU A  96
GLY A 115
THR A 199
ILE A 191
VAL A 192
 None
 1.33A 3wriA-3e0xA:
undetectable		 3wriA-3e0xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 LEU A 242
GLY A 211
THR A 182
ILE A 227
 None
 0.81A 3wriA-3emqA:
undetectable		 3wriA-3emqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4f DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Saccharomyces
cerevisiae) 		PF00692
(dUTPase) 		4 LEU A 117
GLY A  63
ILE A  53
VAL A  92
 None
None
None
UMP  A 200 (-3.6A)
 0.77A 3wriA-3f4fA:
undetectable		 3wriA-3f4fA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 157
THR A 166
ILE A 177
VAL A 176
 None
 0.89A 3wriA-3fbgA:
undetectable		 3wriA-3fbgA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 GLY A 137
THR A 163
ILE A 170
VAL A 166
 None
 0.89A 3wriA-3h7lA:
undetectable		 3wriA-3h7lA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkv POLY [ADP-RIBOSE]
POLYMERASE 10

(Homo sapiens) 		PF00644
(PARP) 		4 LEU A 861
GLY A 901
ILE A 990
VAL A 918
 None
 0.60A 3wriA-3hkvA:
undetectable		 3wriA-3hkvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME

(Corynebacterium
glutamicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 360
GLY A 359
ILE A  48
VAL A  47
 LEU  A 360 ( 0.6A)
GLY  A 359 ( 0.0A)
ILE  A  48 ( 0.7A)
VAL  A  47 ( 0.6A)
 0.85A 3wriA-3i4kA:
undetectable		 3wriA-3i4kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF00588
(SpoU_methylase) 		4 LEU A 176
GLY A 145
ILE A  45
VAL A  46
 None
 0.91A 3wriA-3ic6A:
undetectable		 3wriA-3ic6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in6 FMN-BINDING PROTEIN

(Syntrophomonas
wolfei) 		no annotation 4 LEU A  34
GLY A  79
ILE A 136
VAL A 137
 None
None
MPD  A 149 (-4.4A)
None
 0.81A 3wriA-3in6A:
undetectable		 3wriA-3in6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 368
THR A 317
ILE A 375
VAL A 378
 CAP  A 600 (-3.3A)
None
None
None
 0.89A 3wriA-3kdnA:
undetectable		 3wriA-3kdnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcq THIAMINE-MONOPHOSPHA
TE KINASE

(Methylobacillus
flagellatus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 114
GLY A 117
THR A 119
ILE A 126
 None
 0.84A 3wriA-3mcqA:
undetectable		 3wriA-3mcqA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 492
GLY A 488
ILE A 379
VAL A 380
 None
 0.54A 3wriA-3ne5A:
undetectable		 3wriA-3ne5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 GLY A 362
THR A 366
ILE A 135
VAL A 134
 SO4  A 701 (-3.5A)
None
None
None
 0.66A 3wriA-3nzqA:
undetectable		 3wriA-3nzqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		4 GLY A 185
THR A 219
ILE A 202
VAL A 224
 None
 0.92A 3wriA-3orwA:
undetectable		 3wriA-3orwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p48 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Saccharomyces
cerevisiae) 		PF00692
(dUTPase) 		4 LEU A 117
GLY A  63
ILE A  53
VAL A  92
 None
 0.81A 3wriA-3p48A:
undetectable		 3wriA-3p48A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		4 LEU A  24
GLY A 235
ILE A 140
VAL A 183
 None
None
NDP  A 301 (-4.3A)
None
 0.84A 3wriA-3sjuA:
undetectable		 3wriA-3sjuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 GLY A  71
THR A  57
ILE A  68
VAL A  67
 None
 0.74A 3wriA-3tlkA:
undetectable		 3wriA-3tlkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3two MANNITOL
DEHYDROGENASE

(Helicobacter
pylori) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 152
GLY A  68
ILE A 144
VAL A 143
 None
 0.87A 3wriA-3twoA:
undetectable		 3wriA-3twoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 158
GLY A 182
ILE A 194
VAL A 195
 None
 0.86A 3wriA-3uogA:
undetectable		 3wriA-3uogA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0t PERAKINE REDUCTASE

(Rauvolfia
serpentina) 		PF00248
(Aldo_ket_red) 		4 GLY A  22
THR A 281
ILE A  40
VAL A  39
 None
ATR  A 338 (-3.0A)
None
None
 0.91A 3wriA-3v0tA:
undetectable		 3wriA-3v0tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		4 LEU A  46
GLY A 110
ILE A 145
VAL A 149
 None
 0.75A 3wriA-3vc1A:
undetectable		 3wriA-3vc1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A 388
GLY A 474
THR A 499
ILE A 403
 None
 0.83A 3wriA-3vueA:
undetectable		 3wriA-3vueA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		4 GLY A 288
THR A 327
ILE A  94
VAL A  93
 LLP  A 285 ( 3.8A)
None
None
None
 0.92A 3wriA-3w1hA:
undetectable		 3wriA-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		4 GLY A 289
THR A 327
ILE A  94
VAL A  93
 None
 0.76A 3wriA-3w1hA:
undetectable		 3wriA-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		4 GLY A 289
THR A 327
ILE A  94
VAL A  93
 None
 0.81A 3wriA-3w1jA:
undetectable		 3wriA-3w1jA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 LEU A 229
GLY A 233
THR A 237
VAL A 383
 HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
None
 0.55A 3wriA-3zbyA:
44.3		 3wriA-3zbyA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 LEU A 269
GLY A 281
ILE A 214
VAL A 213
 None
 0.85A 3wriA-4bejA:
undetectable		 3wriA-4bejA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 LEU A  25
GLY A 223
ILE A 139
VAL A 182
 None
 0.80A 3wriA-4bo6A:
undetectable		 3wriA-4bo6A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 LEU A 252
GLY A 256
THR A 260
ILE A 403
VAL A 404
 HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
None
GOL  A1419 (-3.5A)
 0.71A 3wriA-4c9mA:
51.6		 3wriA-4c9mA:
45.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d70 SORTASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF04203
(Sortase) 		4 GLY A  59
THR A  34
ILE A  76
VAL A  75
 None
 0.86A 3wriA-4d70A:
undetectable		 3wriA-4d70A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF00179
(UQ_con)
PF10275
(Peptidase_C65) 		4 LEU A1175
GLY A1097
ILE A1231
VAL A1257
 None
 0.82A 3wriA-4ddiA:
undetectable		 3wriA-4ddiA:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 GLY A 254
THR A 258
ILE A 401
VAL A 402
 PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
None
None
 0.43A 3wriA-4dxyA:
54.9		 3wriA-4dxyA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 LEU A 250
GLY A 254
THR A 258
VAL A 402
 HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
None
 0.59A 3wriA-4dxyA:
54.9		 3wriA-4dxyA:
46.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		4 LEU A 246
GLY A 207
THR A 112
ILE A 216
 None
 0.56A 3wriA-4eysA:
undetectable		 3wriA-4eysA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A  47
GLY A  45
THR A  43
ILE A 412
 None
 0.88A 3wriA-4fozA:
undetectable		 3wriA-4fozA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 GLY A 137
THR A 141
ILE A 130
VAL A 157
 GOL  A 301 ( 4.5A)
None
None
None
 0.87A 3wriA-4fzwA:
undetectable		 3wriA-4fzwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF00361
(Proton_antipo_M) 		4 LEU L 211
GLY L 168
ILE M 400
VAL M 399
 None
 0.83A 3wriA-4heaL:
undetectable		 3wriA-4heaL:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A 407
GLY A 493
THR A 518
ILE A 422
 None
 0.84A 3wriA-4hlnA:
undetectable		 3wriA-4hlnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 GLY A 139
THR A  94
ILE A 111
VAL A 107
 None
 0.82A 3wriA-4hpvA:
undetectable		 3wriA-4hpvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		4 LEU A 105
GLY A 100
ILE A  41
VAL A 464
 None
None
FAD  A 501 (-4.5A)
None
 0.64A 3wriA-4i59A:
undetectable		 3wriA-4i59A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 GLY B 198
THR B 202
ILE B 176
VAL B 175
 None
None
CIT  B 901 (-4.2A)
None
 0.90A 3wriA-4k7gB:
undetectable		 3wriA-4k7gB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		4 GLY A 198
THR A 202
ILE A 176
VAL A 175
 None
 0.84A 3wriA-4k8lA:
undetectable		 3wriA-4k8lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 LEU A 259
GLY A 256
ILE A  81
VAL A  82
 None
LLP  A  61 ( 3.4A)
None
None
 0.84A 3wriA-4kbxA:
undetectable		 3wriA-4kbxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lji CYTOCHROME
C-550-LIKE PROTEIN

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		4 GLY A   3
THR A  37
ILE A   9
VAL A   8
 None
 0.92A 3wriA-4ljiA:
undetectable		 3wriA-4ljiA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 151
THR A 160
ILE A 171
VAL A 170
 None
 0.75A 3wriA-4rvsA:
undetectable		 3wriA-4rvsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR

(Klebsiella
pneumoniae) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A  54
GLY A  59
ILE A  48
VAL A  75
 None
 0.87A 3wriA-4s05A:
undetectable		 3wriA-4s05A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)

(Escherichia
coli) 		PF02223
(Thymidylate_kin) 		4 GLY A  42
THR A  44
ILE A  86
VAL A  85
 None
 0.90A 3wriA-4tmkA:
undetectable		 3wriA-4tmkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE

(Populus
trichocarpa) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 LEU A 221
THR A 179
ILE A 187
VAL A 183
 None
 0.92A 3wriA-4ussA:
undetectable		 3wriA-4ussA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 148
GLY A 146
ILE A 323
VAL A 298
 None
 0.89A 3wriA-4wojA:
undetectable		 3wriA-4wojA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 241
GLY A 268
ILE A 297
VAL A 298
 None
 0.88A 3wriA-4wr3A:
undetectable		 3wriA-4wr3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		4 LEU A 120
GLY A 114
ILE A 152
VAL A 149
 SAH  A 301 ( 4.8A)
SAH  A 301 (-2.9A)
None
None
 0.87A 3wriA-4xboA:
undetectable		 3wriA-4xboA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xei ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 3

(Bos taurus) 		PF04062
(P21-Arc) 		4 LEU E 133
THR E 140
ILE E  41
VAL E  42
 None
 0.87A 3wriA-4xeiE:
1.7		 3wriA-4xeiE:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 389
GLY A 362
ILE A 243
VAL A 240
 None
None
None
NAD  A 500 (-4.0A)
 0.89A 3wriA-4xgiA:
undetectable		 3wriA-4xgiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 LEU A  60
GLY A  64
THR A 159
ILE A  71
 None
 0.90A 3wriA-4y23A:
undetectable		 3wriA-4y23A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A2073
GLY A2078
ILE A1938
VAL A1964
 None
 0.87A 3wriA-5a22A:
undetectable		 3wriA-5a22A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 154
GLY A  80
ILE A 146
VAL A 145
 None
 0.89A 3wriA-5fi5A:
undetectable		 3wriA-5fi5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA
ATP SYNTHASE SUBUNIT
GAMMA CHAIN,
MITOCHONDRIAL

(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF00231
(ATP-synt) 		4 LEU G 292
GLY D 304
ILE D  47
VAL D  50
 None
 0.80A 3wriA-5fl7G:
undetectable		 3wriA-5fl7G:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP41 ENV ECTODOMAIN
GP120 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1;
Human
immunodeficiency
virus 1) 		PF00517
(GP41)
PF00516
(GP120) 		4 LEU G  86
GLY B 524
THR B 536
VAL B 539
 None
 0.83A 3wriA-5fyjG:
undetectable		 3wriA-5fyjG:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		4 GLY A 250
THR A 254
ILE A 397
VAL A 398
 HEM  A 501 (-3.8A)
HEM  A 501 (-3.5A)
None
None
 0.41A 3wriA-5kyoA:
52.0		 3wriA-5kyoA:
40.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10

(Homo sapiens) 		PF00644
(PARP) 		4 LEU A 861
GLY A 901
ILE A 990
VAL A 918
 None
 0.53A 3wriA-5lx6A:
undetectable		 3wriA-5lx6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		4 GLY A  10
THR A  19
ILE A  30
VAL A  29
 None
 0.85A 3wriA-5u9cA:
undetectable		 3wriA-5u9cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 LEU A  35
GLY A 264
ILE A 241
VAL A 126
 None
 0.84A 3wriA-5ugfA:
undetectable		 3wriA-5ugfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 911
GLY A 909
ILE A 926
VAL A 927
 None
 0.86A 3wriA-5vywA:
undetectable		 3wriA-5vywA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L3

(Spinacia
oleracea) 		PF00297
(Ribosomal_L3) 		4 GLY D 140
THR D 124
ILE D 163
VAL D 162
 None
 0.85A 3wriA-5x8tD:
undetectable		 3wriA-5x8tD:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE

(Bacillus
licheniformis) 		no annotation 4 LEU A  60
GLY A  64
THR A 159
ILE A  71
 LEU  A  60 ( 0.6A)
GLY  A  64 ( 0.0A)
THR  A 159 ( 0.8A)
ILE  A  71 ( 0.7A)
 0.91A 3wriA-5xluA:
undetectable		 3wriA-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xww AMPHB

(Streptomyces
nodosus) 		no annotation 4 LEU A 323
GLY A 366
ILE A 150
VAL A 149
 None
 0.71A 3wriA-5xwwA:
undetectable		 3wriA-5xwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 4 LEU B  20
GLY B  19
THR B 188
VAL B 160
 None
 0.87A 3wriA-6b74B:
undetectable		 3wriA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 LEU A  88
GLY A  84
ILE A 116
VAL A 115
 None
 0.78A 3wriA-6bbpA:
undetectable		 3wriA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e9p -

(-) 		no annotation 4 LEU A  12
GLY A 131
ILE A  96
VAL A  93
 None
 0.90A 3wriA-6e9pA:
undetectable		 3wriA-6e9pA:
undetectable