SIMILAR PATTERNS OF AMINO ACIDS FOR 3WIP_G_ACTG306_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ARG A1030
ARG A1020
ASP A1025
 None
 0.91A 3wipG-1c30A:
0.0
3wipH-1c30A:
0.0		 3wipG-1c30A:
12.02
3wipH-1c30A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 ARG A 388
ARG A 275
ASP A 286
 None
 0.87A 3wipG-1flgA:
0.0
3wipH-1flgA:
0.0		 3wipG-1flgA:
17.68
3wipH-1flgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF13247
(Fer4_11) 		3 ARG B  53
ARG B  73
ASP B 123
 None
None
EPE  A1200 (-2.9A)
 0.99A 3wipG-1h0hB:
0.0
3wipH-1h0hB:
0.0		 3wipG-1h0hB:
22.44
3wipH-1h0hB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7p NADH-CYTOCHROME B5
REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ARG A 218
ARG A 225
ASP A 246
 None
 0.99A 3wipG-1i7pA:
0.0
3wipH-1i7pA:
0.0		 3wipG-1i7pA:
20.42
3wipH-1i7pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihn HYPOTHETICAL PROTEIN
MTH938

(Methanothermobacter
thermautotrophicus) 		PF04430
(DUF498) 		3 ARG A 112
ARG A 107
ASP A  36
 None
 0.93A 3wipG-1ihnA:
undetectable
3wipH-1ihnA:
0.0		 3wipG-1ihnA:
19.23
3wipH-1ihnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 ARG A 377
ARG A 272
ASP A 278
 None
 0.95A 3wipG-1kb0A:
0.0
3wipH-1kb0A:
0.0		 3wipG-1kb0A:
14.65
3wipH-1kb0A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 ARG A 365
ARG A 259
ASP A 265
 None
 0.88A 3wipG-1kv9A:
0.0
3wipH-1kv9A:
0.0		 3wipG-1kv9A:
17.49
3wipH-1kv9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8

(Saccharomyces
cerevisiae) 		PF13241
(NAD_binding_7)
PF14823
(Sirohm_synth_C)
PF14824
(Sirohm_synth_M) 		3 ARG A  72
ARG A  15
ASP A  99
 None
 0.91A 3wipG-1kyqA:
0.0
3wipH-1kyqA:
undetectable		 3wipG-1kyqA:
22.18
3wipH-1kyqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A 106
ARG A 169
ASP A 235
 OXM  A 351 (-4.2A)
OXM  A 351 (-3.5A)
None
 0.90A 3wipG-1ldnA:
0.0
3wipH-1ldnA:
0.0		 3wipG-1ldnA:
21.23
3wipH-1ldnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG X 136
ARG X 365
ASP X 113
 None
None
SO4  X2009 (-4.5A)
 1.01A 3wipG-1mw9X:
undetectable
3wipH-1mw9X:
undetectable		 3wipG-1mw9X:
18.58
3wipH-1mw9X:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nog CONSERVED
HYPOTHETICAL PROTEIN
TA0546

(Thermoplasma
acidophilum) 		PF01923
(Cob_adeno_trans) 		3 ARG A 163
ARG A  89
ASP A  49
 None
 0.99A 3wipG-1nogA:
undetectable
3wipH-1nogA:
undetectable		 3wipG-1nogA:
23.01
3wipH-1nogA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ARG A 223
ARG A 131
ASP A  99
 None
 0.98A 3wipG-1qfjA:
1.1
3wipH-1qfjA:
1.1		 3wipG-1qfjA:
22.93
3wipH-1qfjA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ARG A  98
ARG A  73
ASP A  86
 None
 0.73A 3wipG-1qhgA:
undetectable
3wipH-1qhgA:
undetectable		 3wipG-1qhgA:
15.38
3wipH-1qhgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase) 		3 ARG A  98
ARG A  73
ASP A  86
 None
 0.82A 3wipG-1qhhA:
undetectable
3wipH-1qhhA:
undetectable		 3wipG-1qhhA:
20.42
3wipH-1qhhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)

(Escherichia
coli;
Escherichia
virus M13) 		PF05357
(Phage_Coat_A)
PF06519
(TolA) 		3 ARG A 158
ARG A  29
ASP A  49
 None
 0.95A 3wipG-1tolA:
undetectable
3wipH-1tolA:
undetectable		 3wipG-1tolA:
19.84
3wipH-1tolA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG B 275
ARG B 269
ASP B 262
 None
 0.96A 3wipG-1tqyB:
undetectable
3wipH-1tqyB:
undetectable		 3wipG-1tqyB:
20.24
3wipH-1tqyB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		3 ARG A  51
ARG A  67
ASP A  13
 None
 0.97A 3wipG-1uanA:
undetectable
3wipH-1uanA:
undetectable		 3wipG-1uanA:
20.31
3wipH-1uanA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ARG A  88
ARG A 345
ASP A 291
 None
 0.90A 3wipG-1w07A:
undetectable
3wipH-1w07A:
undetectable		 3wipG-1w07A:
15.34
3wipH-1w07A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		3 ARG A  29
ARG A 161
ASP A  12
 None
 0.95A 3wipG-1ybeA:
undetectable
3wipH-1ybeA:
undetectable		 3wipG-1ybeA:
20.04
3wipH-1ybeA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 ARG A 827
ARG A 873
ASP A 835
 None
 0.97A 3wipG-1z63A:
undetectable
3wipH-1z63A:
undetectable		 3wipG-1z63A:
19.22
3wipH-1z63A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 339
ARG A 220
ASP A 226
 None
 0.95A 3wipG-2d1qA:
undetectable
3wipH-2d1qA:
undetectable		 3wipG-2d1qA:
18.07
3wipH-2d1qA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbe PREDICTED: SIMILAR
TO RET FINGER
PROTEIN-LIKE 1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 ARG A  59
ARG A  88
ASP A  17
 None
 0.71A 3wipG-2fbeA:
undetectable
3wipH-2fbeA:
undetectable		 3wipG-2fbeA:
23.81
3wipH-2fbeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd9 HYPOTHETICAL PROTEIN
YYAP

(Bacillus
subtilis) 		PF01872
(RibD_C) 		3 ARG A 173
ARG A 143
ASP A  42
 None
 0.97A 3wipG-2gd9A:
undetectable
3wipH-2gd9A:
undetectable		 3wipG-2gd9A:
18.06
3wipH-2gd9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		3 ARG A 110
ARG A 267
ASP A 293
 None
 0.64A 3wipG-2gljA:
undetectable
3wipH-2gljA:
undetectable		 3wipG-2gljA:
17.77
3wipH-2gljA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jo7 GLYCOSYLPHOSPHATIDYL
INOSITOL-ANCHORED
MEROZOITE SURFACE
PROTEIN

(Babesia
divergens) 		PF11641
(Antigen_Bd37) 		3 ARG A  83
ARG A 278
ASP A 283
 None
 1.01A 3wipG-2jo7A:
undetectable
3wipH-2jo7A:
undetectable		 3wipG-2jo7A:
21.45
3wipH-2jo7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtn LIM DOMAIN-BINDING
PROTEIN 1,
LIM/HOMEOBOX PROTEIN
LHX3

(Mus musculus) 		PF00412
(LIM) 		3 ARG A 104
ARG A  26
ASP A  24
 None
 1.02A 3wipG-2jtnA:
undetectable
3wipH-2jtnA:
undetectable		 3wipG-2jtnA:
16.81
3wipH-2jtnA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		3 ARG A  67
ARG A 283
ASP A 311
 None
 0.90A 3wipG-2og7A:
undetectable
3wipH-2og7A:
undetectable		 3wipG-2og7A:
20.17
3wipH-2og7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		3 ARG A 171
ARG A 266
ASP A  38
 None
 0.70A 3wipG-2q17A:
undetectable
3wipH-2q17A:
undetectable		 3wipG-2q17A:
19.32
3wipH-2q17A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ARG A 382
ARG A 656
ASP A 654
 None
 0.95A 3wipG-2vdaA:
undetectable
3wipH-2vdaA:
undetectable		 3wipG-2vdaA:
15.38
3wipH-2vdaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ARG A1468
ARG A1405
ASP A1313
 None
 1.02A 3wipG-2vz9A:
undetectable
3wipH-2vz9A:
undetectable		 3wipG-2vz9A:
6.81
3wipH-2vz9A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ARG A  28
ARG A  48
ASP A  17
 None
 1.01A 3wipG-2w8sA:
undetectable
3wipH-2w8sA:
undetectable		 3wipG-2w8sA:
17.47
3wipH-2w8sA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvq SMALL S PROTEIN

(Podospora
anserina) 		PF14479
(HeLo) 		3 ARG A 165
ARG A  44
ASP A 208
 None
 1.01A 3wipG-2wvqA:
undetectable
3wipH-2wvqA:
undetectable		 3wipG-2wvqA:
25.00
3wipH-2wvqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		3 ARG A 314
ARG A 204
ASP A 207
 None
 0.72A 3wipG-2xu0A:
undetectable
3wipH-2xu0A:
undetectable		 3wipG-2xu0A:
17.73
3wipH-2xu0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		3 ARG A 314
ARG A 204
ASP A 207
 None
 0.88A 3wipG-2yk0A:
undetectable
3wipH-2yk0A:
undetectable		 3wipG-2yk0A:
14.65
3wipH-2yk0A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		3 ARG A 304
ARG A 140
ASP A 129
 None
 0.91A 3wipG-3beoA:
undetectable
3wipH-3beoA:
undetectable		 3wipG-3beoA:
21.18
3wipH-3beoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION

(Methanothermobacter
thermautotrophicus) 		PF11576
(DUF3236) 		3 ARG A  57
ARG A 142
ASP A  50
 None
 0.87A 3wipG-3brcA:
undetectable
3wipH-3brcA:
undetectable		 3wipG-3brcA:
17.83
3wipH-3brcA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		3 ARG A 275
ARG A 320
ASP A 322
 None
 0.96A 3wipG-3bujA:
undetectable
3wipH-3bujA:
undetectable		 3wipG-3bujA:
19.95
3wipH-3bujA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		3 ARG A 471
ARG A 382
ASP A 483
 None
 0.95A 3wipG-3ckbA:
undetectable
3wipH-3ckbA:
undetectable		 3wipG-3ckbA:
19.18
3wipH-3ckbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		3 ARG A 194
ARG A  20
ASP A 185
 None
 0.82A 3wipG-3egeA:
undetectable
3wipH-3egeA:
undetectable		 3wipG-3egeA:
23.19
3wipH-3egeA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 ARG A 637
ARG A1052
ASP A 865
 None
 0.98A 3wipG-3egwA:
undetectable
3wipH-3egwA:
undetectable		 3wipG-3egwA:
11.68
3wipH-3egwA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 ARG A1052
ARG A 356
ASP A 865
 None
 1.01A 3wipG-3egwA:
undetectable
3wipH-3egwA:
undetectable		 3wipG-3egwA:
11.68
3wipH-3egwA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		3 ARG A  79
ARG B 266
ASP B 454
 None
 0.91A 3wipG-3egwA:
undetectable
3wipH-3egwA:
undetectable		 3wipG-3egwA:
11.68
3wipH-3egwA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		3 ARG A 558
ARG A 683
ASP A 273
 SO4  A1001 (-3.8A)
None
CA  A 801 ( 2.9A)
 0.97A 3wipG-3fbyA:
undetectable
3wipH-3fbyA:
undetectable		 3wipG-3fbyA:
17.85
3wipH-3fbyA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN
GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		no annotation
no annotation 		3 ARG A 170
ARG B 213
ASP B 228
 None
 0.67A 3wipG-3fpnA:
undetectable
3wipH-3fpnA:
undetectable		 3wipG-3fpnA:
18.61
3wipH-3fpnA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy3 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		3 ARG A 251
ARG A 154
ASP A 226
 None
 1.00A 3wipG-3fy3A:
undetectable
3wipH-3fy3A:
undetectable		 3wipG-3fy3A:
20.91
3wipH-3fy3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN

(Gallus gallus) 		PF02271
(UCR_14kD) 		3 ARG F 104
ARG F  49
ASP F  42
 None
 0.89A 3wipG-3h1lF:
undetectable
3wipH-3h1lF:
undetectable		 3wipG-3h1lF:
17.83
3wipH-3h1lF:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A  92
ARG A 155
ASP A 220
 PYR  A 501 (-3.9A)
PYR  A 501 (-2.9A)
None
 0.96A 3wipG-3h3jA:
undetectable
3wipH-3h3jA:
undetectable		 3wipG-3h3jA:
22.39
3wipH-3h3jA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ARG A 266
ARG A  97
ASP A 244
 None
 0.86A 3wipG-3hrdA:
undetectable
3wipH-3hrdA:
undetectable		 3wipG-3hrdA:
19.63
3wipH-3hrdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		3 ARG A  13
ARG A 189
ASP A 232
 None
 1.00A 3wipG-3iahA:
undetectable
3wipH-3iahA:
undetectable		 3wipG-3iahA:
20.36
3wipH-3iahA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		3 ARG A 227
ARG A 146
ASP A 219
 CL  A 258 (-4.3A)
None
None
 0.88A 3wipG-3isaA:
undetectable
3wipH-3isaA:
undetectable		 3wipG-3isaA:
18.31
3wipH-3isaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbf NANOBODY VHH PVSP19B

(Camelus
dromedarius) 		PF07686
(V-set) 		3 ARG 7  98
ARG 7  35
ASP 7 104
 None
 0.92A 3wipG-3jbf7:
undetectable
3wipH-3jbf7:
undetectable		 3wipG-3jbf7:
20.76
3wipH-3jbf7:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		3 ARG A 245
ARG A  80
ASP A 291
 None
GOL  A 397 (-4.4A)
None
 0.99A 3wipG-3jtxA:
undetectable
3wipH-3jtxA:
undetectable		 3wipG-3jtxA:
20.05
3wipH-3jtxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jze DIHYDROOROTASE

(Salmonella
enterica) 		PF01979
(Amidohydro_1) 		3 ARG A 245
ARG A 166
ASP A 190
 None
 0.97A 3wipG-3jzeA:
undetectable
3wipH-3jzeA:
undetectable		 3wipG-3jzeA:
17.96
3wipH-3jzeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhv BH2092 PROTEIN

(Bacillus
halodurans) 		PF00581
(Rhodanese) 		3 ARG A 127
ARG A  55
ASP A 142
 None
 0.95A 3wipG-3nhvA:
undetectable
3wipH-3nhvA:
undetectable		 3wipG-3nhvA:
20.70
3wipH-3nhvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		3 ARG A 196
ARG A  67
ASP A  58
 None
 1.00A 3wipG-3qyjA:
undetectable
3wipH-3qyjA:
undetectable		 3wipG-3qyjA:
20.82
3wipH-3qyjA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		3 ARG A 150
ARG A 332
ASP A 158
 None
 0.99A 3wipG-3racA:
undetectable
3wipH-3racA:
undetectable		 3wipG-3racA:
19.14
3wipH-3racA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		3 ARG A 260
ARG A 244
ASP A 254
 None
 0.89A 3wipG-3tdwA:
undetectable
3wipH-3tdwA:
undetectable		 3wipG-3tdwA:
23.43
3wipH-3tdwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 ARG A 348
ARG A 272
ASP A 275
 None
 0.62A 3wipG-3vuuA:
undetectable
3wipH-3vuuA:
undetectable		 3wipG-3vuuA:
18.63
3wipH-3vuuA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 ARG A 348
ARG A 272
ASP A 275
 None
 0.63A 3wipG-3vuvA:
undetectable
3wipH-3vuvA:
undetectable		 3wipG-3vuvA:
18.05
3wipH-3vuvA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 ARG A 118
ARG A 257
ASP A 263
 None
 0.94A 3wipG-3wfzA:
undetectable
3wipH-3wfzA:
undetectable		 3wipG-3wfzA:
15.59
3wipH-3wfzA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 ARG A 508
ARG A 347
ASP A 669
 None
 0.95A 3wipG-3zifA:
undetectable
3wipH-3zifA:
undetectable		 3wipG-3zifA:
12.40
3wipH-3zifA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Mus musculus;
Homo sapiens) 		PF00957
(Synaptobrevin)
PF13774
(Longin)
PF12796
(Ank_2)
PF13857
(Ank_5) 		3 ARG B 668
ARG B 675
ASP A  67
 None
 0.97A 3wipG-4b93B:
undetectable
3wipH-4b93B:
undetectable		 3wipG-4b93B:
20.27
3wipH-4b93B:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		3 ARG A 241
ARG A 227
ASP A 230
 None
 0.95A 3wipG-4bgbA:
undetectable
3wipH-4bgbA:
undetectable		 3wipG-4bgbA:
20.77
3wipH-4bgbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhy ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ARG A 265
ARG A 292
ASP A 319
 None
 1.00A 3wipG-4bhyA:
undetectable
3wipH-4bhyA:
undetectable		 3wipG-4bhyA:
19.55
3wipH-4bhyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		3 ARG A  28
ARG A  23
ASP A 289
 None
 0.96A 3wipG-4db3A:
undetectable
3wipH-4db3A:
undetectable		 3wipG-4db3A:
18.98
3wipH-4db3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		3 ARG A 240
ARG A 254
ASP A 208
 None
 0.84A 3wipG-4dqvA:
undetectable
3wipH-4dqvA:
undetectable		 3wipG-4dqvA:
18.31
3wipH-4dqvA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffu OXIDASE

(Sinorhizobium
meliloti) 		PF01575
(MaoC_dehydratas) 		3 ARG A  89
ARG A 124
ASP A  86
 None
 0.88A 3wipG-4ffuA:
undetectable
3wipH-4ffuA:
undetectable		 3wipG-4ffuA:
18.61
3wipH-4ffuA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 ARG A 238
ARG A 339
ASP A 322
 None
 1.01A 3wipG-4frxA:
undetectable
3wipH-4frxA:
undetectable		 3wipG-4frxA:
20.22
3wipH-4frxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ARG A 204
ARG A 855
ASP A 852
 None
SO4  A1014 (-3.9A)
None
 0.92A 3wipG-4fysA:
1.8
3wipH-4fysA:
undetectable		 3wipG-4fysA:
13.60
3wipH-4fysA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 ARG A 395
ARG A  40
ASP A  36
 PO4  A 604 (-2.9A)
None
ZN  A 603 (-3.1A)
 0.80A 3wipG-4h1sA:
undetectable
3wipH-4h1sA:
undetectable		 3wipG-4h1sA:
18.62
3wipH-4h1sA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jas HISTIDINE KINASE

(Thermotoga
maritima) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		3 ARG A 423
ARG A 249
ASP A 432
 None
 0.99A 3wipG-4jasA:
undetectable
3wipH-4jasA:
undetectable		 3wipG-4jasA:
21.25
3wipH-4jasA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		3 ARG A 377
ARG A 401
ASP A  88
 None
 0.97A 3wipG-4k2xA:
undetectable
3wipH-4k2xA:
undetectable		 3wipG-4k2xA:
16.44
3wipH-4k2xA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		3 ARG B 579
ARG B 584
ASP B 545
 None
 0.85A 3wipG-4kmoB:
undetectable
3wipH-4kmoB:
undetectable		 3wipG-4kmoB:
20.65
3wipH-4kmoB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		3 ARG A 337
ARG A 218
ASP A 224
 None
 0.93A 3wipG-4m46A:
undetectable
3wipH-4m46A:
undetectable		 3wipG-4m46A:
16.55
3wipH-4m46A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		3 ARG A 369
ARG A 265
ASP A 269
 None
 0.95A 3wipG-4maeA:
undetectable
3wipH-4maeA:
undetectable		 3wipG-4maeA:
17.04
3wipH-4maeA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		3 ARG A 554
ARG A 203
ASP A 174
 None
 0.92A 3wipG-4q6kA:
undetectable
3wipH-4q6kA:
undetectable		 3wipG-4q6kA:
18.47
3wipH-4q6kA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		3 ARG A 196
ARG A 203
ASP A 299
 None
 0.95A 3wipG-4us5A:
undetectable
3wipH-4us5A:
undetectable		 3wipG-4us5A:
21.26
3wipH-4us5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5v SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF14732
(UAE_UbL) 		3 ARG B 512
ARG B 516
ASP B 484
 None
 1.00A 3wipG-4w5vB:
undetectable
3wipH-4w5vB:
undetectable		 3wipG-4w5vB:
21.40
3wipH-4w5vB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ARG A 562
ARG A 568
ASP A 504
 None
 0.78A 3wipG-4woeA:
undetectable
3wipH-4woeA:
undetectable		 3wipG-4woeA:
15.36
3wipH-4woeA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 ARG A  76
ARG A  27
ASP A 279
 None
 0.94A 3wipG-4z0zA:
undetectable
3wipH-4z0zA:
undetectable		 3wipG-4z0zA:
21.94
3wipH-4z0zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		3 ARG A  76
ARG A  27
ASP A 279
 None
 0.97A 3wipG-4z11A:
undetectable
3wipH-4z11A:
undetectable		 3wipG-4z11A:
17.18
3wipH-4z11A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		3 ARG A 967
ARG A 752
ASP A 727
 None
 0.87A 3wipG-4zhjA:
undetectable
3wipH-4zhjA:
undetectable		 3wipG-4zhjA:
10.79
3wipH-4zhjA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		3 ARG C 203
ARG C 132
ASP C 196
 None
 1.00A 3wipG-5b57C:
undetectable
3wipH-5b57C:
undetectable		 3wipG-5b57C:
19.73
3wipH-5b57C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum) 		no annotation 3 ARG A 116
ARG A  98
ASP A  89
 None
 0.94A 3wipG-5bk6A:
undetectable
3wipH-5bk6A:
undetectable		 3wipG-5bk6A:
undetectable
3wipH-5bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		3 ARG A 309
ARG A 136
ASP A 125
 ACT  A 505 (-4.1A)
ACT  A 505 (-3.6A)
None
 1.01A 3wipG-5dldA:
undetectable
3wipH-5dldA:
undetectable		 3wipG-5dldA:
20.76
3wipH-5dldA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		3 ARG A 300
ARG A 136
ASP A 125
 None
 0.72A 3wipG-5enzA:
undetectable
3wipH-5enzA:
undetectable		 3wipG-5enzA:
20.85
3wipH-5enzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exx TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		3 ARG A 306
ARG A 265
ASP A 167
 None
 1.00A 3wipG-5exxA:
undetectable
3wipH-5exxA:
undetectable		 3wipG-5exxA:
18.40
3wipH-5exxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 HEAVY CHAIN
(ANTI-LID)

(Mus musculus) 		no annotation 3 ARG X  67
ARG X  39
ASP X  89
 None
 0.94A 3wipG-5gs0X:
undetectable
3wipH-5gs0X:
undetectable		 3wipG-5gs0X:
18.94
3wipH-5gs0X:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 ARG A1514
ARG A1547
ASP A1539
 None
 0.84A 3wipG-5h64A:
undetectable
3wipH-5h64A:
undetectable		 3wipG-5h64A:
6.79
3wipH-5h64A:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		3 ARG A 125
ARG A  92
ASP A  64
 None
 0.96A 3wipG-5jy9A:
undetectable
3wipH-5jy9A:
undetectable		 3wipG-5jy9A:
20.14
3wipH-5jy9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 337
ARG A 218
ASP A 224
 None
SLU  A 601 ( 4.2A)
None
 0.95A 3wipG-5kyvA:
undetectable
3wipH-5kyvA:
undetectable		 3wipG-5kyvA:
17.64
3wipH-5kyvA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE

(Mycobacterium
marinum) 		PF07993
(NAD_binding_4) 		3 ARG A 968
ARG A 982
ASP A 936
 None
 0.86A 3wipG-5msoA:
undetectable
3wipH-5msoA:
undetectable		 3wipG-5msoA:
11.75
3wipH-5msoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tii 3-OXOACYL-ACP
REDUCTASE

(uncultured
bacterium) 		PF13561
(adh_short_C2) 		3 ARG A  52
ARG A  23
ASP A  45
 None
 0.98A 3wipG-5tiiA:
undetectable
3wipH-5tiiA:
undetectable		 3wipG-5tiiA:
18.95
3wipH-5tiiA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 ARG A 654
ARG A 557
ASP A 284
 None
 0.79A 3wipG-5xblA:
undetectable
3wipH-5xblA:
undetectable		 3wipG-5xblA:
10.22
3wipH-5xblA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 3 ARG A 263
ARG A 386
ASP A 363
 None
 0.99A 3wipG-5xixA:
undetectable
3wipH-5xixA:
undetectable		 3wipG-5xixA:
undetectable
3wipH-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US2
RIBOSOMAL PROTEIN
ES17

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00318
(Ribosomal_S2)
PF00833
(Ribosomal_S17e) 		3 ARG A 181
ARG R  88
ASP A  14
 None
 0.90A 3wipG-5xxuA:
undetectable
3wipH-5xxuA:
undetectable		 3wipG-5xxuA:
22.19
3wipH-5xxuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 3 ARG A 557
ARG A 539
ASP A 548
 None
 1.00A 3wipG-5yknA:
undetectable
3wipH-5yknA:
undetectable		 3wipG-5yknA:
undetectable
3wipH-5yknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 ARG B 571
ARG B 401
ASP B 394
 None
 1.01A 3wipG-6bywB:
undetectable
3wipH-6bywB:
undetectable		 3wipG-6bywB:
undetectable
3wipH-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL3
GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 ARG M 515
ARG N 204
ASP N 173
 None
 0.92A 3wipG-6cetM:
undetectable
3wipH-6cetM:
undetectable		 3wipG-6cetM:
undetectable
3wipH-6cetM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 3 ARG A  22
ARG A 174
ASP A 224
 None
 0.91A 3wipG-6f71A:
undetectable
3wipH-6f71A:
undetectable		 3wipG-6f71A:
undetectable
3wipH-6f71A:
undetectable