SIMILAR PATTERNS OF AMINO ACIDS FOR 3WIP_G_ACHG301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		4 TRP A  20
THR A  19
TYR A 111
TYR A  22
 None
 1.22A 3wipG-1ae7A:
0.0
3wipH-1ae7A:
0.0		 3wipG-1ae7A:
16.50
3wipH-1ae7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR A 172
THR A 566
ARG A 208
LEU A 205
 None
 1.20A 3wipG-1d6mA:
undetectable
3wipH-1d6mA:
undetectable		 3wipG-1d6mA:
16.04
3wipH-1d6mA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyh EPSIN

(Rattus
norvegicus) 		PF01417
(ENTH) 		4 THR A  28
ARG A  63
LEU A  64
MET A  78
 None
 1.30A 3wipG-1eyhA:
undetectable
3wipH-1eyhA:
undetectable		 3wipG-1eyhA:
21.13
3wipH-1eyhA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 TYR A 201
THR A 212
ARG A 336
LEU A 335
 None
 1.30A 3wipG-1guqA:
0.2
3wipH-1guqA:
0.2		 3wipG-1guqA:
20.96
3wipH-1guqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 TRP A 385
THR A 319
TYR A 201
LEU A 343
 None
 1.25A 3wipG-1lnlA:
0.0
3wipH-1lnlA:
0.0		 3wipG-1lnlA:
18.83
3wipH-1lnlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		4 THR A 137
TYR A 437
ARG A 108
LEU A 112
 None
 1.26A 3wipG-1ltdA:
0.0
3wipH-1ltdA:
0.0		 3wipG-1ltdA:
17.95
3wipH-1ltdA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 TYR A 485
TRP A 510
THR A 546
ARG A 517
 None
 1.17A 3wipG-1m1cA:
0.0
3wipH-1m1cA:
0.0		 3wipG-1m1cA:
15.97
3wipH-1m1cA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 TRP A 201
THR A 376
ARG A  23
LEU A  24
 None
 1.07A 3wipG-1pn3A:
0.0
3wipH-1pn3A:
0.0		 3wipG-1pn3A:
19.35
3wipH-1pn3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 THR A 137
TYR A 437
ARG A 108
LEU A 112
 None
 1.08A 3wipG-1qcwA:
0.0
3wipH-1qcwA:
0.0		 3wipG-1qcwA:
20.90
3wipH-1qcwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		4 THR A 103
ARG A  96
LEU A 122
MET A 120
 None
 1.15A 3wipG-1sefA:
0.7
3wipH-1sefA:
0.8		 3wipG-1sefA:
22.60
3wipH-1sefA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		4 TYR A1988
TYR A2015
ARG A2125
LEU A2126
 None
 1.17A 3wipG-1uyvA:
undetectable
3wipH-1uyvA:
undetectable		 3wipG-1uyvA:
14.27
3wipH-1uyvA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  60
THR A 116
ARG A 109
LEU A 105
 None
 1.18A 3wipG-1vzoA:
undetectable
3wipH-1vzoA:
undetectable		 3wipG-1vzoA:
19.56
3wipH-1vzoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 TYR A 651
THR A 615
TYR A 634
ARG A 602
 None
 1.24A 3wipG-1yvlA:
undetectable
3wipH-1yvlA:
undetectable		 3wipG-1yvlA:
13.60
3wipH-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 TYR A 254
THR A 251
TYR A 266
TYR A 252
 None
 1.27A 3wipG-2ayuA:
undetectable
3wipH-2ayuA:
undetectable		 3wipG-2ayuA:
19.52
3wipH-2ayuA:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN

(Bulinus
truncatus) 		PF02931
(Neur_chan_LBD) 		5 TYR A  88
TRP A 142
THR A 143
TYR A 184
TYR A 191
 None
CXS  A1204 (-3.6A)
CXS  A1204 ( 4.7A)
CXS  A1204 (-4.6A)
CXS  A1204 (-4.7A)
 0.68A 3wipG-2bj0A:
25.9
3wipH-2bj0A:
24.8		 3wipG-2bj0A:
40.44
3wipH-2bj0A:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 TRP A   2
THR A   4
TYR A   8
LEU A 124
 None
 1.17A 3wipG-2e8gA:
undetectable
3wipH-2e8gA:
undetectable		 3wipG-2e8gA:
19.92
3wipH-2e8gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpj SIDEROPHORE-INTERACT
ING PROTEIN

(Shewanella
putrefaciens) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 THR A 222
TYR A 225
ARG A 206
LEU A 205
 None
FAD  A 500 (-3.6A)
CL  A 254 (-4.4A)
None
 1.28A 3wipG-2gpjA:
undetectable
3wipH-2gpjA:
undetectable		 3wipG-2gpjA:
21.40
3wipH-2gpjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 441
TRP A 477
TYR A 457
MET A 474
 None
 1.18A 3wipG-2hk5A:
undetectable
3wipH-2hk5A:
undetectable		 3wipG-2hk5A:
22.85
3wipH-2hk5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 TYR A 241
THR A 237
LEU A 213
MET A 216
 None
 1.09A 3wipG-2id5A:
undetectable
3wipH-2id5A:
undetectable		 3wipG-2id5A:
19.25
3wipH-2id5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 THR A 146
TYR A 135
ARG A  21
LEU A  22
 None
 0.97A 3wipG-2ihtA:
undetectable
3wipH-2ihtA:
undetectable		 3wipG-2ihtA:
19.09
3wipH-2ihtA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2

(Homo sapiens) 		PF02174
(IRS) 		4 THR A  41
TYR A  59
LEU A  97
MET A  38
 None
 1.26A 3wipG-2mfqA:
undetectable
3wipH-2mfqA:
undetectable		 3wipG-2mfqA:
17.07
3wipH-2mfqA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 THR A 513
TYR A 529
ARG A 501
LEU A 504
 None
 0.91A 3wipG-2nyfA:
undetectable
3wipH-2nyfA:
undetectable		 3wipG-2nyfA:
16.87
3wipH-2nyfA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 TYR A 364
TYR A 245
LEU A 225
MET A 229
 GOL  A3017 (-4.5A)
None
None
None
 1.15A 3wipG-2okxA:
undetectable
3wipH-2okxA:
undetectable		 3wipG-2okxA:
13.44
3wipH-2okxA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 TYR A 141
TYR A 330
ARG A 118
LEU A 121
 None
 1.29A 3wipG-2p3xA:
undetectable
3wipH-2p3xA:
undetectable		 3wipG-2p3xA:
22.60
3wipH-2p3xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvy PROTEIN B15

(Vaccinia virus) 		PF06227
(Poxvirus) 		4 TYR A  33
TYR A  51
LEU A  20
MET A 148
 None
 1.17A 3wipG-2vvyA:
undetectable
3wipH-2vvyA:
undetectable		 3wipG-2vvyA:
18.18
3wipH-2vvyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 TYR A 145
THR A  62
ARG A  66
LEU A  56
 None
 1.00A 3wipG-2vx4A:
undetectable
3wipH-2vx4A:
undetectable		 3wipG-2vx4A:
20.46
3wipH-2vx4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 TYR A 517
TYR A 544
ARG A 654
LEU A 655
 None
 1.15A 3wipG-2x24A:
undetectable
3wipH-2x24A:
undetectable		 3wipG-2x24A:
16.30
3wipH-2x24A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 TYR A 254
THR A 251
TYR A 266
TYR A 252
 None
 1.31A 3wipG-2z2rA:
undetectable
3wipH-2z2rA:
undetectable		 3wipG-2z2rA:
20.67
3wipH-2z2rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 TYR A 293
THR A 326
TYR A 320
LEU A 355
 None
 1.10A 3wipG-3cihA:
undetectable
3wipH-3cihA:
undetectable		 3wipG-3cihA:
15.73
3wipH-3cihA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 THR A 622
TYR A 657
ARG A 609
LEU A 608
 None
 1.09A 3wipG-3cwgA:
undetectable
3wipH-3cwgA:
2.6		 3wipG-3cwgA:
19.67
3wipH-3cwgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		4 TYR A 323
TYR A 297
ARG A 275
LEU A 280
 None
 1.30A 3wipG-3d3aA:
undetectable
3wipH-3d3aA:
undetectable		 3wipG-3d3aA:
16.20
3wipH-3d3aA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 TYR A2192
TYR A2219
ARG A2329
LEU A2330
 None
 1.20A 3wipG-3ff6A:
undetectable
3wipH-3ff6A:
undetectable		 3wipG-3ff6A:
18.04
3wipH-3ff6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8k LECTIN-RELATED NK
CELL RECEPTOR LY49L1

(Mus musculus) 		PF00059
(Lectin_C) 		4 THR A 241
TYR A 198
ARG A 242
LEU A 243
 None
 1.20A 3wipG-3g8kA:
undetectable
3wipH-3g8kA:
undetectable		 3wipG-3g8kA:
16.89
3wipH-3g8kA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 TRP A 201
THR A 370
ARG A  23
LEU A  24
 None
 1.07A 3wipG-3h4iA:
undetectable
3wipH-3h4iA:
undetectable		 3wipG-3h4iA:
17.38
3wipH-3h4iA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 158
THR A 395
TYR A 466
LEU A 403
 None
 0.96A 3wipG-3hdxA:
undetectable
3wipH-3hdxA:
undetectable		 3wipG-3hdxA:
18.43
3wipH-3hdxA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  94
TRP H  47
THR H  35
LEU H  80
 GM0  H 306 (-4.5A)
None
None
None
 0.99A 3wipG-3v0wL:
undetectable
3wipH-3v0wL:
undetectable		 3wipG-3v0wL:
25.10
3wipH-3v0wL:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 TRP A 250
ARG A 296
LEU A 293
MET A 289
 None
 1.10A 3wipG-3v7iA:
undetectable
3wipH-3v7iA:
undetectable		 3wipG-3v7iA:
19.25
3wipH-3v7iA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 TYR A3601
TRP A3617
ARG A3620
LEU A3621
 None
 0.93A 3wipG-3vkgA:
undetectable
3wipH-3vkgA:
undetectable		 3wipG-3vkgA:
5.57
3wipH-3vkgA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 TYR A 832
TRP A 509
TYR A 607
LEU A 507
 None
 1.15A 3wipG-3wajA:
undetectable
3wipH-3wajA:
undetectable		 3wipG-3wajA:
13.05
3wipH-3wajA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 TRP A 307
THR A 305
ARG A 308
LEU A 311
 None
 1.09A 3wipG-3wjoA:
undetectable
3wipH-3wjoA:
undetectable		 3wipG-3wjoA:
20.36
3wipH-3wjoA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdh ACETYLCHOLINE
BINDING PROTEIN

(Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		5 TYR A  89
TRP A 143
THR A 144
TYR A 185
TYR A 192
 None
XRS  A 301 (-3.6A)
XRS  A 301 ( 4.4A)
XRS  A 301 ( 4.1A)
XRS  A 301 (-3.8A)
 0.39A 3wipG-3zdhA:
33.0
3wipH-3zdhA:
32.1		 3wipG-3zdhA:
100.00
3wipH-3zdhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqt LAMININ SUBUNIT
GAMMA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 TYR A 161
TYR A 175
TYR A 184
ARG A 253
 NAG  A3001 ( 4.1A)
None
None
None
 1.23A 3wipG-4aqtA:
undetectable
3wipH-4aqtA:
undetectable		 3wipG-4aqtA:
20.00
3wipH-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 TYR A2118
TYR A2145
ARG A2255
LEU A2256
 None
 1.20A 3wipG-4asiA:
undetectable
3wipH-4asiA:
undetectable		 3wipG-4asiA:
15.49
3wipH-4asiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b60 FIBRONECTIN-BINDING
PROTEIN A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 THR A 381
TYR A 457
TYR A 442
LEU A 348
 None
 1.12A 3wipG-4b60A:
3.1
3wipH-4b60A:
3.0		 3wipG-4b60A:
21.90
3wipH-4b60A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF12341
(Mcl1_mid) 		4 TRP A 763
THR A 484
TYR A 677
ARG A 492
 None
 1.27A 3wipG-4c95A:
undetectable
3wipH-4c95A:
undetectable		 3wipG-4c95A:
17.82
3wipH-4c95A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbv MYXOBACTERIAL
HEMAGGLUTININ

(Myxococcus
xanthus) 		no annotation 4 TRP A 224
THR A 161
TYR A 138
LEU A  22
 None
 1.29A 3wipG-4fbvA:
undetectable
3wipH-4fbvA:
undetectable		 3wipG-4fbvA:
21.60
3wipH-4fbvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gak ACYL-ACP
THIOESTERASE

(Spirosoma
linguale) 		PF01643
(Acyl-ACP_TE) 		4 TRP A 110
THR A 109
TYR A 204
LEU A 111
 GOL  A 302 ( 4.1A)
None
None
None
 1.15A 3wipG-4gakA:
undetectable
3wipH-4gakA:
undetectable		 3wipG-4gakA:
23.64
3wipH-4gakA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		4 TYR A 314
THR A 280
LEU A 287
MET A 291
 None
 1.28A 3wipG-4gdfA:
undetectable
3wipH-4gdfA:
undetectable		 3wipG-4gdfA:
17.10
3wipH-4gdfA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 TYR A 116
THR A 235
LEU A 322
MET A 312
 None
 1.31A 3wipG-4h0aA:
undetectable
3wipH-4h0aA:
undetectable		 3wipG-4h0aA:
21.79
3wipH-4h0aA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA

(Lymnaea
stagnalis;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 TYR A  91
TRP A 145
THR A 146
TYR A 191
 None
 0.58A 3wipG-4hqpA:
27.2
3wipH-4hqpA:
26.8		 3wipG-4hqpA:
57.52
3wipH-4hqpA:
57.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 TYR B 507
THR B 489
TYR B 651
LEU B 492
 None
 1.21A 3wipG-4iglB:
undetectable
3wipH-4iglB:
undetectable		 3wipG-4iglB:
15.16
3wipH-4iglB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2o UDP-N-ACETYLGLUCOSAM
INE
4,6-DEHYDRATASE/5-EP
IMERASE

(Acinetobacter
baumannii) 		PF02719
(Polysacc_synt_2)
PF08485
(Polysacc_syn_2C) 		4 THR A 230
ARG A 315
LEU A 316
MET A 321
 None
 1.22A 3wipG-4j2oA:
undetectable
3wipH-4j2oA:
undetectable		 3wipG-4j2oA:
23.08
3wipH-4j2oA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6r HEAVY CHAIN OF
ANTIBODY VRC23
LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
TRP H 103
ARG H  94
LEU H  34
 None
None
EDO  H 304 (-2.7A)
None
 1.26A 3wipG-4j6rL:
undetectable
3wipH-4j6rL:
3.3		 3wipG-4j6rL:
23.05
3wipH-4j6rL:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 TRP A 145
THR A 112
ARG A 116
LEU A 150
 None
 1.22A 3wipG-4k17A:
undetectable
3wipH-4k17A:
undetectable		 3wipG-4k17A:
15.84
3wipH-4k17A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbr GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF08718
(GLTP) 		4 TYR A  32
THR A 109
ARG A 108
LEU A 215
 None
None
PO4  A 301 (-2.9A)
None
 1.31A 3wipG-4kbrA:
undetectable
3wipH-4kbrA:
undetectable		 3wipG-4kbrA:
19.58
3wipH-4kbrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 4 TYR E 402
THR E 461
ARG E 434
LEU E 456
 None
 1.26A 3wipG-4kprE:
undetectable
3wipH-4kprE:
undetectable		 3wipG-4kprE:
17.43
3wipH-4kprE:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A  59
THR A 103
TYR A  99
LEU A 225
 None
 0.94A 3wipG-4l1fA:
undetectable
3wipH-4l1fA:
undetectable		 3wipG-4l1fA:
16.88
3wipH-4l1fA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 THR A 392
ARG A 156
LEU A 432
MET A 434
 None
 1.18A 3wipG-4n0iA:
undetectable
3wipH-4n0iA:
undetectable		 3wipG-4n0iA:
20.00
3wipH-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 TYR A 256
THR A 392
LEU A 432
MET A 434
 None
 1.23A 3wipG-4n0iA:
undetectable
3wipH-4n0iA:
undetectable		 3wipG-4n0iA:
20.00
3wipH-4n0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 TRP A 390
THR A 393
TYR A 308
MET A 387
 None
 1.15A 3wipG-4nz6A:
undetectable
3wipH-4nz6A:
undetectable		 3wipG-4nz6A:
21.12
3wipH-4nz6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A1013
THR A 953
TYR A 955
ARG A 952
 None
 1.25A 3wipG-4oliA:
undetectable
3wipH-4oliA:
undetectable		 3wipG-4oliA:
16.43
3wipH-4oliA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quv DELTA(14)-STEROL
REDUCTASE

(Methylomicrobium
alcaliphilum) 		PF01222
(ERG4_ERG24) 		4 TYR A  38
TRP A  63
TYR A  46
ARG A  61
 None
 1.28A 3wipG-4quvA:
undetectable
3wipH-4quvA:
undetectable		 3wipG-4quvA:
18.06
3wipH-4quvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 TYR A  41
THR A  84
TYR A  58
LEU A  70
 None
 1.30A 3wipG-4r6yA:
undetectable
3wipH-4r6yA:
undetectable		 3wipG-4r6yA:
22.26
3wipH-4r6yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		4 TYR A  18
THR A  45
ARG A  48
LEU A  49
 None
 0.94A 3wipG-4tn5A:
undetectable
3wipH-4tn5A:
undetectable		 3wipG-4tn5A:
18.50
3wipH-4tn5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 426
TYR A 439
ARG A 410
LEU A 411
 None
 1.17A 3wipG-4uhiA:
undetectable
3wipH-4uhiA:
undetectable		 3wipG-4uhiA:
17.23
3wipH-4uhiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 TYR A 362
THR A 416
TYR A 341
TYR A 364
 None
None
BOG  A 903 (-4.1A)
None
 1.29A 3wipG-4zgvA:
undetectable
3wipH-4zgvA:
undetectable		 3wipG-4zgvA:
14.07
3wipH-4zgvA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 THR A 295
TYR A 300
ARG A 298
LEU A 361
 None
 1.31A 3wipG-5a5tA:
undetectable
3wipH-5a5tA:
undetectable		 3wipG-5a5tA:
9.98
3wipH-5a5tA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 TYR C 328
TRP C 372
ARG C  59
LEU A  30
 None
 1.30A 3wipG-5aa5C:
undetectable
3wipH-5aa5C:
undetectable		 3wipG-5aa5C:
17.79
3wipH-5aa5C:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		4 TYR A  24
THR A 128
ARG A 140
LEU A 143
 None
 1.25A 3wipG-5aypA:
undetectable
3wipH-5aypA:
undetectable		 3wipG-5aypA:
19.65
3wipH-5aypA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 THR A 621
TYR A 554
ARG A 630
LEU A 631
 None
 1.00A 3wipG-5bxpA:
undetectable
3wipH-5bxpA:
undetectable		 3wipG-5bxpA:
16.32
3wipH-5bxpA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 156
TRP A 194
LEU A 184
MET A 193
 None
 1.28A 3wipG-5c5hA:
undetectable
3wipH-5c5hA:
undetectable		 3wipG-5c5hA:
19.51
3wipH-5c5hA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 THR A 178
TYR A 874
ARG A 435
LEU A 434
 None
 1.24A 3wipG-5chcA:
undetectable
3wipH-5chcA:
undetectable		 3wipG-5chcA:
12.36
3wipH-5chcA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 TYR A 337
ARG A 314
LEU A 316
MET A 486
 None
 1.25A 3wipG-5dtuA:
undetectable
3wipH-5dtuA:
undetectable		 3wipG-5dtuA:
19.50
3wipH-5dtuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 TYR A 122
TRP A 178
THR A 179
TYR A 219
TYR A 226
 EPJ  A 300 (-4.6A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.3A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
 0.64A 3wipG-5fjvA:
23.5
3wipH-5fjvA:
22.7		 3wipG-5fjvA:
27.35
3wipH-5fjvA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 952
ARG A 969
LEU A 985
MET A 984
 None
 1.28A 3wipG-5fm2A:
undetectable
3wipH-5fm2A:
undetectable		 3wipG-5fm2A:
20.70
3wipH-5fm2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC

(Mycobacterium
tuberculosis) 		PF01547
(SBP_bac_1) 		4 TRP A  98
TYR A  77
ARG A  44
LEU A  74
 None
 1.15A 3wipG-5k2yA:
undetectable
3wipH-5k2yA:
undetectable		 3wipG-5k2yA:
17.39
3wipH-5k2yA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kiv PROTEIN-ADP-RIBOSE
HYDROLASE

(Staphylococcus
aureus) 		PF01661
(Macro) 		4 TYR A  13
TYR A  57
ARG A  48
LEU A  44
 None
EOH  A 303 (-2.7A)
EOH  A 303 ( 3.8A)
None
 1.29A 3wipG-5kivA:
undetectable
3wipH-5kivA:
undetectable		 3wipG-5kivA:
20.59
3wipH-5kivA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku1 MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		4 TYR A 306
THR A 299
TYR A 470
LEU A 372
 None
 1.30A 3wipG-5ku1A:
undetectable
3wipH-5ku1A:
undetectable		 3wipG-5ku1A:
20.29
3wipH-5ku1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 TYR A 100
TRP A 156
THR A 157
TYR A 197
TYR A 204
 NCT  A 402 (-4.8A)
NCT  A 402 (-3.9A)
NCT  A 402 (-4.6A)
NCT  A 402 ( 4.9A)
NCT  A 402 (-3.8A)
 0.68A 3wipG-5kxiA:
23.9
3wipH-5kxiA:
23.1		 3wipG-5kxiA:
20.93
3wipH-5kxiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A 255
TYR A 265
ARG A 432
LEU A 429
 None
 1.19A 3wipG-5lx8A:
undetectable
3wipH-5lx8A:
undetectable		 3wipG-5lx8A:
15.95
3wipH-5lx8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm4 KINESIN-5

(Ustilago maydis) 		no annotation 4 TYR K 367
THR K 309
TYR K 108
LEU K 331
 None
 1.00A 3wipG-5mm4K:
undetectable
3wipH-5mm4K:
undetectable		 3wipG-5mm4K:
undetectable
3wipH-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 TYR K 439
THR K 381
TYR K 180
LEU K 403
 None
 1.03A 3wipG-5mm7K:
undetectable
3wipH-5mm7K:
undetectable		 3wipG-5mm7K:
undetectable
3wipH-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 TYR A 527
TYR A 508
ARG A 515
LEU A 516
 BLG  A 601 (-3.6A)
BLG  A 601 (-4.2A)
None
None
 1.12A 3wipG-5mpqA:
undetectable
3wipH-5mpqA:
undetectable		 3wipG-5mpqA:
15.85
3wipH-5mpqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 THR A2421
TYR A2426
ARG A2383
LEU A2382
 None
 1.12A 3wipG-5nugA:
undetectable
3wipH-5nugA:
undetectable		 3wipG-5nugA:
4.18
3wipH-5nugA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 TRP A 688
THR A 660
TYR A 671
LEU A 451
 None
 1.04A 3wipG-5okoA:
undetectable
3wipH-5okoA:
undetectable		 3wipG-5okoA:
23.29
3wipH-5okoA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 TYR A 360
THR A  70
ARG A 183
LEU A 190
 None
CL  A 504 (-3.8A)
CL  A 504 (-3.9A)
None
 1.18A 3wipG-5tvjA:
undetectable
3wipH-5tvjA:
undetectable		 3wipG-5tvjA:
18.98
3wipH-5tvjA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 4 THR B 144
TYR B 370
ARG B 333
LEU B 364
 None
None
SO4  B 406 (-3.7A)
None
 1.11A 3wipG-5u7zB:
undetectable
3wipH-5u7zB:
undetectable		 3wipG-5u7zB:
undetectable
3wipH-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbu CYTOCHROME P450
21-HYDROXYLASE

(Homo sapiens) 		PF00067
(p450) 		4 THR A 157
ARG A 480
LEU A 481
MET A 151
 None
 1.11A 3wipG-5vbuA:
undetectable
3wipH-5vbuA:
undetectable		 3wipG-5vbuA:
17.72
3wipH-5vbuA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 4 TYR E  45
THR E 135
ARG E  56
LEU E 162
 None
None
ADP  E1001 (-4.1A)
None
 1.03A 3wipG-5x06E:
undetectable
3wipH-5x06E:
undetectable		 3wipG-5x06E:
undetectable
3wipH-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3, PUTATIVE
PLECTIN/S10 DOMAIN
CONTAINING PROTEIN

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2)
PF03501
(S10_plectin) 		4 TYR K  42
TYR K  65
ARG D  28
LEU D  25
 None
None
A  21245 ( 3.9A)
None
 1.08A 3wipG-5xyiK:
undetectable
3wipH-5xyiK:
undetectable		 3wipG-5xyiK:
21.98
3wipH-5xyiK:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		4 THR A 261
TYR A 293
LEU A 373
MET A 256
 None
None
None
HEM  A 501 (-4.8A)
 0.93A 3wipG-5y1iA:
undetectable
3wipH-5y1iA:
undetectable		 3wipG-5y1iA:
19.69
3wipH-5y1iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 THR C 965
TYR C 984
ARG C 964
LEU C1009
 None
 1.22A 3wipG-5y3rC:
undetectable
3wipH-5y3rC:
undetectable		 3wipG-5y3rC:
4.75
3wipH-5y3rC:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzn


(;
) 		no annotation
no annotation 		4 THR V  63
TYR U  42
TYR V  82
ARG U  39
 None
None
HEM  V 201 (-4.6A)
None
 1.30A 3wipG-5zznV:
undetectable
3wipH-5zznV:
undetectable		 3wipG-5zznV:
undetectable
3wipH-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 4 TYR A 284
THR A 243
ARG A 251
LEU A  79
 None
 1.29A 3wipG-6co9A:
undetectable
3wipH-6co9A:
undetectable		 3wipG-6co9A:
undetectable
3wipH-6co9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 TYR A 281
THR A 240
ARG A 248
LEU A  76
 None
 1.29A 3wipG-6conA:
undetectable
3wipH-6conA:
undetectable		 3wipG-6conA:
undetectable
3wipH-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 THR A 155
TYR A  65
TYR A  55
ARG A  98
 None
 1.25A 3wipG-6dd3A:
undetectable
3wipH-6dd3A:
undetectable		 3wipG-6dd3A:
undetectable
3wipH-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnf MITOCHONDRIAL
CALCIUM UNIPORTER
MCU

(Cyphellophora
europaea) 		no annotation 4 THR A 163
ARG A 167
LEU A 170
MET A 291
 None
 1.25A 3wipG-6dnfA:
undetectable
3wipH-6dnfA:
undetectable		 3wipG-6dnfA:
undetectable
3wipH-6dnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 4 THR C  37
ARG C 441
LEU C 440
MET C 445
 None
 1.30A 3wipG-6f0kC:
undetectable
3wipH-6f0kC:
undetectable		 3wipG-6f0kC:
undetectable
3wipH-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 4 THR A 362
TYR A 288
ARG A 303
MET A 316
 None
 1.22A 3wipG-6fm9A:
undetectable
3wipH-6fm9A:
undetectable		 3wipG-6fm9A:
undetectable
3wipH-6fm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 6
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT 9

(Mus musculus;
Mus musculus;
Mus musculus) 		no annotation
no annotation
no annotation 		4 TYR m  50
THR n 171
ARG i  18
LEU i  14
 None
 1.18A 3wipG-6g72m:
undetectable
3wipH-6g72m:
undetectable		 3wipG-6g72m:
undetectable
3wipH-6g72m:
undetectable