SIMILAR PATTERNS OF AMINO ACIDS FOR 3WIP_F_ACHF301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Salmonella
enterica)
PF00496
(SBP_bac_5)
4 TYR A 420
THR A 429
TYR A 112
TYR A 115
None
1.13A 3wipF-1b2hA:
0.0
3wipG-1b2hA:
undetectable
3wipF-1b2hA:
16.28
3wipG-1b2hA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A)
PF09220
(LA-virus_coat)
4 TYR A 485
TRP A 510
THR A 546
ARG A 517
None
1.15A 3wipF-1m1cA:
undetectable
3wipG-1m1cA:
0.0
3wipF-1m1cA:
15.97
3wipG-1m1cA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE


(Escherichia
coli)
PF07977
(FabA)
4 THR A 125
TYR A 155
ARG A 127
MET A  86
None
1.46A 3wipF-1mkbA:
0.0
3wipG-1mkbA:
0.0
3wipF-1mkbA:
19.63
3wipG-1mkbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.)
no annotation 4 TYR A 237
THR A 186
TYR A 341
TYR A 187
None
1.44A 3wipF-1nluA:
undetectable
3wipG-1nluA:
undetectable
3wipF-1nluA:
20.21
3wipG-1nluA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN


(Salmonella
enterica)
PF02264
(LamB)
4 THR Q 481
TYR Q 118
TYR Q  78
ARG Q 437
None
1.34A 3wipF-1oh2Q:
0.0
3wipG-1oh2Q:
0.0
3wipF-1oh2Q:
19.74
3wipG-1oh2Q:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA


(Homo sapiens)
PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int)
4 TYR A 651
THR A 615
TYR A 634
ARG A 602
None
1.21A 3wipF-1yvlA:
undetectable
3wipG-1yvlA:
undetectable
3wipF-1yvlA:
13.60
3wipG-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA


(Cichorium
intybus)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 TYR A 206
THR A 240
TYR A 268
TYR A 239
None
1.44A 3wipF-2aeyA:
0.0
3wipG-2aeyA:
0.0
3wipF-2aeyA:
17.21
3wipG-2aeyA:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bj0 ACETYLCHOLINE-BINDIN
G PROTEIN


(Bulinus
truncatus)
PF02931
(Neur_chan_LBD)
5 TYR A  88
TRP A 142
THR A 143
TYR A 184
TYR A 191
None
CXS  A1204 (-3.6A)
CXS  A1204 ( 4.7A)
CXS  A1204 (-4.6A)
CXS  A1204 (-4.7A)
0.66A 3wipF-2bj0A:
24.5
3wipG-2bj0A:
25.9
3wipF-2bj0A:
40.44
3wipG-2bj0A:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 TYR A 441
TRP A 477
TYR A 457
MET A 474
None
1.18A 3wipF-2hk5A:
undetectable
3wipG-2hk5A:
undetectable
3wipF-2hk5A:
22.85
3wipG-2hk5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT


(Pseudomonas
stutzeri;
Pseudomonas
stutzeri)
PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox)
4 TYR B  37
TRP B  46
THR A 182
ARG A 183
None
1.32A 3wipF-2incB:
undetectable
3wipG-2incB:
undetectable
3wipF-2incB:
19.65
3wipG-2incB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7t TRANSCRIPTIONAL
REGULATOR


(Corynebacterium
glutamicum)
PF00440
(TetR_N)
4 TYR A 149
TRP A  85
THR A  86
TYR A 179
None
1.37A 3wipF-2o7tA:
undetectable
3wipG-2o7tA:
undetectable
3wipF-2o7tA:
22.58
3wipG-2o7tA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpt LIPOLYTIC ENZYME

(Ruminiclostridium
thermocellum)
PF13472
(Lipase_GDSL_2)
4 TYR A 159
THR A  46
TYR A 214
ARG A  58
None
1.48A 3wipF-2vptA:
undetectable
3wipG-2vptA:
undetectable
3wipF-2vptA:
21.40
3wipG-2vptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii)
PF16364
(Antigen_C)
4 TYR A1230
THR A1218
TYR A1105
ARG A1142
None
1.29A 3wipF-2wqsA:
undetectable
3wipG-2wqsA:
undetectable
3wipF-2wqsA:
20.75
3wipG-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346


(Corynebacterium
diphtheriae)
PF08903
(DUF1846)
4 TYR A 166
THR A 170
TYR A  32
ARG A 171
None
1.46A 3wipF-3bh1A:
undetectable
3wipG-3bh1A:
undetectable
3wipF-3bh1A:
18.09
3wipG-3bh1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea)
PF00704
(Glyco_hydro_18)
4 TYR A 369
THR A 256
TYR A 259
MET A 362
None
1.42A 3wipF-3g6lA:
undetectable
3wipG-3g6lA:
undetectable
3wipF-3g6lA:
20.54
3wipG-3g6lA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdh ACETYLCHOLINE
BINDING PROTEIN


(Lymnaea
stagnalis)
PF02931
(Neur_chan_LBD)
5 TYR A  89
TRP A 143
THR A 144
TYR A 185
TYR A 192
None
XRS  A 301 (-3.6A)
XRS  A 301 ( 4.4A)
XRS  A 301 ( 4.1A)
XRS  A 301 (-3.8A)
0.39A 3wipF-3zdhA:
32.0
3wipG-3zdhA:
33.0
3wipF-3zdhA:
100.00
3wipG-3zdhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1


(Biomphalaria
glabrata)
PF02931
(Neur_chan_LBD)
4 TRP A 146
THR A 147
TYR A 186
TYR A 193
None
0.84A 3wipF-4aodA:
24.5
3wipG-4aodA:
25.1
3wipF-4aodA:
37.99
3wipG-4aodA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aoe ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 2


(Biomphalaria
glabrata)
PF02931
(Neur_chan_LBD)
4 TYR A  92
TRP A 146
THR A 147
TYR A 186
None
0.81A 3wipF-4aoeA:
24.5
3wipG-4aoeA:
25.1
3wipF-4aoeA:
33.76
3wipG-4aoeA:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqt LAMININ SUBUNIT
GAMMA-1


(Mus musculus)
PF00053
(Laminin_EGF)
PF00055
(Laminin_N)
4 TYR A 161
TYR A 175
TYR A 184
ARG A 253
NAG  A3001 ( 4.1A)
None
None
None
1.20A 3wipF-4aqtA:
undetectable
3wipG-4aqtA:
undetectable
3wipF-4aqtA:
20.00
3wipG-4aqtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN


(Microbacterium
liquefaciens)
PF02133
(Transp_cyt_pur)
4 TYR A 395
THR A  20
TYR A 465
ARG A  25
None
1.40A 3wipF-4d1dA:
undetectable
3wipG-4d1dA:
undetectable
3wipF-4d1dA:
18.09
3wipG-4d1dA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h14 SPIKE GLYCOPROTEIN

(Betacoronavirus
1)
PF16451
(Spike_NTD)
4 TYR A  50
THR A 266
TYR A 213
TYR A  67
None
1.37A 3wipF-4h14A:
undetectable
3wipG-4h14A:
undetectable
3wipF-4h14A:
20.81
3wipG-4h14A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA


(Lymnaea
stagnalis;
Homo sapiens)
PF02931
(Neur_chan_LBD)
4 TYR A  91
TRP A 145
THR A 146
TYR A 191
None
0.63A 3wipF-4hqpA:
26.8
3wipG-4hqpA:
27.2
3wipF-4hqpA:
57.52
3wipG-4hqpA:
57.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT


(Escherichia
coli;
Homo sapiens)
PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
4 TYR A 157
TRP A 342
ARG A  68
MET A 338
None
1.40A 3wipF-4logA:
undetectable
3wipG-4logA:
undetectable
3wipF-4logA:
16.73
3wipG-4logA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
4 TYR A1522
THR A1869
TYR A1874
TYR A1870
None
1.29A 3wipF-4o9xA:
undetectable
3wipG-4o9xA:
undetectable
3wipF-4o9xA:
6.98
3wipG-4o9xA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 TYR A1013
THR A 953
TYR A 955
ARG A 952
None
1.23A 3wipF-4oliA:
undetectable
3wipG-4oliA:
undetectable
3wipF-4oliA:
16.43
3wipG-4oliA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quv DELTA(14)-STEROL
REDUCTASE


(Methylomicrobium
alcaliphilum)
PF01222
(ERG4_ERG24)
4 TYR A  38
TRP A  63
TYR A  46
ARG A  61
None
1.27A 3wipF-4quvA:
undetectable
3wipG-4quvA:
undetectable
3wipF-4quvA:
18.06
3wipG-4quvA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus)
PF00840
(Glyco_hydro_7)
4 TYR A 142
THR A 105
TYR A 168
TYR A 106
CE6  A 505 (-4.3A)
None
None
None
1.49A 3wipF-4xebA:
undetectable
3wipG-4xebA:
undetectable
3wipF-4xebA:
18.69
3wipG-4xebA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum)
PF07715
(Plug)
4 TYR A 362
THR A 416
TYR A 341
TYR A 364
None
None
BOG  A 903 (-4.1A)
None
1.26A 3wipF-4zgvA:
undetectable
3wipG-4zgvA:
undetectable
3wipF-4zgvA:
14.07
3wipG-4zgvA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bop NANOBODY
OCTARELLIN V.1


(Lama glama;
synthetic
construct)
PF07686
(V-set)
no annotation
4 TYR A 106
THR A  54
TYR A  32
ARG B 159
None
1.49A 3wipF-5bopA:
undetectable
3wipG-5bopA:
undetectable
3wipF-5bopA:
20.60
3wipG-5bopA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2


(Homo sapiens)
PF02931
(Neur_chan_LBD)
5 TYR A 122
TRP A 178
THR A 179
TYR A 219
TYR A 226
EPJ  A 300 (-4.6A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.3A)
EPJ  A 300 (-3.7A)
EPJ  A 300 (-3.7A)
0.64A 3wipF-5fjvA:
22.6
3wipG-5fjvA:
23.5
3wipF-5fjvA:
27.35
3wipG-5fjvA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jph ACETYLTRANSFERASE
SACOL1063


(Staphylococcus
aureus)
PF13673
(Acetyltransf_10)
4 TYR A  47
THR A  55
ARG A  18
MET A  74
None
CL  A 203 (-3.8A)
CL  A 203 (-4.0A)
None
1.39A 3wipF-5jphA:
undetectable
3wipG-5jphA:
undetectable
3wipF-5jphA:
19.56
3wipG-5jphA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
no annotation 4 TYR B 963
THR B 801
TYR B 908
TYR B 802
None
1.47A 3wipF-5kdjB:
undetectable
3wipG-5kdjB:
undetectable
3wipF-5kdjB:
15.21
3wipG-5kdjB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
PF13402
(Peptidase_M60)
4 TYR A 963
THR A 801
TYR A 908
TYR A 802
None
1.48A 3wipF-5kdsA:
undetectable
3wipG-5kdsA:
undetectable
3wipF-5kdsA:
16.01
3wipG-5kdsA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4


(Homo sapiens)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 TYR A 100
TRP A 156
THR A 157
TYR A 197
TYR A 204
NCT  A 402 (-4.8A)
NCT  A 402 (-3.9A)
NCT  A 402 (-4.6A)
NCT  A 402 ( 4.9A)
NCT  A 402 (-3.8A)
0.73A 3wipF-5kxiA:
23.2
3wipG-5kxiA:
23.9
3wipF-5kxiA:
20.93
3wipG-5kxiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
4 THR B 300
TYR B 135
TYR B 303
ARG B 266
None
1.41A 3wipF-5ldrB:
undetectable
3wipG-5ldrB:
undetectable
3wipF-5ldrB:
15.17
3wipG-5ldrB:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
4 TYR A 346
THR A 321
TYR A 269
TYR A 322
None
1.34A 3wipF-5mqsA:
undetectable
3wipG-5mqsA:
undetectable
3wipF-5mqsA:
12.50
3wipG-5mqsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR


(Homo sapiens)
PF00002
(7tm_2)
PF02793
(HRM)
4 TYR A  88
TRP A 214
TYR A  69
ARG A 215
None
1.30A 3wipF-5nx2A:
undetectable
3wipG-5nx2A:
undetectable
3wipF-5nx2A:
19.46
3wipG-5nx2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila)
no annotation 4 TYR A 146
THR A 109
TYR A 172
TYR A 110
None
1.50A 3wipF-5w11A:
undetectable
3wipG-5w11A:
undetectable
3wipF-5w11A:
undetectable
3wipG-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 TRP A 188
TYR A 209
ARG A 187
MET A 235
None
1.46A 3wipF-5x8gA:
undetectable
3wipG-5x8gA:
undetectable
3wipF-5x8gA:
19.14
3wipG-5x8gA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzn


(;
)
no annotation
no annotation
4 THR V  63
TYR U  42
TYR V  82
ARG U  39
None
None
HEM  V 201 (-4.6A)
None
1.32A 3wipF-5zznV:
undetectable
3wipG-5zznV:
undetectable
3wipF-5zznV:
undetectable
3wipG-5zznV:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE


(Homo sapiens)
no annotation 4 THR A 155
TYR A  60
TYR A  55
ARG A  98
None
1.34A 3wipF-6dd3A:
undetectable
3wipG-6dd3A:
undetectable
3wipF-6dd3A:
undetectable
3wipG-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE


(Homo sapiens)
no annotation 4 THR A 362
TYR A 288
ARG A 303
MET A 316
None
1.28A 3wipF-6fm9A:
undetectable
3wipG-6fm9A:
undetectable
3wipF-6fm9A:
undetectable
3wipG-6fm9A:
undetectable