SIMILAR PATTERNS OF AMINO ACIDS FOR 3WIP_F_ACHF301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b2h | PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Salmonellaenterica) |
PF00496(SBP_bac_5) | 4 | TYR A 420THR A 429TYR A 112TYR A 115 | None | 1.13A | 3wipF-1b2hA:0.03wipG-1b2hA:undetectable | 3wipF-1b2hA:16.283wipG-1b2hA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1c | MAJOR COAT PROTEIN (Saccharomycescerevisiaevirus L-A) |
PF09220(LA-virus_coat) | 4 | TYR A 485TRP A 510THR A 546ARG A 517 | None | 1.15A | 3wipF-1m1cA:undetectable3wipG-1m1cA:0.0 | 3wipF-1m1cA:15.973wipG-1m1cA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mkb | BETA-HYDROXYDECANOYLTHIOL ESTERDEHYDRASE (Escherichiacoli) |
PF07977(FabA) | 4 | THR A 125TYR A 155ARG A 127MET A 86 | None | 1.46A | 3wipF-1mkbA:0.03wipG-1mkbA:0.0 | 3wipF-1mkbA:19.633wipG-1mkbA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nlu | SEDOLISIN (Pseudomonas sp.) |
no annotation | 4 | TYR A 237THR A 186TYR A 341TYR A 187 | None | 1.44A | 3wipF-1nluA:undetectable3wipG-1nluA:undetectable | 3wipF-1nluA:20.213wipG-1nluA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oh2 | SUCROSE SPECIFICPORIN (Salmonellaenterica) |
PF02264(LamB) | 4 | THR Q 481TYR Q 118TYR Q 78ARG Q 437 | None | 1.34A | 3wipF-1oh2Q:0.03wipG-1oh2Q:0.0 | 3wipF-1oh2Q:19.743wipG-1oh2Q:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvl | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION1-ALPHA/BETA (Homo sapiens) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind)PF02865(STAT_int) | 4 | TYR A 651THR A 615TYR A 634ARG A 602 | None | 1.21A | 3wipF-1yvlA:undetectable3wipG-1yvlA:undetectable | 3wipF-1yvlA:13.603wipG-1yvlA:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aey | FRUCTAN1-EXOHYDROLASE IIA (Cichoriumintybus) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | TYR A 206THR A 240TYR A 268TYR A 239 | None | 1.44A | 3wipF-2aeyA:0.03wipG-2aeyA:0.0 | 3wipF-2aeyA:17.213wipG-2aeyA:17.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2bj0 | ACETYLCHOLINE-BINDING PROTEIN (Bulinustruncatus) |
PF02931(Neur_chan_LBD) | 5 | TYR A 88TRP A 142THR A 143TYR A 184TYR A 191 | NoneCXS A1204 (-3.6A)CXS A1204 ( 4.7A)CXS A1204 (-4.6A)CXS A1204 (-4.7A) | 0.66A | 3wipF-2bj0A:24.53wipG-2bj0A:25.9 | 3wipF-2bj0A:40.443wipG-2bj0A:40.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | TYR A 441TRP A 477TYR A 457MET A 474 | None | 1.18A | 3wipF-2hk5A:undetectable3wipG-2hk5A:undetectable | 3wipF-2hk5A:22.853wipG-2hk5A:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inc | TOLUENE, O-XYLENEMONOOXYGENASEOXYGENASE SUBUNITTOLUENE, O-XYLENEMONOOXYGENASEOXYGENASE SUBUNIT (Pseudomonasstutzeri;Pseudomonasstutzeri) |
PF02332(Phenol_Hydrox)PF04945(YHS)PF02332(Phenol_Hydrox) | 4 | TYR B 37TRP B 46THR A 182ARG A 183 | None | 1.32A | 3wipF-2incB:undetectable3wipG-2incB:undetectable | 3wipF-2incB:19.653wipG-2incB:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7t | TRANSCRIPTIONALREGULATOR (Corynebacteriumglutamicum) |
PF00440(TetR_N) | 4 | TYR A 149TRP A 85THR A 86TYR A 179 | None | 1.37A | 3wipF-2o7tA:undetectable3wipG-2o7tA:undetectable | 3wipF-2o7tA:22.583wipG-2o7tA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpt | LIPOLYTIC ENZYME (Ruminiclostridiumthermocellum) |
PF13472(Lipase_GDSL_2) | 4 | TYR A 159THR A 46TYR A 214ARG A 58 | None | 1.48A | 3wipF-2vptA:undetectable3wipG-2vptA:undetectable | 3wipF-2vptA:21.403wipG-2vptA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqs | AGGLUTININ RECEPTOR (Streptococcusgordonii) |
PF16364(Antigen_C) | 4 | TYR A1230THR A1218TYR A1105ARG A1142 | None | 1.29A | 3wipF-2wqsA:undetectable3wipG-2wqsA:undetectable | 3wipF-2wqsA:20.753wipG-2wqsA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bh1 | UPF0371 PROTEINDIP2346 (Corynebacteriumdiphtheriae) |
PF08903(DUF1846) | 4 | TYR A 166THR A 170TYR A 32ARG A 171 | None | 1.46A | 3wipF-3bh1A:undetectable3wipG-3bh1A:undetectable | 3wipF-3bh1A:18.093wipG-3bh1A:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6l | CHITINASE (Clonostachysrosea) |
PF00704(Glyco_hydro_18) | 4 | TYR A 369THR A 256TYR A 259MET A 362 | None | 1.42A | 3wipF-3g6lA:undetectable3wipG-3g6lA:undetectable | 3wipF-3g6lA:20.543wipG-3g6lA:20.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zdh | ACETYLCHOLINEBINDING PROTEIN (Lymnaeastagnalis) |
PF02931(Neur_chan_LBD) | 5 | TYR A 89TRP A 143THR A 144TYR A 185TYR A 192 | NoneXRS A 301 (-3.6A)XRS A 301 ( 4.4A)XRS A 301 ( 4.1A)XRS A 301 (-3.8A) | 0.39A | 3wipF-3zdhA:32.03wipG-3zdhA:33.0 | 3wipF-3zdhA:100.003wipG-3zdhA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aod | ACETYLCHOLINE-BINDING PROTEIN TYPE 1 (Biomphalariaglabrata) |
PF02931(Neur_chan_LBD) | 4 | TRP A 146THR A 147TYR A 186TYR A 193 | None | 0.84A | 3wipF-4aodA:24.53wipG-4aodA:25.1 | 3wipF-4aodA:37.993wipG-4aodA:37.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aoe | ACETYLCHOLINE-BINDING PROTEIN TYPE 2 (Biomphalariaglabrata) |
PF02931(Neur_chan_LBD) | 4 | TYR A 92TRP A 146THR A 147TYR A 186 | None | 0.81A | 3wipF-4aoeA:24.53wipG-4aoeA:25.1 | 3wipF-4aoeA:33.763wipG-4aoeA:33.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aqt | LAMININ SUBUNITGAMMA-1 (Mus musculus) |
PF00053(Laminin_EGF)PF00055(Laminin_N) | 4 | TYR A 161TYR A 175TYR A 184ARG A 253 | NAG A3001 ( 4.1A)NoneNoneNone | 1.20A | 3wipF-4aqtA:undetectable3wipG-4aqtA:undetectable | 3wipF-4aqtA:20.003wipG-4aqtA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1d | HYDANTOIN TRANSPORTPROTEIN (Microbacteriumliquefaciens) |
PF02133(Transp_cyt_pur) | 4 | TYR A 395THR A 20TYR A 465ARG A 25 | None | 1.40A | 3wipF-4d1dA:undetectable3wipG-4d1dA:undetectable | 3wipF-4d1dA:18.093wipG-4d1dA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h14 | SPIKE GLYCOPROTEIN (Betacoronavirus1) |
PF16451(Spike_NTD) | 4 | TYR A 50THR A 266TYR A 213TYR A 67 | None | 1.37A | 3wipF-4h14A:undetectable3wipG-4h14A:undetectable | 3wipF-4h14A:20.813wipG-4h14A:20.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hqp | ALPHA7 NICOTINICRECEPTOR CHIMERA (Lymnaeastagnalis;Homo sapiens) |
PF02931(Neur_chan_LBD) | 4 | TYR A 91TRP A 145THR A 146TYR A 191 | None | 0.63A | 3wipF-4hqpA:26.83wipG-4hqpA:27.2 | 3wipF-4hqpA:57.523wipG-4hqpA:57.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4log | MALTOSE ABCTRANSPORTERPERIPLASMIC PROTEINAND NR2E3 PROTEINCHIMERIC CONSTRUCT (Escherichiacoli;Homo sapiens) |
PF00104(Hormone_recep)PF13416(SBP_bac_8) | 4 | TYR A 157TRP A 342ARG A 68MET A 338 | None | 1.40A | 3wipF-4logA:undetectable3wipG-4logA:undetectable | 3wipF-4logA:16.733wipG-4logA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 4 | TYR A1522THR A1869TYR A1874TYR A1870 | None | 1.29A | 3wipF-4o9xA:undetectable3wipG-4o9xA:undetectable | 3wipF-4o9xA:6.983wipG-4o9xA:6.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | TYR A1013THR A 953TYR A 955ARG A 952 | None | 1.23A | 3wipF-4oliA:undetectable3wipG-4oliA:undetectable | 3wipF-4oliA:16.433wipG-4oliA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4quv | DELTA(14)-STEROLREDUCTASE (Methylomicrobiumalcaliphilum) |
PF01222(ERG4_ERG24) | 4 | TYR A 38TRP A 63TYR A 46ARG A 61 | None | 1.27A | 3wipF-4quvA:undetectable3wipG-4quvA:undetectable | 3wipF-4quvA:18.063wipG-4quvA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeb | GLUCANASE (Talaromycesfuniculosus) |
PF00840(Glyco_hydro_7) | 4 | TYR A 142THR A 105TYR A 168TYR A 106 | CE6 A 505 (-4.3A)NoneNoneNone | 1.49A | 3wipF-4xebA:undetectable3wipG-4xebA:undetectable | 3wipF-4xebA:18.693wipG-4xebA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgv | FERREDOXIN RECEPTOR (Pectobacteriumatrosepticum) |
PF07715(Plug) | 4 | TYR A 362THR A 416TYR A 341TYR A 364 | NoneNoneBOG A 903 (-4.1A)None | 1.26A | 3wipF-4zgvA:undetectable3wipG-4zgvA:undetectable | 3wipF-4zgvA:14.073wipG-4zgvA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bop | NANOBODYOCTARELLIN V.1 (Lama glama;syntheticconstruct) |
PF07686(V-set)no annotation | 4 | TYR A 106THR A 54TYR A 32ARG B 159 | None | 1.49A | 3wipF-5bopA:undetectable3wipG-5bopA:undetectable | 3wipF-5bopA:20.603wipG-5bopA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjv | NEURONALACETYLCHOLINERECEPTOR SUBUNITALPHA-2 (Homo sapiens) |
PF02931(Neur_chan_LBD) | 5 | TYR A 122TRP A 178THR A 179TYR A 219TYR A 226 | EPJ A 300 (-4.6A)EPJ A 300 (-3.7A)EPJ A 300 (-3.3A)EPJ A 300 (-3.7A)EPJ A 300 (-3.7A) | 0.64A | 3wipF-5fjvA:22.63wipG-5fjvA:23.5 | 3wipF-5fjvA:27.353wipG-5fjvA:27.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jph | ACETYLTRANSFERASESACOL1063 (Staphylococcusaureus) |
PF13673(Acetyltransf_10) | 4 | TYR A 47THR A 55ARG A 18MET A 74 | None CL A 203 (-3.8A) CL A 203 (-4.0A)None | 1.39A | 3wipF-5jphA:undetectable3wipG-5jphA:undetectable | 3wipF-5jphA:19.563wipG-5jphA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdj | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
no annotation | 4 | TYR B 963THR B 801TYR B 908TYR B 802 | None | 1.47A | 3wipF-5kdjB:undetectable3wipG-5kdjB:undetectable | 3wipF-5kdjB:15.213wipG-5kdjB:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kds | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
PF13402(Peptidase_M60) | 4 | TYR A 963THR A 801TYR A 908TYR A 802 | None | 1.48A | 3wipF-5kdsA:undetectable3wipG-5kdsA:undetectable | 3wipF-5kdsA:16.013wipG-5kdsA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kxi | NEURONALACETYLCHOLINERECEPTOR SUBUNITALPHA-4 (Homo sapiens) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 5 | TYR A 100TRP A 156THR A 157TYR A 197TYR A 204 | NCT A 402 (-4.8A)NCT A 402 (-3.9A)NCT A 402 (-4.6A)NCT A 402 ( 4.9A)NCT A 402 (-3.8A) | 0.73A | 3wipF-5kxiA:23.23wipG-5kxiA:23.9 | 3wipF-5kxiA:20.933wipG-5kxiA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldr | BETA-D-GALACTOSIDASE (Paracoccus sp.32d) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 4 | THR B 300TYR B 135TYR B 303ARG B 266 | None | 1.41A | 3wipF-5ldrB:undetectable3wipG-5ldrB:undetectable | 3wipF-5ldrB:15.173wipG-5ldrB:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqs | BETA-L-ARABINOBIOSIDASE (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2) | 4 | TYR A 346THR A 321TYR A 269TYR A 322 | None | 1.34A | 3wipF-5mqsA:undetectable3wipG-5mqsA:undetectable | 3wipF-5mqsA:12.503wipG-5mqsA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nx2 | GLUCAGON-LIKEPEPTIDE 1 RECEPTOR (Homo sapiens) |
PF00002(7tm_2)PF02793(HRM) | 4 | TYR A 88TRP A 214TYR A 69ARG A 215 | None | 1.30A | 3wipF-5nx2A:undetectable3wipG-5nx2A:undetectable | 3wipF-5nx2A:19.463wipG-5nx2A:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w11 | GLUCANASE (Thermothelomycesthermophila) |
no annotation | 4 | TYR A 146THR A 109TYR A 172TYR A 110 | None | 1.50A | 3wipF-5w11A:undetectable3wipG-5w11A:undetectable | 3wipF-5w11A:undetectable3wipG-5w11A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8g | 2-SUCCINYLBENZOATE--COA LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | TRP A 188TYR A 209ARG A 187MET A 235 | None | 1.46A | 3wipF-5x8gA:undetectable3wipG-5x8gA:undetectable | 3wipF-5x8gA:19.143wipG-5x8gA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zzn | (;) |
no annotationno annotation | 4 | THR V 63TYR U 42TYR V 82ARG U 39 | NoneNoneHEM V 201 (-4.6A)None | 1.32A | 3wipF-5zznV:undetectable3wipG-5zznV:undetectable | 3wipF-5zznV:undetectable3wipG-5zznV:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dd3 | CYTOSOLIC PURINE5'-NUCLEOTIDASE (Homo sapiens) |
no annotation | 4 | THR A 155TYR A 60TYR A 55ARG A 98 | None | 1.34A | 3wipF-6dd3A:undetectable3wipG-6dd3A:undetectable | 3wipF-6dd3A:undetectable3wipG-6dd3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fm9 | UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATEN-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (Homo sapiens) |
no annotation | 4 | THR A 362TYR A 288ARG A 303MET A 316 | None | 1.28A | 3wipF-6fm9A:undetectable3wipG-6fm9A:undetectable | 3wipF-6fm9A:undetectable3wipG-6fm9A:undetectable |