SIMILAR PATTERNS OF AMINO ACIDS FOR 3WG7_P_CHDP306_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.93A 3wg7P-1914A:
0.8
3wg7W-1914A:
0.0		 3wg7P-1914A:
19.40
3wg7W-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.96A 3wg7P-1bucA:
1.4
3wg7W-1bucA:
0.0		 3wg7P-1bucA:
17.69
3wg7W-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 0.99A 3wg7P-1c4oA:
undetectable
3wg7W-1c4oA:
0.0		 3wg7P-1c4oA:
16.59
3wg7W-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.75A 3wg7P-1dj3A:
undetectable
3wg7W-1dj3A:
0.0		 3wg7P-1dj3A:
19.00
3wg7W-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 200
PHE A 183
LEU A 179
PHE A 175
 None
 0.75A 3wg7P-1dj3A:
undetectable
3wg7W-1dj3A:
0.0		 3wg7P-1dj3A:
19.00
3wg7W-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 342
PHE A 347
PHE A 108
LEU A 104
 None
 1.03A 3wg7P-1dq3A:
undetectable
3wg7W-1dq3A:
0.0		 3wg7P-1dq3A:
17.80
3wg7W-1dq3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		4 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.05A 3wg7P-1e2tA:
undetectable
3wg7W-1e2tA:
0.0		 3wg7P-1e2tA:
23.15
3wg7W-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 LEU S 540
PHE S 555
LEU S 559
PHE S 569
 None
 0.93A 3wg7P-1i84S:
undetectable
3wg7W-1i84S:
1.7		 3wg7P-1i84S:
10.90
3wg7W-1i84S:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A  69
PHE A 267
LEU A  91
PHE A  53
 None
 0.96A 3wg7P-1idmA:
undetectable
3wg7W-1idmA:
0.0		 3wg7P-1idmA:
18.75
3wg7W-1idmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.86A 3wg7P-1jkwA:
0.7
3wg7W-1jkwA:
0.0		 3wg7P-1jkwA:
20.52
3wg7W-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.98A 3wg7P-1js6A:
0.0
3wg7W-1js6A:
undetectable		 3wg7P-1js6A:
19.84
3wg7W-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  31
PHE A  27
PHE A  93
LEU A  56
 None
 1.05A 3wg7P-1mdfA:
undetectable
3wg7W-1mdfA:
undetectable		 3wg7P-1mdfA:
17.85
3wg7W-1mdfA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 574
PHE B 592
LEU B 596
 None
 0.83A 3wg7P-1ovlB:
undetectable
3wg7W-1ovlB:
undetectable		 3wg7P-1ovlB:
19.94
3wg7W-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.05A 3wg7P-1rrhA:
1.3
3wg7W-1rrhA:
undetectable		 3wg7P-1rrhA:
15.87
3wg7W-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.94A 3wg7P-1u8vA:
3.8
3wg7W-1u8vA:
undetectable		 3wg7P-1u8vA:
19.70
3wg7W-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 1.02A 3wg7P-1vkuA:
undetectable
3wg7W-1vkuA:
undetectable		 3wg7P-1vkuA:
13.64
3wg7W-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		5 LEU A  80
PHE A 230
PHE A 225
LEU A 216
PHE A 212
 None
 1.27A 3wg7P-1wodA:
undetectable
3wg7W-1wodA:
undetectable		 3wg7P-1wodA:
19.08
3wg7W-1wodA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE

(Homo sapiens) 		PF05881
(CNPase) 		4 LEU A 347
PHE A 189
LEU A 193
PHE A 199
 LEU  A 347 ( 0.6A)
PHE  A 189 ( 1.3A)
LEU  A 193 ( 0.6A)
PHE  A 199 ( 1.3A)
 0.99A 3wg7P-1wojA:
undetectable
3wg7W-1wojA:
undetectable		 3wg7P-1wojA:
21.91
3wg7W-1wojA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A   5
PHE A 235
LEU A 231
PHE A 227
 None
 0.92A 3wg7P-1xw8A:
undetectable
3wg7W-1xw8A:
undetectable		 3wg7P-1xw8A:
18.97
3wg7W-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.97A 3wg7P-1y4uA:
undetectable
3wg7W-1y4uA:
undetectable		 3wg7P-1y4uA:
16.99
3wg7W-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		4 LEU X 167
PHE X 119
LEU X  17
PHE X  52
 2HS  X 600 ( 4.5A)
None
2HS  X 600 (-4.1A)
None
 1.02A 3wg7P-1ys2X:
undetectable
3wg7W-1ys2X:
undetectable		 3wg7P-1ys2X:
22.32
3wg7W-1ys2X:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.98A 3wg7P-1yw6A:
undetectable
3wg7W-1yw6A:
undetectable		 3wg7P-1yw6A:
20.54
3wg7W-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 LEU A 236
PHE A 240
PHE A 168
LEU A 172
 None
 0.74A 3wg7P-1z7mA:
undetectable
3wg7W-1z7mA:
undetectable		 3wg7P-1z7mA:
20.44
3wg7W-1z7mA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.02A 3wg7P-2becA:
undetectable
3wg7W-2becA:
undetectable		 3wg7P-2becA:
25.67
3wg7W-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A  61
PHE A 329
LEU A 325
PHE A  89
 None
 1.01A 3wg7P-2d7dA:
undetectable
3wg7W-2d7dA:
undetectable		 3wg7P-2d7dA:
15.51
3wg7W-2d7dA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.95A 3wg7P-2dpyA:
undetectable
3wg7W-2dpyA:
undetectable		 3wg7P-2dpyA:
20.50
3wg7W-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.98A 3wg7P-2gq0A:
undetectable
3wg7W-2gq0A:
undetectable		 3wg7P-2gq0A:
20.30
3wg7W-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.97A 3wg7P-2gwcA:
undetectable
3wg7W-2gwcA:
undetectable		 3wg7P-2gwcA:
19.51
3wg7W-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.96A 3wg7P-2hajA:
undetectable
3wg7W-2hajA:
undetectable		 3wg7P-2hajA:
19.01
3wg7W-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.89A 3wg7P-2ibdA:
undetectable
3wg7W-2ibdA:
undetectable		 3wg7P-2ibdA:
24.73
3wg7W-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.96A 3wg7P-2iopA:
undetectable
3wg7W-2iopA:
undetectable		 3wg7P-2iopA:
16.83
3wg7W-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		4 LEU A  54
PHE A  21
LEU A  17
PHE A   9
 None
 1.01A 3wg7P-2lklA:
undetectable
3wg7W-2lklA:
undetectable		 3wg7P-2lklA:
13.41
3wg7W-2lklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		4 LEU A  84
PHE A  71
LEU A  85
PHE A  36
 None
 1.04A 3wg7P-2lqnA:
undetectable
3wg7W-2lqnA:
undetectable		 3wg7P-2lqnA:
19.49
3wg7W-2lqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.04A 3wg7P-2nmpA:
undetectable
3wg7W-2nmpA:
undetectable		 3wg7P-2nmpA:
20.25
3wg7W-2nmpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 1.03A 3wg7P-2nt8A:
2.7
3wg7W-2nt8A:
undetectable		 3wg7P-2nt8A:
21.30
3wg7W-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.69A 3wg7P-2optA:
3.1
3wg7W-2optA:
undetectable		 3wg7P-2optA:
23.19
3wg7W-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 1.01A 3wg7P-2p25A:
undetectable
3wg7W-2p25A:
undetectable		 3wg7P-2p25A:
17.87
3wg7W-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens) 		PF01630
(Glyco_hydro_56) 		4 ARG A 194
LEU A 193
PHE A 110
LEU A 114
 None
 1.03A 3wg7P-2pe4A:
undetectable
3wg7W-2pe4A:
undetectable		 3wg7P-2pe4A:
21.24
3wg7W-2pe4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk2 CYCLIN-T1, PROTEIN
TAT

(Homo sapiens;
Equine
infectious
anemia virus) 		PF00134
(Cyclin_N) 		4 LEU A  90
PHE A  89
LEU A 141
PHE A 146
 LEU  A  90 ( 0.6A)
PHE  A  89 ( 1.3A)
LEU  A 141 ( 0.6A)
PHE  A 146 ( 1.3A)
 1.04A 3wg7P-2pk2A:
undetectable
3wg7W-2pk2A:
undetectable		 3wg7P-2pk2A:
20.56
3wg7W-2pk2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		4 ARG A 126
LEU A  -6
PHE A  24
LEU A 134
 None
 1.05A 3wg7P-2pyuA:
undetectable
3wg7W-2pyuA:
undetectable		 3wg7P-2pyuA:
21.93
3wg7W-2pyuA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.39A 3wg7P-2q2rA:
undetectable
3wg7W-2q2rA:
undetectable		 3wg7P-2q2rA:
21.78
3wg7W-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ARG A 319
LEU A 320
PHE A 326
LEU A 257
 None
 1.04A 3wg7P-2qjfA:
undetectable
3wg7W-2qjfA:
undetectable		 3wg7P-2qjfA:
20.15
3wg7W-2qjfA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		4 ARG A  36
LEU A  37
PHE A  96
LEU A  91
 None
 0.99A 3wg7P-2qvpA:
undetectable
3wg7W-2qvpA:
undetectable		 3wg7P-2qvpA:
21.97
3wg7W-2qvpA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.95A 3wg7P-2riuA:
undetectable
3wg7W-2riuA:
undetectable		 3wg7P-2riuA:
21.66
3wg7W-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 LEU A 212
PHE A  94
PHE A 210
LEU A 197
PHE A  40
 None
 1.48A 3wg7P-2uurA:
undetectable
3wg7W-2uurA:
undetectable		 3wg7P-2uurA:
17.41
3wg7W-2uurA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0i TWINFILIN-2

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		4 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.01A 3wg7P-2w0iA:
undetectable
3wg7W-2w0iA:
undetectable		 3wg7P-2w0iA:
19.83
3wg7W-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.92A 3wg7P-2y0nA:
undetectable
3wg7W-2y0nA:
undetectable		 3wg7P-2y0nA:
18.22
3wg7W-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 LEU A 386
PHE A  56
LEU A  52
PHE A 112
 None
 1.01A 3wg7P-2y4fA:
undetectable
3wg7W-2y4fA:
undetectable		 3wg7P-2y4fA:
20.78
3wg7W-2y4fA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.76A 3wg7P-2yd0A:
undetectable
3wg7W-2yd0A:
undetectable		 3wg7P-2yd0A:
14.57
3wg7W-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 LEU C  35
PHE C  60
PHE C  33
LEU C  87
 None
 0.99A 3wg7P-2ynmC:
undetectable
3wg7W-2ynmC:
undetectable		 3wg7P-2ynmC:
21.92
3wg7W-2ynmC:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 LEU A  44
PHE A  69
PHE A  42
LEU A  96
 None
 0.98A 3wg7P-3aeuA:
undetectable
3wg7W-3aeuA:
undetectable		 3wg7P-3aeuA:
22.02
3wg7W-3aeuA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 LEU A 123
PHE A 121
PHE A  45
LEU A  18
 None
 0.90A 3wg7P-3ba3A:
undetectable
3wg7W-3ba3A:
undetectable		 3wg7P-3ba3A:
21.19
3wg7W-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 PHE A 344
PHE A 363
LEU A 361
PHE A 130
 None
 1.00A 3wg7P-3cp8A:
undetectable
3wg7W-3cp8A:
undetectable		 3wg7P-3cp8A:
16.93
3wg7W-3cp8A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 1.01A 3wg7P-3degC:
undetectable
3wg7W-3degC:
undetectable		 3wg7P-3degC:
17.43
3wg7W-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  63
PHE A  62
LEU A  22
PHE A  26
 None
 1.00A 3wg7P-3exnA:
undetectable
3wg7W-3exnA:
undetectable		 3wg7P-3exnA:
23.02
3wg7W-3exnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.86A 3wg7P-3g1zA:
undetectable
3wg7W-3g1zA:
undetectable		 3wg7P-3g1zA:
20.94
3wg7W-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 1.02A 3wg7P-3gajA:
2.7
3wg7W-3gajA:
undetectable		 3wg7P-3gajA:
21.16
3wg7W-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.99A 3wg7P-3k40A:
undetectable
3wg7W-3k40A:
undetectable		 3wg7P-3k40A:
19.79
3wg7W-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.87A 3wg7P-3lcrA:
undetectable
3wg7W-3lcrA:
undetectable		 3wg7P-3lcrA:
20.45
3wg7W-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.96A 3wg7P-3lg6A:
3.2
3wg7W-3lg6A:
undetectable		 3wg7P-3lg6A:
20.29
3wg7W-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 LEU A 111
PHE A 135
LEU A  39
PHE A  63
 None
 0.96A 3wg7P-3m33A:
undetectable
3wg7W-3m33A:
undetectable		 3wg7P-3m33A:
19.93
3wg7W-3m33A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 0.97A 3wg7P-3n3zA:
3.2
3wg7W-3n3zA:
undetectable		 3wg7P-3n3zA:
21.17
3wg7W-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.93A 3wg7P-3oqqA:
undetectable
3wg7W-3oqqA:
undetectable		 3wg7P-3oqqA:
20.13
3wg7W-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		4 LEU A 150
PHE A 154
PHE A 254
LEU A   7
 None
 1.01A 3wg7P-3ovaA:
undetectable
3wg7W-3ovaA:
undetectable		 3wg7P-3ovaA:
17.46
3wg7W-3ovaA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.97A 3wg7P-3pjaA:
4.0
3wg7W-3pjaA:
undetectable		 3wg7P-3pjaA:
20.88
3wg7W-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 LEU A  81
PHE A  83
LEU A  94
PHE A 148
 None
 0.95A 3wg7P-3q4iA:
3.5
3wg7W-3q4iA:
undetectable		 3wg7P-3q4iA:
20.44
3wg7W-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 LEU A 236
PHE A 240
PHE A 258
LEU A 262
 None
 0.62A 3wg7P-3qdnA:
undetectable
3wg7W-3qdnA:
undetectable		 3wg7P-3qdnA:
21.02
3wg7W-3qdnA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
PDB  A 600 (-3.5A)
 1.04A 3wg7P-3qi3A:
3.4
3wg7W-3qi3A:
undetectable		 3wg7P-3qi3A:
18.44
3wg7W-3qi3A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 0.99A 3wg7P-3rd5A:
undetectable
3wg7W-3rd5A:
undetectable		 3wg7P-3rd5A:
21.79
3wg7W-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjl PROTOGLOBIN

(Methanosarcina
acetivorans) 		PF11563
(Protoglobin) 		4 LEU A  28
PHE A  34
LEU A 184
PHE A  20
 None
 1.04A 3wg7P-3zjlA:
undetectable
3wg7W-3zjlA:
undetectable		 3wg7P-3zjlA:
20.00
3wg7W-3zjlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LEU A 276
PHE A 237
LEU A 226
PHE A 222
 None
 1.00A 3wg7P-4bgbA:
undetectable
3wg7W-4bgbA:
undetectable		 3wg7P-4bgbA:
19.53
3wg7W-4bgbA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.84A 3wg7P-4c8qH:
undetectable
3wg7W-4c8qH:
undetectable		 3wg7P-4c8qH:
19.40
3wg7W-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 0.99A 3wg7P-4e1eA:
2.8
3wg7W-4e1eA:
undetectable		 3wg7P-4e1eA:
20.44
3wg7W-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
 None
 0.93A 3wg7P-4e5tA:
undetectable
3wg7W-4e5tA:
undetectable		 3wg7P-4e5tA:
21.58
3wg7W-4e5tA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.89A 3wg7P-4flxA:
2.4
3wg7W-4flxA:
undetectable		 3wg7P-4flxA:
13.49
3wg7W-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 LEU A 114
PHE A   8
PHE A 134
LEU A 125
 None
 1.04A 3wg7P-4g9bA:
undetectable
3wg7W-4g9bA:
undetectable		 3wg7P-4g9bA:
21.31
3wg7W-4g9bA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphaerobacter
thermophilus) 		PF00903
(Glyoxalase) 		4 LEU A 127
PHE A 125
PHE A 117
LEU A  94
 None
 0.98A 3wg7P-4hc5A:
undetectable
3wg7W-4hc5A:
undetectable		 3wg7P-4hc5A:
19.38
3wg7W-4hc5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ARG A 176
LEU A 172
PHE A 198
LEU A 202
 None
 0.97A 3wg7P-4hqfA:
undetectable
3wg7W-4hqfA:
undetectable		 3wg7P-4hqfA:
20.74
3wg7W-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 LEU A  74
PHE A  77
PHE A  92
LEU A  46
 None
 0.99A 3wg7P-4lnfA:
undetectable
3wg7W-4lnfA:
undetectable		 3wg7P-4lnfA:
19.33
3wg7W-4lnfA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nso EFFECTOR PROTEIN

(Vibrio cholerae) 		no annotation 4 ARG A 981
LEU A 982
PHE A 943
LEU A 949
 None
 0.86A 3wg7P-4nsoA:
undetectable
3wg7W-4nsoA:
undetectable		 3wg7P-4nsoA:
20.21
3wg7W-4nsoA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio cholerae) 		PF02508
(Rnf-Nqr) 		4 LEU E 157
PHE E  28
LEU E  29
PHE E 180
 None
 0.94A 3wg7P-4p6vE:
2.1
3wg7W-4p6vE:
undetectable		 3wg7P-4p6vE:
22.35
3wg7W-4p6vE:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 296
LEU A 506
PHE A 508
LEU A 503
 None
 0.91A 3wg7P-4pfwA:
undetectable
3wg7W-4pfwA:
undetectable		 3wg7P-4pfwA:
19.14
3wg7W-4pfwA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B  75
PHE B  83
LEU B  87
PHE B  91
 None
 0.85A 3wg7P-4r0mB:
undetectable
3wg7W-4r0mB:
undetectable		 3wg7P-4r0mB:
17.42
3wg7W-4r0mB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.98A 3wg7P-4rgpA:
undetectable
3wg7W-4rgpA:
undetectable		 3wg7P-4rgpA:
20.82
3wg7W-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
 None
 0.79A 3wg7P-4rncA:
undetectable
3wg7W-4rncA:
undetectable		 3wg7P-4rncA:
21.32
3wg7W-4rncA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 LEU A  31
PHE A  29
LEU A  42
PHE A  38
 None
None
None
INS  A 401 (-4.5A)
 0.99A 3wg7P-4rxmA:
undetectable
3wg7W-4rxmA:
undetectable		 3wg7P-4rxmA:
20.81
3wg7W-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 1.00A 3wg7P-4wpxA:
undetectable
3wg7W-4wpxA:
undetectable		 3wg7P-4wpxA:
21.84
3wg7W-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13549
(ATP-grasp_5) 		4 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.04A 3wg7P-4xymB:
undetectable
3wg7W-4xymB:
undetectable		 3wg7P-4xymB:
18.66
3wg7W-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		4 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.96A 3wg7P-4y0iA:
undetectable
3wg7W-4y0iA:
undetectable		 3wg7P-4y0iA:
19.27
3wg7W-4y0iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 LEU A 197
PHE A 193
LEU A 259
PHE A 260
 None
 1.05A 3wg7P-4zzeA:
undetectable
3wg7W-4zzeA:
undetectable		 3wg7P-4zzeA:
21.66
3wg7W-4zzeA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.93A 3wg7P-5aoxB:
undetectable
3wg7W-5aoxB:
undetectable		 3wg7P-5aoxB:
17.86
3wg7W-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		4 LEU A1012
PHE A1064
LEU A1068
PHE A1069
 None
 0.99A 3wg7P-5b16A:
3.2
3wg7W-5b16A:
undetectable		 3wg7P-5b16A:
12.26
3wg7W-5b16A:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 PHE A  93
PHE A  85
LEU A 130
PHE A 123
 None
 0.99A 3wg7P-5b4sA:
undetectable
3wg7W-5b4sA:
undetectable		 3wg7P-5b4sA:
22.65
3wg7W-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 LEU A 463
PHE A 459
PHE A 378
LEU A 343
 None
 1.02A 3wg7P-5bzaA:
undetectable
3wg7W-5bzaA:
undetectable		 3wg7P-5bzaA:
17.12
3wg7W-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caw E3 UBIQUITIN-PROTEIN
LIGASE PARKIN

(Pediculus
humanus) 		PF01485
(IBR) 		4 LEU A 308
PHE A 306
PHE A 266
LEU A 251
 None
 1.03A 3wg7P-5cawA:
undetectable
3wg7W-5cawA:
undetectable		 3wg7P-5cawA:
17.70
3wg7W-5cawA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
 None
 0.99A 3wg7P-5ckmA:
undetectable
3wg7W-5ckmA:
undetectable		 3wg7P-5ckmA:
22.33
3wg7W-5ckmA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6g DE NOVO DESIGNED
PROTEIN CA01

(synthetic
construct) 		no annotation 4 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.90A 3wg7P-5e6gA:
3.6
3wg7W-5e6gA:
undetectable		 3wg7P-5e6gA:
19.51
3wg7W-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.95A 3wg7P-5eytA:
4.6
3wg7W-5eytA:
undetectable		 3wg7P-5eytA:
18.88
3wg7W-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6q METALLOTHIOL
TRANSFERASE FOSB 2

(Bacillus
anthracis) 		PF00903
(Glyoxalase) 		4 LEU A  42
PHE A  69
LEU A  26
PHE A  21
 None
 1.02A 3wg7P-5f6qA:
undetectable
3wg7W-5f6qA:
undetectable		 3wg7P-5f6qA:
19.26
3wg7W-5f6qA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu6 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04153
(NOT2_3_5) 		4 LEU C 671
PHE C 673
LEU C 666
PHE C 662
 None
 0.98A 3wg7P-5fu6C:
undetectable
3wg7W-5fu6C:
undetectable		 3wg7P-5fu6C:
18.59
3wg7W-5fu6C:
16.79