SIMILAR PATTERNS OF AMINO ACIDS FOR 3WG7_J_CHDJ101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 ILE A 179
LEU A 193
ARG A 184
THR A 186
 None
 1.19A 3wg7A-1d0bA:
undetectable
3wg7J-1d0bA:
0.0		 3wg7A-1d0bA:
17.05
3wg7J-1d0bA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1go3 DNA-DIRECTED RNA
POLYMERASE SUBUNIT E

(Methanocaldococcus
jannaschii) 		PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 ILE E 176
LEU E 173
MET E 165
THR E 164
 None
 1.05A 3wg7A-1go3E:
undetectable
3wg7J-1go3E:
0.0		 3wg7A-1go3E:
14.98
3wg7J-1go3E:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 ILE A 119
LEU A 122
MET A 169
THR A 170
 None
 1.01A 3wg7A-1gynA:
2.8
3wg7J-1gynA:
0.1		 3wg7A-1gynA:
20.57
3wg7J-1gynA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ILE A 149
LEU A 237
MET A 227
THR A 226
 None
 0.99A 3wg7A-1iq0A:
2.1
3wg7J-1iq0A:
0.0		 3wg7A-1iq0A:
22.20
3wg7J-1iq0A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyr DNA FRAGMENTATION
FACTOR ALPHA SUBUNIT

(Homo sapiens) 		PF09033
(DFF-C) 		4 ILE A  21
LEU A  22
ARG A   9
THR A   5
 None
 1.03A 3wg7A-1iyrA:
undetectable
3wg7J-1iyrA:
0.0		 3wg7A-1iyrA:
10.96
3wg7J-1iyrA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
ARG A  40
THR A  38
 None
 1.18A 3wg7A-1jedA:
0.0
3wg7J-1jedA:
0.0		 3wg7A-1jedA:
21.17
3wg7J-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ILE A  14
TYR A 169
MET A 180
THR A 188
 None
 1.19A 3wg7A-1lf9A:
3.4
3wg7J-1lf9A:
undetectable		 3wg7A-1lf9A:
20.80
3wg7J-1lf9A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.89A 3wg7A-1mc8A:
0.0
3wg7J-1mc8A:
0.0		 3wg7A-1mc8A:
20.59
3wg7J-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk7 TALIN

(Gallus gallus) 		PF00373
(FERM_M)
PF02174
(IRS) 		4 ILE B 396
LEU B 353
ARG B 358
THR B 367
 None
 1.12A 3wg7A-1mk7B:
undetectable
3wg7J-1mk7B:
0.0		 3wg7A-1mk7B:
15.13
3wg7J-1mk7B:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		4 ILE A 304
TYR A 283
MET A 268
THR A 267
 None
 1.01A 3wg7A-1ofmA:
undetectable
3wg7J-1ofmA:
undetectable		 3wg7A-1ofmA:
20.00
3wg7J-1ofmA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.33A 3wg7A-1pm2A:
0.8
3wg7J-1pm2A:
undetectable		 3wg7A-1pm2A:
19.19
3wg7J-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
ARG A  40
THR A  38
 None
 1.18A 3wg7A-1r6xA:
0.0
3wg7J-1r6xA:
undetectable		 3wg7A-1r6xA:
21.48
3wg7J-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc9 CYSTEINE-RICH
SECRETORY PROTEIN

(Trimeresurus
stejnegeri) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 1.04A 3wg7A-1rc9A:
undetectable
3wg7J-1rc9A:
undetectable		 3wg7A-1rc9A:
17.70
3wg7J-1rc9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LEU A1384
ARG A1364
MET A1366
THR A1367
 None
 1.17A 3wg7A-1tllA:
0.0
3wg7J-1tllA:
undetectable		 3wg7A-1tllA:
19.23
3wg7J-1tllA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u00 CHAPERONE PROTEIN
HSCA

(Escherichia
coli) 		PF00012
(HSP70) 		4 ILE A 409
LEU A 396
ARG A 470
THR A 484
 None
 0.83A 3wg7A-1u00A:
2.4
3wg7J-1u00A:
undetectable		 3wg7A-1u00A:
17.75
3wg7J-1u00A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 ILE A  91
LEU A 101
MET A 140
THR A 305
 None
 1.11A 3wg7A-1wd3A:
undetectable
3wg7J-1wd3A:
undetectable		 3wg7A-1wd3A:
20.44
3wg7J-1wd3A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		4 ILE A  56
LEU A 124
ARG A  53
THR A  31
 None
 1.18A 3wg7A-1wkpA:
undetectable
3wg7J-1wkpA:
undetectable		 3wg7A-1wkpA:
17.54
3wg7J-1wkpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		4 ILE A 174
LEU A 170
ARG A 282
MET A 280
 None
 1.06A 3wg7A-1woyA:
1.7
3wg7J-1woyA:
undetectable		 3wg7A-1woyA:
21.79
3wg7J-1woyA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvr TRIFLIN

(Protobothrops
flavoviridis) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 1.02A 3wg7A-1wvrA:
undetectable
3wg7J-1wvrA:
undetectable		 3wg7A-1wvrA:
15.85
3wg7J-1wvrA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx5 NATRIN 1

(Naja atra) 		PF00188
(CAP)
PF08562
(Crisp) 		4 ILE A  90
LEU A  21
TYR A 147
THR A 117
 None
 1.04A 3wg7A-1xx5A:
undetectable
3wg7J-1xx5A:
undetectable		 3wg7A-1xx5A:
16.47
3wg7J-1xx5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		4 ILE A1428
LEU A1414
MET A1463
THR A1462
 None
 1.18A 3wg7A-1yrzA:
undetectable
3wg7J-1yrzA:
undetectable		 3wg7A-1yrzA:
20.25
3wg7J-1yrzA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
, REGULATORY CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N)
PF01948
(PyrI)
PF02748
(PyrI_C) 		4 ILE B 115
LEU A 114
ARG A 105
MET A 104
 None
 1.04A 3wg7A-2atcB:
undetectable
3wg7J-2atcB:
undetectable		 3wg7A-2atcB:
13.32
3wg7J-2atcB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda;
Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N)
PF01948
(PyrI)
PF02748
(PyrI_C) 		4 ILE D 114
LEU A 115
ARG A 106
MET A 105
 None
 0.88A 3wg7A-2be7D:
undetectable
3wg7J-2be7D:
undetectable		 3wg7A-2be7D:
17.43
3wg7J-2be7D:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 ILE A 679
LEU A 801
ARG A 738
THR A 683
 PMM  A1865 ( 4.7A)
PMM  A1865 (-4.7A)
None
None
 1.19A 3wg7A-2bmbA:
undetectable
3wg7J-2bmbA:
undetectable		 3wg7A-2bmbA:
20.91
3wg7J-2bmbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 ILE A 396
LEU A 411
TYR A 514
THR A 585
 None
 1.12A 3wg7A-2bxyA:
undetectable
3wg7J-2bxyA:
undetectable		 3wg7A-2bxyA:
20.61
3wg7J-2bxyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 TYR B 618
ARG B 619
MET B 622
THR B 623
 None
 0.99A 3wg7A-2c6wB:
undetectable
3wg7J-2c6wB:
undetectable		 3wg7A-2c6wB:
21.23
3wg7J-2c6wB:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ILE A 663
LEU A 678
ARG A 684
THR A 581
 None
 0.92A 3wg7A-2ipcA:
0.2
3wg7J-2ipcA:
undetectable		 3wg7A-2ipcA:
18.02
3wg7J-2ipcA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		4 ILE A   5
LEU A   6
MET A  33
THR A  34
 None
 1.13A 3wg7A-2janA:
undetectable
3wg7J-2janA:
undetectable		 3wg7A-2janA:
23.30
3wg7J-2janA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7n PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE-LIKE 1

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 ILE A 136
LEU A 198
ARG A 131
THR A  93
 None
 1.19A 3wg7A-2k7nA:
undetectable
3wg7J-2k7nA:
undetectable		 3wg7A-2k7nA:
15.18
3wg7J-2k7nA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		4 ILE A 186
ARG A 155
MET A 237
THR A 236
 None
 1.19A 3wg7A-2o04A:
undetectable
3wg7J-2o04A:
undetectable		 3wg7A-2o04A:
20.35
3wg7J-2o04A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 ILE A 213
LEU A 190
TYR A  11
THR A 244
 None
 1.01A 3wg7A-2p4oA:
undetectable
3wg7J-2p4oA:
undetectable		 3wg7A-2p4oA:
20.92
3wg7J-2p4oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		4 ILE A  46
LEU A  51
MET A  56
THR A  30
 None
 1.00A 3wg7A-2ri0A:
undetectable
3wg7J-2ri0A:
undetectable		 3wg7A-2ri0A:
17.89
3wg7J-2ri0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 ILE A 207
LEU A 204
MET A 191
THR A 189
 None
 1.09A 3wg7A-2uvdA:
undetectable
3wg7J-2uvdA:
undetectable		 3wg7A-2uvdA:
18.73
3wg7J-2uvdA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		4 ILE A 230
LEU A 219
ARG A 268
THR A 292
 None
 0.98A 3wg7A-2z67A:
undetectable
3wg7J-2z67A:
undetectable		 3wg7A-2z67A:
20.74
3wg7J-2z67A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		4 ILE A 434
LEU A 431
ARG A 385
THR A 387
 None
 1.15A 3wg7A-2z67A:
undetectable
3wg7J-2z67A:
undetectable		 3wg7A-2z67A:
20.74
3wg7J-2z67A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE B 262
LEU B 265
TYR B 294
MET B 326
 None
 1.19A 3wg7A-2z7xB:
undetectable
3wg7J-2z7xB:
undetectable		 3wg7A-2z7xB:
23.01
3wg7J-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
ARG A 151
MET A 177
THR A 176
 None
 0.89A 3wg7A-2zsgA:
2.6
3wg7J-2zsgA:
undetectable		 3wg7A-2zsgA:
20.79
3wg7J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		4 ILE A 370
LEU A 154
MET A 256
THR A 255
 None
 1.11A 3wg7A-2zu8A:
undetectable
3wg7J-2zu8A:
undetectable		 3wg7A-2zu8A:
20.08
3wg7J-2zu8A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpt RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF16095
(COR) 		4 ILE A 879
LEU A 813
TYR A 802
MET A 800
 None
 1.19A 3wg7A-3dptA:
undetectable
3wg7J-3dptA:
undetectable		 3wg7A-3dptA:
20.27
3wg7J-3dptA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.83A 3wg7A-3ezxA:
undetectable
3wg7J-3ezxA:
undetectable		 3wg7A-3ezxA:
18.16
3wg7J-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ILE A 302
LEU A 290
ARG A 351
THR A 308
 None
None
CL  A 379 ( 3.1A)
None
 1.05A 3wg7A-3fdbA:
undetectable
3wg7J-3fdbA:
undetectable		 3wg7A-3fdbA:
20.93
3wg7J-3fdbA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 ILE A 313
LEU A 311
ARG A 318
THR A 227
 None
 1.13A 3wg7A-3hidA:
undetectable
3wg7J-3hidA:
undetectable		 3wg7A-3hidA:
22.51
3wg7J-3hidA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		4 ILE A  90
LEU A 181
MET A 135
THR A 134
 None
 1.16A 3wg7A-3hvmA:
undetectable
3wg7J-3hvmA:
undetectable		 3wg7A-3hvmA:
20.38
3wg7J-3hvmA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ILE A 552
LEU A 567
ARG A 573
THR A 536
 None
 1.19A 3wg7A-3juxA:
1.4
3wg7J-3juxA:
undetectable		 3wg7A-3juxA:
20.05
3wg7J-3juxA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 ILE A 882
ARG A 808
MET A 811
THR A 812
 None
SO4  A   3 (-4.1A)
None
None
 1.17A 3wg7A-3k7dA:
undetectable
3wg7J-3k7dA:
undetectable		 3wg7A-3k7dA:
21.52
3wg7J-3k7dA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 LEU A 172
TYR A 245
ARG A 126
THR A 143
 None
 1.09A 3wg7A-3kt4A:
undetectable
3wg7J-3kt4A:
undetectable		 3wg7A-3kt4A:
19.94
3wg7J-3kt4A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 1.17A 3wg7A-3l2nA:
undetectable
3wg7J-3l2nA:
undetectable		 3wg7A-3l2nA:
21.32
3wg7J-3l2nA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkz PROTEIN SOPB

(Escherichia
coli) 		no annotation 4 ILE A 179
LEU A 171
ARG A 195
THR A 199
 None
 1.18A 3wg7A-3mkzA:
undetectable
3wg7J-3mkzA:
undetectable		 3wg7A-3mkzA:
12.22
3wg7J-3mkzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		4 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.07A 3wg7A-3sqiA:
undetectable
3wg7J-3sqiA:
undetectable		 3wg7A-3sqiA:
19.72
3wg7J-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t38 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		4 ILE A 201
LEU A 102
ARG A  94
THR A 159
 None
 0.94A 3wg7A-3t38A:
2.6
3wg7J-3t38A:
undetectable		 3wg7A-3t38A:
17.34
3wg7J-3t38A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ILE A 639
LEU A 628
ARG A 661
THR A 665
 None
 1.04A 3wg7A-3u1kA:
undetectable
3wg7J-3u1kA:
undetectable		 3wg7A-3u1kA:
20.16
3wg7J-3u1kA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1e FLAGELLA BASAL-BODY
PROTEIN

(Vibrio
alginolyticus) 		PF16538
(FlgT_C)
PF16539
(FlgT_M)
PF16548
(FlgT_N) 		4 ILE A 266
LEU A 268
TYR A 170
THR A 208
 None
 1.14A 3wg7A-3w1eA:
undetectable
3wg7J-3w1eA:
undetectable		 3wg7A-3w1eA:
21.00
3wg7J-3w1eA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		4 ILE A  93
LEU A 105
ARG A 119
MET A 116
 None
 0.96A 3wg7A-3w7bA:
undetectable
3wg7J-3w7bA:
undetectable		 3wg7A-3w7bA:
18.86
3wg7J-3w7bA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 ILE A 157
LEU A 101
ARG A  58
MET A 164
 None
 1.12A 3wg7A-3wfzA:
undetectable
3wg7J-3wfzA:
undetectable		 3wg7A-3wfzA:
20.23
3wg7J-3wfzA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		4 LEU A 221
TYR A 168
ARG A 193
THR A 197
 None
 1.18A 3wg7A-3wkhA:
1.7
3wg7J-3wkhA:
undetectable		 3wg7A-3wkhA:
19.15
3wg7J-3wkhA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 ILE A 387
LEU A 381
ARG A 340
THR A 402
 None
 1.00A 3wg7A-3wzfA:
undetectable
3wg7J-3wzfA:
undetectable		 3wg7A-3wzfA:
20.90
3wg7J-3wzfA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 ILE A 332
LEU A 335
ARG A 146
THR A 147
 None
 1.18A 3wg7A-4cp8A:
undetectable
3wg7J-4cp8A:
undetectable		 3wg7A-4cp8A:
22.67
3wg7J-4cp8A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 231
LEU A 228
ARG A 220
THR A 182
 None
 1.12A 3wg7A-4ez5A:
undetectable
3wg7J-4ez5A:
undetectable		 3wg7A-4ez5A:
21.01
3wg7J-4ez5A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		4 ILE A 450
LEU A 369
ARG A 223
MET A 226
 None
 1.18A 3wg7A-4f53A:
undetectable
3wg7J-4f53A:
undetectable		 3wg7A-4f53A:
19.76
3wg7J-4f53A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 ILE A 321
LEU A 360
MET A 328
THR A 329
 None
 1.15A 3wg7A-4i5sA:
undetectable
3wg7J-4i5sA:
2.3		 3wg7A-4i5sA:
20.74
3wg7J-4i5sA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		4 ILE A  15
LEU A  39
ARG A 194
THR A 193
 None
None
None
FMN  A 401 (-3.6A)
 1.16A 3wg7A-4iqlA:
undetectable
3wg7J-4iqlA:
undetectable		 3wg7A-4iqlA:
21.09
3wg7J-4iqlA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		4 ILE A  31
LEU A  76
ARG A  56
THR A  54
 None
 1.19A 3wg7A-4izxA:
undetectable
3wg7J-4izxA:
undetectable		 3wg7A-4izxA:
12.92
3wg7J-4izxA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN

(Paraburkholderia
graminis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 169
LEU A 173
TYR A 198
ARG A 195
 None
 1.03A 3wg7A-4kdxA:
undetectable
3wg7J-4kdxA:
undetectable		 3wg7A-4kdxA:
17.55
3wg7J-4kdxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		4 ILE A 427
LEU A 424
ARG A 392
MET A 436
 None
 1.15A 3wg7A-4kvlA:
undetectable
3wg7J-4kvlA:
undetectable		 3wg7A-4kvlA:
22.90
3wg7J-4kvlA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nel TRANSCRIPTIONAL
REGULATOR

(Saccharomonospora
viridis) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 ILE A 282
LEU A 243
ARG A 172
THR A 221
 None
 1.19A 3wg7A-4nelA:
undetectable
3wg7J-4nelA:
undetectable		 3wg7A-4nelA:
15.59
3wg7J-4nelA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nob POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Mus musculus) 		PF07686
(V-set) 		4 ILE A  95
LEU A  84
ARG A  57
THR A  65
 None
None
EDO  A 204 (-4.0A)
None
 0.96A 3wg7A-4nobA:
undetectable
3wg7J-4nobA:
undetectable		 3wg7A-4nobA:
12.43
3wg7J-4nobA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 523
LEU A 520
ARG A 493
THR A 425
 None
 1.06A 3wg7A-4pl0A:
4.1
3wg7J-4pl0A:
undetectable		 3wg7A-4pl0A:
21.25
3wg7J-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		4 ILE A  58
ARG A   2
MET A   1
THR A  41
 None
None
None
A3S  A 500 ( 4.5A)
 1.18A 3wg7A-4rrjA:
undetectable
3wg7J-4rrjA:
undetectable		 3wg7A-4rrjA:
15.58
3wg7J-4rrjA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 ILE D 143
LEU D 178
TYR D 250
THR D  24
 None
 0.95A 3wg7A-4xgcD:
undetectable
3wg7J-4xgcD:
undetectable		 3wg7A-4xgcD:
21.64
3wg7J-4xgcD:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 ILE A 316
LEU A 332
ARG A 321
THR A 320
 None
None
UDP  A 501 (-3.1A)
None
 1.06A 3wg7A-4zhtA:
undetectable
3wg7J-4zhtA:
undetectable		 3wg7A-4zhtA:
20.56
3wg7J-4zhtA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a78 DNA ENDONUCLEASE
I-CVUI

(Chlorella
vulgaris) 		PF00961
(LAGLIDADG_1) 		4 ILE A 113
LEU A 110
ARG A  43
THR A  47
 None
 1.03A 3wg7A-5a78A:
undetectable
3wg7J-5a78A:
undetectable		 3wg7A-5a78A:
16.18
3wg7J-5a78A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		4 ILE A  93
LEU A  87
TYR A  54
THR A  50
 None
 1.06A 3wg7A-5b3fA:
undetectable
3wg7J-5b3fA:
undetectable		 3wg7A-5b3fA:
18.04
3wg7J-5b3fA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		4 ILE A 225
LEU A 341
ARG A 345
THR A   9
 None
 1.07A 3wg7A-5ce0A:
undetectable
3wg7J-5ce0A:
undetectable		 3wg7A-5ce0A:
20.49
3wg7J-5ce0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		4 LEU A 355
ARG A 477
MET A 479
THR A 480
 None
 1.19A 3wg7A-5dj4A:
undetectable
3wg7J-5dj4A:
undetectable		 3wg7A-5dj4A:
21.04
3wg7J-5dj4A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ILE A 373
LEU A 375
ARG A 136
THR A 139
 None
 1.18A 3wg7A-5ehkA:
1.8
3wg7J-5ehkA:
undetectable		 3wg7A-5ehkA:
17.65
3wg7J-5ehkA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 ILE A 119
LEU A 142
MET A 159
THR A 160
 MPG  A 602 ( 4.5A)
None
None
None
 1.11A 3wg7A-5f15A:
5.4
3wg7J-5f15A:
undetectable		 3wg7A-5f15A:
23.90
3wg7J-5f15A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		4 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 1.02A 3wg7A-5f59A:
undetectable
3wg7J-5f59A:
undetectable		 3wg7A-5f59A:
13.20
3wg7J-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ILE A  76
TYR A 304
ARG A 299
THR A 302
 None
 1.06A 3wg7A-5f7cA:
undetectable
3wg7J-5f7cA:
undetectable		 3wg7A-5f7cA:
21.92
3wg7J-5f7cA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		4 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.97A 3wg7A-5gk2A:
undetectable
3wg7J-5gk2A:
undetectable		 3wg7A-5gk2A:
19.85
3wg7J-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn1 ATP-DEPENDENT
HELICASE FUN30

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ILE A 868
LEU A1115
TYR A 830
THR A1075
 None
 1.05A 3wg7A-5gn1A:
2.4
3wg7J-5gn1A:
undetectable		 3wg7A-5gn1A:
19.16
3wg7J-5gn1A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		4 ILE A 446
LEU A 264
ARG A 501
THR A 496
 None
 0.96A 3wg7A-5i5hA:
undetectable
3wg7J-5i5hA:
undetectable		 3wg7A-5i5hA:
21.92
3wg7J-5i5hA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 4 ILE A 116
TYR A  77
MET A  75
THR A   7
 None
 1.07A 3wg7A-5ig9A:
undetectable
3wg7J-5ig9A:
undetectable		 3wg7A-5ig9A:
20.38
3wg7J-5ig9A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 ILE A 415
LEU A 412
ARG A 400
MET A 403
 None
 1.14A 3wg7A-5k0tA:
undetectable
3wg7J-5k0tA:
undetectable		 3wg7A-5k0tA:
21.60
3wg7J-5k0tA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 ILE A 556
LEU A 571
ARG A 577
THR A 511
 None
 1.09A 3wg7A-5k9tA:
undetectable
3wg7J-5k9tA:
undetectable		 3wg7A-5k9tA:
21.11
3wg7J-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		4 LEU A 452
TYR A 392
MET A 396
THR A 397
 5MY  A 502 (-4.6A)
None
None
None
 1.08A 3wg7A-5mwlA:
undetectable
3wg7J-5mwlA:
undetectable		 3wg7A-5mwlA:
19.60
3wg7J-5mwlA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 163
ARG A 149
MET A 604
THR A 603
 None
 0.89A 3wg7A-5nqdA:
undetectable
3wg7J-5nqdA:
undetectable		 3wg7A-5nqdA:
undetectable
3wg7J-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A 628
LEU A 792
TYR A 723
THR A 729
 None
 1.06A 3wg7A-5nz7A:
undetectable
3wg7J-5nz7A:
undetectable		 3wg7A-5nz7A:
18.92
3wg7J-5nz7A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 ILE A 194
LEU A 198
MET A 321
THR A 320
 None
 1.19A 3wg7A-5nzgA:
undetectable
3wg7J-5nzgA:
undetectable		 3wg7A-5nzgA:
undetectable
3wg7J-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		4 ILE A 107
LEU A 142
ARG A 260
THR A 262
 None
 1.18A 3wg7A-5o9eA:
undetectable
3wg7J-5o9eA:
undetectable		 3wg7A-5o9eA:
16.12
3wg7J-5o9eA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 4 ILE A 197
LEU A 248
MET A 113
THR A 111
 None
 1.18A 3wg7A-5oydA:
undetectable
3wg7J-5oydA:
undetectable		 3wg7A-5oydA:
undetectable
3wg7J-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A 124
LEU A 113
ARG A 140
THR A 143
 None
 1.15A 3wg7A-5troA:
undetectable
3wg7J-5troA:
undetectable		 3wg7A-5troA:
21.23
3wg7J-5troA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgc NLEG5-1 EFFECTOR

(Enterobacteria
phage YYZ-2008) 		no annotation 4 ILE A  27
LEU A  24
ARG A  39
THR A   6
 None
 1.10A 3wg7A-5vgcA:
undetectable
3wg7J-5vgcA:
undetectable		 3wg7A-5vgcA:
undetectable
3wg7J-5vgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.00A 3wg7A-5wp5A:
undetectable
3wg7J-5wp5A:
undetectable		 3wg7A-5wp5A:
20.45
3wg7J-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		4 ILE A 213
LEU A 245
TYR A 190
THR A 236
 None
 1.09A 3wg7A-5xcyA:
undetectable
3wg7J-5xcyA:
undetectable		 3wg7A-5xcyA:
19.62
3wg7J-5xcyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 ILE A  86
TYR A  77
MET A 295
THR A 294
 None
 0.84A 3wg7A-5xe0A:
undetectable
3wg7J-5xe0A:
undetectable		 3wg7A-5xe0A:
20.98
3wg7J-5xe0A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhu FERREDOXIN--NADP
REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ILE A 223
LEU A 216
ARG A 157
THR A 182
 None
 1.09A 3wg7A-5xhuA:
undetectable
3wg7J-5xhuA:
undetectable		 3wg7A-5xhuA:
undetectable
3wg7J-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4k DMSP LYASE DDDY

(Acinetobacter
bereziniae) 		no annotation 4 ILE A  91
LEU A  61
MET A 272
THR A 357
 None
 1.16A 3wg7A-5y4kA:
undetectable
3wg7J-5y4kA:
undetectable		 3wg7A-5y4kA:
20.15
3wg7J-5y4kA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydp TETR TRANSCRIPTIONAL
REGULATORY PROTEIN

(Dietzia sp.
DQ12-45-1b) 		PF00440
(TetR_N) 		4 ILE A 205
LEU A 108
ARG A 181
THR A 153
 None
 1.09A 3wg7A-5ydpA:
undetectable
3wg7J-5ydpA:
undetectable		 3wg7A-5ydpA:
18.45
3wg7J-5ydpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yep TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY

(Shewanella
oneidensis) 		no annotation 4 ILE B  19
LEU B 120
ARG B  97
MET B  93
 None
 1.03A 3wg7A-5yepB:
undetectable
3wg7J-5yepB:
undetectable		 3wg7A-5yepB:
undetectable
3wg7J-5yepB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 4 ILE A 183
LEU A 182
ARG A 190
THR A 198
 None
 1.04A 3wg7A-6b5vA:
undetectable
3wg7J-6b5vA:
undetectable		 3wg7A-6b5vA:
undetectable
3wg7J-6b5vA:
undetectable