SIMILAR PATTERNS OF AMINO ACIDS FOR 3WG7_C_CHDC305

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.77A 3wg7C-1914A:
undetectable
3wg7J-1914A:
undetectable		 3wg7C-1914A:
19.40
3wg7J-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.96A 3wg7C-1bucA:
3.7
3wg7J-1bucA:
0.0		 3wg7C-1bucA:
17.69
3wg7J-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 1.07A 3wg7C-1c4oA:
undetectable
3wg7J-1c4oA:
0.0		 3wg7C-1c4oA:
16.59
3wg7J-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.64A 3wg7C-1dj3A:
undetectable
3wg7J-1dj3A:
undetectable		 3wg7C-1dj3A:
19.00
3wg7J-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN

(Kluyveromyces
lactis) 		PF00447
(HSF_DNA-bind) 		4 LEU A 201
PHE A 197
LEU A 252
PHE A 278
 None
 1.00A 3wg7C-1fymA:
undetectable
3wg7J-1fymA:
undetectable		 3wg7C-1fymA:
13.90
3wg7J-1fymA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.02A 3wg7C-1gm5A:
2.9
3wg7J-1gm5A:
0.0		 3wg7C-1gm5A:
15.64
3wg7J-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.90A 3wg7C-1jkwA:
undetectable
3wg7J-1jkwA:
0.0		 3wg7C-1jkwA:
20.52
3wg7J-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.74A 3wg7C-1kl7A:
undetectable
3wg7J-1kl7A:
0.0		 3wg7C-1kl7A:
21.24
3wg7J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.98A 3wg7C-1ny5A:
undetectable
3wg7J-1ny5A:
0.0		 3wg7C-1ny5A:
19.75
3wg7J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 592
LEU B 596
PHE B 598
 None
 0.92A 3wg7C-1ovlB:
undetectable
3wg7J-1ovlB:
undetectable		 3wg7C-1ovlB:
19.94
3wg7J-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32

(Homo sapiens) 		PF02330
(MAM33) 		4 LEU A  86
PHE A  82
LEU A 275
PHE A 271
 None
 1.02A 3wg7C-1p32A:
undetectable
3wg7J-1p32A:
undetectable		 3wg7C-1p32A:
20.22
3wg7J-1p32A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psw ADP-HEPTOSE LPS
HEPTOSYLTRANSFERASE
II

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 LEU A 116
PHE A  91
LEU A  95
PHE A  99
 None
 0.99A 3wg7C-1pswA:
undetectable
3wg7J-1pswA:
undetectable		 3wg7C-1pswA:
20.40
3wg7J-1pswA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.04A 3wg7C-1rrhA:
undetectable
3wg7J-1rrhA:
undetectable		 3wg7C-1rrhA:
15.87
3wg7J-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tx4 P50-RHOGAP

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 171
PHE A 234
LEU A 226
PHE A 222
 None
 1.05A 3wg7C-1tx4A:
undetectable
3wg7J-1tx4A:
undetectable		 3wg7C-1tx4A:
20.82
3wg7J-1tx4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 PHE A  98
PHE A  56
LEU A  68
PHE A  70
 None
 1.05A 3wg7C-1vfnA:
undetectable
3wg7J-1vfnA:
undetectable		 3wg7C-1vfnA:
24.03
3wg7J-1vfnA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhf PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		4 LEU A  21
PHE A  30
PHE A  55
LEU A  69
 None
 1.03A 3wg7C-1vhfA:
undetectable
3wg7J-1vhfA:
undetectable		 3wg7C-1vhfA:
15.71
3wg7J-1vhfA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.89A 3wg7C-1vkuA:
undetectable
3wg7J-1vkuA:
undetectable		 3wg7C-1vkuA:
13.64
3wg7J-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9c CRM1 PROTEIN

(Homo sapiens) 		PF08767
(CRM1_C) 		4 LEU A1015
PHE A 997
LEU A1001
PHE A 950
 None
 1.06A 3wg7C-1w9cA:
2.3
3wg7J-1w9cA:
undetectable		 3wg7C-1w9cA:
22.90
3wg7J-1w9cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 0.93A 3wg7C-1wrjA:
undetectable
3wg7J-1wrjA:
undetectable		 3wg7C-1wrjA:
16.60
3wg7J-1wrjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 320
PHE A 322
PHE A 286
LEU A 282
 None
 1.05A 3wg7C-2dphA:
undetectable
3wg7J-2dphA:
undetectable		 3wg7C-2dphA:
19.30
3wg7J-2dphA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.93A 3wg7C-2dpyA:
undetectable
3wg7J-2dpyA:
undetectable		 3wg7C-2dpyA:
20.50
3wg7J-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A 153
PHE A 151
PHE A 103
LEU A 113
 None
 1.07A 3wg7C-2esnA:
undetectable
3wg7J-2esnA:
undetectable		 3wg7C-2esnA:
23.96
3wg7J-2esnA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.90A 3wg7C-2ibdA:
undetectable
3wg7J-2ibdA:
undetectable		 3wg7C-2ibdA:
24.73
3wg7J-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 3wg7C-2iopA:
undetectable
3wg7J-2iopA:
undetectable		 3wg7C-2iopA:
16.83
3wg7J-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jek RV1873

(Mycobacterium
tuberculosis) 		PF08837
(DUF1810) 		4 LEU A 125
PHE A 122
LEU A 105
PHE A  97
 None
 0.97A 3wg7C-2jekA:
undetectable
3wg7J-2jekA:
undetectable		 3wg7C-2jekA:
19.92
3wg7J-2jekA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.78A 3wg7C-2nt8A:
2.8
3wg7J-2nt8A:
undetectable		 3wg7C-2nt8A:
21.30
3wg7J-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.68A 3wg7C-2optA:
3.1
3wg7J-2optA:
undetectable		 3wg7C-2optA:
23.19
3wg7J-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.86A 3wg7C-2p1nA:
undetectable
3wg7J-2p1nA:
undetectable		 3wg7C-2p1nA:
18.58
3wg7J-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.91A 3wg7C-2riuA:
undetectable
3wg7J-2riuA:
undetectable		 3wg7C-2riuA:
21.66
3wg7J-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vga PROTEIN A41

(Vaccinia virus) 		PF02250
(Orthopox_35kD) 		4 LEU A 128
PHE A 133
LEU A 192
PHE A 196
 None
 1.08A 3wg7C-2vgaA:
undetectable
3wg7J-2vgaA:
undetectable		 3wg7C-2vgaA:
19.71
3wg7J-2vgaA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		4 ARG A 532
LEU A 536
PHE A 543
LEU A 501
 None
 1.04A 3wg7C-2xgoA:
undetectable
3wg7J-2xgoA:
undetectable		 3wg7C-2xgoA:
16.90
3wg7J-2xgoA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 LEU A 386
PHE A  56
LEU A  52
PHE A 112
 None
 1.06A 3wg7C-2y4fA:
undetectable
3wg7J-2y4fA:
undetectable		 3wg7C-2y4fA:
20.78
3wg7J-2y4fA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 LEU C  35
PHE C  60
PHE C  33
LEU C  87
 None
 1.02A 3wg7C-2ynmC:
undetectable
3wg7J-2ynmC:
undetectable		 3wg7C-2ynmC:
21.92
3wg7J-2ynmC:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 LEU A 123
PHE A 121
PHE A  45
LEU A  18
 None
 0.88A 3wg7C-3ba3A:
undetectable
3wg7J-3ba3A:
undetectable		 3wg7C-3ba3A:
21.19
3wg7J-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 0.96A 3wg7C-3degC:
undetectable
3wg7J-3degC:
undetectable		 3wg7C-3degC:
17.43
3wg7J-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C 299
PHE C 338
PHE C 310
LEU C 355
 None
 1.08A 3wg7C-3degC:
undetectable
3wg7J-3degC:
undetectable		 3wg7C-3degC:
17.43
3wg7J-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacteroides
thetaiotaomicron) 		PF13460
(NAD_binding_10) 		4 LEU A 149
PHE A 148
PHE A 144
PHE A 107
 None
 1.04A 3wg7C-3dhnA:
undetectable
3wg7J-3dhnA:
undetectable		 3wg7C-3dhnA:
22.15
3wg7J-3dhnA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 1.03A 3wg7C-3evzA:
undetectable
3wg7J-3evzA:
undetectable		 3wg7C-3evzA:
19.78
3wg7J-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		4 LEU A 108
PHE A 144
LEU A 133
PHE A 129
 None
 1.07A 3wg7C-3fnrA:
undetectable
3wg7J-3fnrA:
undetectable		 3wg7C-3fnrA:
20.22
3wg7J-3fnrA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.88A 3wg7C-3g1zA:
undetectable
3wg7J-3g1zA:
undetectable		 3wg7C-3g1zA:
20.94
3wg7J-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.78A 3wg7C-3gajA:
2.8
3wg7J-3gajA:
undetectable		 3wg7C-3gajA:
21.16
3wg7J-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		4 LEU A  73
PHE A 283
LEU A 279
PHE A 275
 None
 1.05A 3wg7C-3hl1A:
5.8
3wg7J-3hl1A:
undetectable		 3wg7C-3hl1A:
21.45
3wg7J-3hl1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 227
PHE A 187
LEU A 183
PHE A 179
 None
 1.05A 3wg7C-3iayA:
2.5
3wg7J-3iayA:
undetectable		 3wg7C-3iayA:
13.74
3wg7J-3iayA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.89A 3wg7C-3iv0A:
1.8
3wg7J-3iv0A:
undetectable		 3wg7C-3iv0A:
20.57
3wg7J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y UL16

(Homo sapiens) 		PF00252
(Ribosomal_L16) 		4 LEU N 183
PHE N 185
LEU N  97
PHE N 102
 None
 1.04A 3wg7C-3j7yN:
undetectable
3wg7J-3j7yN:
undetectable		 3wg7C-3j7yN:
21.38
3wg7J-3j7yN:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 0.99A 3wg7C-3j9dA:
undetectable
3wg7J-3j9dA:
undetectable		 3wg7C-3j9dA:
13.31
3wg7J-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.81A 3wg7C-3lcrA:
undetectable
3wg7J-3lcrA:
undetectable		 3wg7C-3lcrA:
20.45
3wg7J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 0.98A 3wg7C-3mvuA:
undetectable
3wg7J-3mvuA:
undetectable		 3wg7C-3mvuA:
20.30
3wg7J-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.03A 3wg7C-3n3zA:
3.3
3wg7J-3n3zA:
1.4		 3wg7C-3n3zA:
21.17
3wg7J-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  11
PHE A  21
LEU A  25
PHE A  29
 EDO  A 320 (-4.5A)
None
None
None
 0.97A 3wg7C-3ooxA:
undetectable
3wg7J-3ooxA:
undetectable		 3wg7C-3ooxA:
19.64
3wg7J-3ooxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.91A 3wg7C-3oqqA:
undetectable
3wg7J-3oqqA:
undetectable		 3wg7C-3oqqA:
20.13
3wg7J-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
PDB  A 600 (-3.5A)
 1.06A 3wg7C-3qi3A:
3.4
3wg7J-3qi3A:
undetectable		 3wg7C-3qi3A:
18.44
3wg7J-3qi3A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 1.02A 3wg7C-3rd5A:
undetectable
3wg7J-3rd5A:
undetectable		 3wg7C-3rd5A:
21.79
3wg7J-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.86A 3wg7C-3wvrA:
undetectable
3wg7J-3wvrA:
undetectable		 3wg7C-3wvrA:
19.19
3wg7J-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.71A 3wg7C-4c8qH:
undetectable
3wg7J-4c8qH:
undetectable		 3wg7C-4c8qH:
19.40
3wg7J-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czd PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY
PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF13404
(HTH_AsnC-type)
no annotation 		4 LEU A  40
PHE A  38
PHE B  57
LEU B  45
 None
 1.04A 3wg7C-4czdA:
undetectable
3wg7J-4czdA:
undetectable		 3wg7C-4czdA:
22.56
3wg7J-4czdA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 0.99A 3wg7C-4e1eA:
1.7
3wg7J-4e1eA:
undetectable		 3wg7C-4e1eA:
20.44
3wg7J-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
 None
 0.94A 3wg7C-4e5tA:
undetectable
3wg7J-4e5tA:
undetectable		 3wg7C-4e5tA:
21.58
3wg7J-4e5tA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.92A 3wg7C-4flxA:
2.6
3wg7J-4flxA:
undetectable		 3wg7C-4flxA:
13.49
3wg7J-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 LEU A 114
PHE A   8
PHE A 134
LEU A 125
 None
 1.04A 3wg7C-4g9bA:
undetectable
3wg7J-4g9bA:
undetectable		 3wg7C-4g9bA:
21.31
3wg7J-4g9bA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gib BETA-PHOSPHOGLUCOMUT
ASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		4 LEU A 113
PHE A   7
PHE A 133
LEU A 124
 None
 1.08A 3wg7C-4gibA:
undetectable
3wg7J-4gibA:
undetectable		 3wg7C-4gibA:
21.28
3wg7J-4gibA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ARG A 176
LEU A 172
PHE A 198
LEU A 202
 None
 0.98A 3wg7C-4hqfA:
undetectable
3wg7J-4hqfA:
undetectable		 3wg7C-4hqfA:
20.74
3wg7J-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it4 CG17282

(Drosophila
melanogaster) 		no annotation 4 LEU A  83
PHE A 110
LEU A 112
PHE A  90
 None
 1.05A 3wg7C-4it4A:
4.7
3wg7J-4it4A:
undetectable		 3wg7C-4it4A:
20.44
3wg7J-4it4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 228
PHE A 230
LEU A 203
PHE A 199
 None
 1.01A 3wg7C-4j0mA:
undetectable
3wg7J-4j0mA:
undetectable		 3wg7C-4j0mA:
16.01
3wg7J-4j0mA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 570
PHE A 592
LEU A 596
PHE A 598
 None
 1.08A 3wg7C-4jgvA:
undetectable
3wg7J-4jgvA:
undetectable		 3wg7C-4jgvA:
21.99
3wg7J-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 4 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 1.00A 3wg7C-4kd5C:
undetectable
3wg7J-4kd5C:
undetectable		 3wg7C-4kd5C:
19.08
3wg7J-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.89A 3wg7C-4l4uA:
undetectable
3wg7J-4l4uA:
undetectable		 3wg7C-4l4uA:
18.32
3wg7J-4l4uA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnq INTERFERON-ACTIVABLE
PROTEIN 202

(Mus musculus) 		PF02760
(HIN) 		4 LEU A 218
PHE A 239
LEU A 216
PHE A 188
 None
 1.09A 3wg7C-4lnqA:
undetectable
3wg7J-4lnqA:
undetectable		 3wg7C-4lnqA:
19.62
3wg7J-4lnqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvt E3 SUMO-PROTEIN
LIGASE PIAS3

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 LEU A 192
PHE A 194
LEU A 272
PHE A 160
 None
 1.07A 3wg7C-4mvtA:
undetectable
3wg7J-4mvtA:
undetectable		 3wg7C-4mvtA:
20.45
3wg7J-4mvtA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 245
PHE A 269
LEU A 273
PHE A 277
 None
 1.03A 3wg7C-4n5cA:
3.6
3wg7J-4n5cA:
undetectable		 3wg7C-4n5cA:
14.04
3wg7J-4n5cA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B  75
PHE B  83
LEU B  87
PHE B  91
 None
 0.67A 3wg7C-4r0mB:
undetectable
3wg7J-4r0mB:
undetectable		 3wg7C-4r0mB:
17.42
3wg7J-4r0mB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.99A 3wg7C-4rgpA:
undetectable
3wg7J-4rgpA:
undetectable		 3wg7C-4rgpA:
20.82
3wg7J-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
 None
 0.79A 3wg7C-4rncA:
undetectable
3wg7J-4rncA:
undetectable		 3wg7C-4rncA:
21.32
3wg7J-4rncA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		4 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 1.08A 3wg7C-4roaA:
undetectable
3wg7J-4roaA:
undetectable		 3wg7C-4roaA:
20.50
3wg7J-4roaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 LEU A  31
PHE A  29
LEU A  42
PHE A  38
 None
None
None
INS  A 401 (-4.5A)
 0.96A 3wg7C-4rxmA:
undetectable
3wg7J-4rxmA:
undetectable		 3wg7C-4rxmA:
20.81
3wg7J-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LEU A 145
PHE A 130
LEU A 125
PHE A 121
 None
 1.02A 3wg7C-4ud4A:
undetectable
3wg7J-4ud4A:
undetectable		 3wg7C-4ud4A:
19.95
3wg7J-4ud4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 1.00A 3wg7C-4wpxA:
undetectable
3wg7J-4wpxA:
undetectable		 3wg7C-4wpxA:
21.84
3wg7J-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.77A 3wg7C-5aoxB:
undetectable
3wg7J-5aoxB:
undetectable		 3wg7C-5aoxB:
17.86
3wg7J-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 LEU A 463
PHE A 459
PHE A 378
LEU A 343
 None
 0.99A 3wg7C-5bzaA:
undetectable
3wg7J-5bzaA:
undetectable		 3wg7C-5bzaA:
17.12
3wg7J-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
 None
 0.94A 3wg7C-5ckmA:
undetectable
3wg7J-5ckmA:
undetectable		 3wg7C-5ckmA:
22.33
3wg7J-5ckmA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.02A 3wg7C-5ddbA:
2.5
3wg7J-5ddbA:
undetectable		 3wg7C-5ddbA:
17.43
3wg7J-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6g DE NOVO DESIGNED
PROTEIN CA01

(synthetic
construct) 		no annotation 4 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.81A 3wg7C-5e6gA:
3.6
3wg7J-5e6gA:
undetectable		 3wg7C-5e6gA:
19.51
3wg7J-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.98A 3wg7C-5eytA:
4.6
3wg7J-5eytA:
undetectable		 3wg7C-5eytA:
18.88
3wg7J-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 174
PHE A 101
LEU A  97
PHE A  92
 None
 0.93A 3wg7C-5huuA:
undetectable
3wg7J-5huuA:
undetectable		 3wg7C-5huuA:
19.58
3wg7J-5huuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ARG A 293
LEU A 295
PHE A 173
LEU A 177
 None
 1.02A 3wg7C-5i2hA:
undetectable
3wg7J-5i2hA:
undetectable		 3wg7C-5i2hA:
22.46
3wg7J-5i2hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 LEU A  87
PHE A 204
LEU A 208
PHE A 212
 None
 0.82A 3wg7C-5ipxA:
8.1
3wg7J-5ipxA:
undetectable		 3wg7C-5ipxA:
20.47
3wg7J-5ipxA:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
LEU C 160
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
None
 0.06A 3wg7C-5iy5C:
37.2
3wg7J-5iy5C:
undetectable		 3wg7C-5iy5C:
100.00
3wg7J-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 385
PHE A 434
LEU A 432
PHE A 360
 None
 0.82A 3wg7C-5jbgA:
3.1
3wg7J-5jbgA:
undetectable		 3wg7C-5jbgA:
15.81
3wg7J-5jbgA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		4 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.67A 3wg7C-5jbwA:
undetectable
3wg7J-5jbwA:
undetectable		 3wg7C-5jbwA:
20.91
3wg7J-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
 None
 0.90A 3wg7C-5ju6A:
undetectable
3wg7J-5ju6A:
undetectable		 3wg7C-5ju6A:
13.89
3wg7J-5ju6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 0.87A 3wg7C-5llqA:
undetectable
3wg7J-5llqA:
undetectable		 3wg7C-5llqA:
19.92
3wg7J-5llqA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1) 		4 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.85A 3wg7C-5lskA:
3.1
3wg7J-5lskA:
2.7		 3wg7C-5lskA:
21.82
3wg7J-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
 None
 0.98A 3wg7C-5nbsA:
undetectable
3wg7J-5nbsA:
undetectable		 3wg7C-5nbsA:
undetectable
3wg7J-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 0.84A 3wg7C-5oenA:
undetectable
3wg7J-5oenA:
undetectable		 3wg7C-5oenA:
undetectable
3wg7J-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 PHE A 167
PHE A  98
LEU A  94
PHE A  89
 None
 0.84A 3wg7C-5v0tA:
undetectable
3wg7J-5v0tA:
undetectable		 3wg7C-5v0tA:
20.08
3wg7J-5v0tA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus) 		no annotation 4 LEU D  30
PHE D  33
PHE D  79
LEU D  26
 None
 1.08A 3wg7C-5x2bD:
undetectable
3wg7J-5x2bD:
undetectable		 3wg7C-5x2bD:
undetectable
3wg7J-5x2bD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 LEU A 348
PHE A 344
PHE A 380
LEU A 376
 None
 0.76A 3wg7C-5xjjA:
3.3
3wg7J-5xjjA:
undetectable		 3wg7C-5xjjA:
22.22
3wg7J-5xjjA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT OST5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 LEU 5  73
PHE 5  28
PHE 5  77
PHE 1 447
 None
 0.95A 3wg7C-6c265:
3.2
3wg7J-6c265:
undetectable		 3wg7C-6c265:
undetectable
3wg7J-6c265:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 4 ARG B  36
LEU B  38
PHE B  39
PHE B 158
 None
 1.02A 3wg7C-6dexB:
undetectable
3wg7J-6dexB:
undetectable		 3wg7C-6dexB:
undetectable
3wg7J-6dexB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekt P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.95A 3wg7C-6ektA:
undetectable
3wg7J-6ektA:
undetectable		 3wg7C-6ektA:
19.06
3wg7J-6ektA:
11.14