SIMILAR PATTERNS OF AMINO ACIDS FOR 3WEL_A_ACRA1001

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1fvp	FLAVOPROTEIN 390 (Photobacterium phosphoreum)	no annotation	5	ILE A 168 ASP A  97 ASP A  48 PHE A   9 HIS A 131	None	1.47A	3welA-1fvpA: undetectable	3welA-1fvpA: 13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1i8a	ENDO-1,4-BETA-XYLANA SE A (Thermotoga maritima)	PF06452 (CBM9_1)	5	ASP A  12 ALA A 119 ASN A 103 ILE A  18 ASP A  16	CA  A 191 (-3.0A) None None None CA  A 191 (-2.8A)	1.24A	3welA-1i8aA: 2.1	3welA-1i8aA: 13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1q1n	HYPOTHETICAL ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN IN PRE5-FET4 INTERGENIC REGION (Saccharomyces cerevisiae)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	ALA A 136 PHE A 358 ASN A 137 ILE A  50 ASP A  49	None	1.50A	3welA-1q1nA: undetectable	3welA-1q1nA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xso	COPPER,ZINC SUPEROXIDE DISMUTASE (Xenopus laevis)	PF00080 (Sod_Cu)	5	ASP A  99 PHE A  62 ASP A 122 ARG A  77 HIS A  69	None None None None ZN  A 152 ( 3.1A)	1.40A	3welA-1xsoA: undetectable	3welA-1xsoA: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2c4m	GLYCOGEN PHOSPHORYLASE (Corynebacterium callunae)	PF00343 (Phosphorylase)	5	ALA A 267 PHE A 263 ILE A 170 ASP A 192 ARG A 207	None None None None FMT  A1795 ( 3.8A)	1.46A	3welA-2c4mA: undetectable	3welA-2c4mA: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cun	PHOSPHOGLYCERATE KINASE (Pyrococcus horikoshii)	PF00162 (PGK)	5	ALA A 148 ASN A 146 ASP A  65 ASP A  19 HIS A 360	None None None GOL  A 501 (-2.6A) 3PG  A 503 (-4.0A)	1.44A	3welA-2cunA: undetectable	3welA-2cunA: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2cun	PHOSPHOGLYCERATE KINASE (Pyrococcus horikoshii)	PF00162 (PGK)	5	ALA A 148 ASN A 146 ILE A  29 ASP A  19 HIS A 360	None None None GOL  A 501 (-2.6A) 3PG  A 503 (-4.0A)	1.33A	3welA-2cunA: undetectable	3welA-2cunA: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2d4y	FLAGELLAR HOOK-ASSOCIATED PROTEIN 1 (Salmonella enterica)	no annotation	5	ALA A 250 ASN A 337 ASP A 154 ASP A 291 ASP A 251	None	1.20A	3welA-2d4yA: undetectable	3welA-2d4yA: 18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g3n	ALPHA-GLUCOSIDASE (Sulfolobus solfataricus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ALA A  88 ILE A 249 TRP A 318 ASP A 320 ARG A 400	None None None None BOG  A2000 (-3.1A)	1.17A	3welA-2g3nA: 40.9	3welA-2g3nA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g3n	ALPHA-GLUCOSIDASE (Sulfolobus solfataricus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ALA A  90 ASP A 212 ILE A 249 PHE A 449 HIS A 480	None	0.85A	3welA-2g3nA: 40.9	3welA-2g3nA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g3n	ALPHA-GLUCOSIDASE (Sulfolobus solfataricus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ASP A  87 ASP A 212 ILE A 213 ASP A 416 PHE A 449	BOG  A2000 (-2.7A) None None BOG  A2000 (-3.0A) None	1.49A	3welA-2g3nA: 40.9	3welA-2g3nA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g3n	ALPHA-GLUCOSIDASE (Sulfolobus solfataricus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	9	ASP A  87 ASP A 212 ILE A 249 TRP A 318 ASP A 320 ARG A 400 ASP A 416 PHE A 449 HIS A 480	BOG  A2000 (-2.7A) None None None None BOG  A2000 (-3.1A) BOG  A2000 (-3.0A) None None	0.29A	3welA-2g3nA: 40.9	3welA-2g3nA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g3n	ALPHA-GLUCOSIDASE (Sulfolobus solfataricus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ASP A 416 ASP A  87 ARG A 400 ASP A 320 HIS A 252	BOG  A2000 (-3.0A) BOG  A2000 (-2.7A) BOG  A2000 (-3.1A) None None	1.34A	3welA-2g3nA: 40.9	3welA-2g3nA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2k2o	MYOFERLIN (Homo sapiens)	no annotation	5	ALA A 956 ASN A 957 ILE A 984 ASP A 983 ARG A1022	None	1.44A	3welA-2k2oA: undetectable	3welA-2k2oA: 8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2nvv	ACETYL-COA HYDROLASE/TRANSFERAS E FAMILY PROTEIN (Porphyromonas gingivalis)	PF02550 (AcetylCoA_hydro) PF13336 (AcetylCoA_hyd_C)	5	ASN A  95 ASP A 413 ILE A 376 ASP A 102 HIS A 411	ASN  A  95 ( 0.6A) ASP  A 413 (-0.5A) ILE  A 376 ( 0.7A) ASP  A 102 ( 0.6A) HIS  A 411 (-1.0A)	1.29A	3welA-2nvvA: undetectable	3welA-2nvvA: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	PF01179 (Cu_amine_oxid) PF02727 (Cu_amine_oxidN2) PF02728 (Cu_amine_oxidN3)	5	PHE A 609 ILE A 494 ASP A 689 PHE A 681 HIS A 521	None TPQ  A 470 ( 4.8A) None None CU  A 804 ( 3.3A)	1.43A	3welA-2pncA: 2.9	3welA-2pncA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wgh	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE LARGE SUBUNIT (Homo sapiens)	PF00317 (Ribonuc_red_lgN) PF02867 (Ribonuc_red_lgC)	5	ALA A 450 ASN A 452 ILE A 501 PHE A 198 HIS A 200	None	1.36A	3welA-2wghA: 3.7	3welA-2wghA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2x2i	ALPHA-1,4-GLUCAN LYASE ISOZYME 1 (Gracilariopsis lemaneiformis)	PF01055 (Glyco_hydro_31)	6	ASN A 244 ASP A 412 ASP A 553 ASP A 665 PHE A 698 HIS A 731	None QPS  A1050 (-3.2A) QPS  A1050 (-3.1A) QPS  A1050 (-2.7A) QPS  A1050 (-4.3A) QPS  A1050 (-4.3A)	0.71A	3welA-2x2iA: 32.8	3welA-2x2iA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2x2i	ALPHA-1,4-GLUCAN LYASE ISOZYME 1 (Gracilariopsis lemaneiformis)	PF01055 (Glyco_hydro_31)	8	ASP A 239 ASP A 412 TRP A 551 ASP A 553 ARG A 649 ASP A 665 PHE A 698 HIS A 731	QPS  A1050 (-2.5A) QPS  A1050 (-3.2A) QPS  A1050 (-4.8A) QPS  A1050 (-3.1A) QPS  A1050 (-3.2A) QPS  A1050 (-2.7A) QPS  A1050 (-4.3A) QPS  A1050 (-4.3A)	0.56A	3welA-2x2iA: 32.8	3welA-2x2iA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xr1	CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 100 KD SUBUNIT (Methanosarcina mazei)	PF07521 (RMMBL) PF07650 (KH_2) PF10996 (Beta-Casp) PF16661 (Lactamase_B_6) PF17214 (KH_7)	5	ALA A 327 ASN A 326 ASP A 246 ASP A 209 HIS A 604	None None ZN  A1639 (-2.7A) None ZN  A1639 (-3.3A)	1.32A	3welA-2xr1A: undetectable	3welA-2xr1A: 22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xvg	ALPHA XYLOSIDASE (Cellvibrio japonicus)	PF01055 (Glyco_hydro_31) PF16338 (DUF4968) PF17137 (DUF5110)	7	ASP A 470 TRP A 580 ASP A 582 ARG A 642 ASP A 659 PHE A 692 HIS A 740	None	0.44A	3welA-2xvgA: 34.9	3welA-2xvgA: 25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yky	BETA-TRANSAMINASE (Mesorhizobium sp. LUK)	PF00202 (Aminotran_3)	5	ASP A 169 ALA A 180 ASN A 178 ARG A 388 HIS A 375	None	1.49A	3welA-2ykyA: undetectable	3welA-2ykyA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3af5	PUTATIVE UNCHARACTERIZED PROTEIN PH1404 (Pyrococcus horikoshii)	PF07521 (RMMBL) PF10996 (Beta-Casp) PF16661 (Lactamase_B_6) PF17214 (KH_7)	5	ALA A 342 ASN A 341 ASP A 260 ASP A 217 HIS A 618	None ACY  A 658 (-3.4A) ZN  A 665 ( 2.9A) None ZN  A 665 ( 3.3A)	1.29A	3welA-3af5A: undetectable	3welA-3af5A: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ce1	SUPEROXIDE DISMUTASE [CU-ZN] (Naganishia liquefaciens)	PF00080 (Sod_Cu)	5	ASP A 105 PHE A  68 ASP A 128 ARG A  83 HIS A  75	None None None None ZN  A 202 (-3.1A)	1.42A	3welA-3ce1A: undetectable	3welA-3ce1A: 10.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ctt	MALTASE-GLUCOAMYLASE (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	5	ASN A 207 ASP A 327 ILE A 328 ASP A 542 PHE A 575	None 3CU  A1001 (-2.7A) 3CU  A1001 ( 3.9A) 3CU  A1001 ( 2.5A) 3CU  A1001 (-4.5A)	1.43A	3welA-3cttA: 48.1	3welA-3cttA: 36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ctt	MALTASE-GLUCOAMYLASE (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	9	ASN A 207 ASP A 327 ILE A 364 TRP A 441 ASP A 443 ARG A 526 ASP A 542 PHE A 575 HIS A 600	None 3CU  A1001 (-2.7A) 3CU  A1001 (-4.5A) 3CU  A1001 (-4.9A) 3CU  A1001 (-2.7A) 3CU  A1001 ( 3.5A) 3CU  A1001 ( 2.5A) 3CU  A1001 (-4.5A) 3CU  A1001 (-3.9A)	0.71A	3welA-3cttA: 48.1	3welA-3cttA: 36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ctt	MALTASE-GLUCOAMYLASE (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	9	ASP A 203 ASP A 327 ILE A 364 TRP A 441 ASP A 443 ARG A 526 ASP A 542 PHE A 575 HIS A 600	GOL  A3001 (-2.6A) 3CU  A1001 (-2.7A) 3CU  A1001 (-4.5A) 3CU  A1001 (-4.9A) 3CU  A1001 (-2.7A) 3CU  A1001 ( 3.5A) 3CU  A1001 ( 2.5A) 3CU  A1001 (-4.5A) 3CU  A1001 (-3.9A)	0.33A	3welA-3cttA: 48.1	3welA-3cttA: 36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3fnb	ACYLAMINOACYL PEPTIDASE SMU_737 (Streptococcus mutans)	PF12146 (Hydrolase_4)	5	ASN A  63 ASP A 191 ASP A 171 ARG A  97 PHE A 114	None	1.18A	3welA-3fnbA: undetectable	3welA-3fnbA: 17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gz8	MUTT/NUDIX FAMILY PROTEIN (Shewanella oneidensis)	PF00293 (NUDIX)	5	ALA A  97 ASP A  23 ASP A  96 PHE A 140 HIS A 142	None APR  A 302 (-2.9A) APR  A 302 (-3.6A) APR  A 302 (-3.6A) APR  A 302 (-4.0A)	1.46A	3welA-3gz8A: undetectable	3welA-3gz8A: 11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i1l	HEMAGGLUTININ-ESTERA SE PROTEIN (Porcine torovirus)	PF02710 (Hema_HEFG) PF03996 (Hema_esterase)	5	ASP A  60 ALA A  46 ASN A  52 ILE A 308 ASP A  45	None ACY  A2001 (-3.2A) None None ACY  A2001 (-4.1A)	1.13A	3welA-3i1lA: undetectable	3welA-3i1lA: 16.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3lpp	SUCRASE-ISOMALTASE (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	9	ASP A 231 ASP A 355 ILE A 392 TRP A 470 ASP A 472 ARG A 555 ASP A 571 PHE A 604 HIS A 629	None TRS  A6001 (-2.9A) None None TRS  A6001 (-3.2A) TRS  A6001 ( 4.6A) TRS  A6001 ( 3.7A) TRS  A6001 (-4.4A) TRS  A6001 (-4.2A)	0.28A	3welA-3lppA: 51.9	3welA-3lppA: 35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3om5	LEVANSUCRASE (Bacillus megaterium)	PF02435 (Glyco_hydro_68)	5	ASP A  90 ALA A  79 PHE A 133 ASN A 147 ASP A 448	None	1.46A	3welA-3om5A: undetectable	3welA-3om5A: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3owq	LIN1025 PROTEIN (Listeria innocua)	PF03816 (LytR_cpsA_psr)	5	ASN A 230 ASP A 210 ILE A 179 ASP A 178 ASP A 223	None	1.47A	3welA-3owqA: undetectable	3welA-3owqA: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3poc	ALPHA-GLUCOSIDASE (Blautia obeum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ALA A 448 ASN A 431 ASP A 197 ILE A 234 ASP A 449	None None ACR  A 664 (-2.9A) None None	1.42A	3welA-3pocA: 36.4	3welA-3pocA: 26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3poc	ALPHA-GLUCOSIDASE (Blautia obeum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ALA A 448 ASP A 197 ILE A 234 TRP A 305 ASP A 449	None ACR  A 664 (-2.9A) None None None	1.21A	3welA-3pocA: 36.4	3welA-3pocA: 26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3poc	ALPHA-GLUCOSIDASE (Blautia obeum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	7	ASP A  73 ASP A 197 ILE A 198 ARG A 404 ASP A 420 PHE A 453 HIS A 478	None ACR  A 664 (-2.9A) ACR  A 664 (-3.5A) ACR  A 664 (-4.0A) ACR  A 664 (-2.8A) ACR  A 664 (-4.4A) ACR  A 664 (-4.2A)	1.31A	3welA-3pocA: 36.4	3welA-3pocA: 26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3poc	ALPHA-GLUCOSIDASE (Blautia obeum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	7	ASP A  73 ASP A 197 ILE A 234 ARG A 404 ASP A 420 PHE A 453 HIS A 478	None ACR  A 664 (-2.9A) None ACR  A 664 (-4.0A) ACR  A 664 (-2.8A) ACR  A 664 (-4.4A) ACR  A 664 (-4.2A)	0.30A	3welA-3pocA: 36.4	3welA-3pocA: 26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3poc	ALPHA-GLUCOSIDASE (Blautia obeum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ASP A 197 ILE A 234 TRP A 305 PHE A 453 HIS A 478	ACR  A 664 (-2.9A) None None ACR  A 664 (-4.4A) ACR  A 664 (-4.2A)	0.89A	3welA-3pocA: 36.4	3welA-3pocA: 26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3srz	TOXIN A (Clostridioides difficile)	PF12918 (TcdB_N) PF12919 (TcdA_TcdB)	5	ASP A 285 ALA A 265 ILE A 372 ARG A 272 ASP A 269	UPG  A 556 (-2.8A) UPG  A 556 (-3.7A) None UPG  A 556 (-2.9A) UPG  A 556 (-2.9A)	1.35A	3welA-3srzA: undetectable	3welA-3srzA: 20.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3top	MALTASE-GLUCOAMYLASE , INTESTINAL (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	5	ASP A1157 ASP A1279 ILE A1280 ASP A1526 PHE A1559	ACR  A   1 (-2.6A) ACR  A   1 (-3.2A) ACR  A   1 (-4.1A) ACR  A   1 (-2.8A) ACR  A   1 (-4.3A)	1.34A	3welA-3topA: 45.0	3welA-3topA: 34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3top	MALTASE-GLUCOAMYLASE , INTESTINAL (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	9	ASP A1157 ASP A1279 ILE A1315 TRP A1418 ASP A1420 ARG A1510 ASP A1526 PHE A1559 HIS A1584	ACR  A   1 (-2.6A) ACR  A   1 (-3.2A) None None ACR  A   1 (-3.6A) ACR  A   1 (-2.9A) ACR  A   1 (-2.8A) ACR  A   1 (-4.3A) ACR  A   1 (-3.9A)	0.34A	3welA-3topA: 45.0	3welA-3topA: 34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v4b	STARVATION SENSING PROTEIN RSPA (Cellvibrio japonicus)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	ALA A 299 ASN A 334 ASP A  90 ILE A  63 ARG A 296	None	1.40A	3welA-3v4bA: 5.8	3welA-3v4bA: 18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ayg	GLUCANSUCRASE (Lactobacillus reuteri)	PF01473 (CW_binding_1) PF02324 (Glyco_hydro_70)	5	ASP A 934 ALA A1737 PHE A1753 ASP A1767 ASP A1754	None	1.09A	3welA-4aygA: 3.3	3welA-4aygA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4b9y	ALPHA-GLUCOSIDASE, PUTATIVE, ADG31B (Cellvibrio japonicus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF16338 (DUF4968) PF17137 (DUF5110)	8	ASP A 299 ILE A 341 TRP A 410 ASP A 412 ARG A 463 ASP A 480 PHE A 513 HIS A 540	None	0.38A	3welA-4b9yA: 43.2	3welA-4b9yA: 25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4di5	5-EPI-ARISTOLOCHENE SYNTHASE (Nicotiana tabacum)	PF01397 (Terpene_synth) PF03936 (Terpene_synth_C)	5	ASP A 444 ALA A 447 ASN A 523 ASP A 302 ASP A 525	DPO  A 605 (-2.6A) None None None DPO  A 605 ( 4.6A)	1.38A	3welA-4di5A: undetectable	3welA-4di5A: 20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4frx	ANAEROBICALLY-INDUCE D OUTER MEMBRANE PORIN OPRE (Pseudomonas aeruginosa)	PF03573 (OprD)	5	ALA A 277 ASN A 275 ILE A 223 ASP A 236 PHE A 219	None	1.46A	3welA-4frxA: undetectable	3welA-4frxA: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4gmk	RIBOSE-5-PHOSPHATE ISOMERASE A (Lactobacillus salivarius)	PF06026 (Rib_5-P_isom_A)	5	ALA A  86 ASP A 178 ILE A 176 ASP A  87 PHE A 132	None None None PO4  A 301 (-2.6A) None	1.50A	3welA-4gmkA: undetectable	3welA-4gmkA: 14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kws	D-MANNONATE DEHYDRATASE (Chromohalobacter salexigens)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	ALA A 302 ASN A 337 ASP A  92 ILE A  65 ARG A 299	None	1.44A	3welA-4kwsA: 6.1	3welA-4kwsA: 17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oet	PUTATIVE PEPTIDE ABC-TRANSPORT SYSTEM PERIPLASMIC PEPTIDE-BINDING PROTEIN (Campylobacter jejuni)	PF00496 (SBP_bac_5)	5	PHE A 380 ASP A  25 ASP A 240 ARG A 242 HIS A 393	None	1.48A	3welA-4oetA: undetectable	3welA-4oetA: 18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4r1d	UNCHARACTERIZED PROTEIN (Pseudomonas aeruginosa)	no annotation	5	ASP A 503 ILE A 444 ASP A 442 ARG A 441 ASP A 490	None	1.48A	3welA-4r1dA: undetectable	3welA-4r1dA: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rvp	SUPEROXIDE DISMUTASE (Sedum alfredii)	PF00080 (Sod_Cu)	5	ASP A 113 PHE A  76 ASP A 136 ARG A  91 HIS A  83	None None None None ZN  A 201 (-3.1A)	1.44A	3welA-4rvpA: undetectable	3welA-4rvpA: 10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rxu	PERIPLASMIC SUGAR-BINDING PROTEIN (Chloroflexus aurantiacus)	PF13407 (Peripla_BP_4)	5	ASP A 138 PHE A  72 ASP A 298 ARG A  64 ASP A  68	BGC  A 402 (-3.0A) None BGC  A 402 (-2.7A) BGC  A 402 (-3.9A) None	1.45A	3welA-4rxuA: 2.1	3welA-4rxuA: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4u10	POLY-BETA-1,6-N-ACET YL-D-GLUCOSAMINE N-DEACETYLASE (Aggregatibacter actinomycetemcomitans)	PF01522 (Polysacc_deac_1)	5	ALA A 255 PHE A 237 ILE A  78 TRP A  75 HIS A 252	None	1.18A	3welA-4u10A: 4.9	3welA-4u10A: 14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wqe	THIOSULFATE DEHYDROGENASE (Allochromatium vinosum)	PF13442 (Cytochrome_CBB3)	5	ALA A 174 ASP A  34 ARG A 177 ASP A 173 HIS A  51	None None None None HEC  A1002 (-4.9A)	1.47A	3welA-4wqeA: undetectable	3welA-4wqeA: 15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zd6	HALOHYDRIN EPOXIDASE B (Corynebacterium sp.)	PF13561 (adh_short_C2)	5	ALA A  69 PHE A  71 ASP A 199 ILE A 159 ARG A 135	None	1.39A	3welA-4zd6A: undetectable	3welA-4zd6A: 12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cdc	VP1, STRUCTURAL POLYPROTEIN (Israeli acute paralysis virus)	PF08762 (CRPV_capsid)	5	ASP A  76 ALA A 183 ILE A 156 ASP A  71 PHE A 188	None	1.32A	3welA-5cdcA: undetectable	3welA-5cdcA: 13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5djw	ALPHA-GLUCOSIDASE II (Bacteroides thetaiotaomicron)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF17137 (DUF5110)	5	ASP A 211 ASP A 321 ARG A 385 ASP A 401 PHE A 434	None	1.43A	3welA-5djwA: 37.3	3welA-5djwA: 28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5djw	ALPHA-GLUCOSIDASE II (Bacteroides thetaiotaomicron)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF17137 (DUF5110)	5	ASP A 211 TRP A 319 ASP A 321 ASP A 401 PHE A 434	None	1.45A	3welA-5djwA: 37.3	3welA-5djwA: 28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dkx	ALPHA GLUCOSIDASE-LIKE PROTEIN (Chaetomium thermophilum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF17137 (DUF5110)	7	ASP A 303 ASP A 443 ILE A 444 ARG A 617 ASP A 633 PHE A 666 HIS A 691	None TRS  A1001 (-2.9A) TRS  A1001 ( 4.1A) TRS  A1001 (-4.0A) TRS  A1001 (-2.8A) TRS  A1001 (-4.5A) TRS  A1001 (-4.0A)	1.42A	3welA-5dkxA: 46.5	3welA-5dkxA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dkx	ALPHA GLUCOSIDASE-LIKE PROTEIN (Chaetomium thermophilum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF17137 (DUF5110)	9	ASP A 303 ASP A 443 ILE A 480 TRP A 554 ASP A 556 ARG A 617 ASP A 633 PHE A 666 HIS A 691	None TRS  A1001 (-2.9A) None TRS  A1001 (-4.9A) TRS  A1001 (-3.2A) TRS  A1001 (-4.0A) TRS  A1001 (-2.8A) TRS  A1001 (-4.5A) TRS  A1001 (-4.0A)	0.31A	3welA-5dkxA: 46.5	3welA-5dkxA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dkx	ALPHA GLUCOSIDASE-LIKE PROTEIN (Chaetomium thermophilum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF17137 (DUF5110)	5	ASP A 303 TRP A 415 ASP A 633 PHE A 667 HIS A 693	None None TRS  A1001 (-2.8A) None None	1.41A	3welA-5dkxA: 46.5	3welA-5dkxA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5f7c	ALPHA-GLUCOSIDASE (Bacteroides thetaiotaomicron)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ASP A 228 ASN A 234 ASP A 460 ARG A 507 PHE A 556	None	1.02A	3welA-5f7cA: 38.7	3welA-5f7cA: 24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5f7c	ALPHA-GLUCOSIDASE (Bacteroides thetaiotaomicron)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	7	ASP A 228 ASP A 348 ASP A 460 ARG A 507 ASP A 523 PHE A 556 HIS A 588	None	0.44A	3welA-5f7cA: 38.7	3welA-5f7cA: 24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5f7s	GLYCOSIDE HYDROLASE FAMILY 31 (Trueperella pyogenes)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	ASP A 467 ARG A 516 ASP A 532 PHE A 565 HIS A 591	CA  A 805 (-2.9A) CA  A 805 ( 4.6A) CA  A 805 ( 4.6A) None None	0.54A	3welA-5f7sA: 36.3	3welA-5f7sA: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gai	PORTAL PROTEIN (Salmonella virus P22)	PF16510 (P22_portal)	5	ALA A 456 ASN A 140 ILE A 271 ARG A 513 ASP A 509	None	1.38A	3welA-5gaiA: undetectable	3welA-5gaiA: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hjr	NEUTRAL ALPHA-GLUCOSIDASE AB (Mus musculus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	7	ASP A 305 ASP A 451 ILE A 452 ARG A 624 ASP A 640 PHE A 673 HIS A 698	None 5GF  A1021 (-2.0A) 5GF  A1021 (-3.6A) 5GF  A1021 (-3.4A) 5GF  A1021 (-2.6A) 5GF  A1021 (-3.6A) 5GF  A1021 (-4.0A)	1.45A	3welA-5hjrA: 41.1	3welA-5hjrA: 29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hjr	NEUTRAL ALPHA-GLUCOSIDASE AB (Mus musculus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	9	ASP A 305 ASP A 451 ILE A 488 TRP A 562 ASP A 564 ARG A 624 ASP A 640 PHE A 673 HIS A 698	None 5GF  A1021 (-2.0A) None 5GF  A1021 (-4.6A) 5GF  A1021 (-2.1A) 5GF  A1021 (-3.4A) 5GF  A1021 (-2.6A) 5GF  A1021 (-3.6A) 5GF  A1021 (-4.0A)	0.28A	3welA-5hjrA: 41.1	3welA-5hjrA: 29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jd3	LAE5 (uncultured bacterium)	PF13472 (Lipase_GDSL_2)	5	ALA A 150 ASP A 172 ASP A 178 ARG A 144 ASP A 153	SO4  A 303 (-3.2A) None None None None	1.46A	3welA-5jd3A: 2.7	3welA-5jd3A: 13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jou	ALPHA-XYLOSIDASE BOGH31A (Bacteroides ovatus)	PF01055 (Glyco_hydro_31) PF16338 (DUF4968) PF17137 (DUF5110)	6	ASN A 319 ASP A 441 TRP A 551 ASP A 553 ARG A 613 HIS A 709	None EDO  A1008 (-2.8A) None EDO  A1008 (-2.7A) EDO  A1008 (-4.6A) EDO  A1008 (-4.0A)	1.09A	3welA-5jouA: 34.7	3welA-5jouA: 25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jou	ALPHA-XYLOSIDASE BOGH31A (Bacteroides ovatus)	PF01055 (Glyco_hydro_31) PF16338 (DUF4968) PF17137 (DUF5110)	7	ASP A 441 TRP A 551 ASP A 553 ARG A 613 ASP A 630 PHE A 663 HIS A 709	EDO  A1008 (-2.8A) None EDO  A1008 (-2.7A) EDO  A1008 (-4.6A) EDO  A1008 (-3.0A) EDO  A1008 (-4.3A) EDO  A1008 (-4.0A)	0.39A	3welA-5jouA: 34.7	3welA-5jouA: 25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5nn8	LYSOSOMAL ALPHA-GLUCOSIDASE (Homo sapiens)	no annotation	10	ASP A 282 ALA A 284 ASP A 404 ILE A 441 TRP A 516 ASP A 518 ARG A 600 ASP A 616 PHE A 649 HIS A 674	ACR  A1015 (-2.6A) ACR  A1015 ( 4.6A) ACR  A1015 (-3.0A) ACR  A1015 (-4.3A) None ACR  A1015 (-3.1A) ACR  A1015 (-3.1A) ACR  A1015 (-2.7A) ACR  A1015 (-4.3A) ACR  A1015 (-4.0A)	0.29A	3welA-5nn8A: 47.9	3welA-5nn8A: 37.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5nnl	INACTIVE DIHYDROOROTASE-LIKE DOMAIN (Chaetomium thermophilum)	no annotation	5	ASP A1696 ALA A1531 ASN A1529 ILE A1658 PHE A1617	None	1.13A	3welA-5nnlA: 5.9	3welA-5nnlA: 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ogl	UNDECAPRENYL-DIPHOSP HOOLIGOSACCHARIDE--P ROTEIN GLYCOTRANSFERASE (Campylobacter lari)	no annotation	5	ASP A 481 ALA A  59 PHE A  60 ARG A 471 HIS A  72	None 9UB  A 803 ( 3.8A) 9UB  A 803 ( 4.4A) None None	0.95A	3welA-5oglA: undetectable	3welA-5oglA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5uf2	RIBOSE-5-PHOSPHATE ISOMERASE A (Neisseria gonorrhoeae)	PF06026 (Rib_5-P_isom_A)	5	ALA A  84 ASP A 171 ILE A 169 ASP A  85 PHE A 130	None None None EDO  A 306 (-3.5A) None	1.47A	3welA-5uf2A: undetectable	3welA-5uf2A: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5x7s	GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE (Paenibacillus sp. 598K)	PF01055 (Glyco_hydro_31) PF16338 (DUF4968) PF16990 (CBM_35) PF17137 (DUF5110)	6	TRP A 427 ASP A 429 ARG A 474 ASP A 491 PHE A 533 HIS A 565	None	0.49A	3welA-5x7sA: 18.6	3welA-5x7sA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1dms	DMSO REDUCTASE (Rhodobacter capsulatus)	PF00384 (Molybdopterin) PF01568 (Molydop_binding)	4	ILE A 154 ILE A 220 TRP A 184 MET A 324	None PGD  A 783 (-4.7A) None None	1.49A	3welA-1dmsA: undetectable	3welA-1dmsA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kl7	THREONINE SYNTHASE (Saccharomyces cerevisiae)	PF00291 (PALP) PF14821 (Thr_synth_N)	4	ILE A  84 ILE A  41 MET A 251 TRP A  53	None	1.41A	3welA-1kl7A: undetectable	3welA-1kl7A: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uyp	BETA-FRUCTOSIDASE (Thermotoga maritima)	PF00251 (Glyco_hydro_32N) PF08244 (Glyco_hydro_32C)	4	ILE A 404 TRP A  14 TRP A 256 TRP A 273	None	1.39A	3welA-1uypA: undetectable	3welA-1uypA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wl1	OCTOPRENYL-DIPHOSPHA TE SYNTHASE (Thermotoga maritima)	PF00348 (polyprenyl_synt)	4	ILE A 206 TRP A 251 ILE A 215 MET A 212	None	0.97A	3welA-1wl1A: undetectable	3welA-1wl1A: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xa6	BETA2-CHIMAERIN (Homo sapiens)	PF00017 (SH2) PF00130 (C1_1) PF00620 (RhoGAP)	4	ILE A 150 TRP A 234 ILE A 134 TRP A 225	None	1.15A	3welA-1xa6A: undetectable	3welA-1xa6A: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yhu	HEMOGLOBIN A1 CHAIN (Riftia pachyptila)	PF00042 (Globin)	4	ILE A 114 ILE A  65 TRP A  34 TRP A  16	None	1.41A	3welA-1yhuA: undetectable	3welA-1yhuA: 9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2aey	FRUCTAN 1-EXOHYDROLASE IIA (Cichorium intybus)	PF00251 (Glyco_hydro_32N) PF08244 (Glyco_hydro_32C)	4	ILE A 452 TRP A  19 TRP A 292 TRP A 307	None	1.28A	3welA-2aeyA: undetectable	3welA-2aeyA: 20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dlx	UBX DOMAIN-CONTAINING PROTEIN 7 (Homo sapiens)	PF13899 (Thioredoxin_7)	4	ILE A  49 ILE A  73 MET A  46 TRP A 119	None	1.23A	3welA-2dlxA: undetectable	3welA-2dlxA: 10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dr1	386AA LONG HYPOTHETICAL SERINE AMINOTRANSFERASE (Pyrococcus horikoshii)	PF00266 (Aminotran_5)	4	ILE A 365 ILE A 273 TRP A 282 MET A 285	None	1.45A	3welA-2dr1A: undetectable	3welA-2dr1A: 17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g3n	ALPHA-GLUCOSIDASE (Sulfolobus solfataricus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	4	ILE A 213 TRP A 284 MET A 321 TRP A 413	None None BOG  A2000 ( 4.0A) None	0.48A	3welA-2g3nA: 40.9	3welA-2g3nA: 26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2jir	PERIPLASMIC NITRATE REDUCTASE (Desulfovibrio desulfuricans)	PF00384 (Molybdopterin) PF01568 (Molydop_binding) PF04879 (Molybdop_Fe4S4)	4	ILE A 329 TRP A 306 ILE A 310 MET A 229	None	1.28A	3welA-2jirA: undetectable	3welA-2jirA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wxu	PHOSPHOLIPASE C (Clostridium perfringens)	PF00882 (Zn_dep_PLPC) PF01477 (PLAT)	4	ILE A 262 ILE A 318 MET A 324 TRP A 290	None	1.45A	3welA-2wxuA: undetectable	3welA-2wxuA: 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xrc	HUMAN COMPLEMENT FACTOR I (Homo sapiens)	PF00057 (Ldl_recept_a) PF00089 (Trypsin) PF00530 (SRCR)	4	ILE A 352 ILE A 267 TRP A 438 TRP A 523	None	1.26A	3welA-2xrcA: undetectable	3welA-2xrcA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmn	PUTATIVE HYDROLASE (Chloroflexus aurantiacus)	PF10103 (Zincin_2)	4	ILE A 293 ILE A 315 TRP A 206 MET A 301	None	1.24A	3welA-3cmnA: undetectable	3welA-3cmnA: 18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ctt	MALTASE-GLUCOAMYLASE (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	4	ILE A 328 TRP A 406 MET A 444 TRP A 539	3CU  A1001 ( 3.9A) None 3CU  A1001 ( 3.9A) 3CU  A1001 (-4.6A)	0.45A	3welA-3cttA: 48.1	3welA-3cttA: 36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3f65	CHAPERONE PROTEIN FAEE (Escherichia coli)	PF00345 (PapD_N)	4	ILE A 149 TRP A  84 ILE A  40 MET A 174	None	1.22A	3welA-3f65A: undetectable	3welA-3f65A: 12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3k9y	1,25-DIHYDROXYVITAMI N D(3) 24-HYDROXYLASE, MITOCHONDRIAL (Rattus norvegicus)	PF00067 (p450)	4	ILE A 239 ILE A 131 TRP A 134 MET A 245	None	1.30A	3welA-3k9yA: undetectable	3welA-3k9yA: 20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3lpp	SUCRASE-ISOMALTASE (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	5	TRP A 327 ILE A 356 TRP A 435 MET A 473 TRP A 568	TRS  A6001 ( 3.8A) TRS  A6001 ( 4.0A) TRS  A6001 ( 4.6A) TRS  A6001 ( 3.7A) None	0.32A	3welA-3lppA: 51.9	3welA-3lppA: 35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ml0	PENICILLIN G ACYLASE, ALPHA SUBUNIT PENICILLIN G ACYLASE, BETA SUBUNIT (Alcaligenes faecalis)	PF01804 (Penicil_amidase)	4	ILE B 226 TRP A 139 ILE B  54 TRP B 154	None	1.35A	3welA-3ml0B: 2.0	3welA-3ml0B: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mpn	TRANSPORTER (Aquifex aeolicus)	PF00209 (SNF)	4	ILE A 314 TRP A 114 ILE A 111 TRP A 344	None	1.28A	3welA-3mpnA: undetectable	3welA-3mpnA: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mzs	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME (Bos taurus)	PF00067 (p450)	4	ILE A 196 ILE A  85 TRP A  88 MET A 202	None None HC9  A 501 (-4.7A) None	1.29A	3welA-3mzsA: undetectable	3welA-3mzsA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3na0	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL (Homo sapiens)	PF00067 (p450)	4	ILE A 234 ILE A 123 TRP A 126 MET A 240	None	1.31A	3welA-3na0A: undetectable	3welA-3na0A: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3njc	YSLB PROTEIN (Bacillus subtilis)	PF10702 (DUF2507)	4	TRP A  58 ILE A 115 TRP A 142 MET A 144	None	1.33A	3welA-3njcA: undetectable	3welA-3njcA: 10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3poc	ALPHA-GLUCOSIDASE (Blautia obeum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	TRP A 169 ILE A 198 TRP A 271 MET A 308 TRP A 417	ACR  A 664 (-3.7A) ACR  A 664 (-3.5A) ACR  A 664 (-4.6A) ACR  A 664 ( 3.8A) ACR  A 664 (-4.6A)	0.43A	3welA-3pocA: 36.5	3welA-3pocA: 26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rim	TRANSKETOLASE (Mycobacterium tuberculosis)	PF00456 (Transketolase_N) PF02779 (Transket_pyr) PF02780 (Transketolase_C)	4	ILE A 447 TRP A 533 ILE A 536 TRP A 489	None	1.18A	3welA-3rimA: 2.5	3welA-3rimA: 22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3top	MALTASE-GLUCOAMYLASE , INTESTINAL (Homo sapiens)	PF00088 (Trefoil) PF01055 (Glyco_hydro_31) PF16863 (NtCtMGAM_N)	4	ILE A1280 TRP A1355 MET A1421 TRP A1523	ACR  A   1 (-4.1A) ACR  A   1 (-4.4A) ACR  A   1 (-3.5A) ACR  A   1 (-4.5A)	0.34A	3welA-3topA: 45.0	3welA-3topA: 34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4aqs	LAMININ SUBUNIT BETA-1 (Mus musculus)	PF00053 (Laminin_EGF) PF00055 (Laminin_N)	4	ILE A 206 TRP A 112 ILE A  96 MET A 265	None	1.46A	3welA-4aqsA: undetectable	3welA-4aqsA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4er8	TNPAREP FOR PROTEIN (Escherichia coli)	no annotation	4	ILE A  93 TRP A  64 TRP A  53 MET A  60	None	1.38A	3welA-4er8A: undetectable	3welA-4er8A: 11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4iuw	NEUTRAL ENDOPEPTIDASE (Lactobacillus rhamnosus)	PF01431 (Peptidase_M13) PF05649 (Peptidase_M13_N)	4	ILE A  89 ILE A 141 TRP A 162 TRP A 266	None	1.29A	3welA-4iuwA: undetectable	3welA-4iuwA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k3z	D-ERYTHRULOSE 4-PHOSPHATE DEHYDROGENASE (Brucella melitensis)	no annotation	4	ILE A 197 ILE A 119 MET A 162 TRP A 159	None	1.46A	3welA-4k3zA: 2.0	3welA-4k3zA: 17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4p9a	POLYMERASE PA (Influenza A virus)	PF00603 (Flu_PA)	4	ILE A 483 ILE A 545 TRP A 338 MET A 523	None	1.49A	3welA-4p9aA: undetectable	3welA-4p9aA: 18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q3l	MGS-M2 (unidentified)	PF00561 (Abhydrolase_1)	4	ILE A 154 ILE A  28 TRP A  39 MET A  34	None	1.39A	3welA-4q3lA: undetectable	3welA-4q3lA: 15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rbn	SUCROSE SYNTHASE:GLYCOSYL TRANSFERASES GROUP 1 (Nitrosomonas europaea)	PF00534 (Glycos_transf_1) PF00862 (Sucrose_synth)	4	ILE A 510 ILE A 269 MET A 750 TRP A 743	None	1.43A	3welA-4rbnA: 2.4	3welA-4rbnA: 22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ruh	CYTOSOLIC NON-SPECIFIC DIPEPTIDASE (Homo sapiens)	PF01546 (Peptidase_M20) PF07687 (M20_dimer)	4	ILE A 457 ILE A 206 MET A 462 TRP A 140	None	1.26A	3welA-4ruhA: undetectable	3welA-4ruhA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cw8	HTH-TYPE TRANSCRIPTIONAL REPRESSOR KSTR (Mycobacterium tuberculosis)	PF00440 (TetR_N)	4	ILE A 156 ILE A  75 MET A  96 TRP A 164	None None None 55X  A 201 (-4.0A)	0.99A	3welA-5cw8A: undetectable	3welA-5cw8A: 12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dkx	ALPHA GLUCOSIDASE-LIKE PROTEIN (Chaetomium thermophilum)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2) PF17137 (DUF5110)	5	TRP A 415 ILE A 444 TRP A 517 MET A 557 TRP A 630	None TRS  A1001 ( 4.1A) TRS  A1001 ( 4.9A) TRS  A1001 (-3.5A) None	0.38A	3welA-5dkxA: 46.5	3welA-5dkxA: 27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fuu	HIV-1 ENVELOPE GLYCOPROTEIN GP160 (Human immunodeficiency virus 1)	PF00516 (GP120)	4	ILE A 371 TRP A 112 ILE A 108 MET A 475	None	1.42A	3welA-5fuuA: undetectable	3welA-5fuuA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fyj	GP120 ENV ECTODOMAIN (Human immunodeficiency virus 1)	PF00516 (GP120)	4	ILE G 272 ILE G 333 TRP G 338 MET G 341	None	1.11A	3welA-5fyjG: undetectable	3welA-5fyjG: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5h9f	CRISPR SYSTEM CASCADE SUBUNIT CASA (Escherichia coli)	PF09481 (CRISPR_Cse1)	4	ILE A 226 TRP A  87 ILE A  58 TRP A 211	None	1.30A	3welA-5h9fA: undetectable	3welA-5h9fA: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hjr	NEUTRAL ALPHA-GLUCOSIDASE AB (Mus musculus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	TRP A 423 ILE A 452 TRP A 525 MET A 565 TRP A 637	5GF  A1021 (-3.1A) 5GF  A1021 (-3.6A) 5GF  A1021 (-3.7A) 5GF  A1021 (-2.6A) 5GF  A1021 ( 4.6A)	0.35A	3welA-5hjrA: 41.2	3welA-5hjrA: 29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5iq0	ESTERASE (uncultured bacterium)	PF07859 (Abhydrolase_3)	4	ILE A 196 TRP A 182 ILE A  92 TRP A 219	None	1.17A	3welA-5iq0A: undetectable	3welA-5iq0A: 18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5lx8	SUSD HOMOLOG (Bacteroides thetaiotaomicron)	PF07980 (SusD_RagB) PF14322 (SusD-like_3)	4	ILE A 423 ILE A 108 MET A 154 TRP A  54	None	1.18A	3welA-5lx8A: undetectable	3welA-5lx8A: 20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5nn8	LYSOSOMAL ALPHA-GLUCOSIDASE (Homo sapiens)	no annotation	4	TRP A 376 TRP A 481 MET A 519 TRP A 613	ACR  A1015 ( 4.6A) ACR  A1015 ( 4.6A) ACR  A1015 (-3.3A) ACR  A1015 (-4.8A)	0.66A	3welA-5nn8A: 47.9	3welA-5nn8A: 37.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5o32	COMPLEMENT FACTOR I (Homo sapiens)	PF00057 (Ldl_recept_a) PF00089 (Trypsin) PF00530 (SRCR)	4	ILE I 370 ILE D 285 TRP I 456 TRP I 541	None	1.45A	3welA-5o32I: undetectable	3welA-5o32I: 13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u84	ACID CERAMIDASE (Balaenoptera acutorostrata)	no annotation	4	ILE A  76 ILE A  52 TRP A  62 MET A  66	None	1.46A	3welA-5u84A: undetectable	3welA-5u84A: 6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vyw	PYRUVATE CARBOXYLASE (Lactococcus lactis)	PF00289 (Biotin_carb_N) PF00682 (HMGL-like) PF02436 (PYC_OADA) PF02785 (Biotin_carb_C) PF02786 (CPSase_L_D2)	4	ILE A 633 TRP A 799 ILE A 552 MET A 596	None	1.16A	3welA-5vywA: 8.7	3welA-5vywA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5x1x	MUTATOR MUTT PROTEIN (Staphylococcus aureus)	PF00293 (NUDIX)	4	ILE A 126 ILE A 102 TRP A 104 TRP A  33	None	1.44A	3welA-5x1xA: undetectable	3welA-5x1xA: 8.24