SIMILAR PATTERNS OF AMINO ACIDS FOR 3WDM_D_ADND301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE


(Geobacillus
stearothermophilus)
PF09194
(Endonuc-BsobI)
5 ALA A 145
LEU A 198
LEU A 142
LEU A 316
ILE A 213
None
1.16A 3wdmD-1dc1A:
undetectable
3wdmD-1dc1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebb PHOSPHATASE

(Geobacillus
stearothermophilus)
PF00300
(His_Phos_1)
5 ALA A 130
LEU A   7
LEU A  81
ASP A  78
ILE A 148
None
1.14A 3wdmD-1ebbA:
undetectable
3wdmD-1ebbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0p ANTIGEN 85-B

(Mycobacterium
tuberculosis)
PF00756
(Esterase)
5 ALA A  57
GLY A 268
LEU A  38
ASN A  54
ILE A 123
None
1.12A 3wdmD-1f0pA:
1.9
3wdmD-1f0pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Escherichia
coli)
PF02350
(Epimerase_2)
5 ARG A  40
LEU A   4
LEU A  58
ASN A  59
ILE A  81
None
1.13A 3wdmD-1f6dA:
5.6
3wdmD-1f6dA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE


(Thermus
thermophilus)
PF02446
(Glyco_hydro_77)
5 ALA A  29
GLY A  23
LEU A  49
LEU A  25
ASP A  73
None
1.03A 3wdmD-1fp9A:
undetectable
3wdmD-1fp9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 GLY A 426
LEU A 110
LEU A 419
ASP A 420
ILE A 112
None
1.17A 3wdmD-1kl7A:
undetectable
3wdmD-1kl7A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP


(Rattus
norvegicus)
PF00595
(PDZ)
5 GLY A 743
LEU A 748
LEU A 739
ASN A 723
ILE A 722
None
1.14A 3wdmD-1n7fA:
undetectable
3wdmD-1n7fA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 141
ARG A 261
GLY A 235
LEU A 138
ILE A 150
None
1.13A 3wdmD-1o8cA:
2.2
3wdmD-1o8cA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION


(Saccharomyces
cerevisiae)
no annotation 5 ALA A 269
GLY A 266
LEU A  32
LEU A 265
ILE A  34
None
1.09A 3wdmD-1odfA:
undetectable
3wdmD-1odfA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))


(Sulfolobus
solfataricus)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
5 ALA A 321
LEU A 325
LEU A  62
ASN A  63
ILE A  86
None
1.17A 3wdmD-1qdlA:
undetectable
3wdmD-1qdlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))


(Sulfolobus
solfataricus)
PF00117
(GATase)
5 GLY B 171
LEU B 188
LEU B 122
ASP B 150
ILE B 187
None
1.15A 3wdmD-1qdlB:
2.3
3wdmD-1qdlB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)


(Klebsiella
pneumoniae)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 ALA B 496
LEU B 465
LEU B 493
ASN B 488
ILE B 489
None
1.07A 3wdmD-1qh1B:
undetectable
3wdmD-1qh1B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE


(Aquifex
aeolicus)
PF02446
(Glyco_hydro_77)
5 ALA A  26
GLY A  20
LEU A  46
LEU A  22
ASP A  72
None
1.14A 3wdmD-1tz7A:
undetectable
3wdmD-1tz7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG


(Pseudomonas
aeruginosa)
PF05690
(ThiG)
5 ALA A1096
LEU A1100
LEU A1105
ASN A1104
ILE A1076
None
1.16A 3wdmD-1wv2A:
undetectable
3wdmD-1wv2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA


(Escherichia
coli)
PF04354
(ZipA_C)
5 GLY A  81
LEU A  29
LEU A  61
ASN A  14
ILE A  32
None
1.06A 3wdmD-1y2fA:
undetectable
3wdmD-1y2fA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum)
PF14541
(TAXi_C)
PF14543
(TAXi_N)
5 ALA A 345
ARG A 244
LEU A 302
LEU A 227
ILE A 213
None
1.18A 3wdmD-2b42A:
undetectable
3wdmD-2b42A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6y PUTATIVE TETR FAMILY
REGULATORY PROTEIN


(Streptomyces
coelicolor)
PF00440
(TetR_N)
5 ALA A 127
GLY A 131
LEU A 150
ASP A  76
ILE A  78
None
1.14A 3wdmD-2d6yA:
undetectable
3wdmD-2d6yA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
5 ALA A 403
GLY A 429
LEU A 326
ASP A 377
ILE A 385
None
1.13A 3wdmD-2et6A:
2.6
3wdmD-2et6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ALA A 247
GLY A 291
LEU A 259
ASP A 293
LEU A 292
None
1.01A 3wdmD-2fymA:
undetectable
3wdmD-2fymA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii)
PF00005
(ABC_tran)
5 GLY A 153
LEU A 141
LEU A 156
ASN A 151
ILE A 109
None
1.12A 3wdmD-2ghiA:
undetectable
3wdmD-2ghiA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE


(Xanthomonas
citri)
PF01663
(Phosphodiest)
5 ALA A 233
ARG A 236
GLY A 235
LEU A 238
ILE A  51
None
1.13A 3wdmD-2gsnA:
undetectable
3wdmD-2gsnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7v PROTEIN KINASE YPKA

(Yersinia
pseudotuberculosis)
PF09632
(Rac1)
5 ALA C 565
LEU C 477
ASP C 481
ASN C 498
ILE C 501
None
1.09A 3wdmD-2h7vC:
undetectable
3wdmD-2h7vC:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805


(Mycobacterium
tuberculosis)
PF00149
(Metallophos)
5 ALA A 190
ARG A 193
GLY A 192
LEU A 149
LEU A 195
None
1.16A 3wdmD-2hypA:
undetectable
3wdmD-2hypA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Staphylococcus
aureus)
PF00005
(ABC_tran)
5 ALA A  50
ARG A  77
LEU A   5
LEU A  61
ILE A   3
None
1.17A 3wdmD-2ihyA:
undetectable
3wdmD-2ihyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE


(Homo sapiens)
PF01234
(NNMT_PNMT_TEMT)
6 ALA A 228
ARG A 181
LEU A 255
LEU A 183
ASN A 182
ILE A 195
None
1.33A 3wdmD-2iipA:
undetectable
3wdmD-2iipA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 ALA A 105
LEU A  92
LEU A 102
LEU A  62
ASN A  63
None
1.16A 3wdmD-2j8kA:
undetectable
3wdmD-2j8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 ALA A 105
LEU A 112
LEU A 122
ASP A 121
ILE A 117
None
1.04A 3wdmD-2j8kA:
undetectable
3wdmD-2j8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 ALA A 125
LEU A 112
LEU A 122
ASP A 121
ILE A 117
None
1.00A 3wdmD-2j8kA:
undetectable
3wdmD-2j8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 ALA A 140
LEU A 127
LEU A 137
LEU A  97
ASN A  98
None
None
None
None
MES  A1176 (-2.7A)
0.97A 3wdmD-2j8kA:
undetectable
3wdmD-2j8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme)
PF00805
(Pentapeptide)
5 ALA A 145
LEU A 132
ASP A 121
LEU A 102
ILE A 117
None
1.10A 3wdmD-2j8kA:
undetectable
3wdmD-2j8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF


(Deinococcus
radiodurans)
PF02463
(SMC_N)
5 GLY A 343
LEU A 338
LEU A  42
ASN A  16
ILE A  31
None
1.06A 3wdmD-2o5vA:
undetectable
3wdmD-2o5vA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A 204
LEU A 208
LEU A 333
ASN A 336
ILE A 240
None
1.12A 3wdmD-2q27A:
11.3
3wdmD-2q27A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli)
PF00154
(RecA)
5 GLY A  55
LEU A  45
LEU A 328
LEU A  51
ILE A  49
None
1.17A 3wdmD-2rebA:
undetectable
3wdmD-2rebA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans)
PF14520
(HHH_5)
PF14716
(HHH_8)
5 ALA A 238
GLY A 204
LEU A 224
LEU A 180
ILE A 235
None
1.09A 3wdmD-2w9mA:
undetectable
3wdmD-2w9mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE


(Thermus
brockianus)
PF02446
(Glyco_hydro_77)
5 ALA A  29
GLY A  23
LEU A  49
LEU A  25
ASP A  73
None
1.03A 3wdmD-2x1iA:
undetectable
3wdmD-2x1iA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 ALA A 519
ARG A 523
GLY A 522
LEU A 439
LEU A 525
None
1.12A 3wdmD-2xymA:
undetectable
3wdmD-2xymA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans)
PF12697
(Abhydrolase_6)
5 ALA A 276
ARG A 279
GLY A 278
LEU A  47
ILE A 101
None
1.09A 3wdmD-3bwxA:
undetectable
3wdmD-3bwxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans)
PF12697
(Abhydrolase_6)
5 ALA A 276
ARG A 279
GLY A 278
LEU A 281
ILE A 101
None
0.92A 3wdmD-3bwxA:
undetectable
3wdmD-3bwxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens)
PF01522
(Polysacc_deac_1)
5 ALA A 271
ARG A 274
LEU A 258
LEU A 236
ILE A 256
None
1.18A 3wdmD-3cl6A:
undetectable
3wdmD-3cl6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 ALA A  54
LEU A  13
LEU A  81
ASP A  83
ILE A  47
None
1.14A 3wdmD-3d1jA:
4.3
3wdmD-3d1jA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120)
PF00805
(Pentapeptide)
5 ALA X 160
LEU X 147
LEU X 157
LEU X 112
ASN X 113
None
1.07A 3wdmD-3du1X:
undetectable
3wdmD-3du1X:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A  13
LEU A  36
LEU A  29
ASN A  30
ILE A  21
None
1.16A 3wdmD-3eyaA:
10.4
3wdmD-3eyaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE


(Nocardioides
aromaticivorans)
PF00355
(Rieske)
PF11723
(Aromatic_hydrox)
5 ALA A  64
LEU A  60
LEU A 105
ASP A 106
ILE A  71
None
1.08A 3wdmD-3gcfA:
undetectable
3wdmD-3gcfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4p PROTEASOME SUBUNIT
BETA


(Methanocaldococcus
jannaschii)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 ALA a  60
ARG a  63
LEU a  93
LEU a  65
ILE a  92
None
0.91A 3wdmD-3h4pa:
undetectable
3wdmD-3h4pa:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
5 ALA A 321
GLY A 323
LEU A 113
LEU A 326
ILE A  84
None
0.96A 3wdmD-3hutA:
undetectable
3wdmD-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
5 ALA A 328
ARG A 331
GLY A 330
LEU A  43
LEU A 341
None
1.09A 3wdmD-3hutA:
undetectable
3wdmD-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khf MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00595
(PDZ)
5 GLY A1027
LEU A1032
LEU A1023
ASN A1007
ILE A1006
None
1.15A 3wdmD-3khfA:
undetectable
3wdmD-3khfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Ehrlichia
chaffeensis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ALA A  86
GLY A  84
LEU A  52
ASN A  35
ILE A  38
None
1.04A 3wdmD-3l0gA:
undetectable
3wdmD-3l0gA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1


(Bos taurus)
PF00481
(PP2C)
5 ALA A 203
GLY A  70
LEU A 165
LEU A  88
ILE A  92
None
0.98A 3wdmD-3mq3A:
undetectable
3wdmD-3mq3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqn UNCHARACTERIZED
PROTEIN


(Deinococcus
radiodurans)
PF12723
(DUF3809)
5 ALA A 134
ARG A 137
GLY A 136
LEU A 114
LEU A 139
None
1.15A 3wdmD-3nqnA:
undetectable
3wdmD-3nqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa)
PF00962
(A_deaminase)
5 ALA A 224
GLY A 221
LEU A 210
LEU A 234
ILE A 239
None
1.12A 3wdmD-3paoA:
undetectable
3wdmD-3paoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdl OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE


(Helicobacter
pylori)
PF00881
(Nitroreductase)
5 ALA A  80
LEU A  33
LEU A 188
LEU A 156
ILE A  36
None
1.14A 3wdmD-3qdlA:
undetectable
3wdmD-3qdlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
5 GLY A 309
LEU A 353
LEU A 349
ASN A 348
ILE A 352
None
1.08A 3wdmD-3rr5A:
undetectable
3wdmD-3rr5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 GLY A 148
LEU A 230
LEU A 247
ASP A 243
ILE A 232
None
0.91A 3wdmD-3v9aA:
undetectable
3wdmD-3v9aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx4 PUTATIVE ABC
TRANSPORTER,
ATP-BINDING PROTEIN
COMA


(Streptococcus
mutans)
PF00005
(ABC_tran)
5 ALA A 599
ARG A 602
LEU A 592
LEU A 524
ILE A 587
None
1.12A 3wdmD-3vx4A:
undetectable
3wdmD-3vx4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila')
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ALA A 252
ARG A 255
LEU A 230
LEU A 257
ILE A 239
None
0.88A 3wdmD-3wnvA:
3.0
3wdmD-3wnvA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Thermosynechococcus
elongatus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ALA A  99
GLY A  10
ASN A  15
ASN A  43
ILE A  34
NAD  A1001 (-4.9A)
NAD  A1001 (-3.1A)
None
None
None
1.14A 3wdmD-3zdfA:
3.2
3wdmD-3zdfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION


(Staphylothermus
marinus)
PF00128
(Alpha-amylase)
5 ALA A 494
ARG A 512
LEU A 556
LEU A 491
ASN A 515
None
1.07A 3wdmD-4aeeA:
undetectable
3wdmD-4aeeA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10


(Homo sapiens)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ALA A 461
ARG A 464
GLY A 463
LEU A 160
LEU A 282
None
1.14A 3wdmD-4ayxA:
undetectable
3wdmD-4ayxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans)
PF00128
(Alpha-amylase)
5 LEU A 138
LEU A  70
ASP A  69
ASN A  47
ILE A  93
None
1.14A 3wdmD-4e2oA:
undetectable
3wdmD-4e2oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1)
PF16838
(Caud_tail_N)
5 GLY A 294
ASP A 300
LEU A 295
ASN A 296
ILE A 308
None
1.16A 3wdmD-4ep0A:
undetectable
3wdmD-4ep0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE


(Chromobacterium
violaceum)
PF01979
(Amidohydro_1)
5 ALA A 301
ARG A 353
GLY A 351
LEU A 355
ASN A 128
None
NOS  A 502 (-4.4A)
None
None
None
1.15A 3wdmD-4f0sA:
undetectable
3wdmD-4f0sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN


(Idiomarina
loihiensis)
PF05299
(Peptidase_M61)
PF13180
(PDZ_2)
5 ALA A 489
LEU A 561
LEU A 514
LEU A 498
ILE A 548
None
1.16A 3wdmD-4fgmA:
undetectable
3wdmD-4fgmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
5 ALA A 465
LEU A 290
ASP A 432
ASN A 445
ILE A 293
None
None
GOL  A 512 ( 3.2A)
None
None
1.12A 3wdmD-4fvlA:
undetectable
3wdmD-4fvlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE


(Mycobacterium
tuberculosis)
PF01039
(Carboxyl_trans)
5 ALA A 223
GLY A 226
LEU A 276
ASP A 253
ILE A 251
None
1.08A 3wdmD-4g2rA:
undetectable
3wdmD-4g2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Aneurinibacillus
thermoaerophilus)
PF00483
(NTP_transferase)
5 GLY A 172
LEU A  41
ASP A 108
LEU A 106
ILE A   5
G1P  A 301 ( 4.2A)
None
THM  A 302 (-3.5A)
THM  A 302 (-4.2A)
None
1.17A 3wdmD-4ho4A:
undetectable
3wdmD-4ho4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
5 ALA A 390
ARG A 393
GLY A 392
LEU A 378
ASN A 398
None
0.97A 3wdmD-4ib4A:
undetectable
3wdmD-4ib4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0e PROBABLE
3-HYDROXYACYL-COA
DEHYDROGENASE
F54C8.1


(Caenorhabditis
elegans)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ALA A  50
GLY A  20
LEU A  39
ASP A  41
ILE A  16
None
1.17A 3wdmD-4j0eA:
4.2
3wdmD-4j0eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli)
PF07859
(Abhydrolase_3)
5 GLY A 210
LEU A  10
LEU A 291
ASP A 262
LEU A 209
None
0.98A 3wdmD-4kryA:
undetectable
3wdmD-4kryA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyz DESIGNED PROTEIN
OR327


(synthetic
construct)
no annotation 5 GLY A 160
LEU A  36
LEU A  74
ASN A  77
ILE A  40
None
1.11A 3wdmD-4kyzA:
undetectable
3wdmD-4kyzA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
PF01522
(Polysacc_deac_1)
5 ALA A 238
LEU A  77
LEU A 213
ASN A 210
ILE A 222
None
1.05A 3wdmD-4l1gA:
undetectable
3wdmD-4l1gA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE


(Thermococcus
onnurineus)
PF02006
(PPS_PS)
10 ALA A  36
ARG A  39
GLY A  40
LEU A  83
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
ATP  A 301 (-3.3A)
ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
None
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
0.59A 3wdmD-4mb2A:
39.7
3wdmD-4mb2A:
90.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 ARG A 516
LEU A 473
LEU A 483
LEU A 518
ILE A 470
None
1.13A 3wdmD-4o1oA:
undetectable
3wdmD-4o1oA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00171
(Aldedh)
5 ALA A  40
LEU A   5
LEU A  44
ASP A  47
ILE A   7
None
1.15A 3wdmD-4o6rA:
undetectable
3wdmD-4o6rA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ


(Pseudomonas
putida)
PF16822
(ALGX)
5 ALA A 110
ARG A 113
GLY A 114
LEU A 355
ILE A 363
None
0.94A 3wdmD-4o8vA:
undetectable
3wdmD-4o8vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN


(Agrobacterium
tumefaciens)
PF05544
(Pro_racemase)
5 ALA A  89
LEU A  70
LEU A  41
LEU A  50
ILE A  29
None
1.17A 3wdmD-4q2hA:
undetectable
3wdmD-4q2hA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE


(Brucella
abortus)
PF01041
(DegT_DnrJ_EryC1)
5 ALA A 178
GLY A 183
LEU A  43
ASP A 137
ILE A 167
None
1.07A 3wdmD-4qgrA:
2.1
3wdmD-4qgrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1


(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
5 ALA A 328
ARG A 331
LEU A 357
LEU A 333
ASN A 335
None
1.10A 3wdmD-4r6lA:
undetectable
3wdmD-4r6lA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans)
PF13855
(LRR_8)
5 GLY A 177
LEU A 149
LEU A 185
LEU A 203
ILE A 172
None
1.16A 3wdmD-4tzhA:
undetectable
3wdmD-4tzhA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B


(Neisseria
meningitidis)
PF01298
(TbpB_B_D)
PF17484
(TbpB_A)
5 ARG A 327
GLY A 326
LEU A 245
LEU A 312
ILE A 273
None
1.01A 3wdmD-4u9cA:
undetectable
3wdmD-4u9cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN


(Chaetomium
thermophilum)
PF05783
(DLIC)
5 GLY A 288
LEU A 282
LEU A 139
ASN A 137
ILE A 283
None
1.09A 3wdmD-4w7gA:
undetectable
3wdmD-4w7gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE


(Helicobacter
pylori)
PF00793
(DAHP_synth_1)
5 ALA A  30
GLY A  16
LEU A  73
LEU A  26
ILE A  20
None
1.09A 3wdmD-4z1aA:
undetectable
3wdmD-4z1aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1


(Daucus carota)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 ALA A 214
GLY A 212
LEU A 237
LEU A 211
ILE A 198
None
1.18A 3wdmD-4z61A:
undetectable
3wdmD-4z61A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1


(Daucus carota)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 ALA A 236
LEU A 226
LEU A 213
ASN A 239
ILE A 198
None
1.04A 3wdmD-4z61A:
undetectable
3wdmD-4z61A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
5 GLY A 285
LEU A 588
ASP A 356
LEU A 284
ILE A 339
GLY  A 285 ( 0.0A)
LEU  A 588 ( 0.6A)
ASP  A 356 ( 0.6A)
LEU  A 284 ( 0.6A)
ILE  A 339 ( 0.4A)
1.07A 3wdmD-4zkeA:
undetectable
3wdmD-4zkeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM


(Pseudomonas
aeruginosa)
PF01323
(DSBA)
5 ALA A  93
LEU A 133
ASP A  11
LEU A  13
ILE A 116
ALA  A  93 ( 0.0A)
LEU  A 133 ( 0.6A)
ASP  A  11 ( 0.5A)
LEU  A  13 ( 0.6A)
ILE  A 116 ( 0.7A)
1.17A 3wdmD-5hfiA:
undetectable
3wdmD-5hfiA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450


(Streptomyces
peucetius)
PF00067
(p450)
5 ALA A 143
LEU A 126
LEU A 138
ASP A 137
ILE A 129
None
1.15A 3wdmD-5it1A:
undetectable
3wdmD-5it1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE


(Yersinia pestis)
PF04390
(LptE)
5 GLY B  59
LEU B 135
LEU B  28
ASP B  23
ILE B  32
None
1.13A 3wdmD-5ixmB:
undetectable
3wdmD-5ixmB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT


(Aromatoleum
aromaticum)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
5 ARG b 191
GLY b 179
LEU b 145
LEU b 178
ILE b 158
None
1.13A 3wdmD-5l9wb:
undetectable
3wdmD-5l9wb:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Pseudomonas
protegens)
no annotation 6 ALA A 175
GLY A   7
LEU A 122
LEU A 313
ASP A 178
ILE A 311
None
1.25A 3wdmD-5mg5A:
undetectable
3wdmD-5mg5A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjr PROTEIN THF1

(Thermosynechococcus
elongatus)
PF11264
(ThylakoidFormat)
5 ALA A  53
GLY A  55
LEU A  80
LEU A 134
ILE A  37
None
1.16A 3wdmD-5mjrA:
undetectable
3wdmD-5mjrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1x B-CELL LYMPHOMA 6
PROTEIN


(Homo sapiens)
PF00651
(BTB)
5 ALA D 109
GLY D  82
LEU D  97
ASN D 101
ILE D 102
None
1.12A 3wdmD-5n1xD:
undetectable
3wdmD-5n1xD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6y PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
no annotation 5 ALA B 238
LEU B  77
LEU B 213
ASN B 210
ILE B 222
None
1.10A 3wdmD-5o6yB:
undetectable
3wdmD-5o6yB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis)
no annotation 5 ALA A 848
LEU A 800
LEU A 780
LEU A 853
ILE A 788
None
1.04A 3wdmD-5ve8A:
undetectable
3wdmD-5ve8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE


(Eisenia fetida)
no annotation 5 ALA A 170
GLY A 172
LEU A 376
LEU A  20
ILE A 374
None
1.01A 3wdmD-5y6tA:
undetectable
3wdmD-5y6tA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis)
no annotation 5 ALA A 116
ARG A 138
LEU A 137
ASN A 136
ILE A 189
None
1.07A 3wdmD-5z06A:
undetectable
3wdmD-5z06A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Mycobacterium
tuberculosis)
no annotation 5 GLY A 171
LEU A  41
ASP A 108
LEU A 106
ILE A   5
DAU  A 301 ( 4.3A)
None
MG  A 302 ( 2.5A)
DAU  A 301 (-3.9A)
None
1.12A 3wdmD-6b5eA:
undetectable
3wdmD-6b5eA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY


(Paraburkholderia
phymatum)
no annotation 5 ALA A 162
LEU A 134
LEU A  35
LEU A 168
ILE A 124
None
1.05A 3wdmD-6c0dA:
undetectable
3wdmD-6c0dA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1


(Homo sapiens)
no annotation 5 ALA B  91
LEU B  75
LEU B 119
ASN B  87
ILE B 121
None
1.06A 3wdmD-6d6uB:
undetectable
3wdmD-6d6uB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f85 CYTOCHROME P450
CYP260A1


(Sorangium
cellulosum)
no annotation 5 ALA A 177
ARG A 176
GLY A 179
LEU A 224
ILE A 185
None
1.18A 3wdmD-6f85A:
undetectable
3wdmD-6f85A:
13.16