SIMILAR PATTERNS OF AMINO ACIDS FOR 3WDM_C_ADNC301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		5 ALA A 182
GLY A 184
LEU A 237
LEU A 173
ILE A 189
 None
 1.15A 3wdmC-12asA:
undetectable		 3wdmC-12asA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  12
GLY A  16
LEU A  56
LEU A  39
LEU A  19
 NAX  A 334 ( 4.4A)
None
None
None
None
 1.14A 3wdmC-1bdmA:
3.6		 3wdmC-1bdmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eav MOLYBDOPTERIN
BIOSYNTHESIS CNX1
PROTEIN

(Arabidopsis
thaliana) 		PF00994
(MoCF_biosynth) 		5 GLY A 103
LEU A 133
LEU A 151
LEU A 105
ILE A 135
 None
 1.06A 3wdmC-1eavA:
undetectable		 3wdmC-1eavA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		5 ALA A  29
GLY A  23
LEU A  49
LEU A  25
ASP A  73
 None
 1.19A 3wdmC-1fp9A:
undetectable		 3wdmC-1fp9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 355
GLY A 263
LEU A 352
LEU A 209
ASN A 208
 None
 1.15A 3wdmC-1hkkA:
undetectable		 3wdmC-1hkkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 ALA A  18
GLY A  86
LEU A  12
ASN A   5
ILE A   4
 None
 1.18A 3wdmC-1i2lA:
undetectable		 3wdmC-1i2lA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ALA A  93
GLY A  88
LEU A   3
LEU A  86
ILE A   6
 None
 1.09A 3wdmC-1jf5A:
undetectable		 3wdmC-1jf5A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 ALA B 496
LEU B 465
LEU B 493
ASN B 488
ILE B 489
 None
 0.96A 3wdmC-1qh1B:
1.9		 3wdmC-1qh1B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 200
LEU A 228
LEU A 276
ASN A 296
ILE A 212
 None
 1.05A 3wdmC-1v5fA:
9.7		 3wdmC-1v5fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yln HYPOTHETICAL PROTEIN
VCA0042

(Vibrio cholerae) 		PF07238
(PilZ)
PF12945
(YcgR_2) 		5 LEU A 160
LEU A 233
LEU A 246
ASN A 247
ILE A 189
 None
 1.17A 3wdmC-1ylnA:
undetectable		 3wdmC-1ylnA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		5 ALA A 112
GLY A  57
LEU A  54
LEU A 158
LEU A 150
 None
ACT  A 222 ( 4.7A)
None
None
None
 1.09A 3wdmC-2d3yA:
undetectable		 3wdmC-2d3yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8i T-CELL LYMPHOMA
INVASION AND
METASTASIS 1 VARIANT

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  95
LEU A  35
LEU A  79
ASN A  80
ILE A  68
 None
 1.13A 3wdmC-2d8iA:
undetectable		 3wdmC-2d8iA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ALA A 280
GLY A 284
LEU A  95
LEU A 258
ILE A 324
 PLP  A1001 ( 4.5A)
None
None
None
None
 1.17A 3wdmC-2eo5A:
3.2		 3wdmC-2eo5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 ALA A 465
LEU A 177
LEU A 170
ASN A  97
ILE A 145
 None
 1.12A 3wdmC-2et6A:
3.2		 3wdmC-2et6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		5 GLY A  27
LEU A   5
LEU A  35
LEU A  28
ILE A  12
 None
 1.07A 3wdmC-2f9tA:
undetectable		 3wdmC-2f9tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 LEU A 222
LEU A 171
LEU A 178
ASN A 177
ILE A 163
 None
 1.16A 3wdmC-2fm9A:
undetectable		 3wdmC-2fm9A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		5 ALA A  98
LEU A 108
LEU A 126
LEU A  95
ILE A 112
 None
 1.09A 3wdmC-2fyiA:
undetectable		 3wdmC-2fyiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01923
(Cob_adeno_trans) 		5 ALA A  45
GLY A  47
LEU A  70
LEU A  50
ILE A  66
 None
 1.19A 3wdmC-2g2dA:
undetectable		 3wdmC-2g2dA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghi TRANSPORT PROTEIN

(Plasmodium
yoelii) 		PF00005
(ABC_tran) 		5 GLY A 153
LEU A 141
LEU A 156
ASN A 151
ILE A 109
 None
 1.12A 3wdmC-2ghiA:
undetectable		 3wdmC-2ghiA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idx COB(I)YRINIC ACID
A,C-DIAMIDE
ADENOSYLTRANSFERASE

(Homo sapiens) 		PF01923
(Cob_adeno_trans) 		5 ALA A  95
GLY A  97
LEU A 121
LEU A 100
ILE A 117
 None
 1.21A 3wdmC-2idxA:
undetectable		 3wdmC-2idxA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		5 ALA A 815
GLY A 817
LEU A 799
LEU A 820
ASN A 822
 None
 1.10A 3wdmC-2j7nA:
undetectable		 3wdmC-2j7nA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 ALA A 105
LEU A 112
LEU A 122
ASP A 121
ILE A 117
 None
 1.11A 3wdmC-2j8kA:
undetectable		 3wdmC-2j8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3n TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 ALA A  99
GLY A 101
LEU A 126
LEU A  72
LEU A 104
 None
 1.16A 3wdmC-2k3nA:
undetectable		 3wdmC-2k3nA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mu3 ACINIFORM SPIDROIN 1

(Argiope
trifasciata) 		PF12042
(RP1-2) 		5 ALA A   9
LEU A 117
LEU A 108
ASN A 104
ILE A 105
 None
 1.18A 3wdmC-2mu3A:
undetectable		 3wdmC-2mu3A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 ALA C 144
LEU C 154
LEU C 142
LEU C 134
ILE C 175
 None
 1.18A 3wdmC-2nn3C:
3.7		 3wdmC-2nn3C:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 GLY A 343
LEU A 338
LEU A  42
ASN A  16
ILE A  31
 None
 1.19A 3wdmC-2o5vA:
undetectable		 3wdmC-2o5vA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 ALA A 131
GLY A 133
LEU A 149
LEU A 137
ASP A 138
 None
 1.22A 3wdmC-2pgsA:
undetectable		 3wdmC-2pgsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A   9
GLY A  13
LEU A  46
LEU A  32
LEU A  16
 None
 1.01A 3wdmC-2pwzA:
3.4		 3wdmC-2pwzA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 204
LEU A 208
LEU A 333
ASN A 336
ILE A 240
 None
 1.20A 3wdmC-2q27A:
11.3		 3wdmC-2q27A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw6 AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		5 ALA A 304
GLY A 309
LEU A 317
LEU A 310
ILE A 275
 None
 1.19A 3wdmC-2qw6A:
undetectable		 3wdmC-2qw6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 ALA A 238
GLY A 204
LEU A 224
LEU A 180
ILE A 235
 None
 1.07A 3wdmC-2w9mA:
undetectable		 3wdmC-2w9mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ALA A 351
GLY A 354
LEU A 346
LEU A 355
ILE A 357
 None
 1.18A 3wdmC-2wd9A:
1.8		 3wdmC-2wd9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 GLY A 910
LEU A 983
ASP A 930
ASN A 913
ILE A 916
 None
 1.17A 3wdmC-3asiA:
undetectable		 3wdmC-3asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 ALA A 353
GLY A 377
LEU A 311
LEU A 390
LEU A 378
 None
 1.19A 3wdmC-3caiA:
2.6		 3wdmC-3caiA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A  55
LEU A  45
LEU A 328
LEU A  51
ILE A  49
 None
 1.21A 3wdmC-3cmuA:
undetectable		 3wdmC-3cmuA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A2055
LEU A2045
LEU A2328
LEU A2051
ILE A2049
 None
 1.19A 3wdmC-3cmuA:
undetectable		 3wdmC-3cmuA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLY A4055
LEU A4045
LEU A4328
LEU A4051
ILE A4049
 None
 1.22A 3wdmC-3cmuA:
undetectable		 3wdmC-3cmuA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		5 ALA A  50
LEU A  93
LEU A  19
LEU A  47
ILE A  17
 None
 1.20A 3wdmC-3cn7A:
undetectable		 3wdmC-3cn7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		5 ALA A  22
GLY A 250
LEU A 245
LEU A 275
ASN A 276
 None
 1.21A 3wdmC-3cq0A:
undetectable		 3wdmC-3cq0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 ALA A 321
GLY A 323
LEU A 113
LEU A 326
ILE A  84
 None
 1.06A 3wdmC-3hutA:
3.3		 3wdmC-3hutA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwp TRANSCRIPTIONAL
REGULATORY PROTEIN
SIR2 HOMOLOGUE

(Plasmodium
falciparum) 		PF02146
(SIR2) 		5 ALA A 251
LEU A 196
LEU A  91
ASN A  86
ILE A 198
 None
 1.18A 3wdmC-3jwpA:
9.7		 3wdmC-3jwpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khf MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A1027
LEU A1032
LEU A1023
ASN A1007
ILE A1006
 None
 1.19A 3wdmC-3khfA:
undetectable		 3wdmC-3khfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 203
LEU A 157
ASP A 210
ASN A 208
ILE A 212
 None
 1.21A 3wdmC-3lm5A:
undetectable		 3wdmC-3lm5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1

(Bos taurus) 		PF00481
(PP2C) 		5 ALA A 203
GLY A  70
LEU A 165
LEU A  88
ILE A  92
 None
 1.13A 3wdmC-3mq3A:
undetectable		 3wdmC-3mq3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ALA A   6
LEU A 181
LEU A  38
LEU A  86
ILE A 156
 None
 1.08A 3wdmC-3n05A:
undetectable		 3wdmC-3n05A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		5 ALA A 103
LEU A 141
LEU A 160
ASN A 161
ILE A 152
 None
 1.09A 3wdmC-3or2A:
undetectable		 3wdmC-3or2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		5 ALA A 220
GLY A 222
LEU A 196
LEU A 225
ILE A 193
 None
 1.20A 3wdmC-3pf0A:
undetectable		 3wdmC-3pf0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 ALA A  67
LEU A  55
LEU A  43
ASP A  36
ILE A  46
 None
None
None
EDO  A 315 ( 4.7A)
None
 1.21A 3wdmC-3qatA:
undetectable		 3wdmC-3qatA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLY A 309
LEU A 353
LEU A 349
ASN A 348
ILE A 352
 None
 1.06A 3wdmC-3rr5A:
undetectable		 3wdmC-3rr5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		5 ALA X2013
LEU X1710
LEU X2009
LEU X1734
ILE X1714
 None
 1.05A 3wdmC-3su8X:
undetectable		 3wdmC-3su8X:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ALA A 246
GLY A 291
LEU A 260
ASP A 293
LEU A 292
 MG  A 431 ( 4.8A)
None
None
None
None
 1.12A 3wdmC-3uj2A:
undetectable		 3wdmC-3uj2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 148
LEU A 230
LEU A 247
ASP A 243
ILE A 232
 None
 0.88A 3wdmC-3v9aA:
undetectable		 3wdmC-3v9aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		5 GLY A 293
LEU A 127
LEU A 324
ASN A 140
ILE A 123
 None
None
None
K  A2001 (-4.2A)
None
 1.19A 3wdmC-3w1jA:
3.1		 3wdmC-3w1jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A  99
GLY A  10
ASN A  15
ASN A  43
ILE A  34
 NAD  A1001 (-4.9A)
NAD  A1001 (-3.1A)
None
None
None
 1.22A 3wdmC-3zdfA:
3.5		 3wdmC-3zdfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg1 NICKEL AND COBALT
RESISTANCE PROTEIN
CNRR

(Cupriavidus
metallidurans) 		PF13801
(Metal_resist) 		5 ALA A 142
GLY A 146
LEU A 117
LEU A  41
ASP A  40
 None
 1.11A 3wdmC-3zg1A:
undetectable		 3wdmC-3zg1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 357
GLY A 265
LEU A 354
LEU A 209
ASN A 208
 None
 1.13A 3wdmC-4ay1A:
undetectable		 3wdmC-4ay1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 141
LEU A 227
LEU A 166
ASN A 174
ILE A 201
 None
None
None
CL  A1418 (-4.4A)
None
 1.00A 3wdmC-4bf5A:
undetectable		 3wdmC-4bf5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A   9
GLY A  13
LEU A  46
LEU A  32
LEU A  16
 None
 1.02A 3wdmC-4e0bA:
3.8		 3wdmC-4e0bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 ALA A 489
LEU A 561
LEU A 514
LEU A 498
ILE A 548
 None
 1.08A 3wdmC-4fgmA:
undetectable		 3wdmC-4fgmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdn PROTEIN FLP

(Staphylococcus
aureus) 		PF00144
(Beta-lactamase) 		5 ALA A 312
GLY A 314
LEU A 107
LEU A 145
ILE A 106
 None
 1.12A 3wdmC-4gdnA:
undetectable		 3wdmC-4gdnA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A 211
GLY A  98
LEU A  46
LEU A 216
ILE A 228
 None
CME  A 102 ( 3.4A)
None
None
None
 1.18A 3wdmC-4ha6A:
undetectable		 3wdmC-4ha6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ho4 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Aneurinibacillus
thermoaerophilus) 		PF00483
(NTP_transferase) 		5 GLY A 172
LEU A  41
ASP A 108
LEU A 106
ILE A   5
 G1P  A 301 ( 4.2A)
None
THM  A 302 (-3.5A)
THM  A 302 (-4.2A)
None
 1.22A 3wdmC-4ho4A:
undetectable		 3wdmC-4ho4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  12
GLY A  16
LEU A  56
LEU A  39
LEU A  19
 NAD  A 400 ( 4.0A)
None
None
None
None
 1.17A 3wdmC-4i1iA:
3.8		 3wdmC-4i1iA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		5 GLY A 210
LEU A  10
LEU A 291
ASP A 262
LEU A 209
 None
 1.00A 3wdmC-4kryA:
undetectable		 3wdmC-4kryA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyz DESIGNED PROTEIN
OR327

(synthetic
construct) 		no annotation 5 GLY A 160
LEU A  36
LEU A  74
ASN A  77
ILE A  40
 None
 1.20A 3wdmC-4kyzA:
undetectable		 3wdmC-4kyzA:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		9 ALA A  36
GLY A  40
LEU A  83
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
 ATP  A 301 (-3.3A)
ATP  A 301 (-3.4A)
None
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
 0.13A 3wdmC-4mb2A:
42.8		 3wdmC-4mb2A:
90.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN

(Pseudomonas
aeruginosa) 		PF03480
(DctP) 		5 ALA A 286
GLY A 288
LEU A 284
ASP A 222
ILE A 228
 None
 1.19A 3wdmC-4nf0A:
undetectable		 3wdmC-4nf0A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1r REPLICATIVE DNA
HELICASE

(Nostoc
punctiforme) 		PF14890
(Intein_splicing) 		5 ALA A  69
LEU A  87
LEU A  59
ASN A 133
ILE A 108
 None
 1.20A 3wdmC-4o1rA:
undetectable		 3wdmC-4o1rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqz PUTATIVE
OXIDOREDUCTASE YFJR

(Streptomyces
aurantiacus) 		PF03446
(NAD_binding_2) 		5 ALA A 166
GLY A 116
LEU A 119
LEU A  91
ASN A  90
 None
 1.19A 3wdmC-4oqzA:
4.2		 3wdmC-4oqzA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rni MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ALA A  78
LEU A 117
LEU A  75
ASN A  98
ILE A 113
 None
 1.21A 3wdmC-4rniA:
undetectable		 3wdmC-4rniA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  15
GLY A  19
LEU A  59
LEU A  42
LEU A  22
 NA  A 412 ( 4.9A)
None
None
None
None
 1.10A 3wdmC-4tvoA:
3.9		 3wdmC-4tvoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  13
GLY A  17
LEU A  56
LEU A  39
LEU A  20
 None
 1.16A 3wdmC-4uulA:
4.2		 3wdmC-4uulA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  13
GLY A  17
LEU A  56
LEU A  39
LEU A  20
 NAI  A 345 ( 4.2A)
None
None
None
None
 1.18A 3wdmC-4uupA:
3.9		 3wdmC-4uupA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 ALA A 121
LEU A  17
LEU A  34
ASN A  46
ILE A  89
 None
CSO  A  16 ( 4.5A)
None
GAL  A 201 (-4.4A)
CSO  A  88 ( 3.8A)
 1.14A 3wdmC-4y1yA:
undetectable		 3wdmC-4y1yA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG

(Bacillus
subtilis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ALA A 307
GLY A 287
LEU A 302
LEU A 288
ASN A 289
 None
 1.12A 3wdmC-4yxtA:
undetectable		 3wdmC-4yxtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		5 ALA A  30
GLY A  16
LEU A  73
LEU A  26
ILE A  20
 None
 1.00A 3wdmC-4z1aA:
undetectable		 3wdmC-4z1aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 ALA A 236
LEU A 226
LEU A 213
ASN A 239
ILE A 198
 None
 1.21A 3wdmC-4z61A:
undetectable		 3wdmC-4z61A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 GLY A 212
LEU A 218
LEU A 237
LEU A 211
ILE A 198
 None
 1.06A 3wdmC-4z61A:
undetectable		 3wdmC-4z61A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		5 GLY A 292
LEU A 309
ASP A 301
ASN A 294
ILE A 306
 None
 1.05A 3wdmC-4zdaA:
undetectable		 3wdmC-4zdaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqt PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRMBL2

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 ALA A 206
LEU A 188
LEU A 204
LEU A 152
ILE A 193
 None
 1.14A 3wdmC-5bqtA:
undetectable		 3wdmC-5bqtA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A 318
LEU A 127
LEU A 345
ASP A 341
ASN A 314
 None
 1.09A 3wdmC-5cefA:
3.0		 3wdmC-5cefA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqe MATRIX PROTEIN 1

(Influenza A
virus) 		PF00598
(Flu_M1) 		5 ALA A 123
LEU A 146
LEU A  84
ASN A  85
ILE A 131
 None
 1.22A 3wdmC-5cqeA:
undetectable		 3wdmC-5cqeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 5 ALA Y 399
GLY Y 368
LEU Y 420
ASP Y 412
ILE Y 415
 None
 1.10A 3wdmC-5gaiY:
undetectable		 3wdmC-5gaiY:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 ALA A 198
LEU A 258
LEU A 223
LEU A 188
ILE A 308
 None
 1.15A 3wdmC-5ggyA:
undetectable		 3wdmC-5ggyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 ALA A 193
LEU A 277
LEU A 166
LEU A 225
ASN A 226
 None
 1.21A 3wdmC-5ixdA:
undetectable		 3wdmC-5ixdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 ALA A 400
GLY A 485
LEU A 406
LEU A 396
ASN A 456
 None
 1.16A 3wdmC-5j84A:
undetectable		 3wdmC-5j84A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 ALA A  61
GLY A  34
LEU A 104
LEU A  27
ILE A  25
 None
 1.16A 3wdmC-5kreA:
undetectable		 3wdmC-5kreA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 GLY A 292
LEU A 309
ASP A 301
ASN A 294
ILE A 306
 None
 1.15A 3wdmC-5kvuA:
undetectable		 3wdmC-5kvuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 GLY B 678
LEU B 702
LEU B 675
ASP B 645
ILE B 681
 None
 1.19A 3wdmC-5l9wB:
undetectable		 3wdmC-5l9wB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 GLY A 113
LEU A  72
LEU A 112
ASN A 111
ILE A 240
 None
 1.13A 3wdmC-5lu4A:
undetectable		 3wdmC-5lu4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1x B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		5 ALA D 109
GLY D  82
LEU D  97
ASN D 101
ILE D 102
 None
 1.09A 3wdmC-5n1xD:
undetectable		 3wdmC-5n1xD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 ALA A  69
GLY A  72
LEU A 199
LEU A 250
ILE A 242
 None
 1.11A 3wdmC-5n4lA:
undetectable		 3wdmC-5n4lA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 5 GLY A 321
LEU A 335
LEU A 275
ASN A 293
ILE A 297
 None
 1.17A 3wdmC-5nxkA:
undetectable		 3wdmC-5nxkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td8 KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25

(Saccharomyces
cerevisiae) 		PF08286
(Spc24)
no annotation 		5 ALA D 207
GLY C 169
LEU D 145
LEU C 211
ILE C 207
 None
 1.16A 3wdmC-5td8D:
undetectable		 3wdmC-5td8D:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A   8
LEU A  27
LEU A  49
LEU A  11
ILE A  21
 None
 1.19A 3wdmC-5tx7A:
undetectable		 3wdmC-5tx7A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdr RAS PROTEIN

(Choanoflagellida) 		PF00071
(Ras) 		5 ALA A 130
LEU A 113
LEU A  90
ASP A  91
ILE A  93
 None
 1.15A 3wdmC-5wdrA:
undetectable		 3wdmC-5wdrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 ALA A 350
GLY A 258
LEU A 347
LEU A 204
ASN A 203
 None
 1.18A 3wdmC-5xepA:
undetectable		 3wdmC-5xepA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 ALA A 210
LEU A 191
LEU A 214
ASN A 224
ILE A 231
 None
 1.16A 3wdmC-5ykbA:
undetectable		 3wdmC-5ykbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 5 ALA A  41
GLY A 185
ASP A 181
LEU A 184
ASN A 183
 None
 1.19A 3wdmC-6b2vA:
undetectable		 3wdmC-6b2vA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 5 ALA A1009
GLY A 724
LEU A 861
LEU A 694
ILE A 747
 None
 1.17A 3wdmC-6egtA:
undetectable		 3wdmC-6egtA:
18.80