SIMILAR PATTERNS OF AMINO ACIDS FOR 3WDM_A_ADNA901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ALA A 227
GLY A 409
ASP A 231
LEU A 408
ILE A 209
 ATP  A 500 ( 3.7A)
ATP  A 500 (-3.3A)
None
None
None
 1.32A 3wdmA-1b8aA:
undetectable		 3wdmA-1b8aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqo DEHYDROQUINASE

(Bacillus
subtilis) 		PF01220
(DHquinase_II) 		5 ALA A 128
LEU A  34
LEU A  27
ASN A   7
ILE A   5
 None
 1.32A 3wdmA-1gqoA:
2.6		 3wdmA-1gqoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 355
GLY A 263
LEU A 352
LEU A 209
ASN A 208
 None
 1.14A 3wdmA-1hkkA:
undetectable		 3wdmA-1hkkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 ALA A  18
GLY A  86
LEU A  12
ASN A   5
ILE A   4
 None
 1.18A 3wdmA-1i2lA:
undetectable		 3wdmA-1i2lA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA B 537
ARG B  25
GLY B  20
ASN B 691
ILE B 756
 None
 1.32A 3wdmA-1n60B:
undetectable		 3wdmA-1n60B:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF14681
(UPRTase) 		5 ALA A 135
ARG A 104
GLY A 137
ASP A 131
ILE A 179
 U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
U5P  A 600 (-3.6A)
U5P  A 600 ( 3.9A)
None
 1.28A 3wdmA-1o5oA:
2.3		 3wdmA-1o5oA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		5 ALA A 305
ASP A 300
LEU A 298
ASN A 359
ILE A 351
 None
 1.47A 3wdmA-1pxyA:
undetectable		 3wdmA-1pxyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A  34
GLY A  38
LEU A 344
ASN A 346
ILE A 211
 None
None
None
None
PLP  A 358 (-3.9A)
 1.26A 3wdmA-1rcqA:
undetectable		 3wdmA-1rcqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 ARG C 207
LEU C 197
LEU C 209
ASN C 210
ILE C 178
 None
 1.42A 3wdmA-1sxjC:
undetectable		 3wdmA-1sxjC:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhr SWI/SNF RELATED,
MATRIX ASSOCIATED,
ACTIN DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
D MEMBER 1

(Mus musculus) 		PF02201
(SWIB) 		5 ARG A  20
GLY A  23
LEU A  14
LEU A  22
ILE A  32
 None
 1.31A 3wdmA-1uhrA:
undetectable		 3wdmA-1uhrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 357
GLY A 263
LEU A 354
LEU A 209
ASN A 208
 None
 1.15A 3wdmA-1wb0A:
undetectable		 3wdmA-1wb0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 ALA A 343
GLY A 257
LEU A 340
LEU A 204
ASN A 203
 None
 1.19A 3wdmA-1wnoA:
undetectable		 3wdmA-1wnoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 370
LEU A  19
LEU A  29
ASN A  27
ILE A 282
 None
CME  A  20 ( 4.2A)
None
CME  A 373 (-3.7A)
None
 1.33A 3wdmA-1wz9A:
undetectable		 3wdmA-1wz9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF

(Escherichia
coli) 		PF00899
(ThiF) 		5 ALA 1  44
GLY 1  40
LEU 1 123
LEU 1  39
ILE 1 147
 None
 1.44A 3wdmA-1zud1:
undetectable		 3wdmA-1zud1:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 ALA A 680
GLY A 682
LEU A 685
ASN A 684
ILE A 700
 None
 1.47A 3wdmA-2a3lA:
undetectable		 3wdmA-2a3lA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aan AURACYANIN A

(Chloroflexus
aurantiacus) 		PF00127
(Copper-bind) 		5 ALA A  80
LEU A  87
LEU A 100
ASN A  59
ILE A  61
 None
 1.30A 3wdmA-2aanA:
undetectable		 3wdmA-2aanA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 273
LEU A 236
ASP A 217
ASN A 219
ILE A 234
 None
NAD  A1403 (-4.7A)
NAD  A1403 (-2.9A)
None
None
 1.23A 3wdmA-2dphA:
2.4		 3wdmA-2dphA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2emq HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00571
(CBS) 		5 ARG A  91
GLY A  58
LEU A  59
ASN A  90
ILE A  47
 None
 1.02A 3wdmA-2emqA:
undetectable		 3wdmA-2emqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ARG A 260
GLY A 259
LEU A  56
LEU A 258
ILE A 326
 None
 1.26A 3wdmA-2eo5A:
3.2		 3wdmA-2eo5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 ALA A 465
LEU A 177
LEU A 170
ASN A  97
ILE A 145
 None
 1.13A 3wdmA-2et6A:
3.2		 3wdmA-2et6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzk CYANOVIRIN-N HOMOLOG

(Tuber borchii) 		PF08881
(CVNH) 		5 GLY A  16
LEU A  37
ASP A  36
ASN A  14
ILE A  41
 None
 1.35A 3wdmA-2jzkA:
undetectable		 3wdmA-2jzkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mu3 ACINIFORM SPIDROIN 1

(Argiope
trifasciata) 		PF12042
(RP1-2) 		5 ALA A   9
GLY A  11
LEU A 117
ASN A 104
ILE A 105
 None
 1.38A 3wdmA-2mu3A:
undetectable		 3wdmA-2mu3A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mu3 ACINIFORM SPIDROIN 1

(Argiope
trifasciata) 		PF12042
(RP1-2) 		5 ALA A   9
LEU A 117
LEU A 108
ASN A 104
ILE A 105
 None
 1.18A 3wdmA-2mu3A:
undetectable		 3wdmA-2mu3A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00531
(Death) 		5 ALA H 840
LEU H 836
LEU H 793
ASN H 791
ILE H 832
 None
 1.40A 3wdmA-2of5H:
undetectable		 3wdmA-2of5H:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 204
LEU A 208
LEU A 333
ASN A 336
ILE A 240
 None
 1.24A 3wdmA-2q27A:
11.3		 3wdmA-2q27A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 ALA A 497
GLY A 464
LEU A 424
LEU A 463
ILE A 420
 None
 1.47A 3wdmA-2qk2A:
undetectable		 3wdmA-2qk2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF07992
(Pyr_redox_2) 		5 LEU A   7
ASP A 104
LEU A 105
ASN A 271
ILE A   9
 None
 1.28A 3wdmA-2v3bA:
undetectable		 3wdmA-2v3bA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xc7 PHOSPHORYLATED
ADAPTER RNA EXPORT
PROTEIN

(Homo sapiens) 		PF10258
(RNA_GG_bind) 		5 ARG A  64
GLY A  68
LEU A  19
LEU A  71
ASN A  72
 None
U  P 601 ( 3.6A)
None
A  P 600 ( 3.2A)
None
 1.36A 3wdmA-2xc7A:
undetectable		 3wdmA-2xc7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		5 ALA A  31
GLY A  39
LEU A 299
LEU A  38
ILE A  15
 None
 1.32A 3wdmA-2z6iA:
undetectable		 3wdmA-2z6iA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 ALA A 219
GLY A 223
LEU A 336
LEU A 226
ASN A 225
 None
 1.42A 3wdmA-3aq0A:
undetectable		 3wdmA-3aq0A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 GLY A 910
LEU A 983
ASN A 913
ASN A 908
ILE A 916
 None
 1.40A 3wdmA-3asiA:
undetectable		 3wdmA-3asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 GLY A 910
LEU A 983
ASP A 930
ASN A 913
ILE A 916
 None
 1.21A 3wdmA-3asiA:
undetectable		 3wdmA-3asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0c CENTROMERE PROTEIN W

(Gallus gallus) 		PF15510
(CENP-W) 		5 GLY W   8
LEU W  23
ASP W  28
LEU W  10
ILE W  14
 None
 1.45A 3wdmA-3b0cW:
undetectable		 3wdmA-3b0cW:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		5 ALA A 276
ARG A 279
GLY A 278
LEU A 281
ILE A 101
 None
 0.99A 3wdmA-3bwxA:
undetectable		 3wdmA-3bwxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzm HYPOTHETICAL
CONSERVED PROTEIN

(Thermus
thermophilus) 		no annotation 5 ALA A 137
ARG A 135
GLY A 148
LEU A 146
LEU A 201
 None
 1.12A 3wdmA-3dzmA:
undetectable		 3wdmA-3dzmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 ALA A 343
GLY A 345
LEU A 305
ASN A 738
ILE A 746
 None
 1.46A 3wdmA-3eqnA:
undetectable		 3wdmA-3eqnA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ARG A 393
GLY A 392
LEU A  47
ASN A  45
ILE A 301
 None
 1.38A 3wdmA-3fgqA:
undetectable		 3wdmA-3fgqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 392
LEU A  37
LEU A  47
ASN A  45
ILE A 301
 None
 1.38A 3wdmA-3fgqA:
undetectable		 3wdmA-3fgqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 255
ARG A 249
GLY A 253
LEU A 259
LEU A 252
 None
 1.39A 3wdmA-3fk5A:
undetectable		 3wdmA-3fk5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		5 ALA A 296
ARG A 481
GLY A 484
LEU A 483
ILE A 282
 None
 1.15A 3wdmA-3hjbA:
2.6		 3wdmA-3hjbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 ALA A 350
ARG A 437
GLY A 352
LEU A 347
ILE A 358
 None
 1.37A 3wdmA-3if2A:
2.0		 3wdmA-3if2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		5 ALA A  94
ARG A  98
LEU A  92
ASP A  43
ILE A 108
 None
 1.34A 3wdmA-3jx9A:
6.3		 3wdmA-3jx9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN

(Salmonella
enterica) 		PF01380
(SIS) 		5 ALA A  49
LEU A  36
LEU A 153
ASN A 149
ILE A  34
 None
 1.44A 3wdmA-3knzA:
8.2		 3wdmA-3knzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 ALA A  35
ARG A  38
GLY A  37
LEU A 293
LEU A  27
 None
None
None
PHE  A 400 (-4.1A)
None
 1.47A 3wdmA-3td9A:
3.6		 3wdmA-3td9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		5 ALA A  81
GLY A  85
ASP A  88
ASN A 106
ILE A 107
 None
 1.26A 3wdmA-3un6A:
undetectable		 3wdmA-3un6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 ALA A 122
ARG A  64
LEU A 120
ASN A  62
ILE A  86
 None
 1.38A 3wdmA-3vm7A:
undetectable		 3wdmA-3vm7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 ALA A 122
ARG A  64
LEU A 120
LEU A  66
ASN A  62
 None
 1.35A 3wdmA-3vm7A:
undetectable		 3wdmA-3vm7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbi TRAF PROTEIN

(Escherichia
coli) 		PF03743
(TrbI) 		5 GLY A 835
LEU A 755
ASP A 756
LEU A 877
ILE A 791
 None
 1.43A 3wdmA-3zbiA:
undetectable		 3wdmA-3zbiA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A  99
GLY A  10
ASN A  15
ASN A  43
ILE A  34
 NAD  A1001 (-4.9A)
NAD  A1001 (-3.1A)
None
None
None
 1.21A 3wdmA-3zdfA:
2.3		 3wdmA-3zdfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 ALA A 357
GLY A 265
LEU A 354
LEU A 209
ASN A 208
 None
 1.12A 3wdmA-4ay1A:
undetectable		 3wdmA-4ay1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		5 ALA A  93
GLY A  89
LEU A  61
ASN A  57
ILE A  55
 None
 1.28A 3wdmA-4b0tA:
undetectable		 3wdmA-4b0tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		5 ALA A 195
GLY A 197
ASP A 201
LEU A 200
ILE A 203
 None
 1.39A 3wdmA-4bwcA:
undetectable		 3wdmA-4bwcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ALA A 439
GLY A 418
LEU A  23
LEU A 421
ILE A 436
 None
 1.37A 3wdmA-4cakA:
undetectable		 3wdmA-4cakA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ALA A  93
ARG A  66
GLY A  37
LEU A  38
ILE A  97
 None
 1.11A 3wdmA-4cjxA:
2.2		 3wdmA-4cjxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjx C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC,
PUTATIVE

(Trypanosoma
brucei) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ARG A  66
GLY A  37
LEU A  88
LEU A  38
ILE A  97
 None
 1.27A 3wdmA-4cjxA:
2.2		 3wdmA-4cjxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyd PROBABLE
TRANSCRIPTION
REGULATOR

(Corynebacterium
glutamicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ARG A 204
GLY A 205
LEU A 222
ASP A 218
ILE A 216
 None
 1.40A 3wdmA-4cydA:
undetectable		 3wdmA-4cydA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn9 ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Chloroflexus
aurantiacus) 		PF03992
(ABM) 		5 ALA A  71
GLY A  75
LEU A  22
LEU A  78
ILE A  47
 None
DIO  A 200 ( 4.9A)
None
None
None
 1.46A 3wdmA-4dn9A:
undetectable		 3wdmA-4dn9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ALA A 311
ARG A  81
GLY A  82
LEU A  83
ILE A  97
 None
 1.28A 3wdmA-4dykA:
undetectable		 3wdmA-4dykA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6w CLBP PEPTIDASE

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		5 ALA A 179
GLY A 149
LEU A 138
LEU A 150
ASN A 190
 None
 1.46A 3wdmA-4e6wA:
undetectable		 3wdmA-4e6wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 ALA A  81
GLY A  79
LEU A  75
ASN A  74
ILE A 211
 None
 1.38A 3wdmA-4eb5A:
3.0		 3wdmA-4eb5A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 ALA A  31
GLY A  27
LEU A  21
ASN A  54
ILE A 117
 None
 1.47A 3wdmA-4ei8A:
3.6		 3wdmA-4ei8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 ALA A 301
ARG A 353
GLY A 351
LEU A 355
ASN A 128
 None
NOS  A 502 (-4.4A)
None
None
None
 1.17A 3wdmA-4f0sA:
undetectable		 3wdmA-4f0sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 ALA A 309
ARG A  79
GLY A  80
LEU A  81
ILE A  95
 None
None
None
None
NOS  A 501 (-4.2A)
 1.46A 3wdmA-4f0sA:
undetectable		 3wdmA-4f0sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 ALA A  49
GLY A  51
LEU A 118
LEU A 114
ILE A 107
 None
 1.41A 3wdmA-4gu7A:
undetectable		 3wdmA-4gu7A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 ALA A 417
ARG A 420
LEU A 371
LEU A 422
ILE A 383
 None
 1.11A 3wdmA-4hz8A:
undetectable		 3wdmA-4hz8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		5 ALA A 317
GLY A 312
LEU A 402
ASN A 342
ILE A 385
 None
 1.43A 3wdmA-4ikvA:
undetectable		 3wdmA-4ikvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhr G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF02188
(GoLoco)
PF13176
(TPR_7)
PF13424
(TPR_12) 		5 ALA A 193
ARG A 196
GLY A 195
LEU A 182
ASN A 200
 None
 1.15A 3wdmA-4jhrA:
undetectable		 3wdmA-4jhrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 5 ALA D 183
ARG D 100
GLY D 155
ASN D 157
ILE D 158
 None
 1.13A 3wdmA-4jrmD:
undetectable		 3wdmA-4jrmD:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		5 GLY A 258
LEU A 153
ASN A  76
ASN A 236
ILE A 235
 None
 1.42A 3wdmA-4km3A:
undetectable		 3wdmA-4km3A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ALA A 943
GLY A 941
LEU A 945
LEU A 940
ASN A 939
 None
 1.46A 3wdmA-4knhA:
undetectable		 3wdmA-4knhA:
13.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		9 ALA A  36
ARG A  39
GLY A  40
LEU A 161
ASP A 181
LEU A 182
ASN A 183
ASN A 199
ILE A 200
 ATP  A 301 (-3.3A)
ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
ATP  A 301 (-3.9A)
ATP  A 301 (-2.7A)
ATP  A 301 (-3.8A)
None
ATP  A 301 (-3.0A)
ATP  A 301 (-4.3A)
 0.15A 3wdmA-4mb2A:
43.2		 3wdmA-4mb2A:
90.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		5 ARG A  39
GLY A  40
LEU A 182
ASN A 183
ILE A 180
 ATP  A 301 (-3.2A)
ATP  A 301 (-3.4A)
ATP  A 301 (-3.8A)
None
None
 1.26A 3wdmA-4mb2A:
43.2		 3wdmA-4mb2A:
90.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ARG A 387
LEU A 362
LEU A 389
ASN A 388
ILE A 356
 None
None
None
NAG  A 907 (-1.6A)
None
 1.29A 3wdmA-4mn8A:
undetectable		 3wdmA-4mn8A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf0 PROBABLE
C4-DICARBOXYLATE-BIN
DING PROTEIN

(Pseudomonas
aeruginosa) 		PF03480
(DctP) 		5 ALA A 286
GLY A 288
LEU A 284
ASP A 222
ILE A 228
 None
 1.21A 3wdmA-4nf0A:
undetectable		 3wdmA-4nf0A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		5 GLY Y  34
LEU Y  31
ASP Y  30
ASN Y  38
ILE Y  54
 SFG  Y 301 (-3.1A)
None
SFG  Y 301 ( 4.7A)
SFG  Y 301 ( 4.5A)
None
 1.20A 3wdmA-4ox9Y:
undetectable		 3wdmA-4ox9Y:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ALA C  63
GLY C  65
ASP A 851
LEU A 849
ILE A 846
 None
 1.40A 3wdmA-4qiwC:
undetectable		 3wdmA-4qiwC:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ALA A 223
GLY A 225
LEU A 221
ASN A 254
ILE A 230
 None
 1.39A 3wdmA-4wqmA:
2.3		 3wdmA-4wqmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		5 ALA A 326
LEU A 328
LEU A 323
ASN A 225
ILE A 226
 None
None
None
None
HEC  A 403 ( 4.5A)
 1.46A 3wdmA-4y5rA:
undetectable		 3wdmA-4y5rA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9g MANGANESE SUPEROXIDE
DISMUTASE

(Sphingobacterium
spiritivorum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ALA A 126
GLY A 161
LEU A  78
ASN A  75
ILE A 159
 None
 1.47A 3wdmA-5a9gA:
undetectable		 3wdmA-5a9gA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 ALA E 442
ARG E 443
GLY E 444
LEU E 425
ILE E 430
 None
 1.47A 3wdmA-5b04E:
undetectable		 3wdmA-5b04E:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		5 ALA B 392
ARG B 395
GLY B 371
ASN B 201
ILE B 228
 None
 1.26A 3wdmA-5ccxB:
undetectable		 3wdmA-5ccxB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d76 PUTATIVE PHAGE LYSIN

(Streptococcus
phage phi7917) 		PF05257
(CHAP)
PF08460
(SH3_5) 		5 ALA A  47
GLY A  50
LEU A  45
ASN A  70
ILE A  60
 None
None
None
CL  A 301 (-4.2A)
None
 1.37A 3wdmA-5d76A:
undetectable		 3wdmA-5d76A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d76 PUTATIVE PHAGE LYSIN

(Streptococcus
phage phi7917) 		PF05257
(CHAP)
PF08460
(SH3_5) 		5 ALA A  47
GLY A  50
LEU A  45
ASN A  70
ILE A  65
 None
None
None
CL  A 301 (-4.2A)
None
 1.37A 3wdmA-5d76A:
undetectable		 3wdmA-5d76A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 ALA A 570
LEU A 345
ASP A 178
ASN A 180
ILE A 176
 None
 1.19A 3wdmA-5e31A:
undetectable		 3wdmA-5e31A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		5 GLY A 515
LEU A 520
LEU A 516
ASN A 542
ILE A 539
 None
 1.22A 3wdmA-5e3cA:
undetectable		 3wdmA-5e3cA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 5 ALA B 424
ARG B 427
GLY B 426
ASN B 430
ILE B 377
 None
 1.33A 3wdmA-5e9uB:
4.9		 3wdmA-5e9uB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 ALA A  71
GLY A  73
LEU A  69
ASP A 293
ILE A  49
 None
None
None
MG  A 408 (-2.6A)
None
 1.24A 3wdmA-5esrA:
2.2		 3wdmA-5esrA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ARG A 822
LEU A 668
ASP A 764
LEU A 820
ASN A 821
 None
 1.46A 3wdmA-5fjiA:
undetectable		 3wdmA-5fjiA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn6 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF00041
(fn3)
PF12567
(CD45) 		5 ALA A 244
LEU A 242
LEU A 220
ASN A 219
ILE A 193
 None
None
None
NAG  A1265 (-4.0A)
None
 1.44A 3wdmA-5fn6A:
undetectable		 3wdmA-5fn6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgp NITRATE/NITRITE
SENSOR PROTEIN NARQ

(Escherichia
coli) 		PF00672
(HAMP)
PF13675
(PilJ) 		5 GLY A 209
LEU A 200
ASP A 201
LEU A 204
ASN A 203
 None
 1.33A 3wdmA-5jgpA:
undetectable		 3wdmA-5jgpA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0w CLASS B
CARBAPENEMASE GOB-18

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		5 ALA A 106
GLY A  69
LEU A  52
ASN A  67
ILE A  76
 None
 1.40A 3wdmA-5k0wA:
undetectable		 3wdmA-5k0wA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ARG A 269
GLY A 183
LEU A 181
LEU A 294
ILE A 321
 None
 1.34A 3wdmA-5l3rA:
undetectable		 3wdmA-5l3rA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1b MTRE
PROTEIN,FERRITIN
CHIMERA

(Helicobacter
pylori;
Neisseria
gonorrhoeae) 		no annotation 5 GLY A 150
ASP A 155
LEU A 151
ASN A 146
ILE A 141
 None
 1.46A 3wdmA-5u1bA:
undetectable		 3wdmA-5u1bA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v38 HCHA

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 ARG A1132
GLY A1130
LEU A1128
ASP A1110
ASN A1112
 None
 1.47A 3wdmA-5v38A:
undetectable		 3wdmA-5v38A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		5 ALA A1163
GLY A1291
LEU A1168
ASN A1287
ILE A1278
 U  H   3 ( 3.3A)
U  H   1 ( 3.6A)
None
None
None
 1.41A 3wdmA-5w0mA:
undetectable		 3wdmA-5w0mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 ALA A 350
GLY A 258
LEU A 347
LEU A 204
ASN A 203
 None
 1.18A 3wdmA-5xepA:
undetectable		 3wdmA-5xepA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbb -

(-) 		no annotation 5 ARG A 468
GLY A 467
LEU A  12
ASN A 469
ILE A 114
 None
 1.19A 3wdmA-5zbbA:
undetectable		 3wdmA-5zbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 5 ALA A  41
GLY A 185
ASP A 181
LEU A 184
ASN A 183
 None
 1.18A 3wdmA-6b2vA:
undetectable		 3wdmA-6b2vA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 5 ALA A  18
GLY A  86
LEU A  12
ASN A   5
ILE A   4
 None
 1.15A 3wdmA-6bb9A:
undetectable		 3wdmA-6bb9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ARG A  39
GLY A  38
ASP A  43
LEU A  44
ASN A  40
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.6A)
None
None
None
 1.32A 3wdmA-6ci9A:
3.6		 3wdmA-6ci9A:
19.51