SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_G_W9TG503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 ASP A 127
GLY A 144
TYR A 130
 CA  A 502 (-2.2A)
CA  A 502 (-4.4A)
None
 0.68A 3w9tG-1amyA:
undetectable		 3w9tG-1amyA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 ASP A  38
GLY A  65
TYR A  37
 None
 0.68A 3w9tG-1dgsA:
0.0		 3w9tG-1dgsA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 ASP A 165
GLY A 254
TYR A 231
 None
 0.61A 3w9tG-1ee8A:
undetectable		 3w9tG-1ee8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE
CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 ASP B  40
GLY A  37
TYR B  37
 None
 0.74A 3w9tG-1ffvB:
undetectable		 3w9tG-1ffvB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 3 ASP Y 133
GLY Y 352
TYR Y 135
 None
None
GOL  Y 600 (-4.6A)
 0.79A 3w9tG-1gllY:
0.0		 3w9tG-1gllY:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		3 ASP A 331
GLY A 282
TYR A 187
 None
 0.78A 3w9tG-1k8qA:
undetectable		 3w9tG-1k8qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb5 ANTIBODY DESIRE-1

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP H  52
GLY H  31
TYR H  54
 None
 0.63A 3w9tG-1kb5H:
undetectable		 3w9tG-1kb5H:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knl ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00652
(Ricin_B_lectin) 		3 ASP A 101
GLY A 104
TYR A 116
 None
 0.53A 3w9tG-1knlA:
19.0		 3w9tG-1knlA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN
CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 ASP B  43
GLY A  37
TYR B  40
 None
 0.75A 3w9tG-1n60B:
undetectable		 3w9tG-1n60B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 ASP A 149
GLY A 116
TYR A  91
 None
 0.76A 3w9tG-1ryyA:
undetectable		 3w9tG-1ryyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT

(Pseudomonas
putida) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 ASP B  36
GLY A  43
TYR B  33
 None
 0.76A 3w9tG-1t3qB:
undetectable		 3w9tG-1t3qB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		3 ASP A  13
GLY A 332
TYR A   8
 None
 0.78A 3w9tG-1tz9A:
undetectable		 3w9tG-1tz9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		3 ASP A 316
GLY A  84
TYR A 344
 None
None
AMP  A1456 (-4.6A)
 0.78A 3w9tG-1ua4A:
undetectable		 3w9tG-1ua4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus) 		PF00331
(Glyco_hydro_10) 		3 ASP A 199
GLY A 160
TYR A 200
 None
 0.81A 3w9tG-1ur1A:
undetectable		 3w9tG-1ur1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		3 ASP A 408
GLY A 411
TYR A 423
 XYP  A 471 (-2.8A)
XYP  A 471 (-3.5A)
XYP  A 471 (-3.5A)
 0.58A 3w9tG-1v6uA:
9.0		 3w9tG-1v6uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 ASP A  38
GLY A  65
TYR A  37
 None
 0.67A 3w9tG-1v9pA:
undetectable		 3w9tG-1v9pA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		3 ASP A  23
GLY A  26
TYR A  36
 CA  A1001 (-2.7A)
CA  A1001 (-4.2A)
None
 0.35A 3w9tG-1vclA:
36.9		 3w9tG-1vclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		3 ASP A 121
GLY A 124
TYR A 134
 CA  A1002 (-2.8A)
CA  A1002 (-4.3A)
None
 0.25A 3w9tG-1vclA:
36.9		 3w9tG-1vclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		3 ASP A 168
GLY A 171
TYR A 181
 CA  A1003 (-2.8A)
CA  A1003 (-4.2A)
None
 0.69A 3w9tG-1vclA:
36.9		 3w9tG-1vclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra) 		PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat) 		3 ASP A1186
GLY A1100
TYR A1102
 None
 0.77A 3w9tG-1vprA:
undetectable		 3w9tG-1vprA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vra ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ

(Bacillus
halodurans) 		PF01960
(ArgJ) 		3 ASP B 397
GLY B 284
TYR B 320
 None
EDO  B   7 (-4.2A)
EDO  B   7 (-4.4A)
 0.66A 3w9tG-1vraB:
undetectable		 3w9tG-1vraB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 ASP A  13
GLY A  53
TYR A  12
 None
None
SAH  A1001 (-4.9A)
 0.64A 3w9tG-1wznA:
undetectable		 3w9tG-1wznA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ASP A 486
GLY A 666
TYR A 461
 None
 0.77A 3w9tG-1xfdA:
2.2		 3w9tG-1xfdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		3 ASP A  17
GLY A  54
TYR A  16
 None
None
SAI  A1300 (-4.9A)
 0.60A 3w9tG-2avnA:
undetectable		 3w9tG-2avnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 ASP A 644
GLY A 650
TYR A 310
 None
 0.79A 3w9tG-2fuqA:
undetectable		 3w9tG-2fuqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A  11
GLY A  59
TYR A 424
 None
 0.74A 3w9tG-2hneA:
undetectable		 3w9tG-2hneA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		3 ASP A 302
GLY A 191
TYR A 301
 None
 0.76A 3w9tG-2ho5A:
undetectable		 3w9tG-2ho5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kp1 PROTEIN
DISULFIDE-ISOMERASE

(Humicola
insolens) 		PF00085
(Thioredoxin) 		3 ASP A  27
GLY A  91
TYR A 118
 None
 0.60A 3w9tG-2kp1A:
undetectable		 3w9tG-2kp1A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		3 ASP A 242
GLY A 187
TYR A 244
 None
 0.79A 3w9tG-2npnA:
undetectable		 3w9tG-2npnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ASP A 639
GLY A 605
TYR A 634
 None
 0.80A 3w9tG-2nyaA:
undetectable		 3w9tG-2nyaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		3 ASP A 386
GLY B 209
TYR A 383
 None
 0.71A 3w9tG-2pbiA:
undetectable		 3w9tG-2pbiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ASP A 389
GLY A 367
TYR A 388
 None
SO4  A 688 (-3.1A)
None
 0.68A 3w9tG-2q3zA:
undetectable		 3w9tG-2q3zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		3 ASP A  11
GLY A  70
TYR A  46
 R10  A 200 (-2.8A)
R10  A 200 (-3.1A)
R10  A 200 (-3.6A)
 0.76A 3w9tG-2vvqA:
undetectable		 3w9tG-2vvqA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ASP A  94
GLY A   7
TYR A  99
 None
3CD  A 600 (-3.5A)
3CD  A 600 (-4.9A)
 0.78A 3w9tG-2xf8A:
undetectable		 3w9tG-2xf8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 ASP A 386
GLY A 333
TYR A 390
 None
 0.79A 3w9tG-2xtsA:
undetectable		 3w9tG-2xtsA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxs PROTEIN MXIG

(Shigella
flexneri) 		PF09480
(PrgH) 		3 ASP A  94
GLY A  60
TYR A  93
 None
 0.71A 3w9tG-2xxsA:
undetectable		 3w9tG-2xxsA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		3 ASP A  32
GLY A 346
TYR A  28
 None
 0.77A 3w9tG-3bdkA:
undetectable		 3w9tG-3bdkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		3 ASP A 480
GLY A 378
TYR A 481
 CA  A 488 (-3.4A)
None
None
 0.66A 3w9tG-3c7oA:
undetectable		 3w9tG-3c7oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		3 ASP A 167
GLY A  47
TYR A  12
 None
PO4  A 251 ( 3.7A)
None
 0.76A 3w9tG-3d6jA:
undetectable		 3w9tG-3d6jA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile) 		PF08282
(Hydrolase_3) 		3 ASP A  17
GLY A 128
TYR A  20
 None
 0.74A 3w9tG-3fzqA:
undetectable		 3w9tG-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpu DNA GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 ASP A 178
GLY A 265
TYR A 242
 None
 0.75A 3w9tG-3gpuA:
undetectable		 3w9tG-3gpuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		3 ASP A   8
GLY A  66
TYR A  42
 R5P  A 651 (-2.7A)
R5P  A 651 (-3.5A)
R5P  A 651 (-3.9A)
 0.78A 3w9tG-3heeA:
undetectable		 3w9tG-3heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 ASP A 456
GLY A  62
TYR A 457
 None
 0.51A 3w9tG-3j3iA:
undetectable		 3w9tG-3j3iA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8c RIBOSE 5-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF02502
(LacAB_rpiB) 		3 ASP A  10
GLY A  70
TYR A  46
 RES  A 160 (-3.1A)
RES  A 160 (-3.3A)
RES  A 160 ( 4.3A)
 0.73A 3w9tG-3k8cA:
undetectable		 3w9tG-3k8cA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 ASP A 348
GLY A 695
TYR A 349
 None
 0.80A 3w9tG-3la4A:
undetectable		 3w9tG-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 ASP A 524
GLY A 286
TYR A 523
 None
 0.79A 3w9tG-3lppA:
undetectable		 3w9tG-3lppA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 ASP A 170
GLY A 146
TYR A 169
 None
 0.71A 3w9tG-3mfdA:
undetectable		 3w9tG-3mfdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		3 ASP A 190
GLY A 209
TYR A 205
 None
 0.78A 3w9tG-3njxA:
undetectable		 3w9tG-3njxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsw EXCRETORY-SECRETORY
PROTEIN 2

(Ancylostoma
ceylanicum) 		no annotation 3 ASP A  61
GLY A  -3
TYR A   2
 None
 0.66A 3w9tG-3nswA:
undetectable		 3w9tG-3nswA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		3 ASP A  23
GLY A  58
TYR A  22
 None
None
SAM  A 300 (-4.4A)
 0.66A 3w9tG-3ou6A:
undetectable		 3w9tG-3ou6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 ASP A 139
GLY A 250
TYR A 138
 None
 0.71A 3w9tG-3pf7A:
undetectable		 3w9tG-3pf7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE

(Ruminiclostridium
thermocellum) 		PF02502
(LacAB_rpiB) 		3 ASP A   8
GLY A  66
TYR A  42
 RB5  A 150 (-2.8A)
RB5  A 150 (-3.7A)
RB5  A 150 (-4.1A)
 0.80A 3w9tG-3ph3A:
undetectable		 3w9tG-3ph3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poj MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB) 		3 ASP A 263
GLY A 266
TYR A 225
 NEH  A   2 ( 2.8A)
CA  A   1 ( 4.2A)
NEH  A   2 (-3.6A)
 0.73A 3w9tG-3pojA:
undetectable		 3w9tG-3pojA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		3 ASP A  23
GLY A  62
TYR A  22
 None
None
SAH  A 263 (-4.6A)
 0.54A 3w9tG-3px2A:
undetectable		 3w9tG-3px2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0c HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH5

(Arabidopsis
thaliana) 		no annotation 3 ASP X 418
GLY X 415
TYR X 428
 None
 0.65A 3w9tG-3q0cX:
undetectable		 3w9tG-3q0cX:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ASP C  76
GLY C 423
TYR C  77
 None
 0.76A 3w9tG-3qgkC:
undetectable		 3w9tG-3qgkC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASP A 371
GLY A 296
TYR A 285
 None
 0.69A 3w9tG-3qnkA:
undetectable		 3w9tG-3qnkA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		3 ASP A 120
GLY A  10
TYR A 122
 PO4  A 201 (-2.8A)
PO4  A 201 (-3.5A)
None
 0.77A 3w9tG-3rofA:
undetectable		 3w9tG-3rofA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		3 ASP A 369
GLY A 372
TYR A 374
 None
 0.78A 3w9tG-3upyA:
undetectable		 3w9tG-3upyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		3 ASP A 323
GLY A  43
TYR A 319
 None
 0.74A 3w9tG-3vssA:
undetectable		 3w9tG-3vssA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 ASP A 350
GLY A 345
TYR A 358
 None
 0.80A 3w9tG-3zk4A:
undetectable		 3w9tG-3zk4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A  17
GLY A  63
TYR A 432
 None
EDO  A1447 ( 4.1A)
EDO  A1447 (-4.2A)
 0.77A 3w9tG-4a35A:
undetectable		 3w9tG-4a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A  17
GLY A  65
TYR A 432
 None
None
EDO  A1447 (-4.2A)
 0.46A 3w9tG-4a35A:
undetectable		 3w9tG-4a35A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 ASP A 117
GLY A  98
TYR A 265
 None
PO4  A1356 (-3.5A)
PO4  A1354 (-4.8A)
 0.70A 3w9tG-4aalA:
undetectable		 3w9tG-4aalA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		3 ASP A 119
GLY A   9
TYR A 121
 ASP  A 119 (-0.6A)
GLY  A   9 (-0.0A)
TYR  A 121 ( 1.3A)
 0.74A 3w9tG-4egsA:
undetectable		 3w9tG-4egsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B

(Anaplasma
phagocytophilum) 		PF02502
(LacAB_rpiB) 		3 ASP A  10
GLY A  67
TYR A  45
 None
 0.76A 3w9tG-4em8A:
undetectable		 3w9tG-4em8A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etm LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YFKJ

(Bacillus
subtilis) 		PF01451
(LMWPc) 		3 ASP A 125
GLY A  10
TYR A 128
 PO4  A 201 (-2.9A)
PO4  A 201 (-3.4A)
None
 0.68A 3w9tG-4etmA:
undetectable		 3w9tG-4etmA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		3 ASP C  21
GLY C  24
TYR C  36
 AMG  C 301 (-2.8A)
AMG  C 301 (-3.7A)
AMG  C 301 (-3.6A)
 0.45A 3w9tG-4hr6C:
11.0		 3w9tG-4hr6C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		3 ASP A  22
GLY A  25
TYR A  34
 LAT  A 201 (-2.8A)
LAT  A 201 (-3.5A)
LAT  A 201 ( 3.5A)
 0.53A 3w9tG-4izxA:
16.5		 3w9tG-4izxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 ASP A1026
GLY A 977
TYR A1025
 None
 0.76A 3w9tG-4lnvA:
undetectable		 3w9tG-4lnvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		3 ASP A 109
GLY A  53
TYR A 106
 GOL  A 401 (-2.9A)
GOL  A 401 (-3.0A)
GOL  A 401 ( 4.3A)
 0.79A 3w9tG-4lryA:
undetectable		 3w9tG-4lryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 ASP A 284
GLY A 398
TYR A 282
 None
 0.69A 3w9tG-4mmhA:
undetectable		 3w9tG-4mmhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 ASP M 188
GLY H 169
TYR M 187
 None
 0.70A 3w9tG-4nzrM:
undetectable		 3w9tG-4nzrM:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Lactococcus
lactis) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 ASP A 175
GLY A 261
TYR A 238
 None
 0.69A 3w9tG-4pczA:
undetectable		 3w9tG-4pczA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		3 ASP A 229
GLY A 206
TYR A 228
 None
 0.76A 3w9tG-4pprA:
undetectable		 3w9tG-4pprA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 ASP A 202
GLY A 162
TYR A 203
 None
None
XYP  A 402 ( 3.9A)
 0.77A 3w9tG-4pueA:
undetectable		 3w9tG-4pueA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1g QA1 MONOCLONAL
ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP B  99
GLY B 106
TYR B  33
 None
 0.69A 3w9tG-4u1gB:
undetectable		 3w9tG-4u1gB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ASP A 150
GLY A 382
TYR A 153
 None
 0.80A 3w9tG-4wyrA:
undetectable		 3w9tG-4wyrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za3 RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00652
(Ricin_B_lectin) 		3 ASP B  22
GLY B  25
TYR B  37
 GOL  B 311 (-2.9A)
GOL  B 311 (-3.7A)
GOL  B 311 ( 3.9A)
 0.48A 3w9tG-4za3B:
16.4		 3w9tG-4za3B:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		3 ASP A  59
GLY A  63
TYR A 409
 None
 0.58A 3w9tG-4zm4A:
undetectable		 3w9tG-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		3 ASP A  71
GLY A  62
TYR A 337
 None
 0.65A 3w9tG-4zxoA:
undetectable		 3w9tG-4zxoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		3 ASP A 262
GLY A 265
TYR A 224
 CA  A 303 (-3.1A)
CA  A 303 ( 4.3A)
None
 0.76A 3w9tG-5ckmA:
undetectable		 3w9tG-5ckmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckq MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Rattus
norvegicus) 		PF00431
(CUB)
PF14670
(FXa_inhibition) 		3 ASP A 263
GLY A 266
TYR A 225
 CA  A 303 (-3.7A)
CA  A 303 (-3.5A)
None
 0.74A 3w9tG-5ckqA:
undetectable		 3w9tG-5ckqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		3 ASP A  52
GLY A  33
TYR A  12
 None
 0.78A 3w9tG-5egnA:
undetectable		 3w9tG-5egnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		3 ASP A 369
GLY A 358
TYR A 283
 None
 0.80A 3w9tG-5gwnA:
undetectable		 3w9tG-5gwnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A  54
GLY A  72
TYR A  53
 None
 0.79A 3w9tG-5h83A:
undetectable		 3w9tG-5h83A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 ASP A 355
GLY A 302
TYR A 353
 None
 0.75A 3w9tG-5hqbA:
undetectable		 3w9tG-5hqbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 ASP A 355
GLY A 306
TYR A 353
 None
 0.77A 3w9tG-5hqbA:
undetectable		 3w9tG-5hqbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		3 ASP A 234
GLY A 251
TYR A 237
 None
 0.74A 3w9tG-5i33A:
undetectable		 3w9tG-5i33A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		3 ASP A 243
GLY A 289
TYR A 244
 None
 0.65A 3w9tG-5ijxA:
undetectable		 3w9tG-5ijxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		3 ASP A  55
GLY A 240
TYR A  42
 None
None
6DB  A 304 (-4.7A)
 0.74A 3w9tG-5itoA:
undetectable		 3w9tG-5itoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 ASP A 291
GLY A 405
TYR A 289
 None
 0.75A 3w9tG-5jmdA:
undetectable		 3w9tG-5jmdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 3 ASP B 102
GLY B 196
TYR B  99
 None
 0.74A 3w9tG-5lhsB:
undetectable		 3w9tG-5lhsB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		3 ASP A  72
GLY A  75
TYR A  87
 GAL  A 301 (-2.7A)
GAL  A 301 (-3.4A)
GAL  A 301 (-3.5A)
 0.45A 3w9tG-5muaA:
17.4		 3w9tG-5muaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 ASP A 183
GLY A 160
TYR A 182
 None
 0.75A 3w9tG-5tr7A:
undetectable		 3w9tG-5tr7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		3 ASP A 624
GLY A 674
TYR A 621
 None
 0.76A 3w9tG-5x7sA:
undetectable		 3w9tG-5x7sA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 3 ASP A 108
GLY A 112
TYR A 117
 SAH  A 305 ( 4.3A)
SAH  A 305 (-3.4A)
SAH  A 305 ( 4.8A)
 0.80A 3w9tG-6b92A:
undetectable		 3w9tG-6b92A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chd LYSINE--TRNA LIGASE

(Homo sapiens) 		no annotation 3 ASP A 560
GLY A 377
TYR A 373
 None
SO4  A 606 (-3.3A)
None
 0.80A 3w9tG-6chdA:
undetectable		 3w9tG-6chdA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 3 ASP A 203
GLY A 212
TYR A 206
 None
 0.70A 3w9tG-6cv9A:
undetectable		 3w9tG-6cv9A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1d COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		no annotation 3 ASP A 273
GLY A 276
TYR A 235
 CA  A 300 (-3.1A)
CA  A 300 ( 4.5A)
None
 0.73A 3w9tG-6f1dA:
undetectable		 3w9tG-6f1dA:
11.56