SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_G_W9TG501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III


(Cucumaria
echinata)
PF00652
(Ricin_B_lectin)
4 ASP A 256
GLY A 259
TRP A 269
ASP A 272
CA  A1005 (-2.7A)
CA  A1005 (-4.3A)
None
CA  A1005 ( 4.8A)
0.49A 3w9tG-1vclA:
36.9
3w9tG-1vclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 ASP A 585
GLY A 589
TRP A 586
ASP A 468
CA  A2000 ( 4.6A)
None
None
None
1.20A 3w9tG-3ecqA:
0.0
3w9tG-3ecqA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 ASP A 585
GLY A 589
TRP A 586
ASP A 468
CA  A2419 ( 4.7A)
None
None
None
1.29A 3w9tG-5a55A:
0.0
3w9tG-5a55A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1


(Homo sapiens)
PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3)
4 ASP A 575
GLY A 577
TRP A 574
ASP A 571
None
1.19A 3w9tG-5xjyA:
0.0
3w9tG-5xjyA:
11.25