SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_F_W9TF501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 ASP A 514
SER A 496
GLY A 495
TRP A 515
 None
 1.38A 3w9tF-1n7dA:
0.0		 3w9tF-1n7dA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A 256
SER A 258
GLY A 259
TRP A 269
 CA  A1005 (-2.7A)
None
CA  A1005 (-4.3A)
None
 0.32A 3w9tF-1vclA:
36.7		 3w9tF-1vclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		4 ASP A 325
SER A 294
GLY A 293
TRP A 330
 None
 1.50A 3w9tF-2qpsA:
0.0		 3w9tF-2qpsA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q13 SPONDIN-1

(Homo sapiens) 		PF06468
(Spond_N) 		4 ASP A 325
SER A 359
GLY A 360
TRP A 326
 CA  A 601 (-2.2A)
None
None
None
 1.50A 3w9tF-3q13A:
0.0		 3w9tF-3q13A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ASP B1485
SER B1483
GLY B1482
TRP B1484
 None
 1.26A 3w9tF-3zefB:
0.0		 3w9tF-3zefB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		4 ASP A 109
SER A 111
GLY A 112
TRP A 125
 None
 0.66A 3w9tF-4izxA:
16.3		 3w9tF-4izxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 ASP A 204
SER A 224
GLY A 289
TRP A 292
 None
 1.23A 3w9tF-4tz5A:
0.0		 3w9tF-4tz5A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 4 ASP L 354
SER L 357
GLY L 360
TRP L 335
 None
 1.10A 3w9tF-6ehsL:
0.0		 3w9tF-6ehsL:
9.37