SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_E_W9TE502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 GLU A 283
GLY A 282
LEU A 295
GLU A 275
 None
 1.13A 3w9tE-1cjxA:
0.0		 3w9tE-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.98A 3w9tE-1e9yB:
0.0		 3w9tE-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl5 TYROSINE-PROTEIN
KINASE TEC

(Mus musculus) 		PF00018
(SH3_1) 		4 ASP A 220
GLU A 225
GLY A 223
LEU A 197
 None
 1.14A 3w9tE-1gl5A:
undetectable		 3w9tE-1gl5A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1go3 DNA-DIRECTED RNA
POLYMERASE SUBUNIT E

(Methanocaldococcus
jannaschii) 		PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 GLU E  86
LEU E 173
TYR E 141
GLU E  88
 None
 1.11A 3w9tE-1go3E:
undetectable		 3w9tE-1go3E:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLU A 225
GLY A 224
LEU A 237
GLU A 230
 None
 0.95A 3w9tE-1gytA:
0.0		 3w9tE-1gytA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 GLY A 100
LEU A  63
TYR A 192
GLU A 182
 None
 1.11A 3w9tE-1mdwA:
0.0		 3w9tE-1mdwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		4 ASP A  58
GLU A  52
GLY A  34
LEU A  22
 None
 0.93A 3w9tE-1o9jA:
undetectable		 3w9tE-1o9jA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ASP A  23
GLU A 354
GLY A 353
LEU A  20
 None
 1.09A 3w9tE-1obbA:
0.0		 3w9tE-1obbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 ASP A 418
GLU A 424
GLY A 420
LEU A 428
 None
 1.14A 3w9tE-1pixA:
0.0		 3w9tE-1pixA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 GLY A 103
LEU A  63
TYR A 192
GLU A 182
 None
 0.97A 3w9tE-1qxpA:
undetectable		 3w9tE-1qxpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		4 GLU A  15
GLY A  14
LEU A  62
GLU A 211
 None
 1.09A 3w9tE-1uanA:
undetectable		 3w9tE-1uanA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 GLU A 126
GLY A 128
LEU A  94
GLU A 134
 None
 1.16A 3w9tE-1ub3A:
undetectable		 3w9tE-1ub3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 GLY A 230
LEU A 237
TYR A 245
GLU A 254
 None
 1.05A 3w9tE-1v4aA:
undetectable		 3w9tE-1v4aA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A 168
GLU A 170
GLY A 171
LEU A 179
 CA  A1003 (-2.8A)
None
CA  A1003 (-4.2A)
None
 0.97A 3w9tE-1vclA:
36.9		 3w9tE-1vclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A 168
GLY A 171
LEU A 179
TYR A 181
 CA  A1003 (-2.8A)
CA  A1003 (-4.2A)
None
None
 0.59A 3w9tE-1vclA:
36.9		 3w9tE-1vclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 ASP A 219
GLY A 295
LEU A 224
GLU A 221
 None
 1.02A 3w9tE-1wd3A:
14.9		 3w9tE-1wd3A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLU A  43
GLY A 346
LEU A 314
TYR A 318
 GLA  A 393 (-3.7A)
GLA  A 393 ( 3.4A)
None
None
 0.82A 3w9tE-1wuuA:
undetectable		 3w9tE-1wuuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 ASP A 316
GLY A 265
LEU A 312
GLU A 319
 None
 1.07A 3w9tE-1x3wA:
undetectable		 3w9tE-1x3wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2) 		4 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.11A 3w9tE-1xhcA:
undetectable		 3w9tE-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 GLU A 280
GLY A 279
LEU A 282
TYR A 277
 None
 1.16A 3w9tE-1xknA:
undetectable		 3w9tE-1xknA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B

(Thermotoga
maritima) 		PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2) 		4 GLU A 125
GLY A 124
LEU A 130
TYR A 122
 None
G  B   7 ( 2.9A)
None
None
 0.91A 3w9tE-2ab4A:
undetectable		 3w9tE-2ab4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 ASP A 267
LEU A 262
TYR A 266
GLU A 271
 None
 1.04A 3w9tE-2c8jA:
undetectable		 3w9tE-2c8jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv8 TRNA-SPLICING
ENDONUCLEASE

(Sulfurisphaera
tokodaii) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		4 GLU A  69
GLY A  68
LEU A  71
GLU A   4
 None
 1.01A 3w9tE-2cv8A:
undetectable		 3w9tE-2cv8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 520
LEU A 571
TYR A 643
GLU A 564
 None
 1.12A 3w9tE-2d5lA:
undetectable		 3w9tE-2d5lA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 GLY A 456
LEU A 271
TYR A 279
GLU A 283
 None
 1.14A 3w9tE-2fwrA:
undetectable		 3w9tE-2fwrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		4 GLU A 241
GLY A 240
LEU A 243
TYR A 133
 None
 1.15A 3w9tE-2gx8A:
undetectable		 3w9tE-2gx8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 GLY A  38
LEU A  16
TYR A 340
GLU A 339
 None
 1.11A 3w9tE-2i1jA:
undetectable		 3w9tE-2i1jA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2

(Homo sapiens) 		PF00782
(DSPc) 		4 ASP A 416
GLU A 440
LEU A 415
TYR A 419
 None
 1.16A 3w9tE-2nt2A:
undetectable		 3w9tE-2nt2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4t BH3976 PROTEIN

(Bacillus
halodurans) 		PF06304
(DUF1048) 		4 GLU A  61
GLY A  58
LEU A  23
TYR A  27
 None
 1.03A 3w9tE-2o4tA:
undetectable		 3w9tE-2o4tA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLU A 335
GLY A 336
LEU A 324
GLU A 111
 None
 0.90A 3w9tE-2ogaA:
undetectable		 3w9tE-2ogaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 GLU A 165
GLY A 222
LEU A 195
GLU A 215
 None
 1.12A 3w9tE-2przA:
undetectable		 3w9tE-2przA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ASP A 327
GLU A 367
LEU A 323
TYR A 326
 None
 1.04A 3w9tE-2q1fA:
undetectable		 3w9tE-2q1fA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLU A 167
GLY A 168
LEU A 256
GLU A 171
 None
 0.90A 3w9tE-2v9iA:
undetectable		 3w9tE-2v9iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 352
LEU A 371
TYR A 375
GLU A  38
 None
 1.17A 3w9tE-2vqdA:
undetectable		 3w9tE-2vqdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 GLU A 280
GLY A 279
LEU A 282
GLU A 289
 None
 0.89A 3w9tE-2y4oA:
undetectable		 3w9tE-2y4oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		4 ASP A  58
GLY A 134
LEU A 302
GLU A 116
 MN  A1336 (-2.8A)
None
None
MN  A1336 ( 4.4A)
 1.09A 3w9tE-2ygkA:
undetectable		 3w9tE-2ygkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		4 ASP A 136
GLU A 211
GLY A 212
LEU A 139
 None
 0.97A 3w9tE-2yxeA:
undetectable		 3w9tE-2yxeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta) 		4 GLU B  54
GLY B 168
LEU B  83
GLU B  60
 None
 1.10A 3w9tE-2zpbB:
undetectable		 3w9tE-2zpbB:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		4 GLU A 168
GLY A 167
LEU A  66
GLU A 173
 None
 1.10A 3w9tE-3bt5A:
undetectable		 3w9tE-3bt5A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		4 GLU A  28
GLY A  27
LEU A  52
GLU A 134
 None
 0.98A 3w9tE-3ccfA:
undetectable		 3w9tE-3ccfA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile) 		PF08282
(Hydrolase_3) 		4 GLU A  76
GLY A  75
LEU A  78
TYR A  73
 None
 1.03A 3w9tE-3fzqA:
undetectable		 3w9tE-3fzqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 ASP A 421
GLU A 427
GLY A 423
LEU A 431
 None
 1.16A 3w9tE-3gf7A:
undetectable		 3w9tE-3gf7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		4 ASP A 137
GLU A 224
GLY A 206
LEU A 127
 None
 1.11A 3w9tE-3hh8A:
undetectable		 3w9tE-3hh8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		4 GLU A 332
GLY A 331
TYR A 329
GLU A 268
 None
 1.13A 3w9tE-3hlkA:
undetectable		 3w9tE-3hlkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 GLU 3 273
GLY 3 272
LEU 3 275
GLU 3 250
 None
 0.84A 3w9tE-3i9v3:
undetectable		 3w9tE-3i9v3:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 299
LEU A 374
TYR A 158
GLU A 337
 SO4  A 379 (-3.3A)
None
None
SO4  A 379 ( 4.2A)
 1.16A 3w9tE-3ic1A:
undetectable		 3w9tE-3ic1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 GLU A 301
GLY A 310
LEU A 299
GLU A 225
 None
 1.07A 3w9tE-3il3A:
undetectable		 3w9tE-3il3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr1 PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Histophilus
somni) 		PF03881
(Fructosamin_kin) 		4 GLU A 252
GLY A 249
TYR A 257
GLU A 220
 None
 1.15A 3w9tE-3jr1A:
undetectable		 3w9tE-3jr1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kop UNCHARACTERIZED
PROTEIN

(Arthrobacter
sp. FB24) 		PF12903
(DUF3830) 		4 ASP A 109
LEU A  55
TYR A  53
GLU A  51
 None
 1.03A 3w9tE-3kopA:
undetectable		 3w9tE-3kopA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 GLY A 162
LEU A 221
TYR A 180
GLU A 192
 None
 1.12A 3w9tE-3kveA:
undetectable		 3w9tE-3kveA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0s ADENYLATE KINASE

(Desulfovibrio
gigas) 		PF00406
(ADK) 		4 GLU A 111
GLY A   7
LEU A 185
TYR A 178
 None
 0.93A 3w9tE-3l0sA:
undetectable		 3w9tE-3l0sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ASP A 348
GLY A 695
TYR A 349
GLU A 698
 None
 1.04A 3w9tE-3la4A:
undetectable		 3w9tE-3la4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 ASP A  96
GLY A 102
LEU A 108
TYR A 165
 None
FMT  A 503 (-3.8A)
None
None
 1.11A 3w9tE-3ll7A:
undetectable		 3w9tE-3ll7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 144
GLY A 145
LEU A 288
TYR A 147
 None
 0.98A 3w9tE-3lm5A:
undetectable		 3w9tE-3lm5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		4 GLY A 273
LEU A 303
TYR A 307
GLU A 269
 None
 1.03A 3w9tE-3mfqA:
undetectable		 3w9tE-3mfqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 209
GLU A 205
GLY A 204
GLU A 531
 None
 0.90A 3w9tE-3n0gA:
undetectable		 3w9tE-3n0gA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nua PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Clostridium
perfringens) 		PF01259
(SAICAR_synt) 		4 GLU A 187
GLY A 186
LEU A 189
TYR A 184
 None
 0.89A 3w9tE-3nuaA:
undetectable		 3w9tE-3nuaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Clostridium
perfringens) 		PF00698
(Acyl_transf_1) 		4 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.90A 3w9tE-3ptwA:
undetectable		 3w9tE-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2

(Helicobacter
mustelae) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ASP C  76
GLY C 423
TYR C  77
GLU C 426
 None
 0.94A 3w9tE-3qgkC:
undetectable		 3w9tE-3qgkC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLU A 253
GLY A 252
LEU A  45
TYR A  49
 None
 1.06A 3w9tE-3redA:
undetectable		 3w9tE-3redA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		4 GLU A 960
GLY A 961
LEU A 937
GLU A 968
 None
 0.86A 3w9tE-3un9A:
undetectable		 3w9tE-3un9A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		4 GLY A 288
LEU A 175
TYR A 170
GLU A 167
 None
FAD  A1449 ( 4.7A)
None
None
 1.16A 3w9tE-4bv6A:
undetectable		 3w9tE-4bv6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		4 GLU A 103
GLY A 104
LEU A  79
TYR A  67
 None
 1.12A 3w9tE-4bwcA:
undetectable		 3w9tE-4bwcA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B

(Homo sapiens) 		PF02373
(JmjC) 		4 ASP A1679
GLY A1419
LEU A1416
GLU A1608
 None
 1.15A 3w9tE-4c8dA:
undetectable		 3w9tE-4c8dA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		4 GLU B 220
GLY B 221
TYR B 318
GLU A 324
 None
 1.02A 3w9tE-4cakB:
undetectable		 3w9tE-4cakB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Corynebacterium
diphtheriae) 		PF01625
(PMSR) 		4 GLY A  76
LEU A 179
TYR A 140
GLU A 175
 None
 1.11A 3w9tE-4d7lA:
undetectable		 3w9tE-4d7lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		4 ASP A  78
GLU A 236
GLY A 235
GLU A 148
 None
 1.01A 3w9tE-4f0qA:
undetectable		 3w9tE-4f0qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffk SUPEROXIDE DISMUTASE

(Acidilobus
saccharovorans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A 114
LEU A 155
TYR A 212
GLU A 209
 None
 1.15A 3w9tE-4ffkA:
undetectable		 3w9tE-4ffkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		4 ASP B 348
GLY B 695
TYR B 349
GLU B 698
 None
 1.01A 3w9tE-4g7eB:
undetectable		 3w9tE-4g7eB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE

(Xanthobacter
autotrophicus) 		PF00378
(ECH_1) 		4 GLU A 238
GLY A 142
LEU A  85
GLU A 116
 None
 1.00A 3w9tE-4k29A:
undetectable		 3w9tE-4k29A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 GLU A 270
GLY A 268
LEU A 272
TYR A 296
 None
 0.93A 3w9tE-4pbxA:
undetectable		 3w9tE-4pbxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 GLU A 230
GLY A 229
TYR A 238
GLU A 211
 None
 1.00A 3w9tE-4pc4A:
14.4		 3w9tE-4pc4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 GLY A  91
LEU A 128
TYR A 142
GLU A 145
 None
 0.90A 3w9tE-4ptxA:
undetectable		 3w9tE-4ptxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 169
LEU A  47
TYR A  46
GLU A 253
 None
 1.12A 3w9tE-4qgrA:
undetectable		 3w9tE-4qgrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF04084
(ORC2)
PF07034
(ORC3_N) 		4 ASP B 467
GLY B 359
LEU C 703
GLU B 499
 None
 1.08A 3w9tE-4xgcB:
undetectable		 3w9tE-4xgcB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zey NUCLEAR
RECEPTOR-BINDING
FACTOR 2

(Homo sapiens) 		PF17169
(NRBF2_MIT) 		4 GLU A   5
GLY A   6
TYR A  40
GLU A  43
 None
 1.16A 3w9tE-4zeyA:
undetectable		 3w9tE-4zeyA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 ASP A  59
GLY A  63
LEU A  49
TYR A 409
 None
 0.68A 3w9tE-4zm4A:
undetectable		 3w9tE-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 GLY A 552
LEU A 561
TYR A 531
GLU A 534
 None
 1.15A 3w9tE-4zu9A:
undetectable		 3w9tE-4zu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		4 GLU A  40
GLY A  39
LEU A  42
TYR A  37
 None
 0.86A 3w9tE-5b0sA:
undetectable		 3w9tE-5b0sA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ASP A 693
LEU A 856
TYR A 690
GLU A 689
 None
 1.12A 3w9tE-5e02A:
undetectable		 3w9tE-5e02A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.14A 3w9tE-5ec0A:
undetectable		 3w9tE-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 GLU B 582
GLY B 579
LEU B 732
GLU B 725
 None
 0.97A 3w9tE-5flzB:
undetectable		 3w9tE-5flzB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 4 GLY A 566
LEU A 278
TYR A 685
GLU A 687
 None
 0.97A 3w9tE-5fodA:
undetectable		 3w9tE-5fodA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ASP C  78
GLY C 425
TYR C  79
GLU C 428
 None
 0.97A 3w9tE-5fseC:
undetectable		 3w9tE-5fseC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guj DNA PRIMASE

(Bacillus
subtilis) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		4 GLU A 114
GLY A 113
LEU A 241
GLU A 119
 None
 0.84A 3w9tE-5gujA:
undetectable		 3w9tE-5gujA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00270
(DEAD) 		4 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tE-5gvsA:
undetectable		 3w9tE-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5b THYMIDYLATE KINASE

(Aquifex
aeolicus) 		no annotation 4 GLU B  36
GLY B  38
LEU B  88
TYR B  34
 None
 1.17A 3w9tE-5h5bB:
undetectable		 3w9tE-5h5bB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il5 MLND

(Bacillus
velezensis) 		PF14765
(PS-DH) 		4 GLY A1378
LEU A1500
TYR A1498
GLU A1509
 None
 0.80A 3w9tE-5il5A:
undetectable		 3w9tE-5il5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ASP A 407
GLU A  84
GLY A  83
LEU A  86
 None
 1.10A 3w9tE-5imwA:
undetectable		 3w9tE-5imwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ASP A 189
GLU A 132
GLY A 133
LEU A 191
 None
 1.02A 3w9tE-5itgA:
undetectable		 3w9tE-5itgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASP A 308
GLY A 281
LEU A 304
GLU A 311
 None
 1.10A 3w9tE-5j6sA:
undetectable		 3w9tE-5j6sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkq DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13541
(ChlI) 		4 GLU A 339
GLY A 343
LEU A 346
TYR A 378
 None
 1.15A 3w9tE-5lkqA:
undetectable		 3w9tE-5lkqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 GLY A  91
LEU A 128
TYR A 142
GLU A 145
 None
 0.99A 3w9tE-5ogzA:
undetectable		 3w9tE-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		4 ASP C  87
GLU C 191
GLY C 193
LEU C 180
 None
 1.10A 3w9tE-5osnC:
undetectable		 3w9tE-5osnC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 ASP A 171
GLY A  57
LEU A 175
GLU A 170
 None
 1.06A 3w9tE-5vj1A:
undetectable		 3w9tE-5vj1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 ASP A  72
GLU A 113
GLY A 114
GLU A 119
 None
EPE  A 600 ( 4.9A)
None
None
 1.16A 3w9tE-5w1uA:
undetectable		 3w9tE-5w1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.79A 3w9tE-5wp4A:
undetectable		 3w9tE-5wp4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.66A 3w9tE-5wp5A:
undetectable		 3w9tE-5wp5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 GLU A 424
GLY A 423
LEU A 394
GLU A 458
 None
 1.16A 3w9tE-5xwyA:
undetectable		 3w9tE-5xwyA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 ASP D  64
GLU A 987
GLY A 988
LEU D  53
TYR D  61
 None
 1.28A 3w9tE-6eojD:
undetectable		 3w9tE-6eojD:
20.00