SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_D_W9TD507_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzc ERYTHRINA
CRISTA-GALLI LECTIN

(Erythrina
crista-galli) 		PF00139
(Lectin_legB) 		4 GLU A  10
GLY A  30
TYR A 229
ASP A 227
 None
 1.25A 3w9tD-1gzcA:
0.0		 3w9tD-1gzcA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		4 ASP A  69
GLU A  74
GLY A  73
ASP A  12
 None
 1.19A 3w9tD-1luaA:
0.0		 3w9tD-1luaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 ASP A 392
GLU A 395
GLY A 397
TYR A 394
 None
 1.36A 3w9tD-1m1cA:
0.0		 3w9tD-1m1cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLU A 429
GLY A 428
TYR A 420
ASP A 397
 None
 0.94A 3w9tD-1o5tA:
undetectable		 3w9tD-1o5tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojz ADP-RIBOSYLTRANSFERA
SE

(Staphylococcus
aureus) 		PF03496
(ADPrib_exo_Tox) 		4 GLU A 133
GLY A 186
TYR A 136
ASP A  69
 NAD  A 500 (-3.2A)
None
None
None
 1.42A 3w9tD-1ojzA:
0.0		 3w9tD-1ojzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLU 1  16
GLY 1  13
TYR 1 152
ASP 1  96
 None
 1.37A 3w9tD-1pd21:
0.0		 3w9tD-1pd21:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 GLU A 314
GLY A 317
TYR A 315
ASP A  57
 None
 1.38A 3w9tD-1q5dA:
0.0		 3w9tD-1q5dA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 GLU A 107
GLY A 278
TYR A 251
ASP A 254
 None
 1.26A 3w9tD-1r6vA:
0.0		 3w9tD-1r6vA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		4 GLU A 173
GLY A 216
TYR A  99
ASP A 102
 None
 1.38A 3w9tD-1sgfA:
0.0		 3w9tD-1sgfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 277
GLU A 170
TYR A 412
ASP A 327
 None
 1.34A 3w9tD-1si8A:
undetectable		 3w9tD-1si8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 GLU A  16
GLY A  13
TYR A 152
ASP A  96
 None
O16  A3201 ( 3.7A)
O16  A3201 (-4.9A)
O16  A3201 ( 4.8A)
 1.32A 3w9tD-1v40A:
undetectable		 3w9tD-1v40A:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A  23
GLY A  26
TYR A  36
ASP A  39
 CA  A1001 (-2.7A)
CA  A1001 (-4.2A)
None
CA  A1001 ( 4.5A)
 0.71A 3w9tD-1vclA:
32.6		 3w9tD-1vclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A 121
GLU A 123
GLY A 124
TYR A 134
 CA  A1002 (-2.8A)
None
CA  A1002 (-4.3A)
None
 0.70A 3w9tD-1vclA:
32.6		 3w9tD-1vclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A 209
GLU A 211
GLY A 212
ASP A 225
 CA  A1004 (-2.6A)
None
CL  A1201 ( 3.7A)
CA  A1004 ( 4.7A)
 0.70A 3w9tD-1vclA:
32.6		 3w9tD-1vclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvt HYPOTHETICAL PROTEIN
ST2180

(Sulfurisphaera
tokodaii) 		PF01923
(Cob_adeno_trans) 		4 GLU A  84
GLY A  82
TYR A 142
ASP A  60
 None
 1.20A 3w9tD-1wvtA:
undetectable		 3w9tD-1wvtA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 GLU A 392
GLY A 391
TYR A 394
ASP A  48
 None
None
None
CA  A 601 (-2.8A)
 1.18A 3w9tD-1wzaA:
undetectable		 3w9tD-1wzaA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Lactococcus
lactis) 		PF01634
(HisG) 		4 GLU E 138
GLY E 139
TYR E 117
ASP E 155
 None
 1.17A 3w9tD-1z7mE:
undetectable		 3w9tD-1z7mE:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASP A 433
GLU A 346
GLY A 347
ASP A 381
 None
 1.30A 3w9tD-2am2A:
undetectable		 3w9tD-2am2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 ASP A1220
GLU A1213
GLY A1215
ASP A1274
 MG  A2278 (-3.0A)
None
None
None
 1.40A 3w9tD-2bjiA:
undetectable		 3w9tD-2bjiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ASP A 342
GLY A 336
TYR A 339
ASP A  18
 None
XMP  A1001 (-3.6A)
None
None
 1.19A 3w9tD-2cu0A:
undetectable		 3w9tD-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		4 GLU A  85
GLY A  82
TYR A 110
ASP A 182
 None
None
None
PLP  A1001 (-2.8A)
 1.07A 3w9tD-2dr1A:
undetectable		 3w9tD-2dr1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.41A 3w9tD-2e8yA:
undetectable		 3w9tD-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLU A 415
GLY A 414
TYR A 410
ASP A 381
 None
 1.23A 3w9tD-2h2qA:
undetectable		 3w9tD-2h2qA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		4 GLU A  49
GLY A  48
TYR A  55
ASP A  10
 None
 1.15A 3w9tD-2i7gA:
undetectable		 3w9tD-2i7gA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLU A 475
GLY A 474
TYR A 478
ASP A 355
 None
 1.43A 3w9tD-2jirA:
undetectable		 3w9tD-2jirA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lht CELLOPHANE-INDUCED
PROTEIN 1

(Venturia
inaequalis) 		no annotation 4 GLU A  83
GLY A  80
TYR A  85
ASP A  60
 None
 1.21A 3w9tD-2lhtA:
undetectable		 3w9tD-2lhtA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbz HYPOTHETICAL PROTEIN

(Thermococcus
kodakarensis) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 ASP A 190
GLY A 213
TYR A 172
ASP A 270
 None
None
ATP  A 400 (-4.7A)
None
 1.21A 3w9tD-2pbzA:
undetectable		 3w9tD-2pbzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ASP A 203
GLU A 156
GLY A 154
TYR A 205
 None
 1.42A 3w9tD-2q3rA:
undetectable		 3w9tD-2q3rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 144
GLY A 140
TYR A 151
ASP A 169
 None
 1.27A 3w9tD-2qq6A:
undetectable		 3w9tD-2qq6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 144
GLY A 141
TYR A 151
ASP A 169
 None
 1.32A 3w9tD-2qq6A:
undetectable		 3w9tD-2qq6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 ASP A 428
GLU A 277
GLY A 423
TYR A 429
 EDO  A 607 (-2.7A)
None
None
None
 1.33A 3w9tD-2qqmA:
undetectable		 3w9tD-2qqmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ASP A 254
GLU A  44
GLY A  45
ASP A 166
 None
GOL  A 333 ( 4.7A)
GOL  A 333 ( 4.1A)
None
 1.20A 3w9tD-2rbcA:
undetectable		 3w9tD-2rbcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ASP A 254
GLU A  44
GLY A  45
ASP A 168
 None
GOL  A 333 ( 4.7A)
GOL  A 333 ( 4.1A)
None
 1.30A 3w9tD-2rbcA:
undetectable		 3w9tD-2rbcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A 340
GLY A 341
TYR A 355
ASP A 333
 None
 1.04A 3w9tD-2wekA:
undetectable		 3w9tD-2wekA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLU S 217
GLY S 216
TYR S  99
ASP S 102
 None
 1.35A 3w9tD-2wpmS:
undetectable		 3w9tD-2wpmS:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xc8 GENE 22 PRODUCT

(Bacillus phage
SPP1) 		no annotation 4 GLU A  92
GLY A  90
TYR A  61
ASP A  87
 None
 1.43A 3w9tD-2xc8A:
undetectable		 3w9tD-2xc8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 ASP A 202
GLU A 159
GLY A 158
ASP A 167
 None
 1.04A 3w9tD-2xe5A:
undetectable		 3w9tD-2xe5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 ASP A  55
GLU A  62
GLY A  60
ASP A  87
 None
 0.88A 3w9tD-3a2kA:
undetectable		 3w9tD-3a2kA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep1 PGRP-HD -
PEPTIDOGLYCAN
RECOGNITION PROTEIN
HOMOLOGUE

(Alvinella
pompejana) 		PF01510
(Amidase_2) 		4 ASP A 150
GLU A 165
GLY A 166
ASP A 143
 None
 1.30A 3w9tD-3ep1A:
undetectable		 3w9tD-3ep1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A  94
GLY A  91
TYR A  96
ASP A  71
 None
 1.24A 3w9tD-3ho8A:
undetectable		 3w9tD-3ho8A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		4 GLU A 344
GLY A 343
TYR A 335
ASP A 312
 None
 0.88A 3w9tD-3hzrA:
undetectable		 3w9tD-3hzrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASP A 360
GLU A 359
GLY A 358
ASP A 370
 AZI  A 379 (-3.3A)
None
None
None
 1.18A 3w9tD-3jtmA:
undetectable		 3w9tD-3jtmA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4i HEAT SHOCK 70
(HSP70) PROTEIN

(Cryptosporidium
parvum) 		PF00012
(HSP70) 		4 ASP A 248
GLU A 247
GLY A 219
ASP A 241
 None
 1.26A 3w9tD-3l4iA:
undetectable		 3w9tD-3l4iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 ASP A 257
GLU A 256
GLY A 228
ASP A 250
 None
None
ANP  A 408 (-3.6A)
None
 1.39A 3w9tD-3ldoA:
undetectable		 3w9tD-3ldoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 GLU A 316
GLY A 315
TYR A 313
ASP A 281
 None
 1.20A 3w9tD-3ldoA:
undetectable		 3w9tD-3ldoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 ASP A  96
GLY A 102
TYR A 165
ASP A 167
 None
FMT  A 503 (-3.8A)
None
EDO  A 507 (-4.1A)
 1.41A 3w9tD-3ll7A:
undetectable		 3w9tD-3ll7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 ASP A 379
GLU A 199
GLY A 202
ASP A 390
 None
 1.33A 3w9tD-3lscA:
undetectable		 3w9tD-3lscA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ASP A 234
GLU A 232
GLY A 230
ASP A 177
 None
 1.39A 3w9tD-3mn3A:
undetectable		 3w9tD-3mn3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		4 GLU A 272
GLY A 321
TYR A 235
ASP A 279
 None
 1.04A 3w9tD-3om5A:
undetectable		 3w9tD-3om5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyo HEMOPEXIN FOLD
PROTEIN CP4

(Vigna
unguiculata) 		PF00045
(Hemopexin) 		4 ASP A 146
GLU A 131
GLY A 129
TYR A 145
 None
 1.13A 3w9tD-3oyoA:
undetectable		 3w9tD-3oyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		4 ASP A 427
GLU A 447
TYR A 444
ASP A 382
 None
 1.38A 3w9tD-3qomA:
undetectable		 3w9tD-3qomA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 ASP A 161
GLU A 120
GLY A 119
ASP A 115
 None
 1.09A 3w9tD-3r75A:
undetectable		 3w9tD-3r75A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu CULLIN-1
DCN1-LIKE PROTEIN 1

(Homo sapiens) 		PF03556
(Cullin_binding)
PF10557
(Cullin_Nedd8) 		4 ASP A 241
GLU A 233
GLY A 234
ASP C 754
 None
 1.27A 3w9tD-3tduA:
undetectable		 3w9tD-3tduA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ASP A 170
GLY A 172
TYR A  73
ASP A 202
 None
 1.43A 3w9tD-3tkrA:
undetectable		 3w9tD-3tkrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1w HYPOTHETICAL
PERIPLASMIC PROTEIN

(Parabacteroides
distasonis) 		PF11396
(PepSY_like) 		4 GLU A  56
GLY A  57
TYR A  60
ASP A  77
 None
 0.95A 3w9tD-3u1wA:
undetectable		 3w9tD-3u1wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		4 ASP A 185
GLU A 189
TYR A 188
ASP A 163
 None
 1.29A 3w9tD-4axvA:
undetectable		 3w9tD-4axvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 293
GLU A 186
TYR A 445
ASP A 343
 None
 1.25A 3w9tD-4b7gA:
undetectable		 3w9tD-4b7gA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLU A1514
GLY A1512
TYR A1515
ASP A1459
 None
 1.11A 3w9tD-4bedA:
undetectable		 3w9tD-4bedA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 GLU A 145
GLY A 382
TYR A 151
ASP A 109
 None
 1.25A 3w9tD-4c60A:
undetectable		 3w9tD-4c60A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 GLU A  88
GLY A 115
TYR A 103
ASP A 173
 None
 1.43A 3w9tD-4c89A:
undetectable		 3w9tD-4c89A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ASP A 305
GLU A 688
GLY A 398
ASP A 301
 None
 1.19A 3w9tD-4cakA:
undetectable		 3w9tD-4cakA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz4 UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Streptococcus
suis) 		PF16828
(GAGBD) 		4 GLU A 172
GLY A 173
TYR A 128
ASP A 181
 None
 1.37A 3w9tD-4fz4A:
undetectable		 3w9tD-4fz4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 ASP A 364
GLU A 412
GLY A 414
ASP A 282
 CBI  A 501 ( 3.9A)
TRS  A 503 (-2.7A)
None
CBI  A 501 ( 3.8A)
 0.93A 3w9tD-4haqA:
undetectable		 3w9tD-4haqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbo STRESS-70 PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00012
(HSP70) 		4 ASP A 277
GLU A 276
GLY A 248
ASP A 270
 None
 1.34A 3w9tD-4kboA:
undetectable		 3w9tD-4kboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2)
PF17047
(SMP_LBD) 		4 ASP A 432
GLU A 404
GLY A 382
ASP A 436
 None
 1.35A 3w9tD-4p42A:
undetectable		 3w9tD-4p42A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		4 GLU A  62
GLY A  66
TYR A  69
ASP A 262
 None
 1.40A 3w9tD-4p9kA:
undetectable		 3w9tD-4p9kA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 GLU A  62
GLY A  66
TYR A  69
ASP A 262
 None
 1.35A 3w9tD-4pdhA:
undetectable		 3w9tD-4pdhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4j ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ASP A 396
GLU A 335
GLY A 388
ASP A 384
 None
 1.39A 3w9tD-4q4jA:
undetectable		 3w9tD-4q4jA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		4 ASP B  34
GLU B  50
GLY B  72
ASP B  75
 None
 1.41A 3w9tD-4rt6B:
undetectable		 3w9tD-4rt6B:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvi AMINOTRANSFERASE,
CLASS IV

(Brucella
abortus) 		PF01063
(Aminotran_4) 		4 GLU A  34
GLY A  33
TYR A  31
ASP A 136
 None
 1.30A 3w9tD-4tviA:
undetectable		 3w9tD-4tviA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ASP A 308
GLU A 288
GLY A 311
ASP A 354
 None
 1.39A 3w9tD-4u08A:
undetectable		 3w9tD-4u08A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 GLU A 150
GLY A 159
TYR A 214
ASP A 162
 None
 1.37A 3w9tD-4v15A:
undetectable		 3w9tD-4v15A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF09440
(eIF3_N) 		4 GLU E 149
GLY E 146
TYR E 150
ASP E 115
 None
 1.14A 3w9tD-5a5tE:
undetectable		 3w9tD-5a5tE:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		4 GLU C  63
GLY C  62
TYR C  36
ASP C  56
 None
None
FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
 1.16A 3w9tD-5b8iC:
undetectable		 3w9tD-5b8iC:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 GLU A 336
GLY A 333
TYR A 338
ASP A 254
 None
 1.19A 3w9tD-5czjA:
undetectable		 3w9tD-5czjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		4 GLU A 125
GLY A 126
TYR A  16
ASP A  41
 None
 0.93A 3w9tD-5d6aA:
undetectable		 3w9tD-5d6aA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 481
GLU A 487
GLY A 488
ASP A 438
 None
 0.92A 3w9tD-5f7sA:
undetectable		 3w9tD-5f7sA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  54
GLU A  74
GLY A  72
TYR A  53
 None
ZN  A 901 (-2.9A)
None
None
 1.16A 3w9tD-5h83A:
undetectable		 3w9tD-5h83A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgg CAMELID DERIVED
ANTIBODY FRAGMENT,
NB4

(Vicugna pacos) 		PF07686
(V-set) 		4 GLU S 107
GLY S 102
TYR S 113
ASP S  99
 None
TWN  S 202 ( 4.5A)
None
None
 1.32A 3w9tD-5hggS:
undetectable		 3w9tD-5hggS:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		4 ASP A 259
GLU A 254
TYR A 258
ASP A 190
 None
 1.25A 3w9tD-5iobA:
undetectable		 3w9tD-5iobA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz3 PREDICTED PROTEIN

(Physcomitrella
patens) 		PF00316
(FBPase) 		4 GLU B 169
GLY B 170
TYR B 156
ASP B 202
 None
 1.39A 3w9tD-5iz3B:
undetectable		 3w9tD-5iz3B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnu LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Mus musculus) 		PF01451
(LMWPc) 		4 ASP A 129
GLU A  50
GLY A  14
ASP A  92
 None
 1.00A 3w9tD-5jnuA:
undetectable		 3w9tD-5jnuA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 642
GLY A 644
TYR A 629
ASP A 164
 None
 1.17A 3w9tD-5ju6A:
undetectable		 3w9tD-5ju6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 GLU A 403
GLY A 400
TYR A 405
ASP A 386
 None
 1.31A 3w9tD-5jz8A:
undetectable		 3w9tD-5jz8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k66 NTA1P

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 GLU A 153
GLY A 154
TYR A 134
ASP A 189
 None
 1.41A 3w9tD-5k66A:
undetectable		 3w9tD-5k66A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9o HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU F 340
GLY F 337
TYR F  17
ASP F 441
 None
 1.38A 3w9tD-5k9oF:
undetectable		 3w9tD-5k9oF:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6j NITROPHORIN-7

(Rhodnius
prolixus) 		no annotation 4 ASP A 134
GLU A   4
GLY A   3
ASP A  32
 None
 1.02A 3w9tD-5m6jA:
undetectable		 3w9tD-5m6jA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S4

(Trypanosoma
cruzi) 		no annotation 4 ASP L 140
GLU L  37
GLY L  82
ASP L  70
 None
 1.12A 3w9tD-5optL:
undetectable		 3w9tD-5optL:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 ASP A 465
GLU A 471
GLY A 472
ASP A 422
 None
 0.83A 3w9tD-5x3jA:
undetectable		 3w9tD-5x3jA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9g MAGNESIUM
TRANSPORTER MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF03448
(MgtE_N) 		4 ASP A  95
GLU A 131
GLY A 136
ASP A 247
 MG  A 303 (-2.2A)
None
MG  A 303 (-3.9A)
MG  A 302 (-2.7A)
 1.34A 3w9tD-5x9gA:
undetectable		 3w9tD-5x9gA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4

(Trichomonas
vaginalis) 		PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		4 ASP E 143
GLU E  40
GLY E  85
ASP E  73
 None
 1.34A 3w9tD-5xyiE:
undetectable		 3w9tD-5xyiE:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoj CEG4

(Legionella
pneumophila) 		no annotation 4 ASP A 158
GLU A  21
GLY A  19
ASP A 162
 MG  A 301 (-2.4A)
None
None
None
 1.30A 3w9tD-6aojA:
undetectable		 3w9tD-6aojA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 4 ASP A 372
GLU A   4
TYR A 369
ASP A 304
 None
 1.25A 3w9tD-6bk7A:
undetectable		 3w9tD-6bk7A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 4 ASP A 286
GLU A  42
GLY A  41
TYR A 289
 None
 1.26A 3w9tD-6c87A:
undetectable		 3w9tD-6c87A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs NPL4

(Chaetomium
thermophilum) 		no annotation 4 ASP A 356
GLU A 413
GLY A 412
ASP A 351
 None
 1.20A 3w9tD-6chsA:
undetectable		 3w9tD-6chsA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 4 ASP A 289
GLU A 230
TYR A  66
ASP A 315
 None
 1.34A 3w9tD-6dchA:
undetectable		 3w9tD-6dchA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 ASP A 257
GLU A 256
GLY A 228
ASP A 250
 None
None
SO4  A 602 (-3.4A)
None
 1.34A 3w9tD-6eoeA:
undetectable		 3w9tD-6eoeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2
PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP D  64
GLU A 987
GLY A 988
TYR D  61
 None
 1.34A 3w9tD-6eojD:
undetectable		 3w9tD-6eojD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 ASP A 315
GLU A 316
GLY A 319
ASP A 324
 None
 1.16A 3w9tD-6fwfA:
undetectable		 3w9tD-6fwfA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7mdh PROTEIN (MALATE
DEHYDROGENASE)

(Sorghum bicolor) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A 115
GLU A 121
TYR A 117
ASP A 153
 None
ZN  A 504 (-2.2A)
None
None
 1.42A 3w9tD-7mdhA:
undetectable		 3w9tD-7mdhA:
23.79