SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_C_W9TC1004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ASP A 121
GLY A 124
TYR A 134
GLN A 137
 CA  A1002 (-2.8A)
CA  A1002 (-4.3A)
None
CA  A1002 ( 4.5A)
 0.53A 3w9tC-1vclA:
34.1		 3w9tC-1vclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus) 		PF01593
(Amino_oxidase) 		4 ASP A 358
GLY A 237
TYR A 357
GLN A 103
 None
 1.15A 3w9tC-2jb1A:
0.0		 3w9tC-2jb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 ASP A  86
GLY A 340
TYR A  90
GLN A  49
 None
 1.07A 3w9tC-3a18A:
0.0		 3w9tC-3a18A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		4 ASP A 154
GLY A 123
TYR A 162
GLN A 151
 None
 1.41A 3w9tC-3ebvA:
0.0		 3w9tC-3ebvA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		4 ASP A 314
GLY A 169
TYR A 203
GLN A 388
 None
EDO  A 411 (-3.8A)
LLP  A 226 ( 3.5A)
EDO  A 411 (-3.5A)
 1.17A 3w9tC-3fd0A:
0.0		 3w9tC-3fd0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		4 ASP A 321
GLY A 176
TYR A 210
GLN A 395
 None
 1.13A 3w9tC-3ht4A:
0.0		 3w9tC-3ht4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 161
GLY A 192
TYR A 194
GLN A 157
 None
 1.27A 3w9tC-5i3oA:
0.0		 3w9tC-5i3oA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls2 LYSM TYPE RECEPTOR
KINASE

(Lotus japonicus) 		no annotation 4 ASP A 106
GLY A 145
TYR A 105
GLN A 108
 None
 1.49A 3w9tC-5ls2A:
0.0		 3w9tC-5ls2A:
18.49