SIMILAR PATTERNS OF AMINO ACIDS FOR 3W9T_A_W9TA1002
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bc5 | CHEMOTAXIS RECEPTORMETHYLTRANSFERASE (Salmonellaenterica) |
PF01739(CheR)PF03705(CheR_N) | 3 | ASP A 225GLU A 116GLY A 115 | None | 0.61A | 3w9tA-1bc5A:0.0 | 3w9tA-1bc5A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1coj | PROTEIN (SUPEROXIDEDISMUTASE) (Aquifexpyrophilus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 3 | ASP A 112GLU A 105GLY A 109 | None | 0.65A | 3w9tA-1cojA:undetectable | 3w9tA-1cojA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dv8 | ASIALOGLYCOPROTEINRECEPTOR 1 (Homo sapiens) |
PF00059(Lectin_C) | 3 | ASP A 253GLU A 252GLY A 251 | CA A1001 (-3.4A) CA A1002 ( 2.9A)None | 0.71A | 3w9tA-1dv8A:0.0 | 3w9tA-1dv8A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fzd | FIBRINOGEN-420 (Homo sapiens) |
PF00147(Fibrinogen_C) | 3 | ASP A 661GLU A 685GLY A 686 | None | 0.60A | 3w9tA-1fzdA:0.0 | 3w9tA-1fzdA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggp | PROTEIN (LECTIN 1 BCHAIN) (Trichosantheskirilowii) |
PF00652(Ricin_B_lectin) | 3 | ASP B 239GLU B 241GLY B 242 | None | 0.63A | 3w9tA-1ggpB:16.4 | 3w9tA-1ggpB:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcv | IMMUNOGLOBULIN G (Lama glama) |
PF07686(V-set) | 3 | ASP A 33GLU A 96GLY A 97 | None | 0.57A | 3w9tA-1hcvA:0.0 | 3w9tA-1hcvA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1koa | TWITCHIN (Caenorhabditiselegans) |
PF00069(Pkinase)PF07679(I-set) | 3 | ASP A6302GLU A6335GLY A6334 | None | 0.61A | 3w9tA-1koaA:0.0 | 3w9tA-1koaA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lth | L-LACTATEDEHYDROGENASE (T-AND R- STATETETRAMER COMPLEX) (Bifidobacteriumlongum) |
no annotation | 3 | ASP T 128GLU T 184GLY T 178 | None | 0.69A | 3w9tA-1lthT:0.0 | 3w9tA-1lthT:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lv2 | HEPATOCYTE NUCLEARFACTOR 4-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 3 | ASP A 279GLU A 286GLY A 282 | None | 0.67A | 3w9tA-1lv2A:0.0 | 3w9tA-1lv2A:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7r | HYALURONIDASE (Streptococcuspneumoniae) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 3 | ASP A 457GLU A 470GLY A 471 | None | 0.70A | 3w9tA-1n7rA:undetectable | 3w9tA-1n7rA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o2d | ALCOHOLDEHYDROGENASE,IRON-CONTAINING (Thermotogamaritima) |
PF00465(Fe-ADH) | 3 | ASP A 180GLU A 227GLY A 228 | None | 0.69A | 3w9tA-1o2dA:undetectable | 3w9tA-1o2dA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pe9 | PECTATE LYASE A (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 3 | ASP A 311GLU A 283GLY A 284 | None | 0.65A | 3w9tA-1pe9A:undetectable | 3w9tA-1pe9A:24.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pn4 | PEROXISOMALHYDRATASE-DEHYDROGENASE-EPIMERASE (Candidatropicalis) |
PF01575(MaoC_dehydratas) | 3 | ASP A 117GLU A 90GLY A 89 | None | 0.68A | 3w9tA-1pn4A:undetectable | 3w9tA-1pn4A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qva | INITIATION FACTOR 4A (Saccharomycescerevisiae) |
PF00270(DEAD) | 3 | ASP A 138GLU A 134GLY A 135 | None | 0.61A | 3w9tA-1qvaA:undetectable | 3w9tA-1qvaA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rdu | CONSERVEDHYPOTHETICAL PROTEIN (Thermotogamaritima) |
PF02579(Nitro_FeMo-Co) | 3 | ASP A 19GLU A 90GLY A 91 | None | 0.57A | 3w9tA-1rduA:undetectable | 3w9tA-1rduA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sp3 | CYTOCHROME C,PUTATIVE (Shewanellaoneidensis) |
PF11783(Cytochrome_cB)PF13435(Cytochrome_C554) | 3 | ASP A 339GLU A 386GLY A 385 | None | 0.50A | 3w9tA-1sp3A:undetectable | 3w9tA-1sp3A:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vcl | HEMOLYTIC LECTINCEL-III (Cucumariaechinata) |
PF00652(Ricin_B_lectin) | 3 | ASP A 121GLU A 123GLY A 124 | CA A1002 (-2.8A)None CA A1002 (-4.3A) | 0.45A | 3w9tA-1vclA:36.9 | 3w9tA-1vclA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vcl | HEMOLYTIC LECTINCEL-III (Cucumariaechinata) |
PF00652(Ricin_B_lectin) | 3 | ASP A 209GLU A 211GLY A 212 | CA A1004 (-2.6A)None CL A1201 ( 3.7A) | 0.55A | 3w9tA-1vclA:36.9 | 3w9tA-1vclA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjn | ZN-DEPENDENTHYDROLASE OFMETALLO-BETA-LACTAMASE SUPERFAMILYTM0207 (Thermotogamaritima) |
PF13483(Lactamase_B_3) | 3 | ASP A 128GLU A 100GLY A 103 | None | 0.67A | 3w9tA-1vjnA:undetectable | 3w9tA-1vjnA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrg | PROPIONYL-COACARBOXYLASE, BETASUBUNIT (Thermotogamaritima) |
PF01039(Carboxyl_trans) | 3 | ASP A 74GLU A 104GLY A 103 | None | 0.71A | 3w9tA-1vrgA:undetectable | 3w9tA-1vrgA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xny | PROPIONYL-COACARBOXYLASE COMPLEXB SUBUNIT (Streptomycescoelicolor) |
PF01039(Carboxyl_trans) | 3 | ASP A 85GLU A 115GLY A 114 | None | 0.62A | 3w9tA-1xnyA:undetectable | 3w9tA-1xnyA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xs3 | HYPOTHETICAL PROTEINXC975 (Xanthomonaseuvesicatoria) |
PF01722(BolA) | 3 | ASP A 39GLU A 70GLY A 69 | None | 0.68A | 3w9tA-1xs3A:undetectable | 3w9tA-1xs3A:11.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y25 | PROBABLE THIOLPEROXIDASE (Mycobacteriumtuberculosis) |
PF08534(Redoxin) | 3 | ASP A 68GLU A 99GLY A 97 | None | 0.62A | 3w9tA-1y25A:undetectable | 3w9tA-1y25A:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw1 | PROTEIN YTNJ (Bacillussubtilis) |
PF00296(Bac_luciferase) | 3 | ASP A 114GLU A 211GLY A 210 | None | 0.69A | 3w9tA-1yw1A:undetectable | 3w9tA-1yw1A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7s | PROBABLEPROPIONYL-COACARBOXYLASE BETACHAIN 5 (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 3 | ASP A 96GLU A 126GLY A 125 | None | 0.64A | 3w9tA-2a7sA:undetectable | 3w9tA-2a7sA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cbn | RIBONUCLEASE Z (Escherichiacoli) |
PF12706(Lactamase_B_2) | 3 | ASP A 227GLU A 151GLY A 204 | None | 0.70A | 3w9tA-2cbnA:undetectable | 3w9tA-2cbnA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5l | DIPEPTIDYLAMINOPEPTIDASE IV,PUTATIVE (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 3 | ASP A 358GLU A 380GLY A 379 | None | 0.61A | 3w9tA-2d5lA:undetectable | 3w9tA-2d5lA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpg | SUCCINYL-COA LIGASE[GDP-FORMING]ALPHA-CHAIN,MITOCHONDRIAL (Sus scrofa) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 3 | ASP A 189GLU A 105GLY A 106 | None | 0.65A | 3w9tA-2fpgA:undetectable | 3w9tA-2fpgA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hyx | PROTEIN DIPZ (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 3 | ASP A 560GLU A 527GLY A 528 | None | 0.67A | 3w9tA-2hyxA:undetectable | 3w9tA-2hyxA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip4 | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Thermusthermophilus) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 3 | ASP A 143GLU A 176GLY A 175 | None | 0.63A | 3w9tA-2ip4A:undetectable | 3w9tA-2ip4A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixb | ALPHA-N-ACETYLGALACTOSAMINIDASE (Elizabethkingiameningoseptica) |
PF01408(GFO_IDH_MocA) | 3 | ASP A 198GLU A 201GLY A 191 | None | 0.70A | 3w9tA-2ixbA:undetectable | 3w9tA-2ixbA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjy | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (Francisellatularensis) |
PF13561(adh_short_C2) | 3 | ASP A 97GLU A 110GLY A 111 | None | 0.69A | 3w9tA-2jjyA:undetectable | 3w9tA-2jjyA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k6m | SUPERVILLIN (Homo sapiens) |
PF02209(VHP) | 3 | ASP S 34GLU S 31GLY S 32 | None | 0.70A | 3w9tA-2k6mS:undetectable | 3w9tA-2k6mS:8.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k8h | SMALL UBIQUITINPROTEIN (Trypanosomabrucei) |
PF11976(Rad60-SLD) | 3 | ASP A 77GLU A 14GLY A 13 | None | 0.62A | 3w9tA-2k8hA:undetectable | 3w9tA-2k8hA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nmb | PROTEIN (NUMBPROTEIN) (Drosophilamelanogaster) |
PF00640(PID) | 3 | ASP A 182GLU A 157GLY A 159 | None | 0.60A | 3w9tA-2nmbA:undetectable | 3w9tA-2nmbA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqp | INTERLEUKIN-21 (Homo sapiens) |
no annotation | 3 | ASP A 27GLU A 65GLY A 62 | None | 0.70A | 3w9tA-2oqpA:undetectable | 3w9tA-2oqpA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbj | PROSTAGLANDIN ESYNTHASE 2 (Macacafascicularis) |
PF13417(GST_N_3) | 3 | ASP A 351GLU A 345GLY A 346 | None | 0.64A | 3w9tA-2pbjA:undetectable | 3w9tA-2pbjA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2por | PORIN (Rhodobactercapsulatus) |
PF13609(Porin_4) | 3 | ASP A 136GLU A 141GLY A 140 | CA A 304 (-2.1A)None CA A 304 (-4.3A) | 0.69A | 3w9tA-2porA:undetectable | 3w9tA-2porA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdg | SUPERANTIGEN-LIKEPROTEIN 11 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | ASP A 59GLU A 32GLY A 33 | None | 0.58A | 3w9tA-2rdgA:undetectable | 3w9tA-2rdgA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE ALPHACHAINPHENYLALANYL-TRNASYNTHETASE BETACHAIN (Staphylococcushaemolyticus) |
PF01409(tRNA-synt_2d)PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 3 | ASP A 221GLU B 490GLY B 489 | None | 0.44A | 3w9tA-2rhqA:undetectable | 3w9tA-2rhqA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rik | TITIN (Oryctolaguscuniculus) |
PF07679(I-set) | 3 | ASP A 225GLU A 258GLY A 257 | None | 0.65A | 3w9tA-2rikA:undetectable | 3w9tA-2rikA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wda | PUTATIVE SECRETEDLYASE (Streptomycesviolaceoruber) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 3 | ASP A 594GLU A 560GLY A 561 | None | 0.56A | 3w9tA-2wdaA:undetectable | 3w9tA-2wdaA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfn | ALPHA-GALACTOSIDASE-SUCROSE KINASE AGASK ([Ruminococcus]gnavus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 3 | ASP A 191GLU A 236GLY A 238 | NoneGOL A1722 (-3.1A)None | 0.70A | 3w9tA-2yfnA:undetectable | 3w9tA-2yfnA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv2 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Aeropyrumpernix) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 3 | ASP A 187GLU A 104GLY A 105 | None | 0.61A | 3w9tA-2yv2A:undetectable | 3w9tA-2yv2A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b43 | TITIN (Oryctolaguscuniculus) |
PF07679(I-set) | 3 | ASP A 417GLU A 450GLY A 449 | None | 0.49A | 3w9tA-3b43A:undetectable | 3w9tA-3b43A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh3 | RIBOSOMAL LARGESUBUNITPSEUDOURIDINESYNTHASE F (Escherichiacoli) |
PF00849(PseudoU_synth_2)PF01479(S4) | 3 | ASP A 142GLU A 194GLY A 197 | None | 0.67A | 3w9tA-3dh3A:undetectable | 3w9tA-3dh3A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 3 | ASP A1239GLU A1236GLY A1235 | None | 0.67A | 3w9tA-3egwA:undetectable | 3w9tA-3egwA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fha | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE (Glutamicibacterprotophormiae) |
PF03644(Glyco_hydro_85) | 3 | ASP A 543GLU A 584GLY A 585 | None | 0.66A | 3w9tA-3fhaA:undetectable | 3w9tA-3fhaA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 3 | ASP A 18GLU A 398GLY A 21 | None | 0.52A | 3w9tA-3gipA:undetectable | 3w9tA-3gipA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdi | PROCESSING PROTEASE (Bacillushalodurans) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 3 | ASP A 292GLU A 217GLY A 216 | None | 0.61A | 3w9tA-3hdiA:undetectable | 3w9tA-3hdiA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhs | PHENOLOXIDASESUBUNIT 1 (Manduca sexta) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 3 | ASP B 399GLU B 270GLY B 271 | None | 0.62A | 3w9tA-3hhsB:undetectable | 3w9tA-3hhsB:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibj | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I)PF01590(GAF)PF13185(GAF_2) | 3 | ASP A 769GLU A 722GLY A 723 | None | 0.66A | 3w9tA-3ibjA:undetectable | 3w9tA-3ibjA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixw | HEMOCYANIN AA6 CHAIN (Androctonusaustralis) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 3 | ASP A 354GLU A 231GLY A 232 | None | 0.62A | 3w9tA-3ixwA:undetectable | 3w9tA-3ixwA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jbr | VOLTAGE-DEPENDENTCALCIUM CHANNELSUBUNITALPHA-2/DELTA-1 (Oryctolaguscuniculus) |
PF00092(VWA)PF08399(VWA_N)PF08473(VGCC_alpha2) | 3 | ASP F 397GLU F 368GLY F 367 | None | 0.69A | 3w9tA-3jbrF:undetectable | 3w9tA-3jbrF:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq4 | CUBILIN (Homo sapiens) |
PF00431(CUB) | 3 | ASP B1221GLU B1263GLY B1264 | CA B2016 (-2.2A)None CA B2016 (-4.3A) | 0.62A | 3w9tA-3kq4B:undetectable | 3w9tA-3kq4B:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhx | KETODEOXYGLUCONOKINASE (Shigellaflexneri) |
PF00294(PfkB) | 3 | ASP A 102GLU A 83GLY A 82 | None | 0.59A | 3w9tA-3lhxA:undetectable | 3w9tA-3lhxA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0g | ISOPRENE SYNTHASE (Populus tremulax Populus alba) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | ASP A 209GLU A 205GLY A 204 | None | 0.62A | 3w9tA-3n0gA:undetectable | 3w9tA-3n0gA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pb9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE-LIKE PROTEIN (Homo sapiens) |
PF04389(Peptidase_M28) | 3 | ASP X 327GLU X 226GLY X 224 | None ZN X 400 ( 2.1A)None | 0.70A | 3w9tA-3pb9X:undetectable | 3w9tA-3pb9X:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sdq | ALPHA-BISABOLENESYNTHASE (Abies grandis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | ASP A 412GLU A 408GLY A 407 | None | 0.67A | 3w9tA-3sdqA:undetectable | 3w9tA-3sdqA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3si1 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Mus musculus) |
PF04389(Peptidase_M28) | 3 | ASP A 307GLU A 203GLY A 201 | None ZN A 601 (-2.3A)None | 0.63A | 3w9tA-3si1A:undetectable | 3w9tA-3si1A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdu | DCN1-LIKE PROTEIN 1 (Homo sapiens) |
PF03556(Cullin_binding) | 3 | ASP A 241GLU A 233GLY A 234 | None | 0.55A | 3w9tA-3tduA:undetectable | 3w9tA-3tduA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tw5 | TRANSGLUTAMINASEELICITOR (Phytophthorasojae) |
PF16683(TGase_elicitor) | 3 | ASP A 385GLU A 391GLY A 389 | None | 0.56A | 3w9tA-3tw5A:undetectable | 3w9tA-3tw5A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u95 | GLYCOSIDE HYDROLASE,FAMILY 4 (Thermotoganeapolitana) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | ASP A 20GLU A 344GLY A 343 | None | 0.59A | 3w9tA-3u95A:undetectable | 3w9tA-3u95A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5v | MICRONEMAL PROTEIN 4 (Toxoplasmagondii) |
PF00024(PAN_1) | 3 | ASP A 96GLU A 92GLY A 93 | None | 0.66A | 3w9tA-4a5vA:undetectable | 3w9tA-4a5vA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4avc | LYSINEACETYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF00027(cNMP_binding)PF13302(Acetyltransf_3) | 3 | ASP A 242GLU A 179GLY A 178 | None | 0.66A | 3w9tA-4avcA:undetectable | 3w9tA-4avcA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3k | BETA-GLUCOSIDASE (Streptococcuspyogenes) |
PF00232(Glyco_hydro_1) | 3 | ASP A 336GLU A 374GLY A 373 | None | 0.66A | 3w9tA-4b3kA:undetectable | 3w9tA-4b3kA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cpg | SMALL GLUTAMINE-RICHTETRATRICOPEPTIDEREPEAT-CONTAININGPROTEIN ALPHA (Homo sapiens) |
PF16546(SGTA_dimer) | 3 | ASP A 63GLU A 54GLY A 58 | None | 0.71A | 3w9tA-4cpgA:undetectable | 3w9tA-4cpgA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dg5 | PHOSPHOGLYCERATEKINASE (Staphylococcusaureus) |
PF00162(PGK) | 3 | ASP A 367GLU A 365GLY A 363 | None | 0.66A | 3w9tA-4dg5A:undetectable | 3w9tA-4dg5A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e69 | 2-DEHYDRO-3-DEOXYGLUCONOKINASE (Oceanicolagranulosus) |
PF00294(PfkB) | 3 | ASP A 29GLU A 8GLY A 7 | None | 0.59A | 3w9tA-4e69A:undetectable | 3w9tA-4e69A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | ASP B1415GLU B1411GLY B1410 | None | 0.67A | 3w9tA-4f92B:undetectable | 3w9tA-4f92B:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ft2 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Zea mays) |
PF00145(DNA_methylase)PF00385(Chromo)PF01426(BAH) | 3 | ASP A 474GLU A 473GLY A 470 | None | 0.61A | 3w9tA-4ft2A:undetectable | 3w9tA-4ft2A:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g76 | PHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF14859(Colicin_M) | 3 | ASP A 241GLU A 213GLY A 212 | None | 0.65A | 3w9tA-4g76A:undetectable | 3w9tA-4g76A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4got | METHIONINE-BINDINGLIPOPROTEIN METQ (Bacillussubtilis) |
PF03180(Lipoprotein_9) | 3 | ASP A 198GLU A 179GLY A 130 | None | 0.67A | 3w9tA-4gotA:undetectable | 3w9tA-4gotA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n27 | BACTERIALTRANSFERASEHEXAPEPTIDE REPEAT (Brucellaabortus) |
PF00132(Hexapep) | 3 | ASP A 131GLU A 95GLY A 94 | None | 0.69A | 3w9tA-4n27A:undetectable | 3w9tA-4n27A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nsd | CALCIUM UPTAKEPROTEIN 1,MITOCHONDRIAL (Homo sapiens) |
PF13202(EF-hand_5)PF13833(EF-hand_8) | 3 | ASP A 423GLU A 427GLY A 426 | CA A 502 (-2.8A)NoneNone | 0.71A | 3w9tA-4nsdA:undetectable | 3w9tA-4nsdA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u48 | PUTATIVE INNERMEMBRANE LIPOPROTEIN (Salmonellaenterica) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF10569(Thiol-ester_cl)PF11974(MG1) | 3 | ASP A 892GLU A 987GLY A 986 | None | 0.60A | 3w9tA-4u48A:undetectable | 3w9tA-4u48A:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x68 | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00144(Beta-lactamase) | 3 | ASP A 257GLU A 212GLY A 210 | None | 0.65A | 3w9tA-4x68A:undetectable | 3w9tA-4x68A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x6g | OXYR (Pseudomonasaeruginosa) |
PF00126(HTH_1)PF03466(LysR_substrate) | 3 | ASP A 202GLU A 196GLY A 197 | None | 0.62A | 3w9tA-4x6gA:undetectable | 3w9tA-4x6gA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9l | HEAT SHOCK PROTEIN (Oryza sativa) |
PF00183(HSP90)PF02518(HATPase_c) | 3 | ASP A 163GLU A 167GLY A 166 | NonePG4 A 302 (-2.9A)None | 0.52A | 3w9tA-4x9lA:undetectable | 3w9tA-4x9lA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdy | KETOL-ACIDREDUCTOISOMERASE (unculturedarchaeonGZfos26G2) |
PF01450(IlvC)PF07991(IlvN) | 3 | ASP A 128GLU A 164GLY A 163 | None | 0.53A | 3w9tA-4xdyA:undetectable | 3w9tA-4xdyA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeh | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 3 | ASP A 124GLU A 160GLY A 159 | None | 0.36A | 3w9tA-4xehA:undetectable | 3w9tA-4xehA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a42 | UNCHARACTERIZEDLIPOPROTEIN YFHM (Escherichiacoli) |
PF00207(A2M)PF01835(A2M_N)PF07703(A2M_N_2)PF11974(MG1) | 3 | ASP A 900GLU A 995GLY A 994 | None | 0.58A | 3w9tA-5a42A:undetectable | 3w9tA-5a42A:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II,SUBUNIT BETA (Methanothermobactermarburgensis) |
PF02240(MCR_gamma) | 3 | ASP C 147GLU C 212GLY C 209 | None | 0.62A | 3w9tA-5a8rC:undetectable | 3w9tA-5a8rC:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvw | BIFUNCTIONALHEMOLYSIN/ADENYLATECYCLASE (Bordetellapertussis) |
PF00353(HemolysinCabind)PF06594(HCBP_related) | 3 | ASP A1570GLU A1567GLY A1550 | CA A1705 ( 2.5A) MG A1714 ( 2.5A) CA A1704 (-4.2A) | 0.65A | 3w9tA-5cvwA:undetectable | 3w9tA-5cvwA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4r | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 3 | ASP A 124GLU A 160GLY A 159 | None | 0.58A | 3w9tA-5e4rA:undetectable | 3w9tA-5e4rA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e5b | FACT COMPLEX SUBUNITSPT16 (Homo sapiens) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 3 | ASP A 63GLU A 145GLY A 144 | None | 0.58A | 3w9tA-5e5bA:undetectable | 3w9tA-5e5bA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5y | NON-LEE ENCODEDEFFECTOR PROTEINNLEB (Escherichiacoli) |
no annotation | 3 | ASP A 37GLU A 212GLY A 211 | None | 0.46A | 3w9tA-5h5yA:undetectable | 3w9tA-5h5yA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvf | CARBOXYPEPTIDASE B2 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 3 | ASP A 38GLU A 245GLY A 246 | None | 0.52A | 3w9tA-5hvfA:undetectable | 3w9tA-5hvfA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inf | CARBOXYL TRANSFERASE (Streptomycesambofaciens) |
PF01039(Carboxyl_trans) | 3 | ASP A 86GLU A 116GLY A 115 | None | 0.56A | 3w9tA-5infA:undetectable | 3w9tA-5infA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2r | FUMARATE HYDRATASE (Leishmaniamajor) |
PF05681(Fumerase)PF05683(Fumerase_C) | 3 | ASP A 155GLU A 154GLY A 152 | None | 0.63A | 3w9tA-5l2rA:undetectable | 3w9tA-5l2rA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6g | BETA-GLUCOSIDASE (Saccharopolysporaerythraea) |
no annotation | 3 | ASP A 458GLU A 461GLY A 462 | MG A 706 ( 4.1A)None MG A 706 (-4.0A) | 0.55A | 3w9tA-5m6gA:undetectable | 3w9tA-5m6gA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mms | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
PF00291(PALP) | 3 | ASP A 281GLU A 283GLY A 284 | None | 0.70A | 3w9tA-5mmsA:undetectable | 3w9tA-5mmsA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msy | GLYCOSIDE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF12904(Collagen_bind_2)PF13204(DUF4038) | 3 | ASP A 282GLU A 284GLY A 241 | NoneNH3 A 504 (-4.4A)None | 0.71A | 3w9tA-5msyA:undetectable | 3w9tA-5msyA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o77 | OMPK35 (Klebsiellapneumoniae) |
no annotation | 3 | ASP A 33GLU A 20GLY A 19 | None | 0.65A | 3w9tA-5o77A:undetectable | 3w9tA-5o77A:11.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tlc | DIBENZOTHIOPHENEDESULFURIZATIONENZYME A (Bacillussubtilis) |
PF00296(Bac_luciferase) | 3 | ASP A 125GLU A 222GLY A 221 | None | 0.68A | 3w9tA-5tlcA:undetectable | 3w9tA-5tlcA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wan | PYRIMIDINEMONOOXYGENASE RUTA (Escherichiacoli) |
PF00296(Bac_luciferase) | 3 | ASP A 265GLU A 60GLY A 56 | NoneGOL A 408 (-4.2A)None | 0.58A | 3w9tA-5wanA:undetectable | 3w9tA-5wanA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgg | RADICAL SAM DOMAINPROTEIN (Ruminiclostridiumthermocellum) |
PF04055(Radical_SAM)PF13186(SPASM)PF13353(Fer4_12) | 3 | ASP A 17GLU A 69GLY A 72 | None | 0.67A | 3w9tA-5wggA:undetectable | 3w9tA-5wggA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9s | GLYCOSYL HYDROLASEFAMILY 3 PROTEIN (Bifidobacteriumlongum) |
no annotation | 3 | ASP A 714GLU A 766GLY A 765 | None | 0.57A | 3w9tA-5z9sA:undetectable | 3w9tA-5z9sA:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byx | SHORT ULVAN LYASE (Alteromonas sp.LOR) |
no annotation | 3 | ASP A 165GLU A 144GLY A 135 | None | 0.62A | 3w9tA-6byxA:undetectable | 3w9tA-6byxA:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dft | - (-) |
no annotation | 3 | ASP A 402GLU A 400GLY A 407 | NAD B 500 (-3.8A)NoneNone | 0.53A | 3w9tA-6dftA:undetectable | 3w9tA-6dftA:undetectable |