SIMILAR PATTERNS OF AMINO ACIDS FOR 3W6H_B_AZMB303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
 0.39A 3w6hB-1jd0A:
35.6		 3w6hB-1jd0A:
37.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A1022
HIS A 103
HIS A 978
LEU A1018
HIS A 163
 CU  A1051 (-3.2A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
None
CU  A1050 (-3.3A)
 1.39A 3w6hB-1kcwA:
undetectable		 3w6hB-1kcwA:
12.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 GLN A  69
HIS A  92
HIS A  94
GLU A  98
HIS A 111
LEU A 176
THR A 177
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
 0.86A 3w6hB-1kopA:
29.4		 3w6hB-1kopA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		8 GLN A  90
HIS A  92
HIS A  94
GLU A  98
HIS A 111
LEU A 176
THR A 177
TRP A 187
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
 0.47A 3w6hB-1kopA:
29.4		 3w6hB-1kopA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
GLU A 106
LEU A 198
THR A 199
 None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.5A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
 0.89A 3w6hB-1rj6A:
36.1		 3w6hB-1rj6A:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.5A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
 0.49A 3w6hB-1rj6A:
36.1		 3w6hB-1rj6A:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
GLU A 106
HIS A 119
THR A 199
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.7A)
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.9A)
 0.95A 3w6hB-1urtA:
36.7		 3w6hB-1urtA:
44.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.7A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
 0.47A 3w6hB-1urtA:
36.7		 3w6hB-1urtA:
44.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		8 GLN A 113
HIS A 115
HIS A 117
GLU A 122
HIS A 135
LEU A 216
THR A 217
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 4.5A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
None
 0.38A 3w6hB-1y7wA:
25.2		 3w6hB-1y7wA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.35A 3w6hB-2it4A:
45.1		 3w6hB-2it4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLN A  81
HIS A  78
HIS A  76
HIS A 137
HIS A 285
 None
ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
None
ZN  A 493 (-3.5A)
 1.06A 3w6hB-2pajA:
undetectable		 3w6hB-2pajA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 118
GLU A 128
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
None
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
 0.28A 3w6hB-2w2jA:
35.1		 3w6hB-2w2jA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 4.7A)
None
 0.50A 3w6hB-2zncA:
30.3		 3w6hB-2zncA:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 GLN A 115
HIS A 163
HIS A 165
GLU A 169
HIS A 182
LEU A 259
THR A 260
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
 0.80A 3w6hB-3b1bA:
24.8		 3w6hB-3b1bA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 GLN A 161
HIS A 163
HIS A 165
GLU A 169
HIS A 182
LEU A 259
THR A 260
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
ZN  A 378 (-3.1A)
None
ZN  A 378 ( 4.5A)
None
 0.41A 3w6hB-3b1bA:
24.8		 3w6hB-3b1bA:
25.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  95
HIS A  97
GLU A 107
HIS A 120
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.49A 3w6hB-3da2A:
42.1		 3w6hB-3da2A:
59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A 109
HIS A 111
HIS A 113
GLU A 125
HIS A 138
LEU A 219
THR A 220
TRP A 230
 None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
None
None
 0.72A 3w6hB-3fe4A:
30.3		 3w6hB-3fe4A:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 129
GLU A 141
LEU A 235
THR A 236
TRP A 246
 None
 0.24A 3w6hB-3jxfA:
32.4		 3w6hB-3jxfA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  94
HIS A  96
GLU A 106
THR A 199
 None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
AZM  A 264 (-3.4A)
 0.83A 3w6hB-3ml5A:
40.5		 3w6hB-3ml5A:
50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
 0.39A 3w6hB-3ml5A:
40.5		 3w6hB-3ml5A:
50.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 GLN A 102
HIS A 123
HIS A 125
GLU A 129
HIS A 142
THR A 215
 None
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 4.7A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.3A)
 0.80A 3w6hB-3q31A:
23.5		 3w6hB-3q31A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		8 GLN A 121
HIS A 123
HIS A 125
GLU A 129
HIS A 142
LEU A 214
THR A 215
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 4.7A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-4.9A)
 0.44A 3w6hB-3q31A:
23.5		 3w6hB-3q31A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 HIS A 123
HIS A 142
LEU A 214
THR A 215
TRP A 225
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-4.9A)
 1.50A 3w6hB-3q31A:
23.5		 3w6hB-3q31A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
THR A 198
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.9A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
None
 0.49A 3w6hB-3uyqA:
40.9		 3w6hB-3uyqA:
54.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		8 GLN A  87
HIS A  89
HIS A  91
GLU A  95
HIS A 108
LEU A 173
THR A 174
TRP A 184
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.6A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 0.39A 3w6hB-4g7aA:
28.7		 3w6hB-4g7aA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		5 HIS A 120
HIS A  48
GLU A  45
HIS A 234
TRP A 148
 None
 0.83A 3w6hB-4jqsA:
undetectable		 3w6hB-4jqsA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.5A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
 0.39A 3w6hB-4qk3A:
39.1		 3w6hB-4qk3A:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 HIS A 185
HIS A 253
HIS A 187
LEU A 349
HIS A 321
 ZN  A 501 (-3.6A)
ZN  A 501 ( 3.5A)
ZN  A 501 ( 3.4A)
3PE  A 503 ( 4.6A)
3PE  A 503 (-3.8A)
 1.49A 3w6hB-4qn9A:
undetectable		 3w6hB-4qn9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 HIS A 185
HIS A 253
HIS A 187
LEU A 349
HIS A 343
 ZN  A 501 (-3.6A)
ZN  A 501 ( 3.5A)
ZN  A 501 ( 3.4A)
3PE  A 503 ( 4.6A)
ZN  A 502 ( 3.6A)
 1.43A 3w6hB-4qn9A:
undetectable		 3w6hB-4qn9A:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		8 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
LEU A 197
THR A 198
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 0.42A 3w6hB-4uovA:
30.3		 3w6hB-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 GLN A 110
HIS A 112
HIS A 114
HIS A 131
HIS A  87
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
ZN  A 298 ( 3.2A)
CL  A 304 ( 4.9A)
 1.06A 3w6hB-4uovA:
30.3		 3w6hB-4uovA:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
HIS A  89
HIS A  91
GLU A  95
THR A 174
 None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.5A)
AZM  A 302 (-3.3A)
 0.83A 3w6hB-4x5sA:
28.8		 3w6hB-4x5sA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		8 GLN A  87
HIS A  89
HIS A  91
GLU A  95
HIS A 108
LEU A 173
THR A 174
TRP A 184
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.5A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 0.38A 3w6hB-4x5sA:
28.8		 3w6hB-4x5sA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 HIS A 110
HIS A 112
GLU A 116
HIS A 129
LEU A 190
THR A 191
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-4.9A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 (-4.3A)
None
 0.43A 3w6hB-4xfwA:
25.6		 3w6hB-4xfwA:
29.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 GLN A 138
HIS A 160
HIS A 162
LEU A 253
THR A 254
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
 0.83A 3w6hB-4xixA:
26.1		 3w6hB-4xixA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 GLN A 158
HIS A 160
HIS A 162
GLU A 166
HIS A 179
LEU A 253
THR A 254
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 ( 4.7A)
ZN  A 401 ( 3.1A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
None
 0.48A 3w6hB-4xixA:
26.1		 3w6hB-4xixA:
32.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		8 GLN A 163
HIS A 165
HIS A 167
GLU A 171
HIS A 184
LEU A 251
THR A 252
TRP A 262
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.1A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
 0.43A 3w6hB-4xz5A:
29.2		 3w6hB-4xz5A:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
GLU A 106
HIS A 119
THR A 199
 GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
 0.79A 3w6hB-5cjfA:
35.6		 3w6hB-5cjfA:
34.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
 0.40A 3w6hB-5cjfA:
35.6		 3w6hB-5cjfA:
34.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
GLU A 162
LEU A 256
THR A 257
TRP A 267
 None
 0.29A 3w6hB-5e5uA:
32.5		 3w6hB-5e5uA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		8 GLN X  91
HIS X  93
HIS X  95
GLU X 105
HIS X 118
LEU X 196
THR X 197
TRP X 207
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 ( 4.6A)
ZN  X 301 (-3.1A)
None
ZN  X 301 ( 4.4A)
None
 0.41A 3w6hB-5eztX:
41.5		 3w6hB-5eztX:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		8 GLN A  94
HIS A  96
HIS A  98
GLU A 102
HIS A 115
LEU A 181
THR A 182
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
 0.48A 3w6hB-5hpjA:
28.4		 3w6hB-5hpjA:
31.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
None
 0.42A 3w6hB-5jn9A:
31.1		 3w6hB-5jn9A:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		5 HIS A 304
HIS A 238
GLU A 150
HIS A 183
THR A 136
 FE2  A 502 (-3.8A)
FE2  A 502 (-4.5A)
None
FE2  A 502 (-4.0A)
None
 1.34A 3w6hB-5kjaA:
undetectable		 3w6hB-5kjaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 8 GLN A 115
HIS A 117
HIS A 119
GLU A 123
HIS A 136
LEU A 201
THR A 202
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.2A)
None
ZN  A 301 (-4.4A)
None
 0.42A 3w6hB-6ekiA:
29.9		 3w6hB-6ekiA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 8 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
 0.50A 3w6hB-6fe1A:
32.8		 3w6hB-6fe1A:
15.83