SIMILAR PATTERNS OF AMINO ACIDS FOR 3W68_A_VIVA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 TYR A 390
LEU A  48
VAL A 105
LEU A 109
VAL A  61
 None
 0.91A 3w68A-1cj2A:
undetectable		 3w68A-1cj2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds6 RHO GDP-DISSOCIATION
INHIBITOR 2

(Homo sapiens) 		PF02115
(Rho_GDI) 		5 VAL B 126
LEU B 123
VAL B  69
LEU B  87
PHE B 113
 None
 1.20A 3w68A-1ds6B:
undetectable		 3w68A-1ds6B:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gka CRUSTACYANIN A2
SUBUNIT

(Homarus
gammarus) 		PF00061
(Lipocalin) 		5 VAL B  62
SER B  49
PHE B 133
VAL B  43
VAL B 164
 None
 1.07A 3w68A-1gkaB:
undetectable		 3w68A-1gkaB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		5 LEU A  94
ILE A  21
VAL A 265
LEU A 268
VAL A 216
 None
 1.19A 3w68A-1nnhA:
undetectable		 3w68A-1nnhA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 TYR A 104
LEU A 132
VAL A  99
LEU A   8
VAL A  72
 XMP  A 901 (-4.1A)
None
None
None
None
 1.16A 3w68A-1pl0A:
1.1		 3w68A-1pl0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 SER A 134
LEU A 135
SER A 138
VAL A 164
PHE A 161
 FMT  A3013 (-2.6A)
None
None
None
None
 1.18A 3w68A-1r4pA:
undetectable		 3w68A-1r4pA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TYR A 100
TRP A 122
VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.44A 3w68A-1r5lA:
38.7		 3w68A-1r5lA:
89.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		5 TYR A 185
TRP A  98
VAL A  66
LEU A  10
SER A  12
 None
 1.12A 3w68A-1yx1A:
1.8		 3w68A-1yx1A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 VAL A 229
LEU A 248
PHE A   6
LEU A 260
VAL A   2
 None
 1.17A 3w68A-1zjjA:
2.1		 3w68A-1zjjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 LEU A1551
ILE A1536
VAL A1507
LEU A1508
PHE A1510
 None
 1.18A 3w68A-2ix8A:
undetectable		 3w68A-2ix8A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		5 LEU A 252
SER A 221
VAL A  15
LEU A  38
VAL A 186
 None
 1.18A 3w68A-2p4zA:
3.2		 3w68A-2p4zA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 116
SER A 147
LEU A 177
PHE A 179
VAL A 192
 None
 1.16A 3w68A-2plaA:
undetectable		 3w68A-2plaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 TYR A 215
ILE A 236
VAL A 270
LEU A 267
VAL A 285
 None
None
PEG  A 415 (-4.5A)
None
None
 1.03A 3w68A-2py6A:
undetectable		 3w68A-2py6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax) 		PF00625
(Guanylate_kin) 		5 LEU A 186
ILE A  21
VAL A  24
LEU A  25
PHE A  28
 None
 1.06A 3w68A-2qorA:
undetectable		 3w68A-2qorA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax) 		PF00625
(Guanylate_kin) 		5 VAL A   8
ILE A  21
VAL A  24
LEU A  25
PHE A  28
 None
 1.19A 3w68A-2qorA:
undetectable		 3w68A-2qorA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wia FERROUS IRON
TRANSPORT PROTEIN B

(Klebsiella
pneumoniae) 		PF02421
(FeoB_N) 		5 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.08A 3w68A-2wiaA:
undetectable		 3w68A-2wiaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnb -

(Sus scrofa) 		PF00777
(Glyco_transf_29) 		5 LEU A 201
ILE A 208
VAL A 193
PHE A 198
VAL A 220
 None
 0.99A 3w68A-2wnbA:
undetectable		 3w68A-2wnbA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 VAL A 195
SER A 204
SER A 202
LEU A  90
VAL A  88
 None
None
ATP  A 502 (-4.7A)
None
None
 1.06A 3w68A-2ychA:
undetectable		 3w68A-2ychA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhl GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 101
ILE A 134
VAL A  47
PHE A  45
VAL A  15
 None
 1.13A 3w68A-2zhlA:
undetectable		 3w68A-2zhlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		5 SER A 137
LEU A  56
ILE A 190
LEU A  81
VAL A  65
 None
 1.08A 3w68A-3aq2A:
undetectable		 3w68A-3aq2A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 SER A 638
SER A 642
ILE A 598
VAL A 585
PHE A 589
 None
 1.20A 3w68A-3aqpA:
undetectable		 3w68A-3aqpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 VAL A 264
LEU A 384
ILE A 376
VAL A 430
LEU A 378
 None
 1.09A 3w68A-3boeA:
undetectable		 3w68A-3boeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 VAL A  54
LEU A 174
ILE A 166
VAL A 220
LEU A 168
 None
 1.06A 3w68A-3bohA:
undetectable		 3w68A-3bohA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 VAL A 128
LEU A 133
SER A 136
VAL A 157
VAL A  77
 None
 1.10A 3w68A-3e3pA:
undetectable		 3w68A-3e3pA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 LEU A 827
ILE A 783
VAL A 781
LEU A 760
VAL A 700
 None
 1.02A 3w68A-3h09A:
undetectable		 3w68A-3h09A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		6 VAL A  33
PHE A  74
ILE A  80
LEU A  97
PHE A  86
VAL A  99
 None
 1.39A 3w68A-3i2tA:
undetectable		 3w68A-3i2tA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 SER A 147
ILE A 153
LEU A 107
PHE A 101
VAL A  93
 None
 1.04A 3w68A-3msgA:
2.5		 3w68A-3msgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvc GLOBIN PROTEIN 6

(Caenorhabditis
elegans) 		PF00042
(Globin) 		5 VAL A 260
LEU A 265
VAL A 338
LEU A 342
PHE A 337
 None
None
None
HEM  A 500 ( 4.8A)
None
 1.14A 3w68A-3mvcA:
undetectable		 3w68A-3mvcA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 SER A 103
LEU A 104
ILE A  36
VAL A  64
PHE A 114
 None
 1.18A 3w68A-3oqvA:
undetectable		 3w68A-3oqvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 117
ILE A  46
VAL A  68
LEU A  44
VAL A  40
 None
 0.96A 3w68A-3p11A:
undetectable		 3w68A-3p11A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 5 SER A 195
LEU A 194
PHE A 148
ILE A  75
LEU A 216
 None
 1.13A 3w68A-3phfA:
undetectable		 3w68A-3phfA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		5 SER A  95
SER A 105
ILE A  63
VAL A  67
LEU A  60
 None
 1.14A 3w68A-3psqA:
undetectable		 3w68A-3psqA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		5 VAL A 105
ILE A 149
VAL A 152
LEU A 153
VAL A 159
 None
 1.13A 3w68A-3quvA:
undetectable		 3w68A-3quvA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		5 VAL A 511
SER A 507
SER A 503
ILE A 449
LEU A 103
 None
 1.16A 3w68A-3s7wA:
undetectable		 3w68A-3s7wA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		5 VAL A 166
ILE A 148
VAL A 151
LEU A 152
VAL A 157
 None
 1.09A 3w68A-3sd7A:
undetectable		 3w68A-3sd7A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 211
SER A 269
LEU A 271
VAL A 358
PHE A 359
 None
 1.19A 3w68A-3sunA:
undetectable		 3w68A-3sunA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		5 LEU A  75
PHE A 133
ILE A 115
VAL A  92
VAL A 142
 None
 1.15A 3w68A-3t66A:
undetectable		 3w68A-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		5 PHE A 133
ILE A 115
VAL A  92
LEU A  96
VAL A 142
 None
 1.17A 3w68A-3t66A:
undetectable		 3w68A-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 TYR A  57
VAL A  18
SER A 134
VAL A 128
LEU A 129
 None
 1.18A 3w68A-3ts7A:
2.4		 3w68A-3ts7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1d UNCHARACTERIZED
PROTEIN

(Halomicrobium
mukohataei) 		PF12840
(HTH_20) 		5 LEU A  60
PHE A  22
VAL A  31
LEU A  32
VAL A  73
 None
 1.13A 3w68A-3u1dA:
undetectable		 3w68A-3u1dA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 0.99A 3w68A-3u2pA:
undetectable		 3w68A-3u2pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 1.03A 3w68A-3u7uA:
undetectable		 3w68A-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 VAL A 474
LEU A 594
ILE A 586
VAL A 640
LEU A 588
 None
 1.03A 3w68A-3uk8A:
undetectable		 3w68A-3uk8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 101
ILE A 134
VAL A  47
PHE A  45
VAL A  15
 None
 1.13A 3w68A-3wv6A:
undetectable		 3w68A-3wv6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A 264
LEU A 160
SER A 159
ILE A 163
LEU A 168
 None
4A2  A1367 (-4.9A)
None
None
None
 1.16A 3w68A-3zcwA:
undetectable		 3w68A-3zcwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3x EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.84A 3w68A-4a3xA:
undetectable		 3w68A-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.87A 3w68A-4aslA:
undetectable		 3w68A-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		5 LEU A 193
ILE A 175
VAL A 135
LEU A 138
VAL A  97
 None
 0.97A 3w68A-4atbA:
2.8		 3w68A-4atbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		5 VAL A 208
LEU A 213
ILE A 343
LEU A 341
VAL A 128
 None
 1.19A 3w68A-4bn5A:
undetectable		 3w68A-4bn5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 VAL A  96
LEU A  93
ILE A 156
VAL A  59
LEU A  55
 None
None
None
None
LLP  A  51 ( 3.7A)
 1.18A 3w68A-4d8uA:
undetectable		 3w68A-4d8uA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		5 SER A 283
LEU A 284
ILE A 323
LEU A 313
VAL A 481
 None
 1.20A 3w68A-4ep0A:
undetectable		 3w68A-4ep0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex9 ALNA

(Streptomyces
sp. CM020) 		PF04227
(Indigoidine_A) 		5 SER A 300
LEU A 299
ILE A 118
VAL A 120
VAL A  49
 None
 1.19A 3w68A-4ex9A:
undetectable		 3w68A-4ex9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f55 SPORE CORTEX-LYTIC
ENZYME

(Bacillus cereus) 		PF07486
(Hydrolase_2) 		5 TYR A 232
VAL A 169
LEU A 174
ILE A 190
VAL A 186
 PO4  A 302 (-4.5A)
None
None
None
None
 1.19A 3w68A-4f55A:
undetectable		 3w68A-4f55A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fet SPORE CORTEX-LYTIC
ENZYME PREPEPTIDE

(Bacillus
anthracis) 		no annotation 5 TYR B 226
VAL B 163
LEU B 168
ILE B 184
VAL B 180
 None
 1.18A 3w68A-4fetB:
undetectable		 3w68A-4fetB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 LEU A 569
SER A 430
PHE A 420
LEU A 586
VAL A 438
 None
 1.19A 3w68A-4h1gA:
undetectable		 3w68A-4h1gA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 203
LEU A 205
SER A 207
VAL A 324
PHE A 301
 None
 1.18A 3w68A-4jbhA:
undetectable		 3w68A-4jbhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 356
SER A 334
ILE A  37
VAL A 363
LEU A  14
 None
 1.09A 3w68A-4jhmA:
1.9		 3w68A-4jhmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE

(Pseudomonas
aeruginosa) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  42
SER A 151
ILE A 226
VAL A 228
PHE A 230
 None
 1.20A 3w68A-4k91A:
undetectable		 3w68A-4k91A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C 117
ILE C  46
VAL C  68
LEU C  44
VAL C  40
 None
 0.97A 3w68A-4leoC:
undetectable		 3w68A-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth) 		5 VAL A  76
SER A 141
LEU A 142
PHE A  98
PHE A 108
 None
 1.17A 3w68A-4lhbA:
undetectable		 3w68A-4lhbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4
SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01843
(DIL)
no annotation 		5 VAL E 135
SER E 139
LEU E 140
SER E 143
PHE A1379
 None
 1.04A 3w68A-4ll8E:
undetectable		 3w68A-4ll8E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 VAL A  84
LEU A 211
ILE A  72
VAL A 142
LEU A 141
 None
 1.20A 3w68A-4m0dA:
undetectable		 3w68A-4m0dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		6 SER B 426
LEU B 427
SER B 430
ILE B 417
VAL B 414
VAL B 351
 None
 1.18A 3w68A-4q4aB:
undetectable		 3w68A-4q4aB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qko PYOCIN-S2 IMMUNITY
PROTEIN
PYOCIN-S2

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF01320
(Colicin_Pyocin)
no annotation 		5 VAL B 641
ILE A  35
VAL A  38
LEU A  39
PHE A  41
 BR  B 702 ( 4.1A)
None
None
None
None
 1.11A 3w68A-4qkoB:
undetectable		 3w68A-4qkoB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		5 LEU A 411
ILE A 484
LEU A 480
PHE A 382
VAL A 427
 None
 1.19A 3w68A-4r0cA:
undetectable		 3w68A-4r0cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 TRP A 262
VAL A 245
ILE A 283
VAL A 206
LEU A 285
 None
 1.03A 3w68A-4rcdA:
undetectable		 3w68A-4rcdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 VAL L 311
SER L 592
ILE L 361
VAL L 364
LEU L 365
 None
 1.03A 3w68A-4tkxL:
undetectable		 3w68A-4tkxL:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urp FATTY ACID
REPRESSION MUTANT
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00881
(Nitroreductase) 		5 VAL A 171
LEU A 141
PHE A  96
ILE A  57
VAL A  33
 None
 1.01A 3w68A-4urpA:
undetectable		 3w68A-4urpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A 291
SER A  36
PHE A 313
ILE A 299
PHE A 275
 None
 0.95A 3w68A-4us4A:
undetectable		 3w68A-4us4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		5 LEU A 267
PHE A 273
VAL A  22
LEU A  33
VAL A 220
 None
 1.20A 3w68A-4uy6A:
undetectable		 3w68A-4uy6A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY

(Acinetobacter
baumannii) 		PF05638
(T6SS_HCP) 		5 PHE A  62
ILE A 104
VAL A 135
LEU A 106
VAL A 109
 None
 1.18A 3w68A-4w64A:
undetectable		 3w68A-4w64A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 295
LEU A  36
ILE A  33
LEU A 255
VAL A 242
 None
 1.16A 3w68A-4z26A:
undetectable		 3w68A-4z26A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb3 NUDIX HYDROLASE 7

(Arabidopsis
thaliana) 		PF00293
(NUDIX) 		5 VAL A  33
SER A  37
LEU A  38
SER A  41
VAL A  23
 None
 0.96A 3w68A-4zb3A:
undetectable		 3w68A-4zb3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A  55
ILE A 145
VAL A  70
LEU A 147
VAL A 157
 None
 1.10A 3w68A-4zrsA:
3.3		 3w68A-4zrsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 TRP A 195
VAL A 126
ILE A 161
LEU A 217
VAL A 225
 None
 0.84A 3w68A-4zxoA:
undetectable		 3w68A-4zxoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN

(Homo sapiens) 		PF06632
(XRCC4) 		5 TYR A  66
PHE A  97
ILE A  34
VAL A  22
LEU A  20
 None
None
None
MLY  A   4 ( 4.2A)
None
 1.16A 3w68A-5cj4A:
undetectable		 3w68A-5cj4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 VAL A 193
LEU A 173
ILE A 163
PHE A 488
VAL A 408
 None
 1.16A 3w68A-5ck7A:
undetectable		 3w68A-5ck7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 1.10A 3w68A-5cs4A:
2.2		 3w68A-5cs4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 1.08A 3w68A-5csaA:
3.3		 3w68A-5csaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 0.93A 3w68A-5cslA:
2.7		 3w68A-5cslA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		5 VAL A  81
LEU A  34
ILE A  48
LEU A  40
VAL A 253
 None
 1.15A 3w68A-5ey5A:
2.5		 3w68A-5ey5A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 SER A 101
SER A  55
PHE A 521
ILE A 508
VAL A   9
 None
 1.04A 3w68A-5fxeA:
undetectable		 3w68A-5fxeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 LEU A 156
SER A 159
ILE A 104
VAL A 125
LEU A 102
 None
 1.09A 3w68A-5gt5A:
undetectable		 3w68A-5gt5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		5 SER A 703
ILE A 771
VAL A 774
LEU A 775
PHE A 778
 None
 1.18A 3w68A-5haxA:
undetectable		 3w68A-5haxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjn LD10117P

(Drosophila
melanogaster) 		PF00566
(RabGAP-TBC) 		5 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.71A 3w68A-5hjnA:
2.4		 3w68A-5hjnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		5 TRP A 711
LEU A 695
ILE A 687
LEU A 483
VAL A 490
 None
 1.17A 3w68A-5jrlA:
2.8		 3w68A-5jrlA:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TYR A 100
TRP A 122
VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 302 (-4.4A)
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.38A 3w68A-5mueA:
34.9		 3w68A-5mueA:
92.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE SMALL
SUBUNIT PRIS

(Sulfolobus
solfataricus) 		no annotation 5 VAL A 325
LEU A 322
ILE A 313
VAL A 294
LEU A 295
 None
 1.12A 3w68A-5ofnA:
undetectable		 3w68A-5ofnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 LEU A 285
PHE A 224
VAL A 239
LEU A 237
PHE A 389
 None
 1.11A 3w68A-5oltA:
undetectable		 3w68A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0F02343P
KLLA0E05809P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05859
(Mis12)
PF03980
(Nnf1) 		5 VAL B  23
LEU B  28
SER B  31
ILE A  27
VAL A  31
 None
 1.08A 3w68A-5t58B:
undetectable		 3w68A-5t58B:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		5 LEU A 378
ILE A  45
VAL A 167
LEU A 171
VAL A  28
 None
 1.08A 3w68A-5xaoA:
undetectable		 3w68A-5xaoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		5 VAL B 326
LEU B 250
ILE B 295
VAL B 260
LEU B 293
 None
 1.05A 3w68A-5xeqB:
undetectable		 3w68A-5xeqB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B  29
SER B  25
ILE B  68
LEU B  50
PHE B 133
 None
 1.19A 3w68A-5y58B:
3.1		 3w68A-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B  29
SER B  25
ILE B  68
LEU B  50
VAL B  12
 None
 1.05A 3w68A-5y58B:
3.1		 3w68A-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 5 VAL A  73
LEU A  35
VAL A  56
LEU A  59
VAL A  15
 None
 1.18A 3w68A-5ywwA:
undetectable		 3w68A-5ywwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 5 SER A1089
ILE A1032
VAL A1035
LEU A1036
VAL A1057
 None
 0.99A 3w68A-6d4jA:
undetectable		 3w68A-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 TRP A 671
VAL A 654
ILE A 692
VAL A 615
LEU A 694
 None
 1.01A 3w68A-6ej2A:
undetectable		 3w68A-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 VAL A 174
LEU A 298
ILE A 264
VAL A 235
LEU A 262
 None
 1.02A 3w68A-6evgA:
undetectable		 3w68A-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 PHE A 873
ILE A 846
VAL A 849
LEU A 850
VAL A 907
 None
 1.08A 3w68A-6ez8A:
undetectable		 3w68A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 VAL D  58
SER D  93
ILE D 322
VAL D 294
VAL D  98
 None
 1.20A 3w68A-6fmlD:
4.2		 3w68A-6fmlD:
undetectable