SIMILAR PATTERNS OF AMINO ACIDS FOR 3W67_C_VIVC301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 VAL A 302
ALA A 320
PHE A 394
ILE A 377
LEU A 381
 None
 1.15A 3w67C-1c0aA:
0.0		 3w67C-1c0aA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		5 LEU M 124
ALA M  91
LEU M 459
PHE M  96
VAL M  33
 None
 1.20A 3w67C-1dwaM:
1.6		 3w67C-1dwaM:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 100
ALA A  89
ILE A 198
LEU A  11
VAL A  54
 LEU  A 100 ( 0.6A)
ALA  A  89 ( 0.0A)
ILE  A 198 ( 0.4A)
LEU  A  11 (-0.6A)
VAL  A  54 ( 0.6A)
 1.18A 3w67C-1fxjA:
0.8		 3w67C-1fxjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 280
SER A 184
ALA A 160
LEU A 251
VAL A 164
 None
PLP  A1400 ( 4.5A)
None
None
None
 0.98A 3w67C-1ibjA:
0.0		 3w67C-1ibjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
PF13304
(AAA_21) 		5 ILE A 138
VAL A 160
ALA B 752
LEU B 778
VAL B 767
 None
 1.05A 3w67C-1ii8A:
undetectable		 3w67C-1ii8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
PF13304
(AAA_21) 		5 VAL A 160
ALA B 752
ILE A 146
LEU B 778
VAL B 767
 None
 1.09A 3w67C-1ii8A:
undetectable		 3w67C-1ii8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 VAL A  11
SER A   5
ILE A  21
LEU A  30
VAL A  76
 None
 0.95A 3w67C-1iuqA:
0.0		 3w67C-1iuqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 ILE A 375
TRP A 342
ALA A 414
PHE A 352
LEU A 435
 None
 1.14A 3w67C-1kspA:
undetectable		 3w67C-1kspA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
SER A 140
ALA A 156
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 ( 4.4A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.54A 3w67C-1r5lA:
37.3		 3w67C-1r5lA:
89.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 VAL A 377
LEU A 372
ALA A 356
ILE A 417
VAL A 348
 None
 1.15A 3w67C-1szsA:
undetectable		 3w67C-1szsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897

(Pyrococcus
horikoshii) 		PF00459
(Inositol_P) 		5 ILE A 226
VAL A 234
ALA A 238
ILE A 175
PHE A 153
 None
None
None
EDO  A1002 (-4.0A)
None
 0.99A 3w67C-1vdwA:
undetectable		 3w67C-1vdwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 TYR C 141
LEU C 224
ALA C  66
ILE C 216
LEU C  36
 None
 1.17A 3w67C-1w36C:
undetectable		 3w67C-1w36C:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyp CALPONIN 1

(Homo sapiens) 		PF00307
(CH) 		5 ILE A  76
VAL A 108
LEU A 113
PHE A  79
ILE A  26
 None
 0.97A 3w67C-1wypA:
undetectable		 3w67C-1wypA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5h NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		5 TRP A  39
VAL A  94
ALA A 111
ILE A  81
LEU A  84
 None
 1.16A 3w67C-1x5hA:
undetectable		 3w67C-1x5hA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 ILE A 315
VAL A 373
LEU A 462
ILE A 405
VAL A 387
 None
None
None
COA  A2600 (-4.6A)
None
 1.15A 3w67C-2ahwA:
undetectable		 3w67C-2ahwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 468
LEU A 433
PHE A 469
ILE A 343
VAL A 350
 None
 1.17A 3w67C-2hi4A:
undetectable		 3w67C-2hi4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		5 ALA A 143
PHE A 145
ILE A 131
LEU A 135
VAL A 140
 None
 0.83A 3w67C-2ho5A:
undetectable		 3w67C-2ho5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3d HYPOTHETICAL PROTEIN
ATU1826

(Agrobacterium
fabrum) 		PF02129
(Peptidase_S15) 		5 ILE A  68
ALA A  88
PHE A  63
ILE A 113
LEU A 117
 None
 1.09A 3w67C-2i3dA:
3.4		 3w67C-2i3dA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ILE A  36
LEU A  66
ALA A  28
PHE A  32
LEU A 136
 None
 1.10A 3w67C-2izoA:
undetectable		 3w67C-2izoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		5 ILE A  30
VAL A  66
LEU A  90
ALA A 139
VAL A 117
 None
 1.19A 3w67C-2k7hA:
undetectable		 3w67C-2k7hA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN

(Aeromonas
hydrophila) 		PF08327
(AHSA1) 		5 ILE A   9
PHE A  93
LEU A  45
PHE A  51
VAL A  73
 None
 1.07A 3w67C-2lghA:
undetectable		 3w67C-2lghA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 TYR A1001
ILE A1015
SER A 957
ILE A 964
LEU A1057
 None
 1.10A 3w67C-2nz9A:
undetectable		 3w67C-2nz9A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 100
ALA A  89
ILE A 198
LEU A  11
VAL A  54
 None
None
None
UD1  A4000 (-4.1A)
None
 0.97A 3w67C-2oi6A:
undetectable		 3w67C-2oi6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9w MAL S 1 ALLERGENIC
PROTEIN

(Malassezia
sympodialis) 		no annotation 5 ILE A 347
VAL A 263
ALA A 291
ILE A 260
VAL A 245
 None
 1.02A 3w67C-2p9wA:
undetectable		 3w67C-2p9wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 402
ALA A 430
ILE A 415
LEU A 454
VAL A 440
 None
 1.19A 3w67C-2qaeA:
undetectable		 3w67C-2qaeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		5 ILE A 317
VAL A 253
ALA A 289
ILE A 238
LEU A 242
 None
 1.16A 3w67C-2qgqA:
1.0		 3w67C-2qgqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		5 ILE A 214
VAL A 244
ILE A 196
LEU A 194
VAL A 232
 None
 1.17A 3w67C-2qptA:
undetectable		 3w67C-2qptA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 ILE A 239
LEU A 145
ALA A 189
PHE A 190
VAL A 152
 None
 0.97A 3w67C-2r9hA:
undetectable		 3w67C-2r9hA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wia FERROUS IRON
TRANSPORT PROTEIN B

(Klebsiella
pneumoniae) 		PF02421
(FeoB_N) 		5 VAL A 175
LEU A 172
ILE A 255
LEU A 137
VAL A 145
 None
 1.18A 3w67C-2wiaA:
undetectable		 3w67C-2wiaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		5 ILE A 191
VAL A 134
ILE A 211
LEU A 212
VAL A  58
 None
 1.05A 3w67C-2wsmA:
undetectable		 3w67C-2wsmA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE

(Leishmania
braziliensis) 		PF01182
(Glucosamine_iso) 		5 ILE A  25
VAL A  69
ALA A 212
LEU A 204
VAL A 208
 None
 1.15A 3w67C-3ch7A:
undetectable		 3w67C-3ch7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		5 ILE A 316
ALA A 385
PHE A 323
LEU A 139
VAL A 346
 None
 1.19A 3w67C-3h1wA:
undetectable		 3w67C-3h1wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 VAL A 227
LEU A 256
ALA A 183
LEU A 241
VAL A 237
 None
 1.11A 3w67C-3hpaA:
undetectable		 3w67C-3hpaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  99
ALA A  37
PHE A  28
ILE A  16
VAL A  48
 None
 1.15A 3w67C-3k4xA:
undetectable		 3w67C-3k4xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwg HP0420 HOMOLOGUE

(Helicobacter
felis) 		no annotation 5 ALA A  60
PHE A  94
ILE A  86
LEU A  82
VAL A  80
 None
 1.15A 3w67C-3lwgA:
undetectable		 3w67C-3lwgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne8 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Bartonella
henselae) 		PF01520
(Amidase_3) 		5 ILE A 339
TRP A 383
ALA A 392
ILE A 256
LEU A 184
 None
None
FMT  A 411 ( 3.9A)
None
None
 1.06A 3w67C-3ne8A:
undetectable		 3w67C-3ne8A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ILE A 208
VAL A 240
SER A 246
ILE A  50
PHE A 414
 None
 1.12A 3w67C-3nvsA:
undetectable		 3w67C-3nvsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oru DUF1989 FAMILY
PROTEIN

(Ruegeria sp.
TM1040) 		PF09347
(DUF1989) 		6 TRP A 168
VAL A 192
LEU A 111
ALA A  69
PHE A  67
VAL A 200
 None
 1.43A 3w67C-3oruA:
undetectable		 3w67C-3oruA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 VAL A 132
ALA A  90
PHE A  92
LEU A   3
VAL A  62
 None
 1.07A 3w67C-3qsgA:
undetectable		 3w67C-3qsgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 LEU A 166
ALA A 253
ILE A 243
LEU A 186
VAL A 256
 None
None
UD1  A 366 (-4.0A)
None
None
 1.06A 3w67C-3s2uA:
undetectable		 3w67C-3s2uA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		no annotation 5 ILE B  76
VAL B   9
LEU B  27
SER B  24
ALA B  37
 None
 1.09A 3w67C-3tzqB:
2.0		 3w67C-3tzqB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ILE A 242
VAL A  41
ILE A  28
LEU A 142
VAL A 140
 None
 1.11A 3w67C-3w6oA:
undetectable		 3w67C-3w6oA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 ILE A 119
VAL A  98
ALA A  56
ILE A 114
LEU A 109
 None
 1.16A 3w67C-3wczA:
undetectable		 3w67C-3wczA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 ILE A 244
VAL A 177
LEU A 146
SER A 168
LEU A 215
 None
 1.16A 3w67C-3zfvA:
undetectable		 3w67C-3zfvA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 387
TRP A 467
ALA A 281
LEU A 301
VAL A 356
 None
None
CMH  A 340 ( 4.3A)
None
None
 0.98A 3w67C-4acaA:
1.6		 3w67C-4acaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 ILE A 145
VAL A 163
LEU A 198
ALA A 224
ILE A 215
 None
 1.18A 3w67C-4b4uA:
undetectable		 3w67C-4b4uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		5 VAL A 208
LEU A 213
ILE A 343
LEU A 341
VAL A 128
 None
 1.10A 3w67C-4bn5A:
undetectable		 3w67C-4bn5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 220
SER A 167
ALA A 122
ILE A 227
VAL A 124
 None
 1.03A 3w67C-4btpA:
undetectable		 3w67C-4btpA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 224
SER A 124
ALA A  25
LEU A  34
VAL A  29
 None
 1.10A 3w67C-4dd5A:
undetectable		 3w67C-4dd5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ILE A 164
LEU A  37
PHE A 183
ILE A  34
LEU A  57
 None
 1.20A 3w67C-4dllA:
undetectable		 3w67C-4dllA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g79 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 VAL A  93
LEU A  99
PHE A 132
ILE A  38
LEU A  36
 None
 1.07A 3w67C-4g79A:
undetectable		 3w67C-4g79A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 LEU A 569
SER A 430
PHE A 420
LEU A 586
VAL A 438
 None
 1.10A 3w67C-4h1gA:
undetectable		 3w67C-4h1gA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 LEU A 338
SER A 342
ALA A 187
ILE A 292
PHE A 344
 None
None
MPD  A 605 ( 3.9A)
None
None
 1.17A 3w67C-4ia5A:
undetectable		 3w67C-4ia5A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 ILE A 245
VAL A 178
LEU A 147
SER A 169
LEU A 216
 None
 1.13A 3w67C-4ilrA:
undetectable		 3w67C-4ilrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ILE A 452
SER A 482
PHE A 448
ILE A 346
LEU A 347
 CIT  A 702 (-4.9A)
None
None
None
None
 1.04A 3w67C-4iuwA:
undetectable		 3w67C-4iuwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbu VIRULENCE-ASSOCIATED
V ANTIGEN

(Yersinia pestis) 		PF04792
(LcrV) 		5 VAL A  63
LEU A  71
ALA A 117
ILE A  44
VAL A 121
 None
 1.07A 3w67C-4jbuA:
undetectable		 3w67C-4jbuA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		5 ILE A 317
VAL A 253
ALA A 289
ILE A 238
LEU A 242
 None
 1.05A 3w67C-4jc0A:
1.8		 3w67C-4jc0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 ILE A  66
VAL A  80
ILE A  99
LEU A  94
VAL A 116
 None
None
None
None
ACT  A 303 ( 4.3A)
 1.20A 3w67C-4ohnA:
undetectable		 3w67C-4ohnA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A6123
VAL A6298
ALA A6209
ILE A6221
LEU A6216
 None
 1.01A 3w67C-4opfA:
undetectable		 3w67C-4opfA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oq1 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 VAL A  40
ALA A 123
ILE A  98
LEU A  52
VAL A 110
 None
 1.18A 3w67C-4oq1A:
undetectable		 3w67C-4oq1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 ILE A 267
VAL A 201
ILE A 224
LEU A 227
VAL A  84
 None
 1.06A 3w67C-4pfzA:
undetectable		 3w67C-4pfzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 239
VAL A 148
ILE A 102
LEU A  97
VAL A  94
 None
 0.93A 3w67C-4qavA:
undetectable		 3w67C-4qavA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 5 VAL B 247
LEU B 233
ALA B 277
ILE B 263
LEU B 301
 None
 1.14A 3w67C-4r0mB:
undetectable		 3w67C-4r0mB:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A3311
VAL A3335
LEU A3340
ALA A3317
ILE A3326
 None
 1.10A 3w67C-4rh7A:
undetectable		 3w67C-4rh7A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 ILE A 191
TRP A 129
VAL A 127
LEU A  91
PHE A 115
 None
 1.15A 3w67C-4u3aA:
undetectable		 3w67C-4u3aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A 291
SER A  36
PHE A 313
ILE A 299
PHE A 275
 None
 0.93A 3w67C-4us4A:
undetectable		 3w67C-4us4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 TYR A 311
ILE A 314
VAL A 130
LEU A 135
SER A 138
 None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
None
None
 1.18A 3w67C-4zj8A:
undetectable		 3w67C-4zj8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		5 ILE A  37
VAL A  51
ILE A  70
LEU A  65
VAL A  87
 None
 1.18A 3w67C-4zv1A:
undetectable		 3w67C-4zv1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 TRP A 195
VAL A 126
ILE A 161
LEU A 217
VAL A 225
 None
 0.94A 3w67C-4zxoA:
undetectable		 3w67C-4zxoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 TRP A 195
VAL A 126
LEU A  87
ILE A 161
LEU A 217
 None
 1.13A 3w67C-4zxoA:
undetectable		 3w67C-4zxoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ILE A 463
LEU A1023
ILE A 985
LEU A 973
VAL A 969
 None
 1.13A 3w67C-5a22A:
undetectable		 3w67C-5a22A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 VAL A1445
SER A1384
ALA A1374
ILE A1440
LEU A1408
 None
 1.15A 3w67C-5a22A:
undetectable		 3w67C-5a22A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8d CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43) 		5 ILE A 241
VAL A 321
ILE A 307
LEU A  53
VAL A  48
 None
None
None
None
GOL  A1339 (-4.7A)
 1.18A 3w67C-5a8dA:
undetectable		 3w67C-5a8dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 ILE A 274
LEU A 260
ALA A 181
PHE A 275
ILE A 246
 None
 1.08A 3w67C-5cjuA:
1.3		 3w67C-5cjuA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 VAL A 193
LEU A 173
ILE A 163
PHE A 488
VAL A 408
 None
 1.11A 3w67C-5ck7A:
1.4		 3w67C-5ck7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dy9 HFQ-LIKE PROTEIN

(Methanocaldococcus
jannaschii) 		PF17209
(Hfq) 		5 VAL A  45
LEU A  60
ALA A  40
ILE A  66
LEU A  32
 None
 1.09A 3w67C-5dy9A:
undetectable		 3w67C-5dy9A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 408
ALA A 356
PHE A  73
ILE A 394
PHE A 209
 None
 1.01A 3w67C-5ei0A:
undetectable		 3w67C-5ei0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 ILE A 129
LEU A 140
SER A 217
ILE A 182
VAL A 158
 None
 1.14A 3w67C-5f5oA:
undetectable		 3w67C-5f5oA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 ILE A 393
VAL A 345
ALA A 341
PHE A  56
ILE A 379
 None
 1.03A 3w67C-5hgcA:
undetectable		 3w67C-5hgcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjn LD10117P

(Drosophila
melanogaster) 		PF00566
(RabGAP-TBC) 		5 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.95A 3w67C-5hjnA:
undetectable		 3w67C-5hjnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjz ENDORIBONUCLEASE
MAZF9

(Mycobacterium
tuberculosis) 		PF02452
(PemK_toxin) 		5 ILE A  46
VAL A  10
ILE A   7
LEU A  65
VAL A  63
 None
 1.19A 3w67C-5hjzA:
undetectable		 3w67C-5hjzA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu4 CYSTEINE PROTEASE

(Listeria
monocytogenes) 		PF04203
(Sortase) 		5 VAL A  18
ALA A  37
PHE A  65
ILE A  77
LEU A  79
 None
 1.07A 3w67C-5hu4A:
undetectable		 3w67C-5hu4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE

(Vibrionales
bacterium
SWAT-3) 		no annotation 5 ILE P 196
TRP P 193
LEU P  55
ALA P  40
ILE P  19
 None
 1.15A 3w67C-5im5P:
undetectable		 3w67C-5im5P:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		5 ILE A   9
SER A 274
ALA A 280
ILE A  87
LEU A 250
 None
 1.12A 3w67C-5m5jA:
undetectable		 3w67C-5m5jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc7 COATOMER SUBUNIT
ZETA-1

(Homo sapiens) 		PF01217
(Clat_adaptor_s) 		5 TYR A  31
LEU A  94
ALA A 124
ILE A  18
LEU A 101
 None
 1.18A 3w67C-5mc7A:
undetectable		 3w67C-5mc7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ILE B  67
LEU B 136
SER B 139
LEU B 146
PHE B 175
 C2E  B 304 ( 4.9A)
None
None
None
None
 1.18A 3w67C-5mkgB:
undetectable		 3w67C-5mkgB:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
SER A 140
ALA A 156
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 ( 4.4A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.0A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.56A 3w67C-5mueA:
33.6		 3w67C-5mueA:
92.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6w RETINOSCHISIN

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 ILE A 212
SER A  94
ALA A  98
ILE A 125
VAL A  76
 None
 1.10A 3w67C-5n6wA:
undetectable		 3w67C-5n6wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ILE A 433
VAL A   5
SER A 388
ALA A 359
LEU A 350
 None
 1.18A 3w67C-5neuA:
undetectable		 3w67C-5neuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj8 ARYL HYDROCARBON
RECEPTOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		5 VAL A 129
SER A 139
ALA A 269
PHE A 239
LEU A 146
 None
 1.09A 3w67C-5nj8A:
undetectable		 3w67C-5nj8A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		5 LEU B 356
ALA B 385
ILE B 351
LEU B 314
VAL B 399
 None
 1.16A 3w67C-5sy5B:
undetectable		 3w67C-5sy5B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 TYR A1001
ILE A1015
SER A 957
ILE A 964
LEU A1057
 None
 1.10A 3w67C-5tpcA:
undetectable		 3w67C-5tpcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 TYR D1142
VAL D1031
LEU D1134
ALA D 999
ILE D1210
 None
 1.08A 3w67C-5uheD:
undetectable		 3w67C-5uheD:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF07034
(ORC3_N) 		5 ILE A 682
VAL A 704
LEU A 643
SER A 641
ALA A 652
 None
 1.18A 3w67C-5uj8A:
undetectable		 3w67C-5uj8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utk ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		5 VAL A 486
ALA A 461
PHE A 536
LEU A 481
VAL A 502
 None
 1.17A 3w67C-5utkA:
undetectable		 3w67C-5utkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 VAL A 574
LEU A 565
ALA A 801
ILE A 418
VAL A 797
 None
None
None
None
A  B   5 ( 3.8A)
 1.03A 3w67C-5weaA:
undetectable		 3w67C-5weaA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 ILE B 412
LEU B 362
ALA B 391
LEU B 251
VAL B 342
 None
 1.17A 3w67C-5y3rB:
2.4		 3w67C-5y3rB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A  20
LEU A  16
ALA A 226
LEU A 208
VAL A 215
 None
 1.18A 3w67C-6amsA:
undetectable		 3w67C-6amsA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ans UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF06742
(DUF1214) 		5 ALA A  93
PHE A  71
ILE A 149
LEU A 151
VAL A  95
 None
 1.15A 3w67C-6ansA:
undetectable		 3w67C-6ansA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa) 		no annotation 5 ILE C 121
SER C  75
ALA C 165
PHE C 101
ILE C  71
 None
 1.19A 3w67C-6exvC:
undetectable		 3w67C-6exvC:
undetectable