SIMILAR PATTERNS OF AMINO ACIDS FOR 3W67_B_VIVB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		5 ILE A  77
SER A 205
LEU A 206
ILE A   6
VAL A   4
 None
 1.00A 3w67B-1a2zA:
undetectable		 3w67B-1a2zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 ILE A 313
TRP A 468
TRP A 488
ILE A 501
PHE A 324
 None
 1.02A 3w67B-1aqlA:
undetectable		 3w67B-1aqlA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 LEU A 377
VAL A 534
ILE A 406
VAL A 409
LEU A 410
 None
CLL  A 801 ( 4.9A)
None
None
CLL  A 801 (-4.5A)
 1.05A 3w67B-1cleA:
undetectable		 3w67B-1cleA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 LEU A 377
VAL A 534
ILE A 406
VAL A 409
LEU A 410
 None
 1.04A 3w67B-1crlA:
1.3		 3w67B-1crlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 147
VAL A 164
ILE A 243
ILE A 241
PHE A  77
 None
 0.96A 3w67B-1e5mA:
undetectable		 3w67B-1e5mA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		6 ILE A  73
SER A  24
LEU A  23
VAL A  49
ILE A 105
ILE A 117
 None
 1.42A 3w67B-1ionA:
undetectable		 3w67B-1ionA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		5 ILE A 414
SER A 509
ILE A 398
VAL A 465
PHE A 468
 None
 1.08A 3w67B-1irxA:
undetectable		 3w67B-1irxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 ILE T  89
VAL T 213
ILE T 242
ILE T  47
LEU T 209
 None
ZEN  T   1 (-4.1A)
None
None
None
 1.01A 3w67B-1j17T:
undetectable		 3w67B-1j17T:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		5 ILE A  92
LEU A  18
PHE A  91
VAL A  31
LEU A  33
 None
 1.08A 3w67B-1n3pA:
undetectable		 3w67B-1n3pA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A  65
PHE A  44
ILE A 123
ILE A 118
VAL A 116
 None
 1.00A 3w67B-1pe9A:
undetectable		 3w67B-1pe9A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		5 ILE A 175
LEU A 135
ILE A 217
ILE A 229
VAL A 251
 None
 1.06A 3w67B-1qnlA:
undetectable		 3w67B-1qnlA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A  59
LEU A  57
VAL A  19
ILE A  43
LEU A  16
 None
None
None
SO4  A 328 (-3.6A)
None
 1.04A 3w67B-1qorA:
undetectable		 3w67B-1qorA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		11 ILE A 119
TRP A 122
SER A 136
LEU A 137
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
 None
None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
 0.67A 3w67B-1r5lA:
37.7		 3w67B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		6 ILE A 119
TRP A 122
SER A 136
LEU A 137
VAL A 191
PHE A 158
 None
None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
 1.49A 3w67B-1r5lA:
37.7		 3w67B-1r5lA:
89.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 VAL A  38
ILE A 268
ILE A 239
VAL A 242
LEU A 243
 None
None
None
None
CL  A 501 (-4.3A)
 1.02A 3w67B-1wkyA:
undetectable		 3w67B-1wkyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		5 LEU A 188
VAL A 252
ILE A 163
ILE A 170
VAL A 172
 None
 0.98A 3w67B-1xi9A:
undetectable		 3w67B-1xi9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus) 		PF00092
(VWA) 		5 ILE A 283
PHE A 281
ILE A 151
ILE A 149
LEU A 147
 None
 1.10A 3w67B-2b2xA:
undetectable		 3w67B-2b2xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eiz ANTI-LYSOZYME
ANTIBODY FV REGION

(Homo sapiens) 		PF07686
(V-set) 		5 SER B  62
ILE B  37
ILE B  48
VAL B  67
LEU B  82
 None
 1.03A 3w67B-2eizB:
undetectable		 3w67B-2eizB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 LEU A 193
PHE A  71
ILE A 132
ILE A 136
PHE A 142
 None
 1.02A 3w67B-2g7gA:
undetectable		 3w67B-2g7gA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 LEU A  91
ILE A   8
ILE A 101
VAL A 104
LEU A 105
 None
 1.06A 3w67B-2gmiA:
undetectable		 3w67B-2gmiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hn1 MAGNESIUM AND COBALT
TRANSPORTER

(Archaeoglobus
fulgidus) 		PF01544
(CorA) 		5 LEU A 131
ILE A  31
ILE A  67
VAL A 138
LEU A 137
 None
 1.05A 3w67B-2hn1A:
undetectable		 3w67B-2hn1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		5 VAL A1043
ILE A1172
ILE A1138
VAL A1134
LEU A1053
 None
 1.07A 3w67B-2iusA:
undetectable		 3w67B-2iusA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 VAL A 518
ILE A 646
ILE A 612
VAL A 608
LEU A 528
 None
 0.97A 3w67B-2iutA:
undetectable		 3w67B-2iutA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 VAL A 518
ILE A 646
ILE A 612
VAL A 608
LEU A 528
 None
 0.96A 3w67B-2iuuA:
undetectable		 3w67B-2iuuA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN

(Aeromonas
hydrophila) 		PF08327
(AHSA1) 		5 ILE A   9
PHE A  93
VAL A  43
LEU A  45
PHE A  51
 None
 1.07A 3w67B-2lghA:
undetectable		 3w67B-2lghA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		5 ILE A 245
LEU A  15
VAL A 306
ILE A 175
ILE A   7
 None
 1.05A 3w67B-2o2zA:
undetectable		 3w67B-2o2zA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ILE A 464
LEU A  79
VAL A 134
LEU A 162
PHE A 164
 None
 1.10A 3w67B-2pajA:
1.7		 3w67B-2pajA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		5 TRP A  68
LEU A 140
VAL A  75
ILE A 135
LEU A 125
 None
 1.03A 3w67B-2q0xA:
undetectable		 3w67B-2q0xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0j UBIQUITIN CARRIER
PROTEIN

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		5 LEU A  89
ILE A   6
ILE A  99
VAL A 102
LEU A 103
 None
 1.10A 3w67B-2r0jA:
undetectable		 3w67B-2r0jA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A 168
LEU A 169
ILE A  18
ILE A  15
LEU A 175
 None
 1.06A 3w67B-2rgwA:
undetectable		 3w67B-2rgwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0i TWINFILIN-2

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		5 LEU A 182
ILE A 256
VAL A 283
LEU A 289
PHE A 287
 None
 1.13A 3w67B-2w0iA:
undetectable		 3w67B-2w0iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 ILE A2673
LEU A2656
VAL A2525
ILE A2584
LEU A2548
 None
 0.98A 3w67B-2wjsA:
undetectable		 3w67B-2wjsA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 LEU A 452
TRP A 486
ILE A 270
VAL A 251
LEU A 255
 None
CL  A1626 (-4.7A)
None
None
None
 1.13A 3w67B-2xy9A:
undetectable		 3w67B-2xy9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ILE A 504
VAL A 563
ILE A 483
VAL A 481
LEU A 472
 None
 1.13A 3w67B-3av6A:
undetectable		 3w67B-3av6A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT

(Methanosarcina
barkeri) 		PF02552
(CO_dh) 		5 ILE G 111
LEU G  46
ILE G  63
ILE G  57
LEU G 163
 None
 1.03A 3w67B-3cf4G:
undetectable		 3w67B-3cf4G:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A1225
ILE A1192
ILE A1190
VAL A1140
LEU A1188
 None
 0.82A 3w67B-3cmvA:
undetectable		 3w67B-3cmvA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ILE A2225
ILE A2192
ILE A2190
VAL A2140
LEU A2188
 None
 0.86A 3w67B-3cmvA:
undetectable		 3w67B-3cmvA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A  36
LEU A  95
PHE A  47
ILE A  82
VAL A 127
 None
 0.93A 3w67B-3g7sA:
undetectable		 3w67B-3g7sA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		5 ILE A 244
PHE A 274
ILE A 258
VAL A 261
LEU A 262
 None
 1.04A 3w67B-3gecA:
undetectable		 3w67B-3gecA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 SER A 347
LEU A 348
VAL A 377
ILE A 390
VAL A 388
 None
 1.04A 3w67B-3hhdA:
undetectable		 3w67B-3hhdA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		5 ILE A  54
LEU A  67
ILE A  89
ILE A 109
VAL A 105
 None
 1.08A 3w67B-3hpdA:
undetectable		 3w67B-3hpdA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A   3
LEU A 359
ILE A 100
VAL A 302
LEU A 355
 None
 1.10A 3w67B-3hpfA:
undetectable		 3w67B-3hpfA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 ILE A 503
LEU A 551
VAL A 443
ILE A 627
LEU A 610
 None
 1.03A 3w67B-3k1jA:
undetectable		 3w67B-3k1jA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 284
LEU A 110
ILE A 239
ILE A 248
LEU A 252
 None
 0.99A 3w67B-3khdA:
1.5		 3w67B-3khdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  62
ILE H  37
ILE H  48
VAL H  67
LEU H  82
 None
 1.02A 3w67B-3mlxH:
undetectable		 3w67B-3mlxH:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 144
VAL A 161
ILE A 239
ILE A 237
PHE A  74
 None
 0.97A 3w67B-3o04A:
undetectable		 3w67B-3o04A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 VAL A 225
ILE A 334
ILE A 316
VAL A 284
LEU A 314
 None
 1.09A 3w67B-3odpA:
undetectable		 3w67B-3odpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 ILE A 399
PHE A 424
ILE A 435
ILE A 437
LEU A 443
 None
 0.99A 3w67B-3p11A:
undetectable		 3w67B-3p11A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ILE A 236
SER A 313
VAL A 145
ILE A 280
PHE A 332
 None
 1.03A 3w67B-3p5pA:
undetectable		 3w67B-3p5pA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 ILE A 398
PHE A 422
ILE A 433
ILE A 435
LEU A 441
 None
 1.07A 3w67B-3u2pA:
undetectable		 3w67B-3u2pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU A 111
ILE A  43
ILE A  40
VAL A  62
LEU A  38
 None
 1.10A 3w67B-3u2pA:
undetectable		 3w67B-3u2pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 ILE A 398
PHE A 422
ILE A 433
ILE A 435
LEU A 441
 None
 1.09A 3w67B-3u7uA:
undetectable		 3w67B-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 111
ILE A  43
ILE A  40
VAL A  62
LEU A  38
 None
 1.11A 3w67B-3u7uA:
undetectable		 3w67B-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ILE A 369
VAL A 294
ILE A 359
VAL A 311
PHE A 286
 None
 0.95A 3w67B-3v44A:
undetectable		 3w67B-3v44A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		5 ILE A  97
ILE A 122
VAL A  15
LEU A  58
PHE A  14
 None
 1.04A 3w67B-3vx6A:
undetectable		 3w67B-3vx6A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 315
LEU A 344
ILE A 256
ILE A 248
VAL A 246
 None
 0.91A 3w67B-3zx1A:
undetectable		 3w67B-3zx1A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3x EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 1.04A 3w67B-4a3xA:
undetectable		 3w67B-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4y PROTEIN MXIG

(Shigella
flexneri) 		PF09480
(PrgH) 		5 ILE A  89
PHE A  96
ILE A  35
VAL A  58
LEU A  37
 None
 1.08A 3w67B-4a4yA:
undetectable		 3w67B-4a4yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 1.08A 3w67B-4aslA:
undetectable		 3w67B-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16415
(CNOT1_CAF1_bind) 		5 ILE A1168
LEU A1217
ILE A1205
VAL A1260
LEU A1261
 None
 0.79A 3w67B-4ct4A:
undetectable		 3w67B-4ct4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct4 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16415
(CNOT1_CAF1_bind) 		5 ILE A1168
LEU A1217
ILE A1257
VAL A1260
LEU A1261
 None
 0.78A 3w67B-4ct4A:
undetectable		 3w67B-4ct4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		5 TRP B 253
LEU B 247
VAL B 222
ILE B 240
VAL B 238
 None
 1.09A 3w67B-4gdlB:
undetectable		 3w67B-4gdlB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16415
(CNOT1_CAF1_bind) 		5 ILE A1173
LEU A1222
ILE A1210
VAL A1265
LEU A1266
 None
 0.76A 3w67B-4gmjA:
undetectable		 3w67B-4gmjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 ILE A 433
LEU A 446
ILE A 475
VAL A 484
LEU A 485
 None
 1.06A 3w67B-4i2wA:
undetectable		 3w67B-4i2wA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		5 LEU A 117
ILE A  72
ILE A 102
VAL A  95
LEU A  27
 None
 0.92A 3w67B-4inzA:
1.9		 3w67B-4inzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jed GLUTATHIONE
S-TRANSFERASE

(Methylobacterium
radiotolerans) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 SER A 191
LEU A 194
ILE A 105
ILE A 142
LEU A 146
 None
 1.11A 3w67B-4jedA:
undetectable		 3w67B-4jedA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 ILE C 399
PHE C 424
ILE C 435
ILE C 437
LEU C 443
 None
 0.95A 3w67B-4leoC:
undetectable		 3w67B-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 SER A 230
LEU A   4
ILE A 182
ILE A 137
VAL A  87
 None
 1.12A 3w67B-4mowA:
1.9		 3w67B-4mowA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 ILE A 147
LEU A 115
ILE A 249
VAL A 245
LEU A 248
 None
 1.09A 3w67B-4ow8A:
undetectable		 3w67B-4ow8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		5 VAL A 410
ILE A 309
ILE A 364
VAL A 344
LEU A  32
 None
 0.90A 3w67B-4p3mA:
undetectable		 3w67B-4p3mA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1)
PF10394
(Hat1_N) 		5 LEU A  88
ILE A  46
ILE A  54
VAL A  67
LEU A  56
 None
 1.07A 3w67B-4pswA:
undetectable		 3w67B-4pswA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ILE A 136
LEU A 195
VAL A  94
ILE A 180
LEU A 171
 None
 0.98A 3w67B-4q05A:
undetectable		 3w67B-4q05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 ILE A 199
LEU A  56
ILE A 146
VAL A 149
LEU A 150
 None
 0.97A 3w67B-4qp0A:
1.5		 3w67B-4qp0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 ILE A 250
LEU A  56
ILE A 202
ILE A 146
VAL A 149
 None
 1.04A 3w67B-4qp0A:
1.5		 3w67B-4qp0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 555
ILE A 226
VAL A 230
LEU A 231
PHE A 233
 None
 1.10A 3w67B-4r1dA:
2.3		 3w67B-4r1dA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		5 LEU A 154
ILE A 180
ILE A 173
VAL A 169
LEU A 217
 None
 1.05A 3w67B-4r86A:
undetectable		 3w67B-4r86A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 LEU A 197
ILE A 183
ILE A 113
VAL A 174
LEU A 111
 None
SAH  A 502 (-4.2A)
SAH  A 502 (-4.7A)
None
None
 1.10A 3w67B-4rvhA:
undetectable		 3w67B-4rvhA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 ILE A 171
LEU A  44
ILE A 183
ILE A 222
LEU A 273
 None
 1.10A 3w67B-4ufcA:
undetectable		 3w67B-4ufcA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A  89
VAL A 213
ILE A 242
ILE A  47
LEU A 209
 None
 0.98A 3w67B-4wwyA:
undetectable		 3w67B-4wwyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E  84
ILE E  26
ILE E 156
VAL E 125
LEU E 157
 None
 1.08A 3w67B-4xgcE:
undetectable		 3w67B-4xgcE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 VAL A 620
ILE A 596
ILE A 603
VAL A 606
LEU A 607
 None
 0.94A 3w67B-4xriA:
undetectable		 3w67B-4xriA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6y TBC1 DOMAIN FAMILY
MEMBER 7

(Homo sapiens) 		no annotation 5 ILE B 154
LEU B 215
PHE B 158
VAL B 238
LEU B 235
 None
 1.03A 3w67B-4z6yB:
undetectable		 3w67B-4z6yB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		5 LEU A  54
ILE A 114
ILE A 155
VAL A 158
LEU A 159
 None
 0.94A 3w67B-4z8sA:
undetectable		 3w67B-4z8sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A 192
ILE A 104
ILE A 206
VAL A 209
LEU A 210
 None
 0.98A 3w67B-5a4pA:
undetectable		 3w67B-5a4pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		5 SER A 333
LEU A 339
ILE A 464
ILE A 437
LEU A 435
 None
 1.07A 3w67B-5btrA:
undetectable		 3w67B-5btrA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
delbrueckii) 		PF02361
(CbiQ) 		5 ILE D  76
ILE D 119
VAL D  55
LEU D  52
PHE D  56
 None
 1.10A 3w67B-5d3mD:
undetectable		 3w67B-5d3mD:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 ILE A 294
LEU A  34
ILE A 289
ILE A  31
LEU A  61
 None
 1.10A 3w67B-5dteA:
undetectable		 3w67B-5dteA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A 149
LEU A 213
VAL A 220
ILE A 191
ILE A 299
 None
 1.06A 3w67B-5ilbA:
undetectable		 3w67B-5ilbA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		11 ILE A 119
TRP A 122
SER A 136
LEU A 137
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
 None
None
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.9A)
None
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
 0.66A 3w67B-5mueA:
33.9		 3w67B-5mueA:
92.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		6 ILE A 119
TRP A 122
SER A 136
LEU A 137
VAL A 191
PHE A 158
 None
None
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 ( 4.9A)
VIV  A 302 (-3.9A)
 1.47A 3w67B-5mueA:
33.9		 3w67B-5mueA:
92.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suh MSM0271 PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 VAL A  15
ILE A 192
ILE A 206
VAL A 209
LEU A 210
 None
 0.98A 3w67B-5suhA:
undetectable		 3w67B-5suhA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		5 LEU A 169
VAL A 199
ILE A 308
VAL A 188
LEU A 189
 IOD  A 515 ( 4.6A)
None
None
None
None
 1.06A 3w67B-5suoA:
undetectable		 3w67B-5suoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 VAL A1053
PHE A1026
ILE A1075
VAL A1091
LEU A1078
 None
 0.98A 3w67B-5wblA:
2.4		 3w67B-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		5 ILE A 270
SER A 443
ILE A 263
VAL A 224
LEU A 262
 None
 1.09A 3w67B-5xhqA:
undetectable		 3w67B-5xhqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 ILE A 273
LEU B 558
PHE A 362
ILE A 366
VAL B 529
 None
 1.06A 3w67B-5y58A:
3.4		 3w67B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 5 LEU A 172
ILE A 260
ILE A 228
VAL A 198
LEU A 199
 None
 1.04A 3w67B-5z03A:
undetectable		 3w67B-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 ILE A 100
SER A 113
LEU A 116
VAL A 555
LEU A 556
 None
 0.91A 3w67B-5ze4A:
undetectable		 3w67B-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 SER A 307
LEU A 304
ILE A 100
ILE A 389
VAL A 376
 None
 1.04A 3w67B-6bjaA:
undetectable		 3w67B-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 VAL A 409
PHE A 401
ILE A 314
ILE A 467
VAL A 471
 None
 1.07A 3w67B-6d6vA:
undetectable		 3w67B-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		5 ILE C 200
SER B 664
VAL C  98
ILE B 608
LEU B 589
 None
 1.04A 3w67B-6f5oC:
undetectable		 3w67B-6f5oC:
undetectable