SIMILAR PATTERNS OF AMINO ACIDS FOR 3W67_A_VIVA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		5 ILE A 215
ILE A 224
VAL A 227
LEU A 228
VAL A 203
 None
 0.85A 3w67A-1a3xA:
2.3		 3w67A-1a3xA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avo 11S REGULATOR
11S REGULATOR

(Homo sapiens;
Homo sapiens) 		PF02251
(PA28_alpha)
PF02252
(PA28_beta) 		5 LEU A  40
ILE B 174
ILE B 121
VAL B 124
LEU B 167
 None
 1.09A 3w67A-1avoA:
undetectable		 3w67A-1avoA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 373
PHE A 343
ILE A 629
VAL A 348
LEU A 585
 None
 1.15A 3w67A-1bhgA:
1.0		 3w67A-1bhgA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8o ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		5 ILE A  18
ILE A  23
VAL A  26
LEU A  27
VAL A 258
 None
 1.03A 3w67A-1c8oA:
undetectable		 3w67A-1c8oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A  30
ILE A 167
VAL A 165
LEU A  18
VAL A 146
 None
 0.96A 3w67A-1cynA:
undetectable		 3w67A-1cynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 SER A  40
LEU A  41
ILE A  70
VAL A  57
VAL A  88
 None
 1.15A 3w67A-1e32A:
2.4		 3w67A-1e32A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gka CRUSTACYANIN A2
SUBUNIT

(Homarus
gammarus) 		PF00061
(Lipocalin) 		5 SER B  49
PHE B 133
ILE B  93
VAL B  43
VAL B 164
 None
None
AXT  B1175 (-4.7A)
None
None
 1.00A 3w67A-1gkaB:
undetectable		 3w67A-1gkaB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 TRP A 186
LEU A 146
ILE A 429
ILE A 433
VAL A 383
 None
 1.06A 3w67A-1itzA:
undetectable		 3w67A-1itzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 ILE A 142
ILE A  70
VAL A  74
LEU A  71
VAL A 111
 SAH  A 400 (-4.1A)
None
None
None
None
 1.08A 3w67A-1jqeA:
undetectable		 3w67A-1jqeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzo THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Escherichia
coli) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		5 SER A 101
LEU A 104
ILE A 139
VAL A  92
VAL A 179
 None
 0.94A 3w67A-1jzoA:
undetectable		 3w67A-1jzoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 205
ILE A  31
ILE A  60
VAL A  54
LEU A  59
 None
 1.14A 3w67A-1lcyA:
undetectable		 3w67A-1lcyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2
SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus;
Cowpox virus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 ILE A  18
ILE A  23
VAL A  26
LEU A  27
VAL B 258
 None
 0.94A 3w67A-1m93A:
undetectable		 3w67A-1m93A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		5 SER A 248
LEU A 250
SER A 252
VAL A 232
LEU A 235
 None
 1.16A 3w67A-1oedA:
undetectable		 3w67A-1oedA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		5 ILE D 938
ILE D 747
VAL D 820
LEU D 746
VAL D 812
 None
 1.04A 3w67A-1pytD:
undetectable		 3w67A-1pytD:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		5 SER A 134
LEU A 135
SER A 138
VAL A 164
PHE A 161
 FMT  A3013 (-2.6A)
None
None
None
None
 1.09A 3w67A-1r4pA:
undetectable		 3w67A-1r4pA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		11 TRP A 122
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.68A 3w67A-1r5lA:
37.7		 3w67A-1r5lA:
89.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		5 PHE A 400
ILE A 243
ILE A 270
LEU A 336
VAL A 425
 None
 1.16A 3w67A-1vl4A:
undetectable		 3w67A-1vl4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 SER A 105
ILE A  97
VAL A  36
PHE A 123
VAL A   7
 None
 1.08A 3w67A-1we0A:
undetectable		 3w67A-1we0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 LEU A 115
ILE A  42
ILE A  13
VAL A 133
VAL A 126
 None
 1.12A 3w67A-2e3dA:
undetectable		 3w67A-2e3dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		5 SER A 257
LEU A 256
ILE A 302
LEU A  11
VAL A 195
 None
 1.10A 3w67A-2ejaA:
undetectable		 3w67A-2ejaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE

(Enterococcus
faecalis) 		PF02525
(Flavodoxin_2) 		5 LEU A  27
ILE A 180
ILE A 146
VAL A  99
LEU A 144
 None
 1.02A 3w67A-2hpvA:
undetectable		 3w67A-2hpvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 ILE A 133
ILE A 106
LEU A  32
PHE A  59
VAL A  80
 None
 1.10A 3w67A-2iy8A:
undetectable		 3w67A-2iy8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6e IGM

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  62
ILE H  37
ILE H  48
VAL H  67
LEU H  82
 None
 1.09A 3w67A-2j6eH:
undetectable		 3w67A-2j6eH:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 SER A 794
SER A 799
ILE A 725
VAL A 721
LEU A 665
 None
 1.14A 3w67A-2nz9A:
undetectable		 3w67A-2nz9A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 400
VAL A 417
LEU A 419
PHE A 444
VAL A 277
 None
 1.00A 3w67A-2o3jA:
undetectable		 3w67A-2o3jA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 LEU A 303
ILE A 391
ILE A 352
LEU A 235
VAL A 271
 None
 1.14A 3w67A-2odpA:
undetectable		 3w67A-2odpA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		5 LEU A 252
SER A 221
VAL A  15
LEU A  38
VAL A 186
 None
 1.06A 3w67A-2p4zA:
2.9		 3w67A-2p4zA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		5 SER A  27
ILE A 191
VAL A  89
LEU A 141
PHE A  87
 None
NAD  A1780 (-4.4A)
None
None
None
 1.07A 3w67A-2pd3A:
2.4		 3w67A-2pd3A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 SER A 239
ILE A 236
VAL A 270
LEU A 267
VAL A 285
 None
None
PEG  A 415 (-4.5A)
None
None
 0.96A 3w67A-2py6A:
0.2		 3w67A-2py6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwb CELLULASE

(Tropaeolum
majus) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		5 LEU A 210
SER A 212
ILE A  66
VAL A 175
LEU A  82
 None
 1.06A 3w67A-2uwbA:
undetectable		 3w67A-2uwbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnb -

(Sus scrofa) 		PF00777
(Glyco_transf_29) 		5 LEU A 201
ILE A 208
VAL A 193
PHE A 198
VAL A 220
 None
 0.90A 3w67A-2wnbA:
undetectable		 3w67A-2wnbA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxz LYSINE-SPECIFIC
DEMETHYLASE 6B

(Homo sapiens) 		PF02373
(JmjC) 		5 LEU A1341
ILE A1400
ILE A1478
VAL A1373
VAL A1482
 None
 0.95A 3w67A-2xxzA:
undetectable		 3w67A-2xxzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 347
ILE A 381
ILE A 393
VAL A 411
LEU A 364
 None
 0.94A 3w67A-2xzoA:
undetectable		 3w67A-2xzoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhl GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 101
ILE A 134
VAL A  47
PHE A  45
VAL A  15
 None
 1.09A 3w67A-2zhlA:
undetectable		 3w67A-2zhlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF16916
(ZT_dimer) 		5 ILE A 238
ILE A 220
VAL A 223
LEU A 224
VAL A 230
 None
 0.78A 3w67A-2zztA:
undetectable		 3w67A-2zztA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  66
SER A 178
ILE A 191
ILE A 255
VAL A 257
 None
 1.10A 3w67A-3a3jA:
undetectable		 3w67A-3a3jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq2 6B PROTEIN

(Agrobacterium
vitis) 		PF02027
(RolB_RolC) 		5 SER A 137
LEU A  56
ILE A 190
LEU A  81
VAL A  65
 None
 1.05A 3w67A-3aq2A:
undetectable		 3w67A-3aq2A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 SER A 638
SER A 642
ILE A 598
VAL A 585
PHE A 589
 None
 1.10A 3w67A-3aqpA:
undetectable		 3w67A-3aqpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1g GAG POLYPROTEIN

(Rous sarcoma
virus) 		no annotation 5 SER A 163
ILE A 172
ILE A 219
VAL A 222
LEU A 223
 None
 1.13A 3w67A-3g1gA:
undetectable		 3w67A-3g1gA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 228
ILE A 220
VAL A 271
LEU A 266
VAL A 469
 None
 1.15A 3w67A-3gdnA:
undetectable		 3w67A-3gdnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr5 ESCC

(Escherichia
coli) 		no annotation 5 SER A 163
LEU A 166
ILE A 118
LEU A 122
VAL A 131
 None
 1.07A 3w67A-3gr5A:
undetectable		 3w67A-3gr5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 LEU A  47
SER A  50
ILE A  34
ILE A 435
VAL A 437
 None
 1.16A 3w67A-3kalA:
undetectable		 3w67A-3kalA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 SER A 147
ILE A 153
LEU A 107
PHE A 101
VAL A  93
 None
 0.98A 3w67A-3msgA:
2.2		 3w67A-3msgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrv PUTATIVE
TRANSCRIPTIONAL
REGULATOR (MARR/EMRR
FAMILY)

(Acinetobacter
sp. ADP1) 		PF12802
(MarR_2) 		5 LEU A  61
ILE A  35
ILE A  43
VAL A  45
LEU A  46
 None
 1.14A 3w67A-3nrvA:
undetectable		 3w67A-3nrvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 SER A 187
ILE A 236
VAL A 216
LEU A 237
VAL A 195
 None
 1.14A 3w67A-3owaA:
undetectable		 3w67A-3owaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TRP A  56
LEU A 189
VAL A 460
LEU A 464
VAL A  91
 None
 1.16A 3w67A-3pfeA:
0.3		 3w67A-3pfeA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		5 SER A  95
SER A 105
ILE A  63
VAL A  67
LEU A  60
 None
 1.07A 3w67A-3psqA:
undetectable		 3w67A-3psqA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq8 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 SER A  40
LEU A  41
ILE A  70
VAL A  57
VAL A  88
 None
 1.06A 3w67A-3qq8A:
undetectable		 3w67A-3qq8A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 PHE A 160
ILE A 187
VAL A 183
LEU A 186
VAL A 170
 None
 1.09A 3w67A-3s6pA:
undetectable		 3w67A-3s6pA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL

(Coccidioides
immitis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  36
ILE A 335
LEU A 338
PHE A 341
VAL A 122
 None
 1.09A 3w67A-3sdsA:
undetectable		 3w67A-3sdsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		5 PHE A 133
ILE A 115
VAL A  92
LEU A  96
VAL A 142
 None
 1.15A 3w67A-3t66A:
undetectable		 3w67A-3t66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 287
ILE A 325
VAL A 354
LEU A 324
VAL A 375
 None
 1.09A 3w67A-3tknA:
undetectable		 3w67A-3tknA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 1.06A 3w67A-3u2pA:
undetectable		 3w67A-3u2pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 111
ILE A  40
VAL A  62
LEU A  38
VAL A  34
 None
 1.06A 3w67A-3u7uA:
undetectable		 3w67A-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 111
ILE A  43
ILE A  40
VAL A  62
LEU A  38
 None
 1.10A 3w67A-3u7uA:
undetectable		 3w67A-3u7uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 LEU A  71
ILE A 221
ILE A  78
LEU A  79
VAL A  58
 None
 1.13A 3w67A-3vomA:
undetectable		 3w67A-3vomA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		5 SER A 165
SER A 169
ILE A  41
VAL A 140
LEU A  39
 None
 1.08A 3w67A-3we7A:
undetectable		 3w67A-3we7A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		5 ILE A 197
ILE A 176
VAL A 119
LEU A 175
VAL A 108
 None
 1.08A 3w67A-3wksA:
undetectable		 3w67A-3wksA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 101
ILE A 134
VAL A  47
PHE A  45
VAL A  15
 None
 1.09A 3w67A-3wv6A:
undetectable		 3w67A-3wv6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 ILE A 269
ILE A 431
VAL A 470
LEU A 430
VAL A 422
 None
 1.14A 3w67A-3zk4A:
3.2		 3w67A-3zk4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 SER A 355
LEU A 354
ILE A 422
ILE A 408
VAL A 359
 None
 1.13A 3w67A-4a2lA:
undetectable		 3w67A-4a2lA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3x EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 0.96A 3w67A-4a3xA:
undetectable		 3w67A-4a3xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 207
PHE A 248
ILE A 219
VAL A 169
LEU A 221
 None
 1.00A 3w67A-4aslA:
undetectable		 3w67A-4aslA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00995
(Sec1) 		5 LEU A 364
ILE A 389
VAL A 392
LEU A 393
VAL A 431
 None
 1.04A 3w67A-4ccaA:
undetectable		 3w67A-4ccaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		5 LEU A 535
ILE A 527
ILE A 503
VAL A 505
VAL A 407
 None
 1.02A 3w67A-4fieA:
undetectable		 3w67A-4fieA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		5 PHE A 315
ILE A 534
ILE A 538
VAL A 543
PHE A 223
 None
 1.13A 3w67A-4h3sA:
undetectable		 3w67A-4h3sA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 TRP A 464
ILE A 446
ILE A 473
LEU A 478
VAL A 927
 None
 1.11A 3w67A-4hpfA:
undetectable		 3w67A-4hpfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ILE A 262
ILE A 304
VAL A 232
LEU A 303
VAL A 158
 None
 1.16A 3w67A-4ic6A:
undetectable		 3w67A-4ic6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		5 LEU A 117
ILE A  72
ILE A 102
VAL A  95
LEU A  27
 None
 0.98A 3w67A-4inzA:
undetectable		 3w67A-4inzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 203
LEU A 205
SER A 207
VAL A 324
PHE A 301
 None
 1.02A 3w67A-4jbhA:
undetectable		 3w67A-4jbhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF16024
(DUF4785) 		5 SER A 311
ILE A 370
VAL A 378
LEU A 369
VAL A 305
 None
 1.08A 3w67A-4kh9A:
undetectable		 3w67A-4kh9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU C 117
ILE C  46
VAL C  68
LEU C  44
VAL C  40
 None
 0.99A 3w67A-4leoC:
undetectable		 3w67A-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2

(Homo sapiens) 		PF08558
(TRF) 		5 PHE A 217
ILE A 177
ILE A 133
VAL A 135
LEU A 136
 None
 1.09A 3w67A-4m7cA:
0.9		 3w67A-4m7cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 112
SER A 115
ILE A 336
ILE A 338
LEU A 380
 None
 1.07A 3w67A-4mksA:
undetectable		 3w67A-4mksA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 SER A 230
LEU A   4
ILE A 182
ILE A 137
VAL A  87
 None
 1.16A 3w67A-4mowA:
2.4		 3w67A-4mowA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nem INTERLEUKIN-2

(Homo sapiens) 		PF00715
(IL2) 		5 SER A 125
PHE A 117
ILE A  28
ILE A  24
VAL A  93
 None
 1.14A 3w67A-4nemA:
undetectable		 3w67A-4nemA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 SER B 426
LEU B 427
SER B 430
ILE B 417
VAL B 414
 None
 1.01A 3w67A-4q4aB:
undetectable		 3w67A-4q4aB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r86 RND FAMILY
AMINOGLYCOSIDE/MULTI
DRUG EFFLUX PUMP

(Salmonella
enterica) 		PF00873
(ACR_tran) 		5 LEU A 154
ILE A 180
ILE A 173
VAL A 169
LEU A 217
 None
 1.15A 3w67A-4r86A:
undetectable		 3w67A-4r86A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txw HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		5 ILE A  82
ILE A  67
VAL A 131
LEU A  69
VAL A  47
 None
 1.15A 3w67A-4txwA:
undetectable		 3w67A-4txwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4l BETA-LACTAMASE NDM-1

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A 180
ILE A 109
ILE A  79
VAL A  89
VAL A 247
 None
 0.99A 3w67A-4u4lA:
2.4		 3w67A-4u4lA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A 291
SER A  36
PHE A 313
ILE A 299
PHE A 275
 None
 0.99A 3w67A-4us4A:
undetectable		 3w67A-4us4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E  84
ILE E  26
ILE E 156
VAL E 125
LEU E 157
 None
 1.06A 3w67A-4xgcE:
2.0		 3w67A-4xgcE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		5 LEU A  54
ILE A 114
ILE A 155
VAL A 158
LEU A 159
 None
 0.94A 3w67A-4z8sA:
undetectable		 3w67A-4z8sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 0.95A 3w67A-5cslA:
2.7		 3w67A-5cslA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 229
ILE A 220
VAL A 272
LEU A 267
VAL A 470
 None
 1.10A 3w67A-5eb5A:
1.0		 3w67A-5eb5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A 486
ILE A 402
ILE A 416
LEU A 370
VAL A 386
 None
 1.03A 3w67A-5ey9A:
undetectable		 3w67A-5ey9A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A 140
SER A 217
ILE A  42
ILE A 182
VAL A 158
 None
 1.07A 3w67A-5f5oA:
0.8		 3w67A-5f5oA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8

(Mus musculus) 		PF05527
(DUF758) 		5 LEU A 128
ILE A 198
ILE A 189
LEU A 185
VAL A  57
 None
None
6OU  A 201 ( 4.9A)
None
None
 0.99A 3w67A-5jxdA:
undetectable		 3w67A-5jxdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 LEU B 554
ILE B 468
ILE B 557
PHE B 567
VAL B 565
 None
 1.14A 3w67A-5ldrB:
1.7		 3w67A-5ldrB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 SER X   8
LEU X   7
ILE X 167
VAL X 107
VAL X 149
 None
 1.08A 3w67A-5liyX:
1.6		 3w67A-5liyX:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljy ENVELOPMENT
POLYPROTEIN

(Hantaan
orthohantavirus) 		PF01561
(Hanta_G2) 		5 ILE A 304
ILE A 306
VAL A 308
LEU A  25
VAL A  19
 None
 0.93A 3w67A-5ljyA:
undetectable		 3w67A-5ljyA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU B 136
ILE B 203
VAL B 177
PHE B 147
VAL B 128
 None
 1.12A 3w67A-5mkgB:
2.9		 3w67A-5mkgB:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		11 TRP A 122
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 302 (-3.5A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
VIV  A 302 (-4.4A)
None
VIV  A 302 (-4.0A)
VIV  A 302 ( 4.9A)
 0.61A 3w67A-5mueA:
34.0		 3w67A-5mueA:
92.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 LEU A 365
ILE A 430
ILE A 460
LEU A 400
VAL A 370
 None
 0.93A 3w67A-5o3mA:
undetectable		 3w67A-5o3mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 LEU A 285
PHE A 224
VAL A 239
LEU A 237
PHE A 389
 None
 1.05A 3w67A-5oltA:
undetectable		 3w67A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttx HYDROGENASE 2
MATURATION PEPTIDASE

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF01750
(HycI) 		5 LEU A  55
PHE A 109
VAL A 120
LEU A  81
PHE A  63
 None
 1.14A 3w67A-5ttxA:
undetectable		 3w67A-5ttxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		5 LEU A 378
ILE A  45
VAL A 167
LEU A 171
VAL A  28
 None
 1.11A 3w67A-5xaoA:
undetectable		 3w67A-5xaoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A 124
SER A 201
ILE A  26
ILE A 166
VAL A 142
 None
 1.05A 3w67A-5xsqA:
undetectable		 3w67A-5xsqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 ILE A 134
ILE A  87
VAL A  99
LEU A  86
VAL A  37
 None
 1.07A 3w67A-5z5dA:
undetectable		 3w67A-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 5 LEU A 333
SER A 336
ILE A 356
VAL A 276
VAL A 292
 None
 1.14A 3w67A-6czmA:
undetectable		 3w67A-6czmA:
undetectable