SIMILAR PATTERNS OF AMINO ACIDS FOR 3W1W_B_CHDB504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 159
PHE A  47
LEU A 161
PRO A 258
VAL A 255
 None
 1.20A 3w1wB-1b41A:
2.7		 3w1wB-1b41A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		5 LEU A  73
ILE A 157
PRO A  10
VAL A  12
VAL A 137
 None
 1.37A 3w1wB-1h4oA:
undetectable		 3w1wB-1h4oA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 HIS A 235
PRO A 238
VAL A 241
VAL A 277
TRP A 282
GLU A 314
 None
 0.91A 3w1wB-1lbqA:
48.0		 3w1wB-1lbqA:
49.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 LEU A  62
PHE A  63
ILE A  91
GLN A  94
HIS A 235
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.51A 3w1wB-1lbqA:
48.0		 3w1wB-1lbqA:
49.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 MET A  46
HIS A 235
PRO A 238
VAL A 241
TRP A 282
 None
 1.04A 3w1wB-1lbqA:
48.0		 3w1wB-1lbqA:
49.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 PHE A  63
LEU A  68
GLN A  94
HIS A 235
VAL A 277
TRP A 282
 None
 1.32A 3w1wB-1lbqA:
48.0		 3w1wB-1lbqA:
49.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odu PUTATIVE
ALPHA-L-FUCOSIDASE

(Thermotoga
maritima) 		PF01120
(Alpha_L_fucos) 		5 LEU A 321
PHE A  29
ILE A 286
GLN A 337
VAL A 220
 None
 1.39A 3w1wB-1oduA:
undetectable		 3w1wB-1oduA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 LEU A 794
LEU A 798
PRO A 729
VAL A 709
TRP A 717
 None
 1.36A 3w1wB-1qb4A:
undetectable		 3w1wB-1qb4A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A  64
PHE A  55
ILE A 169
VAL A  27
VAL A 177
 None
 1.16A 3w1wB-1qi7A:
undetectable		 3w1wB-1qi7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		5 LEU A  57
PHE A  68
ILE A  83
VAL A 124
VAL A 103
 None
 1.33A 3w1wB-1qmyA:
undetectable		 3w1wB-1qmyA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU E 248
LEU E 171
ILE E 292
GLN E 289
VAL E 344
 None
 1.28A 3w1wB-1skyE:
3.0		 3w1wB-1skyE:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 PHE B 228
ILE B  87
GLN B 101
VAL B 251
GLU B 264
 None
 1.21A 3w1wB-1t3qB:
undetectable		 3w1wB-1t3qB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 MET C 135
LEU C 115
LEU C 111
GLN C 222
VAL C  86
 None
 1.18A 3w1wB-1t3qC:
undetectable		 3w1wB-1t3qC:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		5 LEU A  30
LEU A  23
VAL A  87
VAL A 192
GLU A  67
 None
 1.38A 3w1wB-1ve4A:
undetectable		 3w1wB-1ve4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.13A 3w1wB-1wa5C:
undetectable		 3w1wB-1wa5C:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A  82
LEU A  41
ILE A  91
PRO A  22
VAL A  37
 None
 1.20A 3w1wB-1wn1A:
undetectable		 3w1wB-1wn1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 LEU A 246
LEU A 306
ILE A 192
VAL A 318
VAL A 233
 None
 1.42A 3w1wB-1x0uA:
undetectable		 3w1wB-1x0uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A 129
LEU A 133
ILE A  64
VAL A 105
GLU A  19
 None
 1.35A 3w1wB-1x42A:
2.1		 3w1wB-1x42A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.06A 3w1wB-1yirA:
undetectable		 3w1wB-1yirA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.13A 3w1wB-2dc0A:
undetectable		 3w1wB-2dc0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha) 		5 LEU A 127
ILE A 173
PRO A 179
VAL A 197
VAL A 104
 None
 1.32A 3w1wB-2dppA:
undetectable		 3w1wB-2dppA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fej CELLULAR TUMOR
ANTIGEN P53

(Homo sapiens) 		PF00870
(P53) 		5 PHE A 270
ILE A 195
PRO A 278
VAL A 122
VAL A 274
 None
 1.39A 3w1wB-2fejA:
undetectable		 3w1wB-2fejA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A   5
LEU A   9
GLN A 224
VAL A  55
VAL A  47
 None
 1.19A 3w1wB-2ffhA:
2.6		 3w1wB-2ffhA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 450
PHE A 451
LEU A 382
ILE A 372
VAL A 227
 HEM  A 900 (-4.0A)
HEM  A 900 (-4.1A)
HEM  A 900 (-4.0A)
None
None
 1.19A 3w1wB-2hi4A:
undetectable		 3w1wB-2hi4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.29A 3w1wB-2nn3C:
undetectable		 3w1wB-2nn3C:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyt PROBABLE
C->U-EDITING ENZYME
APOBEC-2

(Homo sapiens) 		PF08210
(APOBEC_N) 		5 LEU A 169
ILE A 162
VAL A 119
VAL A 151
GLU A  60
 None
None
None
None
ZN  A2000 (-2.8A)
 1.40A 3w1wB-2nytA:
undetectable		 3w1wB-2nytA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.21A 3w1wB-2o8eB:
undetectable		 3w1wB-2o8eB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		5 LEU A  27
ILE A  78
HIS A 174
VAL A 138
GLU A 175
 None
None
CO  A 300 ( 3.6A)
None
BB2  A 400 (-2.8A)
 1.13A 3w1wB-2os3A:
undetectable		 3w1wB-2os3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		5 MET A 241
LEU A 233
ILE A 144
PRO A 254
VAL A 255
 None
 1.39A 3w1wB-2qgqA:
2.1		 3w1wB-2qgqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		5 LEU A  73
LEU A 134
ILE A 164
VAL A 108
VAL A 171
 None
 1.35A 3w1wB-2qq1A:
6.2		 3w1wB-2qq1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 480
LEU A 455
ILE A 515
GLN A 512
GLU A 486
 None
 1.38A 3w1wB-2v26A:
undetectable		 3w1wB-2v26A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		5 LEU A  23
ILE A 127
PRO A  39
VAL A  32
VAL A 458
 None
 1.19A 3w1wB-2w45A:
undetectable		 3w1wB-2w45A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		5 PHE A 144
LEU A  23
ILE A 127
PRO A  39
VAL A  32
 None
 1.41A 3w1wB-2w45A:
undetectable		 3w1wB-2w45A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A 264
PHE A 260
LEU A 238
ILE A 111
VAL A 133
 HEM  A 450 (-4.5A)
None
None
HEM  A 450 (-4.3A)
None
 1.42A 3w1wB-2wm4A:
undetectable		 3w1wB-2wm4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.30A 3w1wB-2x66A:
undetectable		 3w1wB-2x66A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		5 LEU A  23
PHE A 227
ILE A  39
HIS A  10
VAL A  46
 None
 1.38A 3w1wB-2x9oA:
undetectable		 3w1wB-2x9oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 LEU A 268
LEU A 290
ILE A  13
PRO A 170
VAL A 162
 None
 1.39A 3w1wB-2y5wA:
undetectable		 3w1wB-2y5wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU A  29
PHE A  33
LEU A 101
ILE A  46
HIS A  87
 None
None
HEM  A 201 (-4.1A)
None
HEM  A 201 (-3.3A)
 1.26A 3w1wB-3a0gA:
undetectable		 3w1wB-3a0gA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 339
LEU A 323
ILE A 364
PRO A 277
VAL A 214
 None
 1.38A 3w1wB-3af5A:
4.1		 3w1wB-3af5A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		11 MET A  76
LEU A  92
PHE A  93
LEU A  98
ILE A 119
GLN A 122
HIS A 263
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
None
CHD  A   1 ( 4.1A)
CHD  A   1 (-4.3A)
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.41A 3w1wB-3aqiA:
60.3		 3w1wB-3aqiA:
99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 MET A  76
LEU A  98
HIS A 263
PRO A 266
VAL A 269
VAL A 305
TRP A 310
GLU A 343
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.3A)
CHD  A   1 (-4.3A)
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
None
 0.96A 3w1wB-3aqiA:
60.3		 3w1wB-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A  52
PHE A  78
ILE A 104
PRO A  82
VAL A  29
 None
 1.41A 3w1wB-3bc9A:
undetectable		 3w1wB-3bc9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		5 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.21A 3w1wB-3fmsA:
undetectable		 3w1wB-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 221
PHE A 222
ILE A 241
HIS A 231
VAL A 128
 None
 1.34A 3w1wB-3gg9A:
undetectable		 3w1wB-3gg9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.41A 3w1wB-3h77A:
undetectable		 3w1wB-3h77A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 MET A 137
LEU A 133
PHE A 129
LEU A 121
VAL A  74
 None
 1.18A 3w1wB-3hbjA:
3.4		 3w1wB-3hbjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		5 LEU A  64
LEU A  30
ILE A 210
GLN A 208
VAL A  95
 None
 1.25A 3w1wB-3hj9A:
undetectable		 3w1wB-3hj9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 ILE X 143
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.40A 3w1wB-3j8gX:
2.5		 3w1wB-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 LEU X   7
ILE X 143
PRO X   3
VAL X 158
TRP X 162
 None
 1.27A 3w1wB-3j8gX:
2.5		 3w1wB-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.23A 3w1wB-3l6aA:
undetectable		 3w1wB-3l6aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lly AGGLUTININ ALPHA
CHAIN

(Maclura
pomifera) 		PF01419
(Jacalin) 		5 LEU A  28
LEU A 124
ILE A  12
VAL A  72
VAL A  68
 None
 0.97A 3w1wB-3llyA:
undetectable		 3w1wB-3llyA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.08A 3w1wB-3m1mA:
undetectable		 3w1wB-3m1mA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		5 LEU A  43
ILE A 254
GLN A 251
VAL A  77
VAL A 222
 None
 1.27A 3w1wB-3muqA:
undetectable		 3w1wB-3muqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A  33
PHE A  42
ILE A  90
VAL A 334
VAL A 288
 None
 1.35A 3w1wB-3q41A:
3.9		 3w1wB-3q41A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF07729
(FCD) 		5 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.24A 3w1wB-3sxmA:
undetectable		 3w1wB-3sxmA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyt HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN L

(Mus musculus) 		PF13893
(RRM_5) 		5 LEU A 575
PRO A 526
VAL A 529
VAL A 523
GLU A 520
 None
None
None
EDO  A 641 ( 4.8A)
None
 1.18A 3w1wB-3tytA:
undetectable		 3w1wB-3tytA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
ILE A 550
VAL A 380
VAL A 458
 None
 1.21A 3w1wB-3v4oA:
2.3		 3w1wB-3v4oA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
 None
 1.24A 3w1wB-3v4oA:
2.3		 3w1wB-3v4oA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.20A 3w1wB-3zyiA:
undetectable		 3w1wB-3zyiA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.31A 3w1wB-4cr4L:
undetectable		 3w1wB-4cr4L:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 PHE A 247
LEU A  61
ILE A 141
VAL A  74
GLU A 113
 None
 1.12A 3w1wB-4efcA:
undetectable		 3w1wB-4efcA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 176
LEU A  80
ILE A 384
GLN A 222
PRO A  76
 None
 1.25A 3w1wB-4g1pA:
undetectable		 3w1wB-4g1pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		5 PHE A 136
LEU A 165
ILE A  97
VAL A 191
VAL A 151
 None
None
None
EDO  A 908 (-4.5A)
None
 1.29A 3w1wB-4gt6A:
undetectable		 3w1wB-4gt6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
 None
 1.20A 3w1wB-4hq1A:
undetectable		 3w1wB-4hq1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		6 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
VAL A 458
 None
 1.41A 3w1wB-4i1pA:
2.7		 3w1wB-4i1pA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		5 LEU A 347
PHE A 346
LEU A 343
ILE A 289
VAL A 332
 None
 1.40A 3w1wB-4meaA:
2.6		 3w1wB-4meaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrp ABC TRANSPORTER
RELATED PROTEIN

(Novosphingobium
aromaticivorans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 520
LEU A 437
ILE A 392
PRO A 359
VAL A 356
 None
 1.41A 3w1wB-4mrpA:
undetectable		 3w1wB-4mrpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		5 LEU A 269
LEU A 265
ILE A 307
GLN A 310
VAL A 414
 None
None
None
None
EDO  A 505 (-4.1A)
 1.17A 3w1wB-4nqlA:
undetectable		 3w1wB-4nqlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermoplasma
volcanium) 		PF14890
(Intein_splicing) 		5 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.32A 3w1wB-4o1sA:
undetectable		 3w1wB-4o1sA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		5 MET C 696
LEU C 701
LEU C 641
HIS C 742
VAL C 560
 None
 1.36A 3w1wB-4oqaC:
undetectable		 3w1wB-4oqaC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		5 MET A 304
LEU A 104
LEU A 184
GLN A  40
PRO A 188
 None
 1.33A 3w1wB-4ou4A:
2.5		 3w1wB-4ou4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		5 MET A 562
ILE A 619
HIS A 494
VAL A 485
GLU B 172
 None
 1.13A 3w1wB-4oy2A:
undetectable		 3w1wB-4oy2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 LEU A  95
ILE A 128
GLN A 130
HIS A  56
VAL A  19
 None
None
None
LYS  A 301 (-3.9A)
None
 1.36A 3w1wB-4pfmA:
2.0		 3w1wB-4pfmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		5 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
None
None
SO4  A 303 ( 4.9A)
None
 1.39A 3w1wB-4qjkA:
undetectable		 3w1wB-4qjkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		5 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
 1.42A 3w1wB-4u89A:
undetectable		 3w1wB-4u89A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.26A 3w1wB-4z0cA:
undetectable		 3w1wB-4z0cA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 251
LEU A 257
ILE A 228
VAL A 239
VAL A 194
 None
 1.25A 3w1wB-4z6kA:
4.2		 3w1wB-4z6kA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		5 MET A  58
LEU A 100
PHE A 112
LEU A   4
VAL A  17
 None
 1.42A 3w1wB-4zrmA:
2.0		 3w1wB-4zrmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 ILE A 115
GLN A 147
HIS A 160
PRO A 282
VAL A 264
 ST9  A 403 (-4.1A)
ST9  A 403 (-3.5A)
ZN  A 402 (-3.2A)
None
ST9  A 403 (-4.8A)
 1.03A 3w1wB-4zyoA:
undetectable		 3w1wB-4zyoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 LEU A  33
PHE A  42
ILE A  90
VAL A 355
VAL A 309
 None
 1.34A 3w1wB-5b3jA:
4.4		 3w1wB-5b3jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.15A 3w1wB-5cniA:
3.0		 3w1wB-5cniA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.25A 3w1wB-5ddvA:
2.5		 3w1wB-5ddvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU C 288
PHE C 314
LEU C 285
ILE C 268
VAL C 231
 None
 1.39A 3w1wB-5eg6C:
undetectable		 3w1wB-5eg6C:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU C 288
PHE C 314
LEU C 285
VAL C 231
VAL C 213
 None
 1.35A 3w1wB-5eg6C:
undetectable		 3w1wB-5eg6C:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 MET A 478
LEU A 424
LEU A 421
PRO A 394
VAL A 409
 None
 1.36A 3w1wB-5gk9A:
undetectable		 3w1wB-5gk9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.31A 3w1wB-5gslA:
3.0		 3w1wB-5gslA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 119
PHE B 116
LEU B 140
ILE B  77
PRO B 134
 None
 1.35A 3w1wB-5hz1B:
undetectable		 3w1wB-5hz1B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 MET B  88
LEU B  82
LEU B  74
ILE B 126
PRO B  61
 None
 1.39A 3w1wB-5khlB:
2.6		 3w1wB-5khlB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.16A 3w1wB-5kznA:
4.6		 3w1wB-5kznA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.30A 3w1wB-5lcwA:
undetectable		 3w1wB-5lcwA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 128
PHE A 119
LEU A 149
ILE A 111
VAL A 194
 None
 1.28A 3w1wB-5lfnA:
undetectable		 3w1wB-5lfnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 MET A 693
LEU A 680
LEU A 723
ILE A 995
VAL A 765
 None
 1.37A 3w1wB-5mqsA:
undetectable		 3w1wB-5mqsA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsj PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Whitewater
Arroyo
mammarenavirus) 		no annotation 5 LEU A 151
PHE A 157
ILE A 127
PRO A 200
VAL A 209
 None
 1.34A 3w1wB-5nsjA:
undetectable		 3w1wB-5nsjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 31

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF05669
(Med31) 		5 LEU X  85
LEU X  58
ILE X  36
PRO U  17
VAL U  20
 None
 1.31A 3w1wB-5svaX:
undetectable		 3w1wB-5svaX:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3t ANTITOXIN VAPB26
RIBONUCLEASE VAPC26

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF01402
(RHH_1)
PF01850
(PIN) 		5 LEU A  65
PHE A  68
LEU B  46
ILE B  95
VAL B  59
 None
 1.35A 3w1wB-5x3tA:
undetectable		 3w1wB-5x3tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 MET A  74
LEU A  80
LEU A  56
ILE A  90
VAL A  63
 None
 1.18A 3w1wB-5xnpA:
undetectable		 3w1wB-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.31A 3w1wB-5yxgA:
undetectable		 3w1wB-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 5 LEU A 104
PHE A 108
LEU A   7
VAL A   4
VAL A 168
 None
 1.31A 3w1wB-6dxpA:
3.3		 3w1wB-6dxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 LEU A 722
LEU A 707
ILE A 755
VAL A 671
GLU A 686
 None
 1.11A 3w1wB-6fikA:
3.1		 3w1wB-6fikA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 LEU D 269
LEU D 185
ILE D 313
GLN D 310
VAL D 365
 None
 1.27A 3w1wB-6fkhD:
undetectable		 3w1wB-6fkhD:
undetectable