SIMILAR PATTERNS OF AMINO ACIDS FOR 3W1W_A_CHDA1504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbh PROTEIN (HUMAN SOS
1)

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PRO A 340
LEU A 339
ILE A 222
ARG A 227
 None
 1.40A 3w1wA-1dbhA:
undetectable		 3w1wA-1dbhA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0y INTERLEUKIN-1
RECEPTOR, TYPE I

(Homo sapiens) 		PF07679
(I-set)
PF13895
(Ig_2) 		4 PRO R 206
LEU R 201
ILE R 199
ARG R 174
 None
 1.43A 3w1wA-1g0yR:
undetectable		 3w1wA-1g0yR:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 PRO D 174
LEU D 222
ILE D 212
ARG D 162
 None
 1.40A 3w1wA-1h4lD:
undetectable		 3w1wA-1h4lD:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PRO B 711
LEU B 143
ILE B 141
ARG B 702
 None
 1.27A 3w1wA-1m2vB:
3.5		 3w1wA-1m2vB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oft HYPOTHETICAL PROTEIN
PA3008

(Pseudomonas
aeruginosa) 		PF03846
(SulA) 		4 PRO A  83
LEU A 104
ILE A 102
ARG A  99
 None
 1.12A 3w1wA-1oftA:
4.3		 3w1wA-1oftA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 PRO A 289
LEU A 286
ILE A 167
ARG A 169
 None
 1.46A 3w1wA-1przA:
undetectable		 3w1wA-1przA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 PRO A 453
LEU A 460
ILE A 492
ARG A 504
 None
 1.37A 3w1wA-1sqjA:
undetectable		 3w1wA-1sqjA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 PRO A 669
LEU A 668
ILE A 666
ARG A 643
 None
 1.20A 3w1wA-1sy7A:
undetectable		 3w1wA-1sy7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 PRO A 321
LEU A 187
ILE A 327
ARG A 191
 None
 1.36A 3w1wA-1thgA:
3.4		 3w1wA-1thgA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 PRO D 174
LEU D 222
ILE D 212
ARG D 162
 None
 1.36A 3w1wA-1unlD:
undetectable		 3w1wA-1unlD:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		4 PRO A1984
LEU A2126
ILE A1887
ARG A2127
 None
 1.45A 3w1wA-1uyvA:
undetectable		 3w1wA-1uyvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 PRO A 632
LEU A 631
ILE A 583
ARG A 657
 None
 1.11A 3w1wA-1vbgA:
undetectable		 3w1wA-1vbgA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 PRO A 193
LEU A 208
ILE A 245
ARG A 212
 None
 1.34A 3w1wA-1vefA:
undetectable		 3w1wA-1vefA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhm PROTEIN YEBR

(Escherichia
coli) 		PF13185
(GAF_2) 		4 PRO A 129
LEU A 128
ILE A 126
ARG A 105
 None
 1.22A 3w1wA-1vhmA:
undetectable		 3w1wA-1vhmA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3d FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A

(Homo sapiens) 		PF00041
(fn3) 		4 PRO A  24
LEU A  36
ILE A  26
ARG A  29
 None
 1.42A 3w1wA-1x3dA:
undetectable		 3w1wA-1x3dA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 PRO A 340
LEU A 339
ILE A 222
ARG A 227
 None
 1.40A 3w1wA-1xdvA:
undetectable		 3w1wA-1xdvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 PRO A  97
LEU A  22
ILE A  26
ARG A  29
 None
 1.32A 3w1wA-2c4kA:
3.7		 3w1wA-2c4kA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew0 HYPOTHETICAL PROTEIN
ACIAD0353

(Acinetobacter
sp. ADP1) 		PF02622
(DUF179) 		4 PRO A  14
LEU A 145
ILE A 170
ARG A 174
 None
 1.35A 3w1wA-2ew0A:
undetectable		 3w1wA-2ew0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		4 PRO A 423
LEU A 424
ILE A 426
ARG A 218
 None
 1.30A 3w1wA-2f5vA:
undetectable		 3w1wA-2f5vA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		4 PRO A  89
LEU A  98
ILE A 241
ARG A 101
 None
 1.47A 3w1wA-2hekA:
undetectable		 3w1wA-2hekA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifd M-PHASE INDUCER
PHOSPHATASE 2

(Homo sapiens) 		PF00581
(Rhodanese) 		4 PRO A 457
LEU A 454
ILE A 487
ARG A 488
 None
 1.33A 3w1wA-2ifdA:
3.0		 3w1wA-2ifdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans) 		PF03069
(FmdA_AmdA) 		4 PRO A 148
LEU A 155
ILE A 228
ARG A 283
 None
 1.42A 3w1wA-2ii1A:
undetectable		 3w1wA-2ii1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PRO A 445
LEU A 661
ILE A 583
ARG A 681
 None
 1.33A 3w1wA-2ipcA:
3.6		 3w1wA-2ipcA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE

(Mus musculus) 		PF02434
(Fringe) 		4 PRO A 269
LEU A 268
ILE A 286
ARG A 300
 None
 1.22A 3w1wA-2j0aA:
2.3		 3w1wA-2j0aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 PRO A 109
LEU A  34
ILE A  38
ARG A  41
 None
 1.30A 3w1wA-2ji4A:
3.2		 3w1wA-2ji4A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF08416
(PTB) 		4 PRO A1311
LEU A1281
ILE A1365
ARG A1353
 None
 1.14A 3w1wA-2lozA:
undetectable		 3w1wA-2lozA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mez MULTIPROTEIN
BRIDGING FACTOR
(MBP-LIKE)

(Sulfolobus
solfataricus) 		PF01381
(HTH_3) 		4 PRO A  62
LEU A  70
ILE A  27
ARG A  31
 None
 1.44A 3w1wA-2mezA:
undetectable		 3w1wA-2mezA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 PRO A  64
LEU A  62
ILE A  74
ARG A  69
 None
 1.23A 3w1wA-2pnzA:
undetectable		 3w1wA-2pnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		4 PRO A 199
LEU A 232
ILE A  96
ARG A  95
 None
 1.47A 3w1wA-2qkdA:
undetectable		 3w1wA-2qkdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 PRO A 241
LEU A 240
ILE A 238
ARG A 311
 None
 1.31A 3w1wA-2r7dA:
undetectable		 3w1wA-2r7dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzq M-PHASE INDUCER
PHOSPHATASE 2

(Homo sapiens) 		PF00581
(Rhodanese) 		4 PRO A 457
LEU A 454
ILE A 487
ARG A 488
 None
 1.32A 3w1wA-2uzqA:
3.0		 3w1wA-2uzqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PRO A 500
LEU A 499
ILE A 533
ARG A 534
 None
 1.47A 3w1wA-2vk4A:
2.2		 3w1wA-2vk4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 PRO A  93
LEU A  96
ILE A  26
ARG A 111
 ZN  A1565 ( 4.2A)
None
None
None
 1.24A 3w1wA-2w9mA:
undetectable		 3w1wA-2w9mA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y27 PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 PRO A  51
LEU A  30
ILE A 299
ARG A 300
 None
None
None
PG4  A 507 ( 4.5A)
 1.47A 3w1wA-2y27A:
3.1		 3w1wA-2y27A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		4 PRO B 521
LEU B 447
ILE B 451
ARG B 454
 None
 1.23A 3w1wA-2y9yB:
undetectable		 3w1wA-2y9yB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PRO A 298
LEU A 297
ILE A  15
ARG A  11
 None
 1.41A 3w1wA-2ys6A:
2.6		 3w1wA-2ys6A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 PRO A 333
LEU A 336
ILE A  51
ARG A  52
 None
 1.34A 3w1wA-3a31A:
5.0		 3w1wA-3a31A:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 PRO A 102
LEU A 107
ILE A 111
ARG A 114
 CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
CHD  A   2 ( 4.7A)
CHD  A   2 (-3.6A)
 0.41A 3w1wA-3aqiA:
60.5		 3w1wA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		4 PRO A 265
LEU A 274
ILE A 281
ARG A 140
 None
EDO  A 361 (-3.8A)
None
None
 1.43A 3w1wA-3dxpA:
undetectable		 3w1wA-3dxpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejk DTDP SUGAR ISOMERASE

(Desulfovibrio
alaskensis) 		PF00908
(dTDP_sugar_isom) 		4 PRO A  18
LEU A  17
ILE A  15
ARG A 113
 None
None
PG4  A 177 (-4.3A)
None
 0.90A 3w1wA-3ejkA:
undetectable		 3w1wA-3ejkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 PRO A2188
LEU A2330
ILE A2092
ARG A2331
 None
 1.37A 3w1wA-3ff6A:
undetectable		 3w1wA-3ff6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PRO A  88
LEU A  66
ILE A  65
ARG A 301
 None
 1.33A 3w1wA-3ihvA:
undetectable		 3w1wA-3ihvA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus) 		PF00722
(Glyco_hydro_16) 		4 PRO A  25
LEU A  24
ILE A  52
ARG A  51
 None
 1.38A 3w1wA-3ilnA:
undetectable		 3w1wA-3ilnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		4 PRO A  68
LEU A  77
ILE A  81
ARG A  84
 None
 1.36A 3w1wA-3l6nA:
undetectable		 3w1wA-3l6nA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 PRO A  94
LEU A  92
ILE A 137
ARG A 138
 None
 1.18A 3w1wA-3nnkA:
undetectable		 3w1wA-3nnkA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 PRO A 217
LEU A 184
ILE A 180
ARG A 177
 None
 0.97A 3w1wA-3nzqA:
undetectable		 3w1wA-3nzqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qll CITRATE LYASE

(Yersinia pestis) 		PF03328
(HpcH_HpaI) 		4 PRO A  94
LEU A  87
ILE A  55
ARG A  51
 None
 1.38A 3w1wA-3qllA:
undetectable		 3w1wA-3qllA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqc DNA-DIRECTED RNA
POLYMERASE SUBUNIT
B, DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A', DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Pyrococcus
furiosus) 		PF04560
(RNA_pol_Rpb2_7)
PF04997
(RNA_pol_Rpb1_1) 		4 PRO A 260
LEU A 261
ILE A 167
ARG A 166
 None
 1.12A 3w1wA-3qqcA:
undetectable		 3w1wA-3qqcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 4 PRO X 108
LEU X 105
ILE X 101
ARG X  58
 None
 1.36A 3w1wA-3rj2X:
undetectable		 3w1wA-3rj2X:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 PRO A 375
LEU A 369
ILE A 338
ARG A 432
 None
None
None
ACT  A1001 (-3.1A)
 1.08A 3w1wA-3smtA:
undetectable		 3w1wA-3smtA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3

(Homo sapiens) 		PF00617
(RasGEF) 		4 PRO A 708
LEU A 710
ILE A 598
ARG A 595
 None
 1.21A 3w1wA-3t6aA:
undetectable		 3w1wA-3t6aA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 PRO A 428
LEU A 427
ILE A 201
ARG A 200
 None
 1.46A 3w1wA-3v39A:
undetectable		 3w1wA-3v39A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 PRO A  42
LEU A  24
ILE A 194
ARG A 186
 None
 1.37A 3w1wA-3wevA:
undetectable		 3w1wA-3wevA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		4 PRO A 160
LEU A 161
ILE A  95
ARG A  80
 None
 1.40A 3w1wA-3x0uA:
undetectable		 3w1wA-3x0uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 PRO A 165
LEU A 472
ILE A 468
ARG A 469
 None
 1.28A 3w1wA-4ddqA:
undetectable		 3w1wA-4ddqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgn 2-KETO-3-DEOXY-D-MAN
NO-OCTULOSONATE
8-PHOSPHATE
PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 PRO A 124
LEU A 123
ILE A  11
ARG A  10
 None
 1.46A 3w1wA-4hgnA:
3.0		 3w1wA-4hgnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
thermoresistibile) 		PF00082
(Peptidase_S8) 		4 PRO A 352
LEU A 354
ILE A 347
ARG A 362
 None
 1.45A 3w1wA-4hvlA:
undetectable		 3w1wA-4hvlA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iit PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAC

(Klebsiella
pneumoniae) 		PF05138
(PaaA_PaaC) 		4 PRO C   6
LEU C 182
ILE C 187
ARG C 118
 None
 1.42A 3w1wA-4iitC:
undetectable		 3w1wA-4iitC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		4 PRO A  26
LEU A  27
ILE A  63
ARG A  64
 None
 1.28A 3w1wA-4iusA:
undetectable		 3w1wA-4iusA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 PRO A  39
LEU A 638
ILE A 634
ARG A 635
 None
 1.43A 3w1wA-4jzaA:
2.5		 3w1wA-4jzaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 PRO A 357
LEU A 358
ILE A 313
ARG A 317
 None
 1.40A 3w1wA-4ksfA:
undetectable		 3w1wA-4ksfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00002
(7tm_2)
PF07361
(Cytochrom_B562) 		4 PRO A1046
LEU A1106
ILE A1102
ARG A1098
 None
 1.45A 3w1wA-4l6rA:
undetectable		 3w1wA-4l6rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		4 PRO A   5
LEU A   6
ILE A  52
ARG A  14
 None
 1.39A 3w1wA-4lh7A:
undetectable		 3w1wA-4lh7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 PRO A  90
LEU A  15
ILE A  19
ARG A  22
 None
 1.39A 3w1wA-4m0pA:
3.7		 3w1wA-4m0pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 PRO A  87
LEU A  35
ILE A  18
ARG A  20
 None
 1.40A 3w1wA-4qfeA:
undetectable		 3w1wA-4qfeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PRO A 199
LEU A 200
ILE A 106
ARG A 105
 None
 1.13A 3w1wA-4qiwA:
undetectable		 3w1wA-4qiwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 PRO A 501
LEU A 502
ILE A 510
ARG A 512
 None
 1.19A 3w1wA-4qjyA:
undetectable		 3w1wA-4qjyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7a HISTONE-BINDING
PROTEIN RBBP4

(Homo sapiens) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 PRO B 363
LEU B 366
ILE B 369
ARG B 341
 None
 1.42A 3w1wA-4r7aB:
undetectable		 3w1wA-4r7aB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9r CZCP CATION EFFLUX
P1-ATPASE

(Cupriavidus
metallidurans) 		no annotation 4 PRO A  35
LEU A  34
ILE A  99
ARG A  47
 None
 1.47A 3w1wA-4u9rA:
undetectable		 3w1wA-4u9rA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PRO A 444
LEU A 525
ILE A 506
ARG A 545
 None
 1.42A 3w1wA-4uaqA:
undetectable		 3w1wA-4uaqA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PRO A 452
LEU A 400
ILE A 396
ARG A 398
 None
 1.43A 3w1wA-4up7A:
undetectable		 3w1wA-4up7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A 456
LEU A 417
ILE A 445
ARG A 509
 None
 1.34A 3w1wA-4wv3A:
3.8		 3w1wA-4wv3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		4 PRO A 391
LEU A 338
ILE A 341
ARG A 340
 None
 1.36A 3w1wA-4xguA:
2.4		 3w1wA-4xguA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PRO A 311
LEU A 315
ILE A 353
ARG A 264
 None
 1.30A 3w1wA-4xh9A:
undetectable		 3w1wA-4xh9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb8 PCURE2P6

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PRO A 174
LEU A 173
ILE A 209
ARG A 206
 None
 1.30A 3w1wA-4zb8A:
undetectable		 3w1wA-4zb8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 PRO A  76
LEU A  75
ILE A  94
ARG A  63
 None
 1.45A 3w1wA-4zpqA:
undetectable		 3w1wA-4zpqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 PRO A 229
LEU A 232
ILE A   5
ARG A 253
 None
 1.37A 3w1wA-4zrqA:
undetectable		 3w1wA-4zrqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3g M50

(Murid
betaherpesvirus
1) 		PF04541
(Herpes_U34) 		4 PRO A  57
LEU A 164
ILE A 168
ARG A 171
 None
 1.28A 3w1wA-5a3gA:
undetectable		 3w1wA-5a3gA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv5 CYTOCHROME P450 119

(Sulfolobus
solfataricus) 		PF00067
(p450) 		4 PRO A 124
LEU A 121
ILE A 110
ARG A 337
 None
 1.37A 3w1wA-5bv5A:
undetectable		 3w1wA-5bv5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		4 PRO B 239
LEU B 269
ILE B 276
ARG B 273
 None
 1.42A 3w1wA-5do7B:
undetectable		 3w1wA-5do7B:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PRO A 686
LEU A 717
ILE A 714
ARG A 558
 None
 1.00A 3w1wA-5fd2A:
undetectable		 3w1wA-5fd2A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 PRO A 856
LEU A 857
ILE A 877
ARG A 873
 None
 1.15A 3w1wA-5h42A:
undetectable		 3w1wA-5h42A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 PRO Z  82
LEU Z 113
ILE Z 141
ARG Z 118
 None
 1.27A 3w1wA-5hxbZ:
undetectable		 3w1wA-5hxbZ:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 PRO A 743
LEU A 874
ILE A 892
ARG A 908
 None
 1.42A 3w1wA-5jouA:
undetectable		 3w1wA-5jouA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 PRO A 844
LEU A 874
ILE A 892
ARG A 908
 None
 1.30A 3w1wA-5jouA:
undetectable		 3w1wA-5jouA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 PRO A 445
LEU A 444
ILE A 426
ARG A 428
 None
 1.44A 3w1wA-5jrlA:
3.3		 3w1wA-5jrlA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		4 PRO A  27
LEU A 101
ILE A  38
ARG A 104
 None
 1.43A 3w1wA-5lx0A:
undetectable		 3w1wA-5lx0A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr4 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 4 PRO C  89
LEU C  90
ILE C 112
ARG C  61
 None
 1.39A 3w1wA-5mr4C:
undetectable		 3w1wA-5mr4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 PRO A  11
LEU A  10
ILE A   7
ARG A   5
 None
 1.35A 3w1wA-5nqdA:
undetectable		 3w1wA-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 PRO A 236
LEU A 211
ILE A  34
ARG A 117
 None
 1.46A 3w1wA-5ol0A:
undetectable		 3w1wA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owg PCYX_EBK42635

(marine
metagenome) 		no annotation 4 PRO A 110
LEU A 111
ILE A 172
ARG A 173
 None
 1.33A 3w1wA-5owgA:
undetectable		 3w1wA-5owgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td8 KINETOCHORE PROTEIN
SPC24

(Saccharomyces
cerevisiae) 		PF08286
(Spc24) 		4 PRO C 193
LEU C 192
ILE C 181
ARG C 210
 None
 1.40A 3w1wA-5td8C:
undetectable		 3w1wA-5td8C:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		4 PRO A 143
LEU A 148
ILE A 156
ARG A 154
 None
 1.43A 3w1wA-5tqiA:
3.6		 3w1wA-5tqiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 PRO A1373
LEU A1400
ILE A1398
ARG A1240
 None
 0.95A 3w1wA-5w81A:
undetectable		 3w1wA-5w81A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 4 PRO A 180
LEU A 216
ILE A 144
ARG A 141
 None
 1.36A 3w1wA-5y6tA:
undetectable		 3w1wA-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 4 PRO A 196
LEU A 133
ILE A 135
ARG A 108
 None
 1.38A 3w1wA-5zh5A:
undetectable		 3w1wA-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 4 PRO A 756
LEU A 759
ILE A 835
ARG A 761
 None
 1.35A 3w1wA-5zq6A:
undetectable		 3w1wA-5zq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 4 PRO A 201
LEU A 200
ILE A 195
ARG A 194
 None
 0.97A 3w1wA-6enxA:
2.7		 3w1wA-6enxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 4 PRO W 607
LEU W 606
ILE W 808
ARG W 807
 None
None
None
ADP  W1302 (-2.8A)
 1.27A 3w1wA-6ftxW:
2.6		 3w1wA-6ftxW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 PRO B 362
LEU B 361
ILE B 325
ARG B 283
 None
 1.31A 3w1wA-6reqB:
5.8		 3w1wA-6reqB:
20.53