SIMILAR PATTERNS OF AMINO ACIDS FOR 3W1W_A_CHDA1503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		4 ILE A 173
ARG A 176
LEU A 177
MET A  73
 None
 0.81A 3w1wA-1a0dA:
undetectable		 3w1wA-1a0dA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1x HMTCP-1

(Homo sapiens) 		PF01840
(TCL1_MTCP1) 		4 ILE A  88
LEU A 100
VAL A   7
GLY A   8
 None
 0.89A 3w1wA-1a1xA:
undetectable		 3w1wA-1a1xA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 ILE A 337
LEU A 334
VAL A 283
GLY A 282
 None
 0.84A 3w1wA-1cenA:
2.4		 3w1wA-1cenA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		4 ARG A  55
LEU A  58
VAL A   8
GLY A  41
 None
 0.79A 3w1wA-1cfzA:
4.8		 3w1wA-1cfzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0k DNA HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C) 		4 ILE A 422
LEU A 339
GLY A 330
MET A 333
 None
 0.83A 3w1wA-1e0kA:
2.5		 3w1wA-1e0kA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 377
LEU A 537
VAL A 254
GLY A 253
 None
 0.89A 3w1wA-1eovA:
undetectable		 3w1wA-1eovA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epv ALANINE RACEMASE

(Geobacillus
stearothermophilus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 317
LEU A 319
VAL A 325
GLY A 326
 None
 0.85A 3w1wA-1epvA:
undetectable		 3w1wA-1epvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		4 ILE A 470
LEU A 458
VAL A 218
GLY A 219
 None
None
FAD  A 522 (-4.9A)
FAD  A 522 (-3.3A)
 0.87A 3w1wA-1fl2A:
undetectable		 3w1wA-1fl2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 ILE A 466
LEU A 468
VAL A 505
GLY A 506
 None
 0.87A 3w1wA-1g7rA:
4.0		 3w1wA-1g7rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 ILE A 127
LEU A 129
GLY A 172
TRP A 206
 None
 0.79A 3w1wA-1gcyA:
undetectable		 3w1wA-1gcyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 ILE A 324
LEU A 321
VAL A  76
GLY A  75
 None
 0.82A 3w1wA-1gzvA:
2.1		 3w1wA-1gzvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 148
LEU A 145
VAL A 131
GLY A 130
 None
 0.73A 3w1wA-1hkwA:
4.4		 3w1wA-1hkwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 ILE A  88
LEU A  91
VAL A  77
GLY A  78
 None
 0.78A 3w1wA-1i2wA:
undetectable		 3w1wA-1i2wA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		4 ILE P  31
LEU P  33
VAL P 167
GLY P 168
 None
 0.81A 3w1wA-1ikoP:
undetectable		 3w1wA-1ikoP:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ith HEMOGLOBIN (CYANO
MET)

(Urechis caupo) 		PF00042
(Globin) 		4 ILE A  10
LEU A  79
VAL A 135
GLY A 134
 None
 0.90A 3w1wA-1ithA:
undetectable		 3w1wA-1ithA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdl CYTOCHROME C2, ISO-2

(Rhodospirillum
centenum) 		PF00034
(Cytochrom_C) 		4 ILE A  69
LEU A  72
VAL A  11
GLY A   8
 None
HEM  A 500 ( 4.7A)
None
None
 0.81A 3w1wA-1jdlA:
undetectable		 3w1wA-1jdlA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		4 ILE A 227
LEU A 216
VAL A 181
GLY A 182
 None
 0.90A 3w1wA-1k3rA:
undetectable		 3w1wA-1k3rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 ILE A 183
LEU A 185
VAL A 159
GLY A 158
 None
 0.85A 3w1wA-1kyhA:
undetectable		 3w1wA-1kyhA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		4 ILE A  83
VAL A 277
GLY A 278
TRP A 282
 None
 0.70A 3w1wA-1lbqA:
48.0		 3w1wA-1lbqA:
49.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 149
LEU A 152
VAL A 203
GLY A 202
 None
 0.86A 3w1wA-1lk5A:
undetectable		 3w1wA-1lk5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 ILE A 363
LEU A 361
VAL A 331
GLY A 330
 None
 0.89A 3w1wA-1qfxA:
undetectable		 3w1wA-1qfxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		4 ILE A 242
LEU A 245
VAL A 162
GLY A 163
 None
None
None
HEA  A 601 (-3.6A)
 0.73A 3w1wA-1qleA:
undetectable		 3w1wA-1qleA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 MET A 380
LEU A 190
GLY A 397
TRP A 455
 None
None
SO4  A 475 (-4.0A)
None
 0.90A 3w1wA-1svdA:
undetectable		 3w1wA-1svdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		5 ILE A 164
ARG A 128
LEU A 165
VAL A 159
GLY A 147
 SF4  A1432 (-3.9A)
None
None
SF4  A1432 ( 4.7A)
None
 1.49A 3w1wA-1uwvA:
undetectable		 3w1wA-1uwvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		4 ILE A 255
ARG A  66
LEU A 257
VAL A 269
 None
 0.64A 3w1wA-1w6fA:
undetectable		 3w1wA-1w6fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 ILE A 116
ARG A  98
VAL A 238
GLY A 236
 None
 0.89A 3w1wA-1x0lA:
4.9		 3w1wA-1x0lA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A  86
LEU A 310
VAL A 267
GLY A 268
 None
 0.90A 3w1wA-1yaaA:
2.3		 3w1wA-1yaaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 ARG A 233
VAL A 404
GLY A 403
TRP A 399
 None
 0.87A 3w1wA-1yfoA:
undetectable		 3w1wA-1yfoA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 ILE A 310
LEU A 313
GLY A 359
TRP A 357
 None
 0.89A 3w1wA-1yt3A:
undetectable		 3w1wA-1yt3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ziq GAMMA CRYSTALLIN E

(Rattus
norvegicus) 		PF00030
(Crystall) 		4 ILE A1089
LEU A1145
VAL A1163
GLY A1164
 None
 0.82A 3w1wA-1ziqA:
undetectable		 3w1wA-1ziqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 242
LEU A 246
VAL A 151
GLY A 152
 None
 0.85A 3w1wA-1zklA:
undetectable		 3w1wA-1zklA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		4 ILE A 297
LEU A 298
VAL A 310
GLY A 214
 None
 0.67A 3w1wA-1zmrA:
2.5		 3w1wA-1zmrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znp HYPOTHETICAL PROTEIN
ATU3615

(Agrobacterium
fabrum) 		PF06172
(Cupin_5) 		4 ILE A  10
LEU A  16
GLY A 121
TRP A  65
 None
 0.87A 3w1wA-1znpA:
undetectable		 3w1wA-1znpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		4 MET A 164
ILE A 126
LEU A 195
VAL A 156
 None
 0.90A 3w1wA-2a4dA:
undetectable		 3w1wA-2a4dA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		4 ILE A 127
LEU A 129
GLY A 172
TRP A 206
 None
 0.69A 3w1wA-2amgA:
undetectable		 3w1wA-2amgA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		4 MET A  14
ILE A 301
LEU A  22
GLY A 194
 None
 0.87A 3w1wA-2bdeA:
undetectable		 3w1wA-2bdeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A1096
LEU A1093
VAL A1130
GLY A1129
MET A1163
 None
 1.41A 3w1wA-2bzlA:
undetectable		 3w1wA-2bzlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A  55
ARG A 261
LEU A 265
GLY A 273
 None
 0.89A 3w1wA-2ctzA:
2.6		 3w1wA-2ctzA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		4 ILE A 325
LEU A 322
VAL A  77
GLY A  76
 None
 0.83A 3w1wA-2cxnA:
2.5		 3w1wA-2cxnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 252
LEU A 400
VAL A 358
GLY A 359
 None
 0.75A 3w1wA-2d52A:
undetectable		 3w1wA-2d52A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)

(Streptococcus
pneumoniae) 		PF02086
(MethyltransfD12) 		4 ILE A 166
LEU A 171
VAL A  44
GLY A  47
 None
None
None
SAM  A 300 (-4.5A)
 0.83A 3w1wA-2dpmA:
2.6		 3w1wA-2dpmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		4 ILE A 115
LEU A 112
VAL A  81
GLY A  82
 None
 0.84A 3w1wA-2drhA:
undetectable		 3w1wA-2drhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eel CELL DEATH ACTIVATOR
CIDE-A

(Homo sapiens) 		PF02017
(CIDE-N) 		4 ILE A  76
LEU A  50
VAL A  25
GLY A  24
 None
 0.88A 3w1wA-2eelA:
undetectable		 3w1wA-2eelA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A1114
LEU A1149
VAL A1179
GLY A1141
 None
 0.90A 3w1wA-2gjtA:
undetectable		 3w1wA-2gjtA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 ILE A 429
ARG A 452
GLY A 369
TRP A 291
 None
 0.88A 3w1wA-2gq3A:
undetectable		 3w1wA-2gq3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 ILE A 165
LEU A 271
VAL A 247
GLY A 246
 None
 0.90A 3w1wA-2gt1A:
3.5		 3w1wA-2gt1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 ILE A  38
LEU A  36
VAL A 297
GLY A 298
 None
 0.86A 3w1wA-2guuA:
undetectable		 3w1wA-2guuA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hle EPHRIN-B2

(Homo sapiens) 		PF00812
(Ephrin) 		4 ILE B  31
LEU B  33
VAL B 167
GLY B 168
 None
 0.78A 3w1wA-2hleB:
undetectable		 3w1wA-2hleB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		4 ILE A 214
LEU A 212
VAL A 201
GLY A 200
 None
 0.83A 3w1wA-2ie8A:
3.0		 3w1wA-2ie8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		4 ILE A  50
LEU A  54
VAL A 116
GLY A 115
 None
 0.79A 3w1wA-2is8A:
6.2		 3w1wA-2is8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkz RNA-BINDING PROTEIN
5

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  26
LEU A  30
VAL A  89
GLY A  88
 None
 0.77A 3w1wA-2lkzA:
undetectable		 3w1wA-2lkzA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ILE A 165
LEU A 167
VAL A 188
GLY A 189
 None
 0.76A 3w1wA-2obeA:
undetectable		 3w1wA-2obeA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923

(Corynebacterium
glutamicum) 		PF09754
(PAC2) 		4 ILE A  58
LEU A  93
VAL A 132
GLY A 131
 None
 0.88A 3w1wA-2p90A:
2.4		 3w1wA-2p90A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 ILE A 182
LEU A 187
VAL A 242
GLY A 243
 None
 0.75A 3w1wA-2pncA:
undetectable		 3w1wA-2pncA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 MET A 149
ILE A  38
VAL A  10
GLY A   9
 None
 0.76A 3w1wA-2qq1A:
6.1		 3w1wA-2qq1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 ILE A 545
VAL A 606
GLY A 605
TRP A 602
 None
 0.80A 3w1wA-2qr7A:
undetectable		 3w1wA-2qr7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 ILE A 851
ARG A 812
LEU A 810
GLY A 834
 None
None
None
CA  A1947 ( 4.8A)
 0.86A 3w1wA-2w1qA:
undetectable		 3w1wA-2w1qA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 ILE A  45
LEU A   7
VAL A 241
GLY A 240
 None
 0.88A 3w1wA-2w21A:
3.8		 3w1wA-2w21A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		5 ILE A  40
LEU A 149
VAL A  52
GLY A  37
MET A  26
 None
 1.44A 3w1wA-2whxA:
3.6		 3w1wA-2whxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 ILE A  53
ARG A  50
LEU A  49
VAL A   6
 None
 0.86A 3w1wA-2wteA:
4.7		 3w1wA-2wteA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y30 PUTATIVE REPRESSOR
SIMREG2

(Streptomyces
antibioticus) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ILE A 237
LEU A 241
VAL A 145
GLY A 144
 None
 0.89A 3w1wA-2y30A:
undetectable		 3w1wA-2y30A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 MET A  99
ILE A 111
ARG A 114
LEU A 115
VAL A 305
GLY A 306
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 ( 4.7A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
None
CHD  A   2 (-4.7A)
 0.26A 3w1wA-3aqiA:
60.5		 3w1wA-3aqiA:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 ILE A  77
LEU A 102
VAL A  89
GLY A  88
 None
 0.89A 3w1wA-3egcA:
5.3		 3w1wA-3egcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ILE A 111
LEU A 115
VAL A  87
GLY A  86
 None
 0.81A 3w1wA-3g0oA:
3.2		 3w1wA-3g0oA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g69 SORTASE C

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 ILE A 156
LEU A 139
VAL A 147
GLY A 148
 None
 0.90A 3w1wA-3g69A:
undetectable		 3w1wA-3g69A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6n PEPTIDE DEFORMYLASE

(Enterococcus
faecium) 		PF01327
(Pep_deformylase) 		4 ILE A 153
ARG A 127
VAL A  75
GLY A  60
 None
 0.90A 3w1wA-3g6nA:
undetectable		 3w1wA-3g6nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 ILE A 287
LEU A 289
VAL A 162
GLY A 163
 None
 0.89A 3w1wA-3gveA:
undetectable		 3w1wA-3gveA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 338
LEU A 349
VAL A 327
GLY A 328
 None
 0.83A 3w1wA-3iplA:
undetectable		 3w1wA-3iplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxo TRKA-N DOMAIN
PROTEIN

(Thermotoga sp.
RQ2) 		PF02080
(TrkA_C) 		4 ILE A 178
LEU A 199
VAL A 160
GLY A 161
 None
 0.83A 3w1wA-3jxoA:
undetectable		 3w1wA-3jxoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5r CADHERIN 13

(Mus musculus) 		PF00028
(Cadherin) 		4 ILE A   7
LEU A  93
VAL A  42
GLY A  41
 None
 0.84A 3w1wA-3k5rA:
undetectable		 3w1wA-3k5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		4 ILE D 197
LEU D 193
VAL D 165
GLY D 164
 None
 0.78A 3w1wA-3k8pD:
undetectable		 3w1wA-3k8pD:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 203
LEU A 206
VAL A 162
GLY A 163
 None
 0.88A 3w1wA-3kumA:
3.2		 3w1wA-3kumA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv8 THYMIDYLATE KINASE

(Vibrio cholerae) 		PF02223
(Thymidylate_kin) 		4 ILE A 198
LEU A 202
VAL A  95
GLY A  96
 None
 0.89A 3w1wA-3lv8A:
undetectable		 3w1wA-3lv8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 ILE A 370
LEU A 374
VAL A 331
GLY A 329
 None
 0.89A 3w1wA-3m1lA:
2.7		 3w1wA-3m1lA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 375
LEU A 421
VAL A 266
MET A 271
 None
 0.70A 3w1wA-3m4pA:
undetectable		 3w1wA-3m4pA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 ILE A  63
LEU A  44
VAL A  15
GLY A  16
 None
 0.86A 3w1wA-3m8yA:
undetectable		 3w1wA-3m8yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcq THIAMINE-MONOPHOSPHA
TE KINASE

(Methylobacillus
flagellatus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 219
LEU A 220
VAL A 229
GLY A 289
 None
 0.59A 3w1wA-3mcqA:
undetectable		 3w1wA-3mcqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 MET A 486
ILE A 398
LEU A 995
VAL A 936
GLY A 935
 None
 1.23A 3w1wA-3ne5A:
undetectable		 3w1wA-3ne5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		4 ILE A 145
LEU A 147
VAL A 127
GLY A 128
 None
 0.88A 3w1wA-3nk7A:
2.2		 3w1wA-3nk7A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		4 ARG A 149
LEU A 151
VAL A 100
GLY A 101
 None
 0.86A 3w1wA-3nomA:
undetectable		 3w1wA-3nomA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5y SENSOR PROTEIN

(Bacillus
halodurans) 		PF13492
(GAF_3) 		4 ILE A  14
LEU A  10
VAL A 113
GLY A 114
 None
 0.74A 3w1wA-3o5yA:
undetectable		 3w1wA-3o5yA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piw TYPE I INTERFERON 2

(Danio rerio) 		PF00143
(Interferon) 		4 ILE A  38
LEU A 128
VAL A 152
GLY A 151
 None
 0.85A 3w1wA-3piwA:
undetectable		 3w1wA-3piwA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnu DIHYDROOROTASE

(Campylobacter
jejuni) 		PF04909
(Amidohydro_2) 		4 ILE A  91
LEU A 128
VAL A 106
GLY A 105
 KCX  A  92 ( 4.0A)
None
None
None
 0.90A 3w1wA-3pnuA:
undetectable		 3w1wA-3pnuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqi HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 120
LEU A 121
VAL A 204
GLY A 205
 None
 0.86A 3w1wA-3qqiA:
undetectable		 3w1wA-3qqiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.88A 3w1wA-3sfzA:
2.2		 3w1wA-3sfzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 194
LEU A 191
VAL A 161
GLY A 162
 None
 0.90A 3w1wA-3thzA:
undetectable		 3w1wA-3thzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 217
LEU A 213
VAL A 161
GLY A 162
 None
 0.85A 3w1wA-3thzA:
undetectable		 3w1wA-3thzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqz DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Coxiella
burnetii) 		PF00692
(dUTPase) 		4 ILE A 125
LEU A 123
VAL A  86
GLY A  87
 None
 0.86A 3w1wA-3tqzA:
undetectable		 3w1wA-3tqzA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.60A 3w1wA-3ubcA:
undetectable		 3w1wA-3ubcA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Actinomyces
odontolyticus) 		PF03180
(Lipoprotein_9) 		4 ILE A  53
LEU A 255
VAL A  43
GLY A  44
 None
 0.89A 3w1wA-3up9A:
undetectable		 3w1wA-3up9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhj BFPC

(Escherichia
coli) 		no annotation 4 ILE A 150
LEU A 153
VAL A 101
GLY A 100
 None
 0.89A 3w1wA-3vhjA:
undetectable		 3w1wA-3vhjA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		4 ILE A 330
LEU A 331
VAL A 273
GLY A 272
 None
 0.83A 3w1wA-3zrhA:
undetectable		 3w1wA-3zrhA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		4 ILE X 139
LEU X 142
VAL X  86
GLY X  87
 None
 0.90A 3w1wA-4ac1X:
undetectable		 3w1wA-4ac1X:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 ILE A 578
LEU A 581
VAL A 599
GLY A 598
 None
 0.86A 3w1wA-4bq4A:
undetectable		 3w1wA-4bq4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 ILE A 626
LEU A 629
VAL A 587
GLY A 586
 None
 0.84A 3w1wA-4bqiA:
3.4		 3w1wA-4bqiA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 MET A 202
ILE A 117
LEU A 118
VAL A 244
 None
 0.81A 3w1wA-4eqmA:
undetectable		 3w1wA-4eqmA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		4 ILE A1041
LEU A 971
VAL A1018
GLY A1019
 None
 0.86A 3w1wA-4f1nA:
3.0		 3w1wA-4f1nA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ILE A 257
LEU A 270
VAL A 337
GLY A 336
 None
 0.90A 3w1wA-4gtnA:
3.3		 3w1wA-4gtnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Staphylococcus
aureus) 		PF01255
(Prenyltransf) 		4 ILE A 237
LEU A 236
VAL A  69
GLY A  68
 None
 0.85A 3w1wA-4h8eA:
2.9		 3w1wA-4h8eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 ILE A  21
LEU A  26
VAL A  44
GLY A  45
 None
 0.70A 3w1wA-4imdA:
2.1		 3w1wA-4imdA:
23.02