SIMILAR PATTERNS OF AMINO ACIDS FOR 3VYW_D_SAMD401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 GLY A  96
GLY A  27
LEU A  30
ALA A 101
LEU A 117
 None
PPI  A 278 ( 3.7A)
None
None
None
 1.22A 3vywD-1a8sA:
undetectable		 3vywD-1a8sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 GLY A 109
GLY A 112
LEU A 115
ALA A 296
LEU A 305
 None
 1.18A 3vywD-1azwA:
undetectable		 3vywD-1azwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 GLY A 551
LEU A 556
TYR A 558
ALA A 396
LEU A 421
 None
 1.14A 3vywD-1cjyA:
undetectable		 3vywD-1cjyA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLY A1430
GLY A1446
LEU A1449
ALA A1514
LEU A1435
 None
 1.07A 3vywD-1e6yA:
undetectable		 3vywD-1e6yA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
GLY A  84
GLY A  82
TYR A 183
ALA A 116
 EPE  A 455 (-4.0A)
EPE  A 455 (-3.3A)
EPE  A 455 (-3.5A)
None
None
 1.10A 3vywD-1evqA:
undetectable		 3vywD-1evqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 TYR B1047
GLY B 564
GLY B 567
LEU B 559
TYR B 578
 None
 1.01A 3vywD-1gl9B:
3.0		 3vywD-1gl9B:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 TYR A 439
LEU A 498
ALA A 425
PHE A 436
LEU A 429
 None
 1.10A 3vywD-1ikpA:
undetectable		 3vywD-1ikpA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 138
GLY A 432
LEU A 435
ALA A 183
LEU A 191
 None
 1.15A 3vywD-1itzA:
2.5		 3vywD-1itzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 HIS A 285
GLY A  89
GLY A  87
TYR A 188
ALA A 121
 EPE  A 455 (-4.6A)
EPE  A 455 (-3.4A)
EPE  A 455 ( 4.0A)
None
None
 1.14A 3vywD-1jjiA:
undetectable		 3vywD-1jjiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 GLY C 412
GLY C 443
LEU C 444
TYR C 420
LEU C 292
 None
 1.16A 3vywD-1n8yC:
undetectable		 3vywD-1n8yC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 120
GLY A 122
ALA A 132
PHE A 397
LEU A 145
 None
 1.05A 3vywD-1ogyA:
1.5		 3vywD-1ogyA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		6 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
LEU A 145
 MGD  A1803 ( 4.8A)
None
None
None
None
None
 0.80A 3vywD-1ogyA:
1.5		 3vywD-1ogyA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 124
GLY A 100
LEU A  73
ALA A 178
PHE A 156
 None
 1.22A 3vywD-1pgpA:
2.2		 3vywD-1pgpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		5 HIS A 110
GLY A  48
GLY A  50
ALA A 222
LEU A  46
 None
 1.19A 3vywD-1s5pA:
undetectable		 3vywD-1s5pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		5 GLY G  69
LEU G  73
ASN G  71
ALA G 112
LEU G  46
 None
 1.21A 3vywD-1sgfG:
undetectable		 3vywD-1sgfG:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 GLY A 202
GLY A 199
ALA A 157
PHE A 173
LEU A 170
 None
 1.16A 3vywD-1upxA:
undetectable		 3vywD-1upxA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.06A 3vywD-1yrwA:
undetectable		 3vywD-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.11A 3vywD-1z7eA:
5.1		 3vywD-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		5 TYR B 150
LEU B 378
ASN B 376
ALA B 383
LEU B 386
 None
 1.24A 3vywD-1zunB:
3.4		 3vywD-1zunB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
GLY A  83
GLY A  81
TYR A 182
ALA A 115
 None
 1.09A 3vywD-2c7bA:
undetectable		 3vywD-2c7bA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 TYR A 331
GLY A 315
GLY A 110
ALA A 320
LEU A 327
 None
 1.16A 3vywD-2ch6A:
undetectable		 3vywD-2ch6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 TYR A  81
TYR A 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.11A 3vywD-2e0wA:
undetectable		 3vywD-2e0wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 TYR A  81
TYR B 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.06A 3vywD-2e0xA:
undetectable		 3vywD-2e0xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 GLY A 153
GLY A 130
TYR A 422
ASN A 424
ALA A 159
 None
GLN  A 501 (-3.2A)
None
None
None
 1.15A 3vywD-2f2aA:
undetectable		 3vywD-2f2aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9z PROTEIN (CHEMOTAXIS
METHYLATION PROTEIN)

(Thermotoga
maritima) 		PF03975
(CheD) 		5 GLY C  89
GLY C 125
ASN C  99
ALA C  29
LEU C  24
 None
 1.21A 3vywD-2f9zC:
undetectable		 3vywD-2f9zC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 TYR A 285
GLY A 284
ALA A 248
PHE A 302
LEU A 274
 None
 1.17A 3vywD-2i9kA:
6.9		 3vywD-2i9kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 GLY A  69
LEU A  72
ASN A  81
ALA A 145
LEU A 100
 None
 0.98A 3vywD-2nqoA:
undetectable		 3vywD-2nqoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 HIS A 142
GLY A 111
ASN A 447
ALA A 123
PHE A 387
 MGD  A3001 ( 4.9A)
None
None
None
None
 0.79A 3vywD-2nyaA:
2.2		 3vywD-2nyaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 124
GLY A 100
LEU A  73
ALA A 177
PHE A 156
 None
 1.23A 3vywD-2p4qA:
3.4		 3vywD-2p4qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		5 HIS A 247
GLY A  35
GLY A  33
TYR A 129
ALA A  67
 PO4  A 273 (-4.0A)
PO4  A 273 (-3.5A)
PO4  A 273 ( 3.7A)
None
None
 1.12A 3vywD-2qruA:
undetectable		 3vywD-2qruA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		6 TYR A  48
GLY A  86
GLY A  88
ASN A  92
LYS A 122
PHE A 200
 None
 0.62A 3vywD-2qy6A:
23.4		 3vywD-2qy6A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 TYR A 242
GLY A 200
LEU A 179
TYR A 177
ALA A 205
 None
 1.17A 3vywD-2qzuA:
undetectable		 3vywD-2qzuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A  82
GLY A 197
GLY A 348
ALA A  21
LEU A  90
 None
 1.16A 3vywD-2wgeA:
undetectable		 3vywD-2wgeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj6 ASCORBATE PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		5 TYR A 235
GLY A 161
TYR A 224
ALA A 167
PHE A 186
 None
None
None
HEM  A1001 (-4.6A)
None
 1.12A 3vywD-2xj6A:
undetectable		 3vywD-2xj6A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 GLY A  86
GLY A  84
TYR A 185
ALA A 118
PHE A  33
 None
 1.08A 3vywD-2yh2A:
undetectable		 3vywD-2yh2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 HIS A 284
GLY A  86
GLY A  84
TYR A 185
ALA A 118
 None
 1.16A 3vywD-2yh2A:
undetectable		 3vywD-2yh2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		5 HIS A 273
GLY A  80
GLY A  78
TYR A 177
ALA A 112
 DEP  A 304 (-4.1A)
DEP  A 304 (-3.5A)
DEP  A 304 ( 3.8A)
None
None
 1.10A 3vywD-3ailA:
undetectable		 3vywD-3ailA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 TYR A 166
GLY A 175
GLY A 172
ASN A 199
LEU A 144
 None
 1.22A 3vywD-3bn1A:
undetectable		 3vywD-3bn1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE

(Deinococcus
radiodurans) 		PF08450
(SGL) 		5 TYR A 135
GLY A 222
GLY A 176
LEU A 177
LYS A 219
 None
 1.17A 3vywD-3e5zA:
undetectable		 3vywD-3e5zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 GLY A 356
GLY A 380
LEU A 268
ALA A 441
PHE A 434
 None
 1.04A 3vywD-3fcrA:
undetectable		 3vywD-3fcrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		5 TYR A 177
GLY A 156
LEU A 183
ALA A 130
LEU A 163
 None
 1.14A 3vywD-3gvzA:
undetectable		 3vywD-3gvzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLY A 429
GLY A 408
ASN A 383
PHE A 173
LEU A 452
 None
 1.18A 3vywD-3h09A:
undetectable		 3vywD-3h09A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 TYR B 269
GLY B 400
TYR B 378
ALA B 410
PHE B 375
 None
 1.20A 3vywD-3h32B:
undetectable		 3vywD-3h32B:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		5 HIS A 353
GLY A 216
GLY A 377
LEU A 380
LEU A 220
 ADP  A 439 (-4.2A)
ADP  A 439 (-3.0A)
ADP  A 439 (-3.1A)
None
None
 1.17A 3vywD-3h4mA:
undetectable		 3vywD-3h4mA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		5 TYR 1 313
GLY 1 248
GLY 1 242
LYS 1 250
LEU 1  62
 None
 1.09A 3vywD-3i9v1:
undetectable		 3vywD-3i9v1:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 HIS A  88
GLY A 174
LEU A 159
TYR A 163
ALA A 273
 None
 1.22A 3vywD-3ik2A:
undetectable		 3vywD-3ik2A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 117
GLY A 297
GLY A 305
TYR A 178
ALA A 240
 None
 1.18A 3vywD-3il7A:
undetectable		 3vywD-3il7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.04A 3vywD-3ktnA:
undetectable		 3vywD-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 TYR A 257
GLY A 256
ALA A 161
PHE A 251
LEU A 250
 None
 1.21A 3vywD-3lijA:
undetectable		 3vywD-3lijA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		5 TYR A 331
GLY A 362
GLY A 341
ALA A 278
LEU A 360
 None
 1.20A 3vywD-3lrkA:
undetectable		 3vywD-3lrkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 TYR A 437
TYR A 340
GLY A 142
GLY A 346
ALA A 184
 None
 1.12A 3vywD-3nd0A:
undetectable		 3vywD-3nd0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
 MGD  A1803 ( 4.6A)
None
None
None
FMT  A 803 (-3.6A)
 0.70A 3vywD-3o5aA:
undetectable		 3vywD-3o5aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 TYR A  28
GLY A  66
GLY A  68
ASN A  72
PHE A 180
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
 0.26A 3vywD-3ps9A:
22.6		 3vywD-3ps9A:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		6 TYR A  63
GLY A 104
LEU A 137
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-3.6A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 1.49A 3vywD-3vywA:
50.6		 3vywD-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		12 TYR A  63
TYR A  67
HIS A  68
GLY A 104
GLY A 106
LEU A 107
TYR A 109
ASN A 110
LYS A 134
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-4.5A)
SAM  A 501 (-4.2A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 0.33A 3vywD-3vywA:
50.6		 3vywD-3vywA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
GLY A  86
GLY A  84
TYR A 184
ALA A 118
 None
 1.23A 3vywD-3wj2A:
undetectable		 3vywD-3wj2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 GLY A 126
GLY A 182
TYR A 180
PHE A 100
LEU A 124
 None
 1.23A 3vywD-4bptA:
undetectable		 3vywD-4bptA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 251
GLY A 258
ASN A 188
ALA A 275
LEU A 267
 None
 1.15A 3vywD-4c7vA:
2.6		 3vywD-4c7vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		5 TYR A 233
GLY A 234
ASN A 102
ALA A 251
LEU A 291
 LDA  A1372 (-4.3A)
None
None
None
None
 0.98A 3vywD-4d65A:
undetectable		 3vywD-4d65A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		5 GLY A  72
GLY A 255
LEU A 256
PHE A  70
LEU A 156
 None
 1.22A 3vywD-4humA:
undetectable		 3vywD-4humA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Yersinia pestis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 HIS A  70
GLY A  48
ASN A  75
ALA A  36
LEU A  60
 None
 1.22A 3vywD-4hv4A:
2.6		 3vywD-4hv4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		5 GLY A 146
GLY A 144
LEU A  87
ALA A 151
LEU A 163
 None
 1.21A 3vywD-4jfcA:
undetectable		 3vywD-4jfcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		5 GLY A 192
GLY A 194
ALA A 123
PHE A 149
LEU A 189
 None
 1.20A 3vywD-4kfvA:
undetectable		 3vywD-4kfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 223
GLY A 240
ASN A 208
ALA A 225
LEU A 329
 None
 1.18A 3vywD-4n54A:
4.1		 3vywD-4n54A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6b NON-STRUCTURAL
PROTEIN 1

(Dengue virus) 		PF00948
(Flavi_NS1) 		5 TYR A 331
HIS A 269
GLY A 328
GLY A 325
LEU A 273
 None
 1.21A 3vywD-4o6bA:
undetectable		 3vywD-4o6bA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 HIS A 274
GLY A  81
GLY A  79
TYR A 177
ALA A 113
 None
 1.11A 3vywD-4p9nA:
undetectable		 3vywD-4p9nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q14 5-HYDROXYISOURATE
HYDROLASE

(Brucella
abortus) 		PF00576
(Transthyretin) 		5 TYR A  62
TYR A 101
HIS A 102
GLY A   2
GLY A  99
 None
None
CL  A 201 ( 4.6A)
None
None
 0.87A 3vywD-4q14A:
undetectable		 3vywD-4q14A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		5 TYR A 205
GLY A 201
GLY A 221
LEU A 217
ASN A 199
 289  A 414 (-4.6A)
289  A 422 ( 4.0A)
None
None
None
 0.95A 3vywD-4q1qA:
undetectable		 3vywD-4q1qA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 TYR A 241
TYR A 182
GLY A 181
ALA A 228
PHE A 222
 None
 1.15A 3vywD-4qjyA:
undetectable		 3vywD-4qjyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.04A 3vywD-4qqfD:
undetectable		 3vywD-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 MAOC FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas) 		5 GLY B  67
GLY B  64
LEU B  61
ALA B 137
PHE B 104
 None
 1.10A 3vywD-4rv2B:
undetectable		 3vywD-4rv2B:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 TYR A 199
GLY A 150
ALA A 153
PHE A 108
LEU A 146
 None
 1.22A 3vywD-4uvkA:
undetectable		 3vywD-4uvkA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 248
LEU A 249
TYR A  17
ALA A 179
LEU A 228
 PEG  A 503 ( 4.4A)
PEG  A 503 ( 4.7A)
None
None
None
 1.17A 3vywD-4wyrA:
undetectable		 3vywD-4wyrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		5 GLY A  52
LEU A  35
ASN A 221
ALA A 152
LEU A 124
 None
None
None
None
HEM  A 304 (-4.0A)
 1.07A 3vywD-4ybnA:
undetectable		 3vywD-4ybnA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		5 HIS A 283
GLY A  88
GLY A  86
TYR A 187
ALA A 120
 None
 1.08A 3vywD-4ypvA:
undetectable		 3vywD-4ypvA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b26 PROTEIN SEL-1
HOMOLOG 1

(Mus musculus) 		PF08238
(Sel1) 		5 GLY A 448
GLY A 450
LEU A 454
TYR A 455
ALA A 437
 None
 1.14A 3vywD-5b26A:
undetectable		 3vywD-5b26A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		5 GLY A 311
GLY A 309
TYR A 420
ALA A 254
LEU A 318
 None
 1.18A 3vywD-5b2dA:
undetectable		 3vywD-5b2dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 HIS A  56
GLY A  17
GLY A  19
PHE A 128
LEU A  47
 None
 1.03A 3vywD-5cqfA:
undetectable		 3vywD-5cqfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 GLY A 231
GLY A 237
LEU A 238
ASN A 205
ALA A 154
 None
 1.22A 3vywD-5dkvA:
3.1		 3vywD-5dkvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		5 GLY A  62
LEU A  61
ASN A  29
ALA A 531
PHE A  69
 None
 1.19A 3vywD-5dztA:
undetectable		 3vywD-5dztA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		5 TYR A 123
LEU A 155
ASN A 161
LYS A 166
LEU A  78
 None
 1.20A 3vywD-5f1uA:
undetectable		 3vywD-5f1uA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 HIS H 114
GLY H 128
TYR H  97
ALA H 158
LEU H 138
 None
 1.16A 3vywD-5fg9H:
undetectable		 3vywD-5fg9H:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 GLY A  51
LEU A 133
ALA A  89
PHE A  85
LEU A  87
 None
 1.08A 3vywD-5gw7A:
undetectable		 3vywD-5gw7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 286
GLY A  90
GLY A  88
TYR A 189
ALA A 122
 BAM  A 407 (-3.9A)
BAM  A 407 (-3.5A)
BAM  A 407 ( 3.9A)
None
None
 1.02A 3vywD-5jd4A:
undetectable		 3vywD-5jd4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 GLY A 243
LEU A 200
ALA A 472
PHE A 166
LEU A 195
 None
 1.16A 3vywD-5jijA:
2.7		 3vywD-5jijA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7l ELP3 FAMILY, ELP3
FAMILY

(Dehalococcoides
mccartyi) 		PF04055
(Radical_SAM)
PF16199
(Radical_SAM_C) 		5 GLY A 382
LEU A 370
TYR A 190
ALA A 408
LEU A 363
 None
 1.14A 3vywD-5l7lA:
undetectable		 3vywD-5l7lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 177
GLY A 472
LEU A 475
ALA A 223
LEU A 231
 None
 1.12A 3vywD-5nd5A:
2.9		 3vywD-5nd5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 5 TYR A 243
GLY A 244
ASN A 105
ALA A 259
LEU A 300
 None
 0.97A 3vywD-5nxnA:
undetectable		 3vywD-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 5 TYR A 295
TYR A 252
GLY A 337
GLY A 253
PHE A 332
 None
 0.73A 3vywD-5nxnA:
undetectable		 3vywD-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 GLY C 411
GLY C 442
LEU C 443
TYR C 419
LEU C 291
 None
 1.07A 3vywD-5o4gC:
undetectable		 3vywD-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 TYR A 560
GLY A 454
GLY A 460
LEU A 101
ALA A 501
 None
 1.13A 3vywD-5oynA:
undetectable		 3vywD-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		5 TYR A 191
TYR A 103
ALA A 177
PHE A 150
LEU A 144
 None
 1.06A 3vywD-5uncA:
undetectable		 3vywD-5uncA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 TYR A1127
GLY A1245
GLY A1219
ALA A1182
PHE A1248
 None
 1.23A 3vywD-5vadA:
undetectable		 3vywD-5vadA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 5 TYR A 445
GLY A 563
GLY A 537
ALA A 500
PHE A 566
 None
 1.14A 3vywD-5xiiA:
undetectable		 3vywD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 5 TYR A 365
GLY A 483
GLY A 457
ALA A 420
PHE A 486
 None
 1.23A 3vywD-5xipA:
undetectable		 3vywD-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 GLY A 718
GLY A 714
TYR A 654
ALA A 733
LEU A 676
 None
 1.19A 3vywD-5xqoA:
undetectable		 3vywD-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 5 TYR A   8
GLY A  11
GLY A 133
LEU A 136
LEU A 450
 None
 1.08A 3vywD-6b3bA:
8.1		 3vywD-6b3bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 5 TYR A 467
GLY A 476
LEU A 475
ALA A 595
LEU A 421
 None
 0.99A 3vywD-6b5vA:
undetectable		 3vywD-6b5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 5 HIS A 280
GLY A 263
GLY A 267
LYS A 290
ALA A 292
 None
 1.22A 3vywD-6c5cA:
2.4		 3vywD-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fel 14-3-3 PROTEIN GAMMA

(Homo sapiens) 		no annotation 5 TYR A 183
GLY A 128
ALA A 157
PHE A 182
LEU A 175
 None
 1.17A 3vywD-6felA:
undetectable		 3vywD-6felA:
undetectable