SIMILAR PATTERNS OF AMINO ACIDS FOR 3VYW_C_SAMC401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 GLY A 551
LEU A 556
TYR A 558
ALA A 396
LEU A 421
 None
 1.14A 3vywC-1cjyA:
undetectable		 3vywC-1cjyA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 TYR A 439
LEU A 498
ALA A 425
PHE A 436
LEU A 429
 None
 1.13A 3vywC-1ikpA:
undetectable		 3vywC-1ikpA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 TYR A  65
GLY A  56
LEU A  96
GLY A  95
ASN A  58
 None
 1.11A 3vywC-1ipaA:
undetectable		 3vywC-1ipaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		5 HIS A 188
LEU A 212
GLY A 210
ALA A 144
LEU A 260
 None
 1.01A 3vywC-1nd4A:
undetectable		 3vywC-1nd4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		6 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
LEU A 145
 MGD  A1803 ( 4.8A)
None
None
None
None
None
 0.83A 3vywC-1ogyA:
2.3		 3vywC-1ogyA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		5 GLY A 386
LEU A 353
GLY A 258
ALA A 363
PHE A 249
 None
 0.94A 3vywC-1p9wA:
undetectable		 3vywC-1p9wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 HIS A 723
LEU A 611
GLY A 613
ALA A 603
LEU A 677
 None
 0.95A 3vywC-1ru3A:
3.3		 3vywC-1ru3A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 GLY A 355
GLY A 359
TYR A 360
ALA A 100
LEU A 856
 EDO  A9008 (-3.5A)
None
None
None
None
 1.16A 3vywC-1xc6A:
undetectable		 3vywC-1xc6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 TYR A 363
GLY A 355
GLY A 359
TYR A 360
ALA A 100
 None
EDO  A9008 (-3.5A)
None
None
None
 1.08A 3vywC-1xc6A:
undetectable		 3vywC-1xc6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.06A 3vywC-1yrwA:
3.8		 3vywC-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.11A 3vywC-1z7eA:
4.5		 3vywC-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 TYR A 222
ASN A 224
ALA A 107
PHE A   6
LEU A  64
 None
 1.08A 3vywC-2cuyA:
undetectable		 3vywC-2cuyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 TYR A  85
LEU A 211
GLY A 210
ALA A 232
LEU A 118
 None
 1.08A 3vywC-2d52A:
undetectable		 3vywC-2d52A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		5 TYR A 210
HIS A 252
GLY A  11
LEU A   7
GLY A   8
 None
 1.16A 3vywC-2e67A:
undetectable		 3vywC-2e67A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 TYR A 251
LEU A 258
GLY A 254
ALA A 492
PHE A 245
 None
 1.12A 3vywC-2fuqA:
undetectable		 3vywC-2fuqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		6 GLY A 194
GLY A 143
TYR A 144
ASN A 449
ALA A 191
LEU A 479
 None
FAD  A 801 (-2.9A)
FAD  A 801 (-4.5A)
FAD  A 801 (-3.5A)
None
None
 1.49A 3vywC-2ipiA:
undetectable		 3vywC-2ipiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A 277
LEU A 258
GLY A 259
ALA A 305
LEU A 280
 None
 1.06A 3vywC-2iu3A:
undetectable		 3vywC-2iu3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2leq UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF08327
(AHSA1) 		5 LEU A 103
GLY A 106
ASN A  14
ALA A  23
LEU A 136
 None
 1.06A 3vywC-2leqA:
undetectable		 3vywC-2leqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 HIS A 142
GLY A 111
ASN A 447
ALA A 123
PHE A 387
 MGD  A3001 ( 4.9A)
None
None
None
None
 0.79A 3vywC-2nyaA:
2.3		 3vywC-2nyaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og3 NUCLEOCAPSID PROTEIN

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF00937
(Corona_nucleoca) 		5 GLY A  72
GLY A  70
ALA A 174
PHE A 111
LEU A  57
 None
 1.04A 3vywC-2og3A:
undetectable		 3vywC-2og3A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		5 TYR A  48
GLY A  86
GLY A  90
ASN A  92
PHE A 200
 None
 0.56A 3vywC-2qy6A:
23.3		 3vywC-2qy6A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 GLY A  11
GLY A  17
TYR A 358
ASN A  14
ALA A  34
 FAD  A 600 ( 4.6A)
None
None
FAD  A 600 (-3.7A)
FAD  A 600 ( 3.3A)
 0.95A 3vywC-2r4jA:
undetectable		 3vywC-2r4jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 199
GLY A 156
LEU A 213
GLY A 216
ALA A 143
 None
 0.94A 3vywC-2uxtA:
undetectable		 3vywC-2uxtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v72 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		5 GLY A  74
GLY A  71
ASN A  72
ALA A 121
LEU A  46
 None
 1.12A 3vywC-2v72A:
undetectable		 3vywC-2v72A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 HIS A 579
GLY A 419
GLY A 534
ALA A 451
LEU A 272
 PO4  A1639 (-3.9A)
None
None
None
None
 1.17A 3vywC-2ycbA:
undetectable		 3vywC-2ycbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		5 LEU A  66
GLY A  67
ALA A 102
PHE A  23
LEU A  56
 None
 1.05A 3vywC-3alyA:
undetectable		 3vywC-3alyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnh HYDROLASE FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 LEU A  15
GLY A  11
ASN A 107
PHE A 126
LEU A   6
 None
PO4  A 201 ( 3.5A)
PO4  A 201 (-4.5A)
None
None
 0.99A 3vywC-3cnhA:
undetectable		 3vywC-3cnhA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		5 TYR A 243
GLY A 279
ASN A 276
ALA A 179
PHE A 244
 None
None
HEM  A 600 ( 4.0A)
None
None
 1.17A 3vywC-3danA:
undetectable		 3vywC-3danA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLY A 429
GLY A 386
ASN A 383
PHE A 173
LEU A 452
 None
 1.14A 3vywC-3h09A:
undetectable		 3vywC-3h09A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 677
GLY A 729
LEU A 697
GLY A 726
ASN A 441
 None
 1.11A 3vywC-3hmjA:
4.7		 3vywC-3hmjA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 HIS 3 468
GLY 3 510
LEU 3 399
GLY 3 400
ALA 3 376
 None
 1.10A 3vywC-3i9v3:
3.4		 3vywC-3i9v3:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 GLY A 387
LEU A 393
GLY A 394
ASN A 414
ALA A 368
 None
 1.00A 3vywC-3ihgA:
undetectable		 3vywC-3ihgA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 GLY A 228
ASN A 229
ALA A 108
PHE A   8
LEU A  66
 None
 1.09A 3vywC-3im8A:
undetectable		 3vywC-3im8A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		5 GLY F 211
TYR F 246
ASN F 480
ALA F 222
LEU F 456
 None
 1.16A 3vywC-3jbrF:
undetectable		 3vywC-3jbrF:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.05A 3vywC-3ktnA:
undetectable		 3vywC-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 GLY A 711
LEU A 687
GLY A 704
TYR A 693
PHE A 682
 None
 0.96A 3vywC-3mi6A:
undetectable		 3vywC-3mi6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		5 GLY X 219
LEU X 251
GLY X 250
ALA X 208
PHE X 264
 None
 1.08A 3vywC-3n5nX:
undetectable		 3vywC-3n5nX:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 GLY A 487
LEU A 493
GLY A 492
ALA A 451
PHE A 389
 None
 1.16A 3vywC-3nvaA:
undetectable		 3vywC-3nvaA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 HIS A 151
GLY A 120
ASN A 457
ALA A 132
PHE A 397
 MGD  A1803 ( 4.6A)
None
None
None
FMT  A 803 (-3.6A)
 0.71A 3vywC-3o5aA:
2.7		 3vywC-3o5aA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 TYR A  28
GLY A  66
GLY A  70
ASN A  72
PHE A 180
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 ( 4.5A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
 0.31A 3vywC-3ps9A:
22.5		 3vywC-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqm MLR3007 PROTEIN

(Mesorhizobium
loti) 		PF01063
(Aminotran_4) 		5 TYR A 196
GLY A 151
GLY A 208
ASN A 155
ALA A 127
 None
None
None
LLP  A 117 ( 3.7A)
None
 1.13A 3vywC-3qqmA:
undetectable		 3vywC-3qqmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		5 LEU A 267
GLY A 268
ALA A 116
PHE A  91
LEU A 120
 None
 1.15A 3vywC-3s6oA:
undetectable		 3vywC-3s6oA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sky COPPER-EXPORTING
P-TYPE ATPASE B

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		6 GLY A 582
LEU A 615
GLY A 601
ALA A 590
PHE A 388
LEU A 536
 None
 1.44A 3vywC-3skyA:
undetectable		 3vywC-3skyA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		5 TYR A  53
TYR A  49
GLY A  77
LEU A  85
GLY A  84
 None
 1.17A 3vywC-3t4cA:
undetectable		 3vywC-3t4cA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 GLY A 239
LEU A 214
GLY A 216
PHE A 248
LEU A 243
 None
 1.07A 3vywC-3ta6A:
undetectable		 3vywC-3ta6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcv GCN5-RELATED
N-ACETYLTRANSFERASE

(Brucella
abortus) 		PF13302
(Acetyltransf_3) 		5 TYR A 133
LEU A 138
GLY A 139
TYR A 140
PHE A  18
 None
 1.16A 3vywC-3tcvA:
undetectable		 3vywC-3tcvA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		12 TYR A  63
TYR A  67
HIS A  68
GLY A 104
LEU A 107
GLY A 108
TYR A 109
ASN A 110
LYS A 134
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-4.5A)
SAM  A 501 (-4.2A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 0.41A 3vywC-3vywA:
50.3		 3vywC-3vywA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 TYR A 302
GLY A  25
LEU A 299
GLY A 340
ALA A  46
 None
None
None
ACT  A1392 (-3.4A)
None
 1.16A 3vywC-4aweA:
undetectable		 3vywC-4aweA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 129
LEU A 100
GLY A  96
ASN A  93
ALA A 163
 None
 1.14A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 228
LEU A 199
GLY A 195
ASN A 192
ALA A 262
 None
 1.16A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 294
LEU A 265
GLY A 261
ASN A 258
ALA A 328
 None
 1.16A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 327
LEU A 298
GLY A 294
ASN A 291
ALA A 361
 None
 1.12A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 360
LEU A 331
GLY A 327
ASN A 324
ALA A 366
 None
 1.07A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 360
LEU A 331
GLY A 327
ASN A 324
ALA A 394
 None
 1.16A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 393
LEU A 364
GLY A 360
ASN A 357
ALA A 399
 None
 1.05A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 393
LEU A 364
GLY A 360
ASN A 357
ALA A 427
 None
 1.09A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 426
LEU A 397
GLY A 393
ASN A 390
ALA A 432
 None
 1.06A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 459
LEU A 430
GLY A 426
ASN A 423
ALA A 465
 None
 1.07A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 558
LEU A 529
GLY A 525
ASN A 522
ALA A 564
 None
 1.13A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 591
LEU A 562
GLY A 558
ASN A 555
ALA A 597
 None
 1.06A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 591
LEU A 562
GLY A 558
ASN A 555
ALA A 625
 None
 1.17A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 624
LEU A 595
GLY A 591
ASN A 588
ALA A 630
 None
 1.05A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 657
LEU A 628
GLY A 624
ASN A 621
ALA A 663
 None
 1.10A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		5 GLY A 657
LEU A 628
GLY A 624
ASN A 621
ALA A 691
 None
 1.16A 3vywC-4cjaA:
undetectable		 3vywC-4cjaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		5 GLY A  21
LEU A 127
GLY A 128
ALA A  26
LEU A 327
 None
 1.04A 3vywC-4emeA:
undetectable		 3vywC-4emeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		5 GLY A  21
LEU A 303
GLY A 128
ALA A  26
LEU A 327
 None
 1.16A 3vywC-4emeA:
undetectable		 3vywC-4emeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gjp HAX3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		5 GLY A 711
LEU A 681
GLY A 677
ASN A 674
ALA A 717
 None
 1.06A 3vywC-4gjpA:
undetectable		 3vywC-4gjpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 TYR A 362
GLY A 354
GLY A 358
TYR A 359
ALA A 100
 None
 1.04A 3vywC-4iugA:
undetectable		 3vywC-4iugA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 447
LEU A 249
GLY A 453
TYR A 454
PHE A 457
 None
None
None
NK  A 502 ( 4.2A)
None
 1.10A 3vywC-4jz6A:
undetectable		 3vywC-4jz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 HIS A 397
GLY A 417
ASN A 415
ALA A 522
PHE A 337
 ZN  A1001 ( 3.2A)
None
None
None
None
 1.03A 3vywC-4kxbA:
undetectable		 3vywC-4kxbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw4 CYSTEINE
DESULFURATION
PROTEIN CSDE

(Escherichia
coli) 		PF02657
(SufE) 		5 LEU C 133
GLY C 132
ASN C  63
ALA C  55
LEU C  47
 None
 1.02A 3vywC-4lw4C:
undetectable		 3vywC-4lw4C:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvt TRIOSEPHOSPHATE
ISOMERASE

(Brucella
melitensis) 		PF00121
(TIM) 		5 GLY A 235
LEU A 210
GLY A 212
PHE A 244
LEU A 239
 None
 1.07A 3vywC-4nvtA:
undetectable		 3vywC-4nvtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		5 GLY Y  32
GLY Y  36
ASN Y  38
ALA Y  87
LEU Y 110
 SFG  Y 301 (-3.9A)
None
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.0A)
 1.08A 3vywC-4ox9Y:
7.1		 3vywC-4ox9Y:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 GLY A 298
LEU A 295
GLY A 294
TYR A 410
ASN A 412
PHE A 396
 None
 1.27A 3vywC-4ph9A:
undetectable		 3vywC-4ph9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 GLY A 382
LEU A 349
GLY A 254
ALA A 359
PHE A 245
 None
 1.04A 3vywC-4phtA:
undetectable		 3vywC-4phtA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 436
GLY A 208
TYR A  88
ALA A 203
LEU A 474
 FAD  A 601 (-4.5A)
None
FAD  A 601 ( 3.7A)
None
None
 1.16A 3vywC-4pveA:
undetectable		 3vywC-4pveA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.08A 3vywC-4qqfD:
undetectable		 3vywC-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		5 TYR A  77
TYR A  72
LEU A  41
GLY A  40
LEU A 156
 None
 0.97A 3vywC-4r6wA:
10.2		 3vywC-4r6wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		5 TYR A  84
GLY A 131
GLY A 115
ALA A 308
PHE A  85
 LBT  A 401 ( 3.7A)
None
None
None
None
 1.00A 3vywC-4rkrA:
3.6		 3vywC-4rkrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14629
(ORC4_C) 		5 GLY D  56
LEU D  65
GLY D  61
ALA A 825
LEU D 184
 None
 1.15A 3vywC-4xgcD:
undetectable		 3vywC-4xgcD:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvs CAPSID PROTEIN VP0

(Enterovirus A) 		PF00073
(Rhv) 		5 TYR C 148
GLY C 213
TYR C 130
ALA C  96
LEU C 207
 None
 1.12A 3vywC-4yvsC:
undetectable		 3vywC-4yvsC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 GLY A  51
LEU A 133
ALA A  89
PHE A  85
LEU A  87
 None
 1.08A 3vywC-5gw7A:
undetectable		 3vywC-5gw7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		5 TYR A 190
GLY A 188
LEU A 423
GLY A 426
ALA A 456
 None
 0.97A 3vywC-5h6sA:
undetectable		 3vywC-5h6sA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		5 GLY A 318
LEU A 352
GLY A 349
ALA A 249
LEU A 173
 None
 1.16A 3vywC-5hy4A:
undetectable		 3vywC-5hy4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		5 GLY A 318
LEU A 352
GLY A 350
ALA A 249
LEU A 173
 None
 1.09A 3vywC-5hy4A:
undetectable		 3vywC-5hy4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 TYR A 362
GLY A 354
GLY A 358
TYR A 359
ALA A 100
 None
 1.06A 3vywC-5ihrA:
undetectable		 3vywC-5ihrA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 GLY A 297
LEU A 294
GLY A 293
TYR A 409
ASN A 411
PHE A 395
 None
COH  A 602 ( 4.4A)
None
None
None
COH  A 602 ( 4.8A)
 1.31A 3vywC-5ikrA:
undetectable		 3vywC-5ikrA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 GLY A 243
LEU A 200
GLY A 202
PHE A 166
LEU A 195
 None
 0.99A 3vywC-5jijA:
undetectable		 3vywC-5jijA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B

(Mus musculus) 		no annotation 5 LEU A 731
ASN A 733
ALA A 744
PHE A 819
LEU A 815
 None
 1.11A 3vywC-5ml0A:
undetectable		 3vywC-5ml0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		5 LEU N 517
GLY N 516
ASN N 512
ALA N 446
LEU N 443
 None
 1.06A 3vywC-5mpdN:
undetectable		 3vywC-5mpdN:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 427
GLY A 407
ALA A 343
PHE A 387
LEU A 377
 None
 1.06A 3vywC-5oljA:
undetectable		 3vywC-5oljA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 GLY A 197
GLY A 204
TYR A 205
PHE A 299
LEU A 145
 None
 1.12A 3vywC-5tu0A:
undetectable		 3vywC-5tu0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		5 TYR A 191
TYR A 103
ALA A 177
PHE A 150
LEU A 144
 None
 1.02A 3vywC-5uncA:
undetectable		 3vywC-5uncA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A   7
GLY A  15
GLY A  39
ALA A 317
LEU A 301
 None
FAD  A 501 (-3.5A)
None
None
None
 1.12A 3vywC-5v36A:
undetectable		 3vywC-5v36A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vy3 PROTEASOME SUBUNIT
ALPHA

(Thermoplasma
acidophilum) 		no annotation 5 TYR A 180
GLY A  39
LEU A 192
GLY A 193
ALA A 139
 None
 0.99A 3vywC-5vy3A:
undetectable		 3vywC-5vy3A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2p -

(-) 		no annotation 5 TYR A  11
LEU A  58
GLY A  55
ALA A 100
LEU A 115
 None
 1.04A 3vywC-5y2pA:
undetectable		 3vywC-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 GLY A 374
LEU A 654
GLY A 663
ALA A 399
LEU A 669
 None
 0.99A 3vywC-6byiA:
undetectable		 3vywC-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 TYR A 576
GLY A 374
GLY A 663
ALA A 399
LEU A 669
 None
 1.06A 3vywC-6byiA:
undetectable		 3vywC-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1

(Homo sapiens) 		no annotation 5 GLY A 836
LEU A 482
GLY A 468
ALA A 428
LEU A 811
 None
 1.11A 3vywC-6caaA:
undetectable		 3vywC-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 TYR G  55
LEU G  59
GLY G  60
TYR G  61
LEU G  87
 None
 1.00A 3vywC-6criG:
undetectable		 3vywC-6criG:
undetectable