SIMILAR PATTERNS OF AMINO ACIDS FOR 3VYW_B_SAMB401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1azw | PROLINEIMINOPEPTIDASE (Xanthomonascitri) |
PF00561(Abhydrolase_1) | 5 | GLY A 109GLY A 112LEU A 115ALA A 296LEU A 305 | None | 1.18A | 3vywB-1azwA:undetectable | 3vywB-1azwA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjy | PROTEIN (CYTOSOLICPHOSPHOLIPASE A2) (Homo sapiens) |
PF00168(C2)PF01735(PLA2_B) | 5 | GLY A 551LEU A 556TYR A 558ALA A 396LEU A 421 | None | 1.09A | 3vywB-1cjyA:undetectable | 3vywB-1cjyA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanosarcinabarkeri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | GLY A1430GLY A1446LEU A1449ALA A1514LEU A1435 | None | 1.13A | 3vywB-1e6yA:undetectable | 3vywB-1e6yA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evq | SERINE HYDROLASE (Alicyclobacillusacidocaldarius) |
PF07859(Abhydrolase_3) | 5 | HIS A 282GLY A 84GLY A 82TYR A 183ALA A 116 | EPE A 455 (-4.0A)EPE A 455 (-3.3A)EPE A 455 (-3.5A)NoneNone | 1.12A | 3vywB-1evqA:undetectable | 3vywB-1evqA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ikp | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 5 | TYR A 439LEU A 498ALA A 425PHE A 436LEU A 429 | None | 1.12A | 3vywB-1ikpA:undetectable | 3vywB-1ikpA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 138GLY A 432LEU A 435ALA A 183LEU A 191 | None | 1.12A | 3vywB-1itzA:2.6 | 3vywB-1itzA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jji | CARBOXYLESTERASE (Archaeoglobusfulgidus) |
PF07859(Abhydrolase_3) | 5 | HIS A 285GLY A 89GLY A 87TYR A 188ALA A 121 | EPE A 455 (-4.6A)EPE A 455 (-3.4A)EPE A 455 ( 4.0A)NoneNone | 1.17A | 3vywB-1jjiA:undetectable | 3vywB-1jjiA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN BETACHAIN (Gallus gallus) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | TYR B 274GLY B 404TYR B 382ALA B 414PHE B 379 | None | 1.22A | 3vywB-1m1jB:undetectable | 3vywB-1m1jB:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n8y | PROTOONCOPROTEIN (Rattusnorvegicus) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 5 | GLY C 412GLY C 443LEU C 444TYR C 420LEU C 292 | None | 1.22A | 3vywB-1n8yC:undetectable | 3vywB-1n8yC:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nlu | SEDOLISIN (Pseudomonas sp.) |
no annotation | 5 | GLY A 234GLY A 172LEU A 230ALA A 193LEU A 259 | None | 1.25A | 3vywB-1nluA:undetectable | 3vywB-1nluA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogy | PERIPLASMIC NITRATEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | GLY A 120GLY A 122ALA A 132PHE A 397LEU A 145 | None | 1.01A | 3vywB-1ogyA:undetectable | 3vywB-1ogyA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogy | PERIPLASMIC NITRATEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 6 | HIS A 151GLY A 120ASN A 457ALA A 132PHE A 397LEU A 145 | MGD A1803 ( 4.8A)NoneNoneNoneNoneNone | 0.81A | 3vywB-1ogyA:undetectable | 3vywB-1ogyA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ps9 | 2,4-DIENOYL-COAREDUCTASE (Escherichiacoli) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | GLY A 225GLY A 541LEU A 543ASN A 169LEU A 172 | None | 0.93A | 3vywB-1ps9A:undetectable | 3vywB-1ps9A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1r | PUTIDAREDOXINREDUCTASE (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | TYR A 70GLY A 16LEU A 77ALA A 305PHE A 21 | NoneNoneNoneFAD A 749 ( 3.8A)None | 1.23A | 3vywB-1q1rA:2.0 | 3vywB-1q1rA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 5 | HIS A 110GLY A 48GLY A 50ALA A 222LEU A 46 | None | 1.23A | 3vywB-1s5pA:undetectable | 3vywB-1s5pA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgj | CITRATE LYASE, BETASUBUNIT (Deinococcusradiodurans) |
PF03328(HpcH_HpaI) | 5 | TYR A 156GLY A 133GLY A 131LEU A 160PHE A 151 | None | 1.22A | 3vywB-1sgjA:undetectable | 3vywB-1sgjA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yrw | PROTEIN ARNA (Escherichiacoli) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 5 | TYR A 24GLY A 15ALA A 169PHE A 80LEU A 103 | None | 1.07A | 3vywB-1yrwA:2.7 | 3vywB-1yrwA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7e | PROTEIN ARNA (Escherichiacoli) |
PF00551(Formyl_trans_N)PF01370(Epimerase)PF02911(Formyl_trans_C) | 5 | TYR A 24GLY A 15ALA A 169PHE A 80LEU A 103 | None | 1.14A | 3vywB-1z7eA:4.9 | 3vywB-1z7eA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zap | SECRETED ASPARTICPROTEINASE (Candidaalbicans) |
PF00026(Asp) | 5 | GLY A 127GLY A 125LEU A 38ASN A 153LEU A 320 | None | 1.25A | 3vywB-1zapA:undetectable | 3vywB-1zapA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zun | SULFATE ADENYLATETRANSFERASE, SUBUNIT1/ADENYLYLSULFATEKINASE (Pseudomonassyringae groupgenomosp. 3) |
PF00009(GTP_EFTU) | 5 | TYR B 150LEU B 378ASN B 376ALA B 383LEU B 386 | None | 1.17A | 3vywB-1zunB:3.6 | 3vywB-1zunB:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | TYR A 242GLY A 128GLY A 145ASN A 300ASN A 413 | NoneFAD A 600 ( 3.7A)NoneNoneFAD A 600 (-3.8A) | 1.23A | 3vywB-2bvgA:undetectable | 3vywB-2bvgA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 5 | HIS A 281GLY A 83GLY A 81TYR A 182ALA A 115 | None | 1.12A | 3vywB-2c7bA:undetectable | 3vywB-2c7bA:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cuy | MALONYL COA-[ACYLCARRIER PROTEIN]TRANSACYLASE (Thermusthermophilus) |
PF00698(Acyl_transf_1) | 5 | TYR A 222ASN A 224ALA A 107PHE A 6LEU A 64 | None | 1.11A | 3vywB-2cuyA:undetectable | 3vywB-2cuyA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Staphylococcusaureus) |
PF01425(Amidase) | 5 | GLY A 153GLY A 130TYR A 422ASN A 424ALA A 159 | NoneGLN A 501 (-3.2A)NoneNoneNone | 1.16A | 3vywB-2f2aA:undetectable | 3vywB-2f2aA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2b | AQUAPORIN AQPM (Methanothermobactermarburgensis) |
PF00230(MIP) | 5 | GLY A 50GLY A 53ALA A 33ASN A 43LEU A 48 | None | 1.24A | 3vywB-2f2bA:undetectable | 3vywB-2f2bA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9z | PROTEIN (CHEMOTAXISMETHYLATION PROTEIN) (Thermotogamaritima) |
PF03975(CheD) | 5 | GLY C 89GLY C 125ASN C 99ALA C 29LEU C 24 | None | 1.26A | 3vywB-2f9zC:undetectable | 3vywB-2f9zC:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggs | 273AA LONGHYPOTHETICALDTDP-4-DEHYDRORHAMNOSE REDUCTASE (Sulfurisphaeratokodaii) |
PF04321(RmlD_sub_bind) | 5 | TYR A 39GLY A 38ALA A 65PHE A 52LEU A 43 | NoneNoneNDP A 900 (-3.7A)NoneNDP A 900 (-3.8A) | 1.18A | 3vywB-2ggsA:undetectable | 3vywB-2ggsA:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqf | HYPOTHETICAL PROTEINHI0933 (Haemophilusinfluenzae) |
PF03486(HI0933_like) | 5 | GLY A 13GLY A 40LEU A 44ALA A 163PHE A 384 | FAD A 403 (-3.1A)NoneNoneFAD A 403 (-4.6A)FAD A 403 (-3.7A) | 1.26A | 3vywB-2gqfA:undetectable | 3vywB-2gqfA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 5 | TYR A 285GLY A 284ALA A 248PHE A 302LEU A 274 | None | 1.20A | 3vywB-2i9kA:5.9 | 3vywB-2i9kA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lbp | LEUCINE-BINDINGPROTEIN (Escherichiacoli) |
PF13458(Peripla_BP_6) | 5 | TYR A 202GLY A 224GLY A 227TYR A 203ALA A 128 | None | 0.96A | 3vywB-2lbpA:undetectable | 3vywB-2lbpA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nqo | GAMMA-GLUTAMYLTRANSPEPTIDASE (Helicobacterpylori) |
PF01019(G_glu_transpept) | 5 | GLY A 69LEU A 72ASN A 81ALA A 145LEU A 100 | None | 0.98A | 3vywB-2nqoA:undetectable | 3vywB-2nqoA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nya | PERIPLASMIC NITRATEREDUCTASE (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | HIS A 142GLY A 111ASN A 447ALA A 123PHE A 387 | MGD A3001 ( 4.9A)NoneNoneNoneNone | 0.81A | 3vywB-2nyaA:2.2 | 3vywB-2nyaA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4q | 6-PHOSPHOGLUCONATEDEHYDROGENASE,DECARBOXYLATING 1 (Saccharomycescerevisiae) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | GLY A 124GLY A 100LEU A 73ALA A 177PHE A 156 | None | 1.20A | 3vywB-2p4qA:3.4 | 3vywB-2p4qA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | HIS A 103GLY A 124GLY A 126ALA A 179LEU A 207 | S4M A 501 (-3.7A)S4M A 501 (-3.4A)S4M A 501 ( 4.4A)S4M A 501 (-3.5A)S4M A 501 (-4.4A) | 1.22A | 3vywB-2pt6A:14.6 | 3vywB-2pt6A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qru | UNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF07859(Abhydrolase_3) | 5 | HIS A 247GLY A 35GLY A 33TYR A 129ALA A 67 | PO4 A 273 (-4.0A)PO4 A 273 (-3.5A)PO4 A 273 ( 3.7A)NoneNone | 1.17A | 3vywB-2qruA:undetectable | 3vywB-2qruA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy6 | UPF0209 PROTEIN YFCK (Escherichiacoli) |
PF05430(Methyltransf_30) | 5 | GLY A 86GLY A 88ASN A 92LYS A 122ASN A 205 | None | 1.02A | 3vywB-2qy6A:23.8 | 3vywB-2qy6A:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy6 | UPF0209 PROTEIN YFCK (Escherichiacoli) |
PF05430(Methyltransf_30) | 6 | TYR A 48GLY A 86GLY A 88ASN A 92PHE A 200ASN A 205 | None | 0.62A | 3vywB-2qy6A:23.8 | 3vywB-2qy6A:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrc | TRIPHENYLMETHANEREDUCTASE (Citrobacter sp.MY-5) |
PF05368(NmrA) | 5 | HIS A 121GLY A 75LEU A 83ALA A 8PHE A 72 | None | 1.25A | 3vywB-2vrcA:4.4 | 3vywB-2vrcA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yh2 | ESTERASE (Pyrobaculumcalidifontis) |
PF07859(Abhydrolase_3) | 5 | HIS A 284GLY A 86GLY A 84TYR A 185ALA A 118 | None | 1.17A | 3vywB-2yh2A:2.1 | 3vywB-2yh2A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b78 | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly) | 5 | TYR B 439LEU B 498ALA B 425PHE B 436LEU B 429 | None | 1.11A | 3vywB-3b78B:undetectable | 3vywB-3b78B:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdi | UNCHARACTERIZEDPROTEIN TA0194 (Thermoplasmaacidophilum) |
PF00561(Abhydrolase_1)PF12146(Hydrolase_4) | 5 | HIS A 185GLY A 109GLY A 34ALA A 85LEU A 82 | None | 1.24A | 3vywB-3bdiA:undetectable | 3vywB-3bdiA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvh | FIBRINOGEN BETACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | TYR B 269GLY B 400TYR B 378ALA B 410PHE B 375 | None | 1.22A | 3vywB-3bvhB:undetectable | 3vywB-3bvhB:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3j | ENHANCER OFMRNA-DECAPPINGPROTEIN 3 (Homo sapiens) |
PF03853(YjeF_N)PF09532(FDF) | 5 | GLY A 342GLY A 347ASN A 409ASN A 416LEU A 419 | None | 1.08A | 3vywB-3d3jA:5.0 | 3vywB-3d3jA:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcr | PUTATIVEAMINOTRANSFERASE (Ruegeria sp.TM1040) |
PF00202(Aminotran_3) | 5 | GLY A 356GLY A 380LEU A 268ALA A 441PHE A 434 | None | 1.01A | 3vywB-3fcrA:undetectable | 3vywB-3fcrA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fut | DIMETHYLADENOSINETRANSFERASE (Thermusthermophilus) |
PF00398(RrnaAD) | 5 | GLY A 54GLY A 56LEU A 57LYS A 76ALA A 100 | None | 0.77A | 3vywB-3futA:8.8 | 3vywB-3futA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fut | DIMETHYLADENOSINETRANSFERASE (Thermusthermophilus) |
PF00398(RrnaAD) | 5 | GLY A 54GLY A 56LEU A 57LYS A 76LEU A 118 | None | 0.97A | 3vywB-3futA:8.8 | 3vywB-3futA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvz | UNCHARACTERIZEDPROTEIN CV2077 (Chromobacteriumviolaceum) |
PF03417(AAT) | 5 | TYR A 177GLY A 156LEU A 183ALA A 130LEU A 163 | None | 1.14A | 3vywB-3gvzA:undetectable | 3vywB-3gvzA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h09 | IMMUNOGLOBULIN A1PROTEASE (Haemophilusinfluenzae) |
PF02395(Peptidase_S6)PF03212(Pertactin) | 5 | GLY A 429GLY A 408ASN A 383PHE A 173LEU A 452 | None | 1.16A | 3vywB-3h09A:undetectable | 3vywB-3h09A:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h32 | FIBRINOGEN BETACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 5 | TYR B 269GLY B 400TYR B 378ALA B 410PHE B 375 | None | 1.20A | 3vywB-3h32B:undetectable | 3vywB-3h32B:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4m | PROTEASOME-ACTIVATING NUCLEOTIDASE (Methanocaldococcusjannaschii) |
PF00004(AAA) | 5 | HIS A 353GLY A 216GLY A 377LEU A 380LEU A 220 | ADP A 439 (-4.2A)ADP A 439 (-3.0A)ADP A 439 (-3.1A)NoneNone | 1.13A | 3vywB-3h4mA:undetectable | 3vywB-3h4mA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il7 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Staphylococcusaureus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | TYR A 117GLY A 297GLY A 305TYR A 178ALA A 240 | None | 1.14A | 3vywB-3il7A:undetectable | 3vywB-3il7A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwp | TRANSCRIPTIONALREGULATORY PROTEINSIR2 HOMOLOGUE (Plasmodiumfalciparum) |
PF02146(SIR2) | 5 | HIS A 88GLY A 28GLY A 30ALA A 207LEU A 26 | NoneAMP A 266 ( 4.0A)AMP A 266 (-3.2A)NoneNone | 1.10A | 3vywB-3jwpA:undetectable | 3vywB-3jwpA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktn | CARBOHYDRATE KINASE,PFKB FAMILY (Enterococcusfaecalis) |
PF00294(PfkB) | 5 | TYR A 185GLY A 197LEU A 205ALA A 281PHE A 164 | None | 1.10A | 3vywB-3ktnA:2.6 | 3vywB-3ktnA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrk | ALPHA-GALACTOSIDASE1 (Saccharomycescerevisiae) |
PF16499(Melibiase_2) | 5 | TYR A 331GLY A 362GLY A 341ALA A 278LEU A 360 | None | 1.17A | 3vywB-3lrkA:undetectable | 3vywB-3lrkA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5a | PERIPLASMIC NITRATEREDUCTASE (Cupriavidusnecator) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | HIS A 151GLY A 120ASN A 457ALA A 132PHE A 397 | MGD A1803 ( 4.6A)NoneNoneNoneFMT A 803 (-3.6A) | 0.72A | 3vywB-3o5aA:2.9 | 3vywB-3o5aA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ps9 | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Escherichiacoli) |
PF01266(DAO)PF05430(Methyltransf_30) | 6 | TYR A 28GLY A 66GLY A 68ASN A 72PHE A 180ASN A 185 | SAM A 670 (-4.5A)SAM A 670 (-3.5A)SAM A 670 (-3.2A)SAM A 670 ( 3.7A)SAM A 670 (-3.6A)SAM A 670 ( 4.1A) | 0.48A | 3vywB-3ps9A:22.8 | 3vywB-3ps9A:19.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 6 | GLY A 104LEU A 137ALA A 175PHE A 195ASN A 200LEU A 203 | SAM A 501 (-3.6A)NoneSAM A 501 (-3.8A)SAM A 501 (-3.7A)SAM A 501 (-3.2A)SAM A 501 (-4.6A) | 1.40A | 3vywB-3vywA:49.9 | 3vywB-3vywA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vyw | MNMC2 (Aquifexaeolicus) |
PF05430(Methyltransf_30) | 12 | TYR A 67HIS A 68GLY A 104GLY A 106LEU A 107TYR A 109ASN A 110LYS A 134ALA A 175PHE A 195ASN A 200LEU A 203 | SAM A 501 (-4.5A)SAM A 501 (-4.2A)SAM A 501 (-3.6A)SAM A 501 (-3.3A)SAM A 501 (-4.3A)SAM A 501 (-4.6A)SAM A 501 (-3.6A)SAM A 501 (-4.4A)SAM A 501 (-3.8A)SAM A 501 (-3.7A)SAM A 501 (-3.2A)SAM A 501 (-4.6A) | 0.39A | 3vywB-3vywA:49.9 | 3vywB-3vywA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4azc | BETA-N-ACETYLHEXOSAMINIDASE (Streptococcuspneumoniae) |
PF00728(Glyco_hydro_20) | 5 | HIS A 665GLY A 669LEU A 666ASN A 800ALA A 745 | None | 1.25A | 3vywB-4azcA:undetectable | 3vywB-4azcA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 251GLY A 258ASN A 188ALA A 275LEU A 267 | None | 1.15A | 3vywB-4c7vA:2.7 | 3vywB-4c7vA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d65 | PORIN 2 (Providenciastuartii) |
PF00267(Porin_1) | 5 | TYR A 233GLY A 234ASN A 102ALA A 251LEU A 291 | LDA A1372 (-4.3A)NoneNoneNoneNone | 1.05A | 3vywB-4d65A:undetectable | 3vywB-4d65A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hum | MULTIDRUG EFFLUXPROTEIN (Neisseriagonorrhoeae) |
PF01554(MatE) | 5 | GLY A 72GLY A 255LEU A 256PHE A 70LEU A 156 | None | 1.19A | 3vywB-4humA:undetectable | 3vywB-4humA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hv4 | UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE (Yersinia pestis) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | HIS A 70GLY A 48ASN A 75ALA A 36LEU A 60 | None | 1.20A | 3vywB-4hv4A:3.2 | 3vywB-4hv4A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jfc | ENOYL-COA HYDRATASE (Polaromonas sp.JS666) |
PF00378(ECH_1) | 5 | GLY A 146GLY A 144LEU A 87ALA A 151LEU A 163 | None | 1.22A | 3vywB-4jfcA:undetectable | 3vywB-4jfcA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kfv | GOLGIREASSEMBLY-STACKINGPROTEIN 1 (Rattusnorvegicus) |
PF04495(GRASP55_65) | 5 | GLY A 192GLY A 194ALA A 123PHE A 149LEU A 189 | None | 1.19A | 3vywB-4kfvA:undetectable | 3vywB-4kfvA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mbz | MAJOR CAPSID PROTEINVP1 (African greenmonkeypolyomavirus) |
PF00718(Polyoma_coat) | 5 | TYR A 222GLY A 156ASN A 216PHE A 153LEU A 262 | NoneNoneNoneIPA A 405 (-4.6A)None | 1.20A | 3vywB-4mbzA:undetectable | 3vywB-4mbzA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4od5 | 4-HYDROXYBENZOATEOCTAPRENYLTRANSFERASE (Aeropyrumpernix) |
PF01040(UbiA) | 5 | GLY A 140GLY A 19ALA A 101PHE A 27LEU A 97 | None | 1.24A | 3vywB-4od5A:undetectable | 3vywB-4od5A:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ojx | 3',5'-CYCLIC-NUCLEOTIDEPHOSPHODIESTERASE 1 (Saccharomycescerevisiae) |
PF02112(PDEase_II) | 5 | TYR A 18GLY A 41GLY A 19ALA A 37ASN A 140 | None | 1.15A | 3vywB-4ojxA:undetectable | 3vywB-4ojxA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p9n | CARBOXYLESTERASE (Sulfolobusshibatae) |
PF07859(Abhydrolase_3) | 5 | HIS A 274GLY A 81GLY A 79TYR A 177ALA A 113 | None | 1.13A | 3vywB-4p9nA:2.2 | 3vywB-4p9nA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pot | VP1 (Humanpolyomavirus 9) |
PF00718(Polyoma_coat) | 5 | TYR A 225GLY A 159ASN A 219PHE A 156LEU A 265 | NoneNoneNoneIPA A 404 (-4.6A)None | 1.20A | 3vywB-4potA:undetectable | 3vywB-4potA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pve | POLLEN ALLERGEN PHLP 4.0202 (Phleum pratense) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | TYR A 436GLY A 208TYR A 88ALA A 203LEU A 474 | FAD A 601 (-4.5A)NoneFAD A 601 ( 3.7A)NoneNone | 1.10A | 3vywB-4pveA:undetectable | 3vywB-4pveA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qqf | MITOCHONDRIAL IMPORTINNER MEMBRANETRANSLOCASE SUBUNITTIM50 (Saccharomycescerevisiae) |
no annotation | 5 | LEU D 228TYR D 232ALA D 249PHE D 201LEU D 198 | None | 1.09A | 3vywB-4qqfD:undetectable | 3vywB-4qqfD:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | HIS A 103GLY A 124GLY A 126ALA A 179LEU A 207 | NoneMTA A 401 (-3.5A)MTA A 401 ( 4.5A)MTA A 401 (-3.6A)MTA A 401 (-4.4A) | 1.24A | 3vywB-4uoeA:14.9 | 3vywB-4uoeA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbt | PROBABLEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Sinorhizobiummeliloti) |
PF00155(Aminotran_1_2) | 5 | GLY A 236GLY A 93ALA A 265ASN A 70LEU A 73 | NonePLP A 401 (-3.2A)NoneNoneNone | 1.16A | 3vywB-4wbtA:undetectable | 3vywB-4wbtA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wyr | ACETYL-COAACETYLTRANSFERASE (Clostridiumacetobutylicum) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLY A 248LEU A 249TYR A 17ALA A 179LEU A 228 | PEG A 503 ( 4.4A)PEG A 503 ( 4.7A)NoneNoneNone | 1.15A | 3vywB-4wyrA:undetectable | 3vywB-4wyrA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ybn | FLAVIN-NUCLEOTIDE-BINDING PROTEIN (Mycolicibacteriumsmegmatis) |
PF12900(Pyridox_ox_2) | 5 | GLY A 52LEU A 35ASN A 221ALA A 152LEU A 124 | NoneNoneNoneNoneHEM A 304 (-4.0A) | 1.08A | 3vywB-4ybnA:undetectable | 3vywB-4ybnA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypv | EST8 (Parvibaculum) |
PF07859(Abhydrolase_3) | 5 | HIS A 283GLY A 88GLY A 86TYR A 187ALA A 120 | None | 1.11A | 3vywB-4ypvA:undetectable | 3vywB-4ypvA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8x | ATP-DEPENDENT ZINCMETALLOPROTEASE FTSH (Aquifexaeolicus) |
PF00004(AAA)PF01434(Peptidase_M41) | 5 | HIS A 338GLY A 200GLY A 362LEU A 365LEU A 204 | ADP A 702 ( 4.1A)ADP A 702 ( 3.4A)ADP A 702 ( 3.6A)NoneNone | 1.09A | 3vywB-4z8xA:undetectable | 3vywB-4z8xA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b26 | PROTEIN SEL-1HOMOLOG 1 (Mus musculus) |
PF08238(Sel1) | 5 | GLY A 448GLY A 450LEU A 454TYR A 455ALA A 437 | None | 1.20A | 3vywB-5b26A:undetectable | 3vywB-5b26A:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2d | HN PROTEIN (Mumpsrubulavirus) |
PF00423(HN) | 5 | GLY A 311GLY A 309TYR A 420ALA A 254LEU A 318 | None | 1.13A | 3vywB-5b2dA:undetectable | 3vywB-5b2dA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cqf | L-LYSINE6-MONOOXYGENASE (Pseudomonassyringae groupgenomosp. 3) |
PF13434(K_oxygenase) | 5 | HIS A 56GLY A 17GLY A 19PHE A 128LEU A 47 | None | 1.04A | 3vywB-5cqfA:2.5 | 3vywB-5cqfA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d79 | BERBERINE BRIDGEENZYME-LIKE PROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | TYR A 470GLY A 232TYR A 113ALA A 227LEU A 507 | FAD A 603 (-4.5A)NoneFAD A 603 (-4.9A)NoneNone | 1.16A | 3vywB-5d79A:undetectable | 3vywB-5d79A:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkv | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (RIBOSE) (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 5 | GLY A 231GLY A 237LEU A 238ASN A 205ALA A 154 | None | 1.26A | 3vywB-5dkvA:undetectable | 3vywB-5dkvA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fg9 | PROTEASOME SUBUNITBETA TYPE-2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 5 | HIS H 114GLY H 128TYR H 97ALA H 158LEU H 138 | None | 1.18A | 3vywB-5fg9H:undetectable | 3vywB-5fg9H:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grh | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT GAMMA,MITOCHONDRIAL (Homo sapiens) |
PF00180(Iso_dh) | 5 | HIS B 51GLY B 27GLY B 23ALA B 284ASN B 280 | None | 1.22A | 3vywB-5grhB:2.4 | 3vywB-5grhB:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 5 | GLY A 51LEU A 133ALA A 89PHE A 85LEU A 87 | None | 1.14A | 3vywB-5gw7A:undetectable | 3vywB-5gw7A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3k | SLR0280 PROTEIN (Synechocystissp. PCC 6803) |
no annotation | 5 | GLY A 352GLY A 363LEU A 403ALA A 501ASN A 603 | None | 1.01A | 3vywB-5h3kA:undetectable | 3vywB-5h3kA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyz | GRAS FAMILYTRANSCRIPTION FACTORCONTAINING PROTEIN,EXPRESSED (Oryza sativa) |
PF03514(GRAS) | 5 | GLY A 443LEU A 412ASN A 409ALA A 560LEU A 531 | None | 1.09A | 3vywB-5hyzA:10.0 | 3vywB-5hyzA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd4 | LAE6 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | HIS A 286GLY A 90GLY A 88TYR A 189ALA A 122 | BAM A 407 (-3.9A)BAM A 407 (-3.5A)BAM A 407 ( 3.9A)NoneNone | 1.07A | 3vywB-5jd4A:undetectable | 3vywB-5jd4A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 5 | GLY A 243LEU A 200ALA A 472PHE A 166LEU A 195 | None | 1.19A | 3vywB-5jijA:2.4 | 3vywB-5jijA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2p | ARYLESTERASE (Sulfolobussolfataricus) |
PF07859(Abhydrolase_3) | 5 | GLY A 213ALA A 125PHE A 185ASN A 160LEU A 161 | None | 1.08A | 3vywB-5l2pA:undetectable | 3vywB-5l2pA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2v | CHITIN-BINDINGPROTEIN (Listeriamonocytogenes) |
PF03067(LPMO_10) | 5 | TYR A 157GLY A 145LEU A 144ALA A 127LEU A 81 | None | 1.16A | 3vywB-5l2vA:undetectable | 3vywB-5l2vA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lun | 2-OXOGLUTARATE-DEPENDENTETHYLENE/SUCCINATE-FORMING ENZYME (Pseudomonassavastanoi) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 5 | GLY A 187GLY A 185LEU A 272LYS A 89ALA A 87 | None | 1.10A | 3vywB-5lunA:undetectable | 3vywB-5lunA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd5 | TRANSKETOLASE (Chlamydomonasreinhardtii) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 177GLY A 472LEU A 475ALA A 223LEU A 231 | None | 1.09A | 3vywB-5nd5A:2.7 | 3vywB-5nd5A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxn | PORIN 1 (Providenciastuartii) |
no annotation | 5 | TYR A 243GLY A 244ASN A 105ALA A 259LEU A 300 | None | 1.04A | 3vywB-5nxnA:undetectable | 3vywB-5nxnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o4g | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
no annotation | 5 | GLY C 411GLY C 442LEU C 443TYR C 419LEU C 291 | None | 1.12A | 3vywB-5o4gC:undetectable | 3vywB-5o4gC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyn | DEHYDRATASE,ILVD/EDD FAMILY (Caulobactervibrioides) |
no annotation | 5 | TYR A 560GLY A 454GLY A 460LEU A 101ALA A 501 | None | 1.14A | 3vywB-5oynA:undetectable | 3vywB-5oynA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veh | KYNURENINEAMINOTRANSFERASE (Aedes aegypti) |
no annotation | 5 | GLY A 345GLY A 196LEU A 195ASN A 193LEU A 321 | NoneNoneNoneLLP A 255 ( 3.9A)None | 1.26A | 3vywB-5vehA:undetectable | 3vywB-5vehA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dft | - (-) |
no annotation | 5 | GLY B 260GLY B 262ALA B 317ASN B 73LEU B 74 | NAD B 500 (-3.5A)NAD A 502 (-3.6A)NAD B 500 (-3.6A)NAD B 500 (-3.5A)None | 1.25A | 3vywB-6dftB:2.3 | 3vywB-6dftB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6grw | - (-) |
no annotation | 5 | GLY A 138LEU A 139ALA A 422PHE A 283LEU A 285 | NoneNoneNoneNoneEDO A 509 ( 4.9A) | 1.26A | 3vywB-6grwA:undetectable | 3vywB-6grwA:undetectable |