SIMILAR PATTERNS OF AMINO ACIDS FOR 3VYW_A_SAMA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		5 TYR A  74
TYR A 170
GLU A  80
ALA A 201
LEU A 125
 None
 1.02A 3vywA-1a2zA:
undetectable		 3vywA-1a2zA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 GLY A 109
GLY A 112
LEU A 115
ALA A 296
LEU A 305
 None
 1.18A 3vywA-1azwA:
undetectable		 3vywA-1azwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 GLY A 551
LEU A 556
TYR A 558
ALA A 396
LEU A 421
 None
 1.11A 3vywA-1cjyA:
undetectable		 3vywA-1cjyA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		5 TYR A 159
GLY A 315
GLY A 261
LEU A 262
GLU A 227
 CD  A 811 (-4.9A)
None
None
None
CD  A 811 (-3.2A)
 1.08A 3vywA-1cvmA:
undetectable		 3vywA-1cvmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLY A1430
GLY A1446
LEU A1449
ALA A1514
LEU A1435
 None
 1.10A 3vywA-1e6yA:
undetectable		 3vywA-1e6yA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 GLY A 230
TYR A  14
GLU A  22
ALA A 184
LEU A 226
 None
 1.17A 3vywA-1f2jA:
undetectable		 3vywA-1f2jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 TYR B1047
GLY B 564
GLY B 567
LEU B 559
TYR B 578
 None
 1.03A 3vywA-1gl9B:
undetectable		 3vywA-1gl9B:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 TYR A 439
LEU A 498
ALA A 425
PHE A 436
LEU A 429
 None
 1.11A 3vywA-1ikpA:
undetectable		 3vywA-1ikpA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipf TROPINONE
REDUCTASE-II

(Datura
stramonium) 		PF13561
(adh_short_C2) 		5 GLY A  17
GLY A  22
GLU A  27
ALA A  62
LEU A  46
 NDP  A 261 ( 4.8A)
None
None
None
None
 1.18A 3vywA-1ipfA:
5.3		 3vywA-1ipfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 138
GLY A 432
LEU A 435
ALA A 183
LEU A 191
 None
 1.13A 3vywA-1itzA:
undetectable		 3vywA-1itzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 GLY C 412
GLY C 443
LEU C 444
TYR C 420
LEU C 292
 None
 1.18A 3vywA-1n8yC:
undetectable		 3vywA-1n8yC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 120
ASN A 457
ALA A 132
PHE A 397
LEU A 145
 None
 0.85A 3vywA-1ogyA:
2.4		 3vywA-1ogyA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 120
GLY A 122
ALA A 132
PHE A 397
LEU A 145
 None
 1.03A 3vywA-1ogyA:
2.4		 3vywA-1ogyA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 124
GLY A 100
LEU A  73
ALA A 178
PHE A 156
 None
 1.15A 3vywA-1pgpA:
2.8		 3vywA-1pgpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		5 TYR A 156
GLY A 133
GLY A 131
LEU A 160
PHE A 151
 None
 1.17A 3vywA-1sgjA:
2.4		 3vywA-1sgjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		5 LEU A 112
TYR A 115
ASN A 117
GLU A  99
LEU A  75
 None
 1.15A 3vywA-1vbfA:
7.5		 3vywA-1vbfA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.08A 3vywA-1yrwA:
2.8		 3vywA-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.14A 3vywA-1z7eA:
4.1		 3vywA-1z7eA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		5 TYR B 150
LEU B 378
ASN B 376
ALA B 383
LEU B 386
 None
 1.18A 3vywA-1zunB:
undetectable		 3vywA-1zunB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		5 LEU A 257
ASN A 264
GLU A 249
ALA A 278
LEU A 309
 None
 1.16A 3vywA-2au3A:
undetectable		 3vywA-2au3A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bas YKUI PROTEIN

(Bacillus
subtilis) 		PF00563
(EAL)
PF10388
(YkuI_C) 		6 TYR A 219
TYR A 188
GLY A 155
ASN A 153
ALA A 199
LEU A 206
 None
 1.50A 3vywA-2basA:
undetectable		 3vywA-2basA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 TYR A 331
GLY A 315
GLY A 110
ALA A 320
LEU A 327
 None
 1.16A 3vywA-2ch6A:
undetectable		 3vywA-2ch6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 TYR A 222
ASN A 224
ALA A 107
PHE A   6
LEU A  64
 None
 1.11A 3vywA-2cuyA:
undetectable		 3vywA-2cuyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 TYR A  81
TYR A 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.10A 3vywA-2e0wA:
undetectable		 3vywA-2e0wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 TYR A  81
TYR B 408
GLY A 149
GLY A  96
PHE A 154
 None
 1.05A 3vywA-2e0xA:
undetectable		 3vywA-2e0xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		5 GLY A 548
GLY A 253
ASN A 295
GLU A 273
LEU A 524
 None
 1.12A 3vywA-2et6A:
4.0		 3vywA-2et6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		6 GLY A 548
GLY A 253
LEU A 286
GLU A 273
PHE A 256
LEU A 524
 None
 1.30A 3vywA-2et6A:
4.0		 3vywA-2et6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 GLY A 153
GLY A 130
TYR A 422
ASN A 424
ALA A 159
 None
GLN  A 501 (-3.2A)
None
None
None
 1.12A 3vywA-2f2aA:
undetectable		 3vywA-2f2aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		5 TYR A  39
GLY A  38
ALA A  65
PHE A  52
LEU A  43
 None
None
NDP  A 900 (-3.7A)
None
NDP  A 900 (-3.8A)
 1.17A 3vywA-2ggsA:
2.7		 3vywA-2ggsA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 GLY A 187
GLY A 192
LEU A 193
GLU A 243
ALA A 298
 None
 0.95A 3vywA-2gzsA:
undetectable		 3vywA-2gzsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 TYR A 254
GLY A  94
GLY A  90
LEU A  89
GLU A 270
 None
 1.13A 3vywA-2h1yA:
undetectable		 3vywA-2h1yA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 TYR A 285
GLY A 284
ALA A 248
PHE A 302
LEU A 274
 None
 1.18A 3vywA-2i9kA:
6.9		 3vywA-2i9kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		5 GLY A  69
LEU A  72
ASN A  81
ALA A 145
LEU A 100
 None
 0.95A 3vywA-2nqoA:
undetectable		 3vywA-2nqoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A 124
GLY A 100
LEU A  73
ALA A 177
PHE A 156
 None
 1.18A 3vywA-2p4qA:
3.3		 3vywA-2p4qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE

(Aneurinibacillus
thermoaerophilus) 		PF16363
(GDP_Man_Dehyd) 		5 TYR A 118
GLY A 113
LEU A 134
GLU A 130
PHE A 168
 None
 1.10A 3vywA-2pk3A:
undetectable		 3vywA-2pk3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Novosphingobium
aromaticivorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 369
GLY A 371
GLU A 366
ALA A 101
LEU A 108
 None
 0.98A 3vywA-2qjjA:
2.0		 3vywA-2qjjA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		6 TYR A  48
GLY A  86
GLY A  88
ASN A  92
LYS A 122
PHE A 200
 None
 0.68A 3vywA-2qy6A:
23.1		 3vywA-2qy6A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 TYR A 242
GLY A 200
LEU A 179
TYR A 177
ALA A 205
 None
 1.20A 3vywA-2qzuA:
undetectable		 3vywA-2qzuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 TYR A  79
GLY A 118
GLY A 122
TYR A 124
LEU A  39
 None
 1.04A 3vywA-2uz0A:
undetectable		 3vywA-2uz0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		5 GLY A 243
GLY A 149
GLU A 146
PHE A 276
LEU A 291
 None
 1.14A 3vywA-2w9xA:
undetectable		 3vywA-2w9xA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A  82
GLY A 197
GLY A 348
ALA A  21
LEU A  90
 None
 1.16A 3vywA-2wgeA:
undetectable		 3vywA-2wgeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 GLY A  83
GLY A  73
GLU A  75
ALA A 160
LEU A 157
 None
 1.16A 3vywA-2ww9A:
undetectable		 3vywA-2ww9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 350
GLY A 352
GLU A 347
ALA A 117
LEU A 124
 None
 1.12A 3vywA-3eezA:
3.2		 3vywA-3eezA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		5 TYR A 177
GLY A 156
LEU A 183
ALA A 130
LEU A 163
 None
 1.15A 3vywA-3gvzA:
undetectable		 3vywA-3gvzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLY A 429
GLY A 408
ASN A 383
PHE A 173
LEU A 452
 None
 1.19A 3vywA-3h09A:
undetectable		 3vywA-3h09A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 TYR B 269
GLY B 400
TYR B 378
ALA B 410
PHE B 375
 None
 1.19A 3vywA-3h32B:
undetectable		 3vywA-3h32B:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hst PROTEIN
RV2228C/MT2287

(Mycobacterium
tuberculosis) 		PF13456
(RVT_3) 		5 GLY B  52
GLY B  21
LEU B 125
GLU B   6
LEU B  57
 None
 1.10A 3vywA-3hstB:
2.1		 3vywA-3hstB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 117
GLY A 297
GLY A 305
TYR A 178
ALA A 240
 None
 1.16A 3vywA-3il7A:
undetectable		 3vywA-3il7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 TYR A 185
GLY A 197
LEU A 205
ALA A 281
PHE A 164
 None
 1.09A 3vywA-3ktnA:
undetectable		 3vywA-3ktnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 GLY A  16
GLY A  21
GLU A  26
ALA A  63
LEU A  45
 NDP  A 301 ( 4.6A)
None
None
None
None
 1.08A 3vywA-3lf2A:
3.4		 3vywA-3lf2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		5 TYR A 331
GLY A 362
GLY A 341
ALA A 278
LEU A 360
 None
 1.19A 3vywA-3lrkA:
undetectable		 3vywA-3lrkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 TYR A 437
TYR A 340
GLY A 142
GLY A 346
ALA A 184
 None
 1.09A 3vywA-3nd0A:
undetectable		 3vywA-3nd0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 TYR A  28
GLY A  66
GLY A  68
ASN A  72
PHE A 180
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.5A)
SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
SAM  A 670 (-3.6A)
 0.22A 3vywA-3ps9A:
22.3		 3vywA-3ps9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 GLY A  66
GLY A  68
ASN A  72
LYS A 102
PHE A 180
 None
 0.81A 3vywA-3pvcA:
20.0		 3vywA-3pvcA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 366
GLY A 368
GLU A 363
ALA A 107
LEU A 114
 None
 1.11A 3vywA-3s47A:
2.1		 3vywA-3s47A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)

(Borreliella
burgdorferi) 		PF04069
(OpuAC) 		5 GLY A  77
GLY A  31
GLU A  57
ALA A 234
LEU A 227
 None
 1.13A 3vywA-3tmgA:
undetectable		 3vywA-3tmgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 346
GLY A 348
GLU A 343
ALA A  97
LEU A 104
 None
 0.98A 3vywA-3u4fA:
undetectable		 3vywA-3u4fA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		6 TYR A  63
GLY A 104
LEU A 137
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-3.6A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 1.42A 3vywA-3vywA:
54.1		 3vywA-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		12 TYR A  63
TYR A  67
GLY A 104
GLY A 106
LEU A 107
TYR A 109
ASN A 110
LYS A 134
GLU A 135
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-4.5A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 0.00A 3vywA-3vywA:
54.1		 3vywA-3vywA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 251
GLY A 258
ASN A 188
ALA A 275
LEU A 267
 None
 1.13A 3vywA-4c7vA:
2.5		 3vywA-4c7vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		5 TYR A 233
GLY A 234
ASN A 102
ALA A 251
LEU A 291
 LDA  A1372 (-4.3A)
None
None
None
None
 1.02A 3vywA-4d65A:
undetectable		 3vywA-4d65A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 371
GLY A 373
GLU A 368
ALA A 101
LEU A 108
 None
 1.03A 3vywA-4e4fA:
undetectable		 3vywA-4e4fA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Caulobacter sp.
K31) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 370
GLY A 372
GLU A 367
ALA A 102
LEU A 109
 None
 1.03A 3vywA-4fi4A:
undetectable		 3vywA-4fi4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 364
GLY A 366
GLU A 361
ALA A 105
LEU A 112
 None
 1.17A 3vywA-4gisA:
undetectable		 3vywA-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 382
GLY A 384
GLU A 379
ALA A 112
LEU A 119
 None
 1.07A 3vywA-4il2A:
undetectable		 3vywA-4il2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		5 GLY A 192
GLY A 194
ALA A 123
PHE A 149
LEU A 189
 None
 1.19A 3vywA-4kfvA:
undetectable		 3vywA-4kfvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 192
GLY A 190
LEU A 128
TYR A 132
GLU A 121
 None
 1.15A 3vywA-4l7tA:
undetectable		 3vywA-4l7tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbz MAJOR CAPSID PROTEIN
VP1

(African green
monkey
polyomavirus) 		PF00718
(Polyoma_coat) 		5 TYR A 222
GLY A 156
ASN A 216
PHE A 153
LEU A 262
 None
None
None
IPA  A 405 (-4.6A)
None
 1.19A 3vywA-4mbzA:
undetectable		 3vywA-4mbzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		5 GLY A 356
GLY A 366
LEU A 361
TYR A 363
GLU A 391
 None
 1.14A 3vywA-4n0rA:
undetectable		 3vywA-4n0rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 436
GLY A 208
TYR A  88
ALA A 203
LEU A 474
 FAD  A 601 (-4.5A)
None
FAD  A 601 ( 3.7A)
None
None
 1.17A 3vywA-4pveA:
undetectable		 3vywA-4pveA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		5 TYR A 205
GLY A 201
GLY A 221
LEU A 217
ASN A 199
 289  A 414 (-4.6A)
289  A 422 ( 4.0A)
None
None
None
 0.95A 3vywA-4q1qA:
undetectable		 3vywA-4q1qA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 TYR A 241
TYR A 182
GLY A 181
ALA A 228
PHE A 222
 None
 1.17A 3vywA-4qjyA:
undetectable		 3vywA-4qjyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqf MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM50

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 228
TYR D 232
ALA D 249
PHE D 201
LEU D 198
 None
 1.09A 3vywA-4qqfD:
undetectable		 3vywA-4qqfD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		5 TYR A  85
GLY A 123
GLY A 127
TYR A 129
LEU A  45
 None
 1.10A 3vywA-4rgyA:
undetectable		 3vywA-4rgyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		5 TYR A  82
GLY A 121
GLY A 125
TYR A 127
LEU A  42
 None
 1.05A 3vywA-4rotA:
undetectable		 3vywA-4rotA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA

(Deinococcus
radiodurans) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 GLY A  47
LEU A  18
ASN A  49
GLU A  37
PHE A 120
 None
 1.07A 3vywA-4trtA:
undetectable		 3vywA-4trtA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 GLY A  72
GLY A  74
LEU A 167
GLU A  43
LEU A  93
 None
None
None
NA  A1338 (-3.2A)
None
 1.11A 3vywA-4us5A:
undetectable		 3vywA-4us5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 248
LEU A 249
TYR A  17
ALA A 179
LEU A 228
 PEG  A 503 ( 4.4A)
PEG  A 503 ( 4.7A)
None
None
None
 1.17A 3vywA-4wyrA:
undetectable		 3vywA-4wyrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		5 GLY A  52
LEU A  35
ASN A 221
ALA A 152
LEU A 124
 None
None
None
None
HEM  A 304 (-4.0A)
 1.12A 3vywA-4ybnA:
undetectable		 3vywA-4ybnA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 TYR A 389
GLY A 280
GLY A 283
LYS A 273
GLU A 378
 None
 1.18A 3vywA-4yhjA:
undetectable		 3vywA-4yhjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		5 GLY B 345
LEU B 299
TYR B 290
GLU B 236
LEU B 110
 None
 1.10A 3vywA-4ztuB:
undetectable		 3vywA-4ztuB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b26 PROTEIN SEL-1
HOMOLOG 1

(Mus musculus) 		PF08238
(Sel1) 		5 GLY A 448
GLY A 450
LEU A 454
TYR A 455
ALA A 437
 None
 1.16A 3vywA-5b26A:
undetectable		 3vywA-5b26A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		5 GLY A 311
GLY A 309
TYR A 420
ALA A 254
LEU A 318
 None
 1.17A 3vywA-5b2dA:
undetectable		 3vywA-5b2dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		5 GLY B 345
LEU B 299
TYR B 290
GLU B 236
LEU B 110
 None
 1.11A 3vywA-5c53B:
undetectable		 3vywA-5c53B:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 GLY A  51
LEU A 133
ALA A  89
PHE A  85
LEU A  87
 None
 1.11A 3vywA-5gw7A:
undetectable		 3vywA-5gw7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 TYR A  35
GLY A  67
GLY A   9
ALA A 267
LEU A  65
 None
 1.07A 3vywA-5hn4A:
undetectable		 3vywA-5hn4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 GLY A  83
GLY A  87
GLU A  54
ALA A  70
LEU A  67
 None
 1.13A 3vywA-5kt0A:
2.3		 3vywA-5kt0A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvy ADHESIN PROTEIN

(Escherichia
coli) 		no annotation 5 GLY A  80
TYR A  33
ASN A  35
PHE A  54
LEU A  13
 None
 1.11A 3vywA-5lvyA:
undetectable		 3vywA-5lvyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 TYR A  82
GLY A 146
GLY A   6
GLU A   8
ALA A  34
 None
 1.10A 3vywA-5mrrA:
undetectable		 3vywA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 TYR A  86
GLY A 151
GLY A   6
GLU A   8
ALA A  38
 None
 1.03A 3vywA-5mrtA:
undetectable		 3vywA-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 177
GLY A 472
LEU A 475
ALA A 223
LEU A 231
 None
 1.10A 3vywA-5nd5A:
2.7		 3vywA-5nd5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 5 TYR A 243
GLY A 244
ASN A 105
ALA A 259
LEU A 300
 None
 1.02A 3vywA-5nxnA:
undetectable		 3vywA-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 5 TYR A 295
TYR A 252
GLY A 337
GLY A 253
PHE A 332
 None
 0.76A 3vywA-5nxnA:
undetectable		 3vywA-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 GLY C 411
GLY C 442
LEU C 443
TYR C 419
LEU C 291
 None
 1.09A 3vywA-5o4gC:
undetectable		 3vywA-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 TYR A 560
GLY A 454
GLY A 460
LEU A 101
ALA A 501
 None
 1.11A 3vywA-5oynA:
undetectable		 3vywA-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 GLY A  19
GLY A  17
LEU A  16
GLU A 170
LEU A 174
 None
 1.18A 3vywA-5tkfA:
undetectable		 3vywA-5tkfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		5 TYR A 191
TYR A 103
ALA A 177
PHE A 150
LEU A 144
 None
 1.06A 3vywA-5uncA:
undetectable		 3vywA-5uncA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		5 GLY A 155
GLY A 150
LEU A  62
GLU A  68
LEU A 238
 None
 1.18A 3vywA-5volA:
undetectable		 3vywA-5volA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 5 TYR A 467
GLY A 476
LEU A 475
ALA A 595
LEU A 421
 None
 1.00A 3vywA-6b5vA:
undetectable		 3vywA-6b5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 TYR L 322
GLY L 302
GLU L 305
ALA L 381
PHE L 370
 None
 1.16A 3vywA-6ehsL:
undetectable		 3vywA-6ehsL:
undetectable