SIMILAR PATTERNS OF AMINO ACIDS FOR 3VWQ_A_ACAA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR

(Escherichia
coli) 		PF12849
(PBP_like_2) 		5 ALA A  54
TYR A 281
TYR A  33
GLY A  53
ILE A 258
 None
 1.33A 3vwqA-1a40A:
0.0		 3vwqA-1a40A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 MET A 240
ALA A 239
SER A 247
ASN A 236
GLY A 212
 ADP  A4000 (-4.0A)
None
K  A4003 (-2.7A)
K  A4003 (-3.9A)
None
 1.41A 3vwqA-1c30A:
0.0		 3vwqA-1c30A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H

(Streptomyces
plicatus) 		PF00704
(Glyco_hydro_18) 		5 ALA A 174
TYR A  14
ASP A 128
GLY A 171
ILE A 170
 ALA  A 174 ( 0.0A)
TYR  A  14 (-1.3A)
ASP  A 128 ( 0.5A)
GLY  A 171 ( 0.0A)
ILE  A 170 ( 0.7A)
 1.20A 3vwqA-1c8xA:
undetectable		 3vwqA-1c8xA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ALA A  75
SER A  39
ASN A  71
GLY A  45
ILE A  44
 None
None
PLP  A 501 ( 3.9A)
None
None
 1.10A 3vwqA-1d6sA:
0.0		 3vwqA-1d6sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 ALA A 161
TYR A  40
TYR A 118
PHE A 218
GLY A 162
 EPE  A 455 (-3.4A)
None
None
EPE  A 455 ( 4.9A)
None
 1.13A 3vwqA-1jjiA:
0.0		 3vwqA-1jjiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.38A 3vwqA-1mg1A:
0.0		 3vwqA-1mg1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 5 ALA P 230
TYR P  16
TYR P 209
ASN P 233
GLY P 227
 None
 1.35A 3vwqA-1r6zP:
0.0		 3vwqA-1r6zP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ALA B 263
TYR B 281
ASP B 224
GLY B 264
ILE B 265
 None
 1.30A 3vwqA-1tyeB:
undetectable		 3vwqA-1tyeB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.35A 3vwqA-1y4cA:
0.0		 3vwqA-1y4cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 MET A 262
ALA A 260
TYR A 215
PHE A 269
GLY A 258
 None
 1.05A 3vwqA-2bxyA:
undetectable		 3vwqA-2bxyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 ALA A 254
TRP A 310
SER A 326
ASN A 178
GLY A 253
 None
 1.50A 3vwqA-2hihA:
undetectable		 3vwqA-2hihA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9i RHAMNULOSE-1-PHOSPHA
TE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 MET A 140
ASP A  26
ASN A  32
GLY A 216
ILE A 228
 None
 1.43A 3vwqA-2v9iA:
undetectable		 3vwqA-2v9iA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
None
None
SO4  A1467 (-3.5A)
None
 1.37A 3vwqA-2vgqA:
undetectable		 3vwqA-2vgqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 ALA A 257
TYR A  43
TYR A 236
ASN A 260
GLY A 254
 None
 1.36A 3vwqA-2xz3A:
undetectable		 3vwqA-2xz3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 5 ALA X  54
TYR X 281
TYR X  33
GLY X  53
ILE X 258
 None
 1.33A 3vwqA-2z22X:
undetectable		 3vwqA-2z22X:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus) 		PF13714
(PEP_mutase) 		5 ALA A 226
PHE A 186
ASN A 208
GLY A 225
ILE A 196
 None
AKG  A 276 ( 4.8A)
None
None
None
 1.48A 3vwqA-2ze3A:
undetectable		 3vwqA-2ze3A:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		7 MET A 111
LYS A 115
TRP A 186
TYR A 215
SER A 217
GLY A 344
ILE A 345
 MES  A 504 (-3.8A)
MES  A 504 (-3.1A)
MES  A 504 (-4.0A)
GOL  A 505 ( 4.4A)
MES  A 504 ( 2.7A)
MES  A 501 (-3.5A)
MES  A 504 ( 3.7A)
 0.19A 3vwqA-2zm2A:
68.6		 3vwqA-2zm2A:
97.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		7 MET A 111
LYS A 115
TYR A 170
TYR A 215
SER A 217
GLY A 344
ILE A 345
 MES  A 504 (-3.8A)
MES  A 504 (-3.1A)
None
GOL  A 505 ( 4.4A)
MES  A 504 ( 2.7A)
MES  A 501 (-3.5A)
MES  A 504 ( 3.7A)
 1.46A 3vwqA-2zm2A:
68.6		 3vwqA-2zm2A:
97.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxv SULFUR
OXYGENASE/REDUCTASE

(Acidianus
tengchongensis) 		PF07682
(SOR) 		5 ALA A 190
TYR A 121
ASP A 123
TYR A 273
GLY A 263
 None
 1.44A 3vwqA-3bxvA:
undetectable		 3vwqA-3bxvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 MET A 352
ALA A 351
PHE A 392
GLY A 329
ILE A 328
 None
 1.36A 3vwqA-3ce6A:
undetectable		 3vwqA-3ce6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 MET A 322
TYR A 300
PHE A 330
GLY A 318
ILE A 629
 None
 1.44A 3vwqA-3cihA:
undetectable		 3vwqA-3cihA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		5 ALA A  13
TYR A 100
TYR A  89
GLY A  12
ILE A  16
 FAD  A 500 (-3.5A)
None
None
FAD  A 500 (-3.5A)
None
 1.37A 3vwqA-3d1cA:
undetectable		 3vwqA-3d1cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		5 MET D 184
ALA D 171
SER D 166
ASN D 164
GLY D 172
 CYG  D  86 ( 3.4A)
None
None
None
None
 1.35A 3vwqA-3d54D:
undetectable		 3vwqA-3d54D:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 176
ASP A 174
PHE A 238
ASN A 231
ILE A 505
 None
None
None
None
CU  A 601 ( 4.0A)
 1.40A 3vwqA-3dkhA:
undetectable		 3vwqA-3dkhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.32A 3vwqA-3f5fA:
undetectable		 3vwqA-3f5fA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g69 SORTASE C

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 MET A 124
ALA A 137
TYR A 191
GLY A 138
ILE A 156
 None
 1.47A 3vwqA-3g69A:
undetectable		 3vwqA-3g69A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
NA  A1216 ( 4.4A)
None
None
None
 1.32A 3vwqA-3h4zA:
undetectable		 3vwqA-3h4zA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 ALA A 969
TYR A 755
TYR A 948
ASN A 972
GLY A 966
 None
 1.39A 3vwqA-3mp6A:
undetectable		 3vwqA-3mp6A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ALA A-139
TYR A-353
TYR A-160
ASN A-136
GLY A-142
 None
 1.39A 3vwqA-3n93A:
undetectable		 3vwqA-3n93A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ALA A-117
TYR A-331
TYR A-138
ASN A-114
GLY A-120
 None
 1.38A 3vwqA-3n94A:
undetectable		 3vwqA-3n94A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 ALA N 231
TYR N  17
TYR N 210
ASN N 234
GLY N 228
 None
 1.35A 3vwqA-3o3uN:
undetectable		 3vwqA-3o3uN:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.36A 3vwqA-3oaiA:
undetectable		 3vwqA-3oaiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
None
None
SO4  A1159 (-3.2A)
None
 1.31A 3vwqA-3ob4A:
undetectable		 3vwqA-3ob4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 ALA A 479
TYR A  17
TYR A 458
ASN A 482
GLY A 476
 None
 1.37A 3vwqA-3osqA:
undetectable		 3vwqA-3osqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.35A 3vwqA-3osrA:
undetectable		 3vwqA-3osrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 177
ASP A 175
PHE A 239
ASN A 232
ILE A 506
 None
None
None
None
CU  A 601 ( 4.1A)
 1.44A 3vwqA-3ppsA:
undetectable		 3vwqA-3ppsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.32A 3vwqA-3py7A:
undetectable		 3vwqA-3py7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr2 CYSTEINE SYNTHASE

(Mycobacterium
marinum) 		PF00291
(PALP) 		5 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.21A 3vwqA-3rr2A:
undetectable		 3vwqA-3rr2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  57
ASP A 247
ASN A  59
GLY A  28
ILE A  25
 None
 1.28A 3vwqA-3s5sA:
undetectable		 3vwqA-3s5sA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl1 POLYKETIDE CYCLASE

(Streptomyces
coelicolor) 		PF03364
(Polyketide_cyc) 		5 MET A 137
ALA A 138
TYR A  97
PHE A  32
ILE A   9
 None
 1.48A 3vwqA-3tl1A:
undetectable		 3vwqA-3tl1A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		5 ALA B 166
SER B 163
PHE B 116
GLY B 148
ILE B 139
 None
 1.50A 3vwqA-3u1jB:
undetectable		 3vwqA-3u1jB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.34A 3vwqA-3vd8A:
undetectable		 3vwqA-3vd8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
None
PLP  A1301 (-3.8A)
None
None
 1.16A 3vwqA-3zeiA:
undetectable		 3vwqA-3zeiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.48A 3vwqA-4edqA:
undetectable		 3vwqA-4edqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.37A 3vwqA-4egcA:
undetectable		 3vwqA-4egcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.31A 3vwqA-4exkA:
undetectable		 3vwqA-4exkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		5 ASP A  45
TYR A 117
SER A 116
GLY A  64
ILE A 184
 None
 1.48A 3vwqA-4gl8A:
undetectable		 3vwqA-4gl8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 ALA A-139
TYR A-353
TYR A-160
ASN A-136
GLY A-142
 None
 1.36A 3vwqA-4h1gA:
undetectable		 3vwqA-4h1gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A  16
SER A  20
ASN A 428
GLY A  82
ILE A  81
 None
 1.31A 3vwqA-4ha4A:
undetectable		 3vwqA-4ha4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		5 ALA A 179
TYR A 256
ASN A 216
GLY A 180
ILE A 183
 None
 1.36A 3vwqA-4houA:
undetectable		 3vwqA-4houA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.37A 3vwqA-4ifpA:
undetectable		 3vwqA-4ifpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.29A 3vwqA-4irlA:
undetectable		 3vwqA-4irlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.06A 3vwqA-4li3X:
undetectable		 3vwqA-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lma CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.09A 3vwqA-4lmaA:
undetectable		 3vwqA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa) 		PF00291
(PALP) 		5 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.12A 3vwqA-4lmbA:
undetectable		 3vwqA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.36A 3vwqA-4pe2A:
undetectable		 3vwqA-4pe2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 3vwqA-4pqkA:
undetectable		 3vwqA-4pqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		5 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.30A 3vwqA-4qfhA:
undetectable		 3vwqA-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql9 ALKYLHYDROPEROXIDE
REDUCTASE SUBUNIT C

(Escherichia
coli) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ALA A  90
TYR A  39
ASP A  42
SER A  86
ILE A  92
 None
 1.23A 3vwqA-4ql9A:
undetectable		 3vwqA-4ql9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.36A 3vwqA-4qvhA:
undetectable		 3vwqA-4qvhA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 ALA A 233
TYR A  19
TYR A 212
ASN A 236
GLY A 230
 None
EDO  A2203 (-3.4A)
None
None
None
 1.34A 3vwqA-4rwfA:
undetectable		 3vwqA-4rwfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.32A 3vwqA-4tsmA:
undetectable		 3vwqA-4tsmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ALA B 266
TYR B 284
ASP B 227
GLY B 267
ILE B 268
 None
 1.28A 3vwqA-4um8B:
undetectable		 3vwqA-4um8B:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 ALA A 237
TYR A  23
TYR A 216
ASN A 240
GLY A 234
 None
 1.41A 3vwqA-4wviA:
undetectable		 3vwqA-4wviA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.37A 3vwqA-4xa2A:
undetectable		 3vwqA-4xa2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.33A 3vwqA-5c7rA:
undetectable		 3vwqA-5c7rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 ALA A  57
PHE A 274
ASN A 291
GLY A 347
ILE A  59
 None
 1.42A 3vwqA-5cerA:
12.0		 3vwqA-5cerA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Acinetobacter
nosocomialis;
Escherichia
coli) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.36A 3vwqA-5cfvA:
undetectable		 3vwqA-5cfvA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxo EPOXIDE HYDROLASE

(Streptomyces
albus) 		PF12680
(SnoaL_2) 		5 MET A  87
ALA A  61
ASP A  38
SER A  57
ASN A  58
 P6G  A 202 (-3.1A)
None
P6G  A 202 (-3.8A)
P6G  A 202 (-3.2A)
P6G  A 202 (-3.2A)
 1.11A 3vwqA-5cxoA:
undetectable		 3vwqA-5cxoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
SO4  A 606 (-4.5A)
None
None
None
 1.39A 3vwqA-5dfmA:
undetectable		 3vwqA-5dfmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA B 339
TYR B 125
TYR B 318
ASN B 342
GLY B 336
 None
 1.36A 3vwqA-5eduB:
undetectable		 3vwqA-5eduB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffo INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta) 		5 ALA B 266
TYR B 284
ASP B 227
GLY B 267
ILE B 268
 None
 1.18A 3vwqA-5ffoB:
undetectable		 3vwqA-5ffoB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 ALA A-141
TYR A-355
TYR A-162
ASN A-138
GLY A-144
 None
 1.36A 3vwqA-5fsgA:
undetectable		 3vwqA-5fsgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.32A 3vwqA-5gpqA:
undetectable		 3vwqA-5gpqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.36A 3vwqA-5h7nA:
undetectable		 3vwqA-5h7nA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.30A 3vwqA-5hz7A:
undetectable		 3vwqA-5hz7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ALA A 598
TYR A 384
TYR A 577
ASN A 601
GLY A 595
 None
 1.33A 3vwqA-5hzvA:
undetectable		 3vwqA-5hzvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 ALA A3898
TYR A3684
TYR A3877
ASN A3901
GLY A3895
 None
 1.39A 3vwqA-5ii5A:
undetectable		 3vwqA-5ii5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 MET A 273
TYR A 293
SER A 593
GLY A 277
ILE A 280
 None
 1.32A 3vwqA-5iq6A:
undetectable		 3vwqA-5iq6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA C 231
TYR C  17
TYR C 210
ASN C 234
GLY C 228
 None
 1.31A 3vwqA-5jj4C:
undetectable		 3vwqA-5jj4C:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		5 ALA A  25
TYR A 109
ASP A  79
GLY A  51
ILE A  52
 None
 1.41A 3vwqA-5k9xA:
undetectable		 3vwqA-5k9xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 MET A 554
ALA A 553
ASN A 490
GLY A 565
ILE A 551
 None
None
ZN  A 805 ( 4.8A)
None
None
 1.40A 3vwqA-5m11A:
undetectable		 3vwqA-5m11A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 ALA A 337
TYR A 472
TRP A 497
SER A 492
GLY A 338
 None
 0.99A 3vwqA-5mqpA:
undetectable		 3vwqA-5mqpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ALA B 263
TYR B 281
ASP B 224
GLY B 264
ILE B 265
 None
 1.30A 3vwqA-5nemB:
undetectable		 3vwqA-5nemB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.36A 3vwqA-5osqA:
undetectable		 3vwqA-5osqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
EDO  A1418 ( 4.0A)
None
None
None
 1.32A 3vwqA-5t03A:
undetectable		 3vwqA-5t03A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.34A 3vwqA-5tj2A:
undetectable		 3vwqA-5tj2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 ALA A 237
TYR A  23
TYR A 216
ASN A 240
GLY A 234
 None
 1.35A 3vwqA-5ttdA:
undetectable		 3vwqA-5ttdA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.39A 3vwqA-5wq6A:
undetectable		 3vwqA-5wq6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		5 TYR A 174
ASP A 270
PHE A 402
ASN A 431
ILE A 427
 None
 1.28A 3vwqA-5wrrA:
undetectable		 3vwqA-5wrrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3vwqA-5xa2A:
undetectable		 3vwqA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 5 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.34A 3vwqA-5z0rA:
undetectable		 3vwqA-5z0rA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 5 ALA A 311
TYR A  97
TYR A 290
ASN A 314
GLY A 308
 None
None
PEG  A 509 (-3.6A)
PEG  A 509 (-4.0A)
None
 1.35A 3vwqA-6anvA:
undetectable		 3vwqA-6anvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 5 ALA A 181
TYR A 258
ASN A 218
GLY A 182
ILE A 185
 None
U  E   3 ( 4.4A)
None
None
None
 1.27A 3vwqA-6c6kA:
undetectable		 3vwqA-6c6kA:
10.96