SIMILAR PATTERNS OF AMINO ACIDS FOR 3VW7_A_VPXA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		5 HIS A4066
LEU A2010
LEU A2013
ALA A2082
TYR A2083
 None
 1.09A 3vw7A-1914A:
0.0		 3vw7A-1914A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 LEU A 167
PHE A  31
LEU A 121
ALA A 129
ALA A 133
 None
 0.97A 3vw7A-1am5A:
0.0		 3vw7A-1am5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		5 LEU A 583
LEU A 567
LEU A 596
ALA A 517
ALA A 519
 None
 1.10A 3vw7A-1ciiA:
0.0		 3vw7A-1ciiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		6 TYR A 180
LEU A 561
LEU A 599
LEU A 602
ALA A 168
TYR A 172
 None
 1.47A 3vw7A-1d6mA:
0.0		 3vw7A-1d6mA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 402
LEU A 131
LEU A 134
ALA A 368
ALA A 371
 None
 1.10A 3vw7A-1gwiA:
0.0		 3vw7A-1gwiA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 TYR A  33
HIS A  15
LEU A 243
LEU A 266
ALA A 250
 10A  A1901 ( 3.5A)
None
None
None
None
 1.06A 3vw7A-1kphA:
undetectable		 3vw7A-1kphA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqk PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN

(Pseudomonas
aeruginosa) 		PF00903
(Glyoxalase) 		5 TYR A  22
LEU A  47
PHE A  67
LEU A 102
LEU A 109
 None
 0.87A 3vw7A-1lqkA:
0.0		 3vw7A-1lqkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 HIS A   7
LEU A 366
LEU A 422
ALA A 430
ALA A 428
 None
 1.16A 3vw7A-1musA:
0.0		 3vw7A-1musA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		5 LEU A 268
LEU A 253
ALA A 197
ALA A 196
TYR A 195
 None
 1.10A 3vw7A-1rdrA:
undetectable		 3vw7A-1rdrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 LEU A  24
LEU A 134
LEU A 131
ALA A  67
ALA A  71
 None
None
None
HEM  A 144 (-3.4A)
None
 1.07A 3vw7A-1spgA:
undetectable		 3vw7A-1spgA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 TYR A  33
HIS A  15
LEU A 243
LEU A 266
ALA A 250
 16A  A1901 ( 3.5A)
None
None
None
None
 1.09A 3vw7A-1tpyA:
undetectable		 3vw7A-1tpyA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A  14
LEU A  32
LEU A  35
ALA A  65
ALA A  67
 None
 1.03A 3vw7A-1tuoA:
undetectable		 3vw7A-1tuoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		5 LEU A  67
PHE A  37
LEU A  42
TYR A  38
ALA A  55
 None
None
BRF  A1397 (-4.6A)
None
BRF  A1397 (-3.2A)
 1.09A 3vw7A-1uuoA:
undetectable		 3vw7A-1uuoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		5 LEU A 154
LEU A 180
LEU A 179
ALA A 207
ALA A 210
 None
 1.13A 3vw7A-1z9aA:
undetectable		 3vw7A-1z9aA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb1 BRO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF03097
(BRO1) 		5 LEU A 292
LEU A 191
PHE A   6
LEU A 216
ALA A 212
 None
 1.07A 3vw7A-1zb1A:
2.4		 3vw7A-1zb1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 PHE A 134
LEU A 142
LEU A 138
TYR A 135
ALA A 184
 None
 1.06A 3vw7A-1zl9A:
undetectable		 3vw7A-1zl9A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 224
LEU A 198
LEU A 201
ALA A 328
ALA A 332
 None
 1.00A 3vw7A-2ag1A:
undetectable		 3vw7A-2ag1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6s CELL FILAMENTATION
PROTEIN, PUTATIVE

(Helicobacter
pylori) 		PF02661
(Fic) 		5 TYR A  89
LEU A 149
LEU A 150
ALA A 131
TYR A 132
 None
 0.78A 3vw7A-2f6sA:
undetectable		 3vw7A-2f6sA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 LEU A 384
LEU A 463
ALA A 451
ALA A 373
TYR A 374
 None
 1.10A 3vw7A-2gj4A:
undetectable		 3vw7A-2gj4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		5 TYR A  61
LEU A 206
PHE A 234
LEU A 424
ALA A 410
 None
 1.16A 3vw7A-2higA:
undetectable		 3vw7A-2higA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 HIS A  67
LEU A  26
LEU A  30
TYR A  35
ALA A  17
 None
 1.07A 3vw7A-2i3aA:
undetectable		 3vw7A-2i3aA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		5 LEU 1 451
LEU 1 436
ALA 1 380
ALA 1 379
TYR 1 378
 None
 1.01A 3vw7A-2ijd1:
undetectable		 3vw7A-2ijd1:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5t UNCHARACTERIZED
PROTEIN YHHK

(Escherichia
coli) 		PF12568
(DUF3749) 		5 LEU A  63
LEU A   8
ALA A  51
ALA A  41
TYR A  40
 None
 1.07A 3vw7A-2k5tA:
undetectable		 3vw7A-2k5tA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 LEU A 727
LEU A 676
LEU A 712
ALA A 486
ALA A 485
 None
 1.17A 3vw7A-2odpA:
undetectable		 3vw7A-2odpA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		5 TYR A  23
LEU A  54
LEU A  74
PHE A  79
LEU A 122
 None
 1.17A 3vw7A-2p25A:
undetectable		 3vw7A-2p25A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A  82
LEU A 259
ALA A 286
ALA A 285
TYR A 318
 None
 1.12A 3vw7A-2p2mA:
undetectable		 3vw7A-2p2mA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Geobacillus
stearothermophilus) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A 372
LEU A 388
LEU A 195
TYR A 327
ALA A 425
 None
 0.97A 3vw7A-2w8zA:
undetectable		 3vw7A-2w8zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A  56
PHE A  99
LEU A 108
LEU A 105
TYR A 102
 None
 1.13A 3vw7A-2wrdA:
undetectable		 3vw7A-2wrdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  36
LEU A   4
LEU A   5
ALA A  16
ALA A  20
 None
 1.09A 3vw7A-2yquA:
undetectable		 3vw7A-2yquA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A 203
LEU A 283
ALA A 254
ALA A 257
TYR A 258
 None
 1.17A 3vw7A-2yzmA:
undetectable		 3vw7A-2yzmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A 283
TYR A 295
ALA A 254
ALA A 257
TYR A 258
 None
 0.97A 3vw7A-2yzmA:
undetectable		 3vw7A-2yzmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG

(Escherichia
coli) 		PF05368
(NmrA) 		5 LEU A 256
LEU A  11
ALA A 178
ALA A 175
TYR A 174
 None
NDP  A 400 (-4.0A)
None
None
None
 1.05A 3vw7A-2zcvA:
undetectable		 3vw7A-2zcvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A 371
LEU A 387
LEU A 196
TYR A 326
ALA A 424
 None
 1.03A 3vw7A-2zygA:
undetectable		 3vw7A-2zygA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zym SOLUTE-BINDING
PROTEIN

(Thermoactinomyces
vulgaris) 		PF13416
(SBP_bac_8) 		5 TYR A 147
LEU A 150
PHE A 179
LEU A 180
ALA A 371
 None
 1.17A 3vw7A-2zymA:
undetectable		 3vw7A-2zymA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a75 GAMMA-GLUTAMYLTRANSP
EPTIDASE LARGE CHAIN

(Bacillus
subtilis) 		PF01019
(G_glu_transpept) 		5 LEU A 249
PHE A 229
LEU A 225
ALA A 202
ALA A 203
 None
 1.03A 3vw7A-3a75A:
undetectable		 3vw7A-3a75A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		5 PHE A 100
LEU A 104
TYR A 101
ALA A 116
TYR A  76
 None
 1.01A 3vw7A-3ahxA:
undetectable		 3vw7A-3ahxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 LEU A  89
LEU A 315
LEU A 314
ALA A  95
ALA A  99
 None
 1.12A 3vw7A-3d8uA:
undetectable		 3vw7A-3d8uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1

(Streptococcus
pneumoniae) 		PF01625
(PMSR)
PF01641
(SelR) 		5 LEU A 242
LEU A 290
LEU A 310
LEU A 306
TYR A 303
 None
 1.17A 3vw7A-3e0mA:
undetectable		 3vw7A-3e0mA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpd HYDROXYETHYLTHIAZOLE
KINASE

(Pyrococcus
horikoshii) 		PF02110
(HK) 		5 LEU A 187
LEU A  37
LEU A 246
TYR A 243
ALA A 203
 None
 1.02A 3vw7A-3hpdA:
undetectable		 3vw7A-3hpdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 263
LEU P 249
LEU P 277
LEU P 274
ALA P 221
 None
 1.04A 3vw7A-3j9tP:
undetectable		 3vw7A-3j9tP:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 TYR A  41
LEU A 332
LEU A  84
LEU A  11
ALA A  90
 None
1ZZ  A 589 (-4.6A)
None
None
None
 1.17A 3vw7A-3kxwA:
undetectable		 3vw7A-3kxwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8r PUTATIVE PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIA COMPONENT

(Streptococcus
mutans) 		PF02255
(PTS_IIA) 		5 HIS A  54
LEU A  60
LEU A  61
ALA A  10
ALA A   9
 None
 1.16A 3vw7A-3l8rA:
undetectable		 3vw7A-3l8rA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 LEU A 163
LEU A 122
PHE A  89
LEU A 174
ALA A  41
 None
 1.08A 3vw7A-3m8uA:
undetectable		 3vw7A-3m8uA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 415
LEU A 427
PHE A 445
LEU A 270
LEU A 267
 None
 1.06A 3vw7A-3mtlA:
2.2		 3vw7A-3mtlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n00 REV-ERBA-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 592
LEU A 527
PHE A 585
LEU A 570
ALA A 293
 None
 1.07A 3vw7A-3n00A:
undetectable		 3vw7A-3n00A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 LEU A 339
LEU A 223
TYR A 220
ALA A 228
TYR A 225
 None
None
LLP  A 252 ( 3.7A)
GOL  A 519 (-3.3A)
None
 1.05A 3vw7A-3nraA:
undetectable		 3vw7A-3nraA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		5 LEU A 141
LEU A 142
TYR A 147
ALA A  21
ALA A  25
 None
 1.05A 3vw7A-3nxsA:
undetectable		 3vw7A-3nxsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 LEU A 268
LEU A 232
PHE A 255
LEU A 251
ALA A 187
 None
 1.10A 3vw7A-3o75A:
undetectable		 3vw7A-3o75A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 LEU A 473
LEU A 500
LEU A 503
ALA A 494
ALA A 492
 None
 1.13A 3vw7A-3sfzA:
undetectable		 3vw7A-3sfzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		5 LEU A 225
LEU A 117
PHE A  -2
LEU A 190
ALA A 161
 None
 1.14A 3vw7A-3umcA:
undetectable		 3vw7A-3umcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw1 PUTATIVE REGULATORY
PROTEIN

(Salmonella
enterica) 		PF00440
(TetR_N) 		5 LEU A  97
LEU A  62
LEU A  66
ALA A 101
ALA A 105
 None
None
None
SO4  A 201 (-3.4A)
None
 1.11A 3vw7A-3vw1A:
undetectable		 3vw7A-3vw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmd PROBABLE MONENSIN
BIOSYNTHESIS
ISOMERASE

(Streptomyces
cinnamonensis) 		PF12680
(SnoaL_2) 		5 TYR A  54
HIS A  13
LEU A  35
ALA A  30
TYR A  29
 None
 1.14A 3vw7A-3wmdA:
undetectable		 3vw7A-3wmdA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		5 LEU A 213
LEU A  10
LEU A  30
ALA A 156
ALA A 159
 None
 0.84A 3vw7A-3wvoA:
undetectable		 3vw7A-3wvoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		5 PHE A  34
LEU A  10
LEU A  30
ALA A 156
ALA A 159
 None
 0.99A 3vw7A-3wvoA:
undetectable		 3vw7A-3wvoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 860
LEU A 847
ALA A 633
ALA A 854
TYR A 853
 None
 1.14A 3vw7A-3zifA:
undetectable		 3vw7A-3zifA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		6 TYR A 116
PHE A 301
LEU A 102
LEU A 103
ALA A 338
ALA A 337
 None
 1.50A 3vw7A-4a6uA:
undetectable		 3vw7A-4a6uA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 LEU A  60
LEU A 113
LEU A  79
ALA A 130
ALA A 133
 MIY  A1204 ( 4.9A)
MIY  A1204 (-4.9A)
None
None
None
 1.07A 3vw7A-4ac0A:
undetectable		 3vw7A-4ac0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		5 LEU A  25
LEU A  39
LEU A  83
ALA A 106
TYR A  28
 None
 1.09A 3vw7A-4d2iA:
undetectable		 3vw7A-4d2iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 TYR L 124
LEU L 176
LEU L 263
LEU L 252
ALA L 310
 None
 1.16A 3vw7A-4heaL:
3.0		 3vw7A-4heaL:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A   6
LEU A  79
LEU A  37
LEU A  50
ALA A  26
 None
 1.09A 3vw7A-4hk1A:
undetectable		 3vw7A-4hk1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		5 LEU A 254
LEU A 130
LEU A 133
ALA A 370
ALA A 373
 None
 1.17A 3vw7A-4j6cA:
undetectable		 3vw7A-4j6cA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		5 LEU A  87
PHE A  60
LEU A  16
ALA A  34
ALA A  38
 None
 1.09A 3vw7A-4jfcA:
undetectable		 3vw7A-4jfcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 339
LEU A 303
LEU A 325
ALA A 267
ALA A 263
 None
 1.03A 3vw7A-4k17A:
undetectable		 3vw7A-4k17A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 PHE A 677
LEU A 693
LEU A 690
ALA A 578
ALA A 581
 None
 1.04A 3vw7A-4nmeA:
undetectable		 3vw7A-4nmeA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		5 LEU A 313
LEU A  64
LEU A  44
ALA A 303
TYR A 306
 None
 1.08A 3vw7A-4ns4A:
undetectable		 3vw7A-4ns4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		5 LEU A 531
TYR A 528
ALA A 570
ALA A 536
TYR A 535
 None
 1.08A 3vw7A-4oe1A:
undetectable		 3vw7A-4oe1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omj SEC14-LIKE PROTEIN 2

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		5 TYR A 153
LEU A 189
PHE A 198
ALA A 167
TYR A 171
 2TX  A 310 (-4.3A)
2TX  A 310 (-4.8A)
2TX  A 310 (-4.7A)
2TX  A 310 (-3.9A)
2TX  A 310 (-4.1A)
 1.17A 3vw7A-4omjA:
undetectable		 3vw7A-4omjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		5 LEU A 208
LEU A 290
LEU A 185
ALA A 156
ALA A 165
 None
 1.13A 3vw7A-4ou4A:
undetectable		 3vw7A-4ou4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozv ALGINATE LYASE

(Pseudomonas
aeruginosa) 		PF05426
(Alginate_lyase) 		5 LEU A 264
LEU A 261
TYR A 328
ALA A 234
ALA A 233
 None
 1.04A 3vw7A-4ozvA:
undetectable		 3vw7A-4ozvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 LEU A 421
LEU A 460
LEU A 461
ALA A  59
ALA A 412
 None
 1.00A 3vw7A-4qs9A:
undetectable		 3vw7A-4qs9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 LEU A1245
LEU A1382
ALA A1299
ALA A1302
TYR A1303
 None
 1.13A 3vw7A-4u48A:
undetectable		 3vw7A-4u48A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp6 MRNA EXPORT PROTEIN

(Chaetomium
thermophilum) 		PF14580
(LRR_9) 		5 TYR A 253
LEU A 286
LEU A 268
LEU A 200
LEU A 204
 None
 1.14A 3vw7A-4wp6A:
undetectable		 3vw7A-4wp6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yl6 MALCAVERNIN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3

(Homo sapiens) 		PF16545
(CCM2_C)
no annotation 		5 LEU A 338
LEU A 310
LEU A 299
LEU B  14
TYR A 302
 None
 1.12A 3vw7A-4yl6A:
undetectable		 3vw7A-4yl6A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 LEU A  22
LEU A  10
LEU A  96
LEU A  91
ALA A 279
 None
None
None
None
NAP  A 401 (-4.0A)
 1.16A 3vw7A-4zqbA:
undetectable		 3vw7A-4zqbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 5 LEU A 244
LEU A 221
LEU A 218
ALA A 225
ALA A 176
 None
 1.14A 3vw7A-5b01A:
5.1		 3vw7A-5b01A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		5 LEU A 702
LEU A 574
ALA A 694
ALA A 692
TYR A 696
 None
 1.13A 3vw7A-5bv9A:
undetectable		 3vw7A-5bv9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		5 LEU A 145
LEU A 125
LEU A 137
TYR A 176
TYR A  90
 None
 1.15A 3vw7A-5diyA:
3.0		 3vw7A-5diyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 TYR A 151
LEU A 141
PHE A 374
LEU A 172
ALA A  57
 None
 1.16A 3vw7A-5du9A:
undetectable		 3vw7A-5du9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		5 TYR A 351
LEU A 397
LEU A 466
PHE A 326
ALA A 430
 None
 0.86A 3vw7A-5ed7A:
undetectable		 3vw7A-5ed7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		5 LEU A 411
LEU A 263
LEU A 203
ALA A 150
ALA A 153
 None
 1.15A 3vw7A-5gweA:
1.5		 3vw7A-5gweA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 TYR A 565
LEU A 343
HIS A 607
LEU A1003
ALA A 600
 None
 1.03A 3vw7A-5h42A:
undetectable		 3vw7A-5h42A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 TYR A 136
LEU A 203
LEU A 179
ALA A 257
ALA A 194
 None
 1.17A 3vw7A-5jd5A:
undetectable		 3vw7A-5jd5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		5 LEU A 274
LEU A 346
ALA A 172
ALA A 174
TYR A 175
 None
 1.10A 3vw7A-5jr3A:
undetectable		 3vw7A-5jr3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		5 LEU A  67
PHE A  37
LEU A  42
TYR A  38
ALA A  55
 None
None
None
None
U91  A 403 (-3.6A)
 1.01A 3vw7A-5mvdA:
undetectable		 3vw7A-5mvdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		5 TYR A 160
HIS A 227
LEU A 306
LEU A 307
TYR A 326
 None
 1.12A 3vw7A-5ndzA:
18.7		 3vw7A-5ndzA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		5 TYR A 160
PHE A 243
LEU A 306
LEU A 307
TYR A 311
 None
 1.05A 3vw7A-5ndzA:
18.7		 3vw7A-5ndzA:
28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 LEU A 479
LEU A 320
LEU A 353
ALA A 328
ALA A 332
 None
 1.09A 3vw7A-5nh1A:
undetectable		 3vw7A-5nh1A:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TYR A 156
TYR A 160
LEU A 209
HIS A 227
LEU A 307
TYR A 326
 None
 1.33A 3vw7A-5nj6A:
33.1		 3vw7A-5nj6A:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TYR A 156
TYR A 160
LEU A 209
LEU A 230
LEU A 307
TYR A 326
 None
 1.39A 3vw7A-5nj6A:
33.1		 3vw7A-5nj6A:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TYR A 160
LEU A 209
HIS A 227
LEU A 306
LEU A 307
TYR A 326
 None
 1.21A 3vw7A-5nj6A:
33.1		 3vw7A-5nj6A:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 TYR A 160
PHE A 243
LEU A 306
LEU A 307
TYR A 311
 None
 1.09A 3vw7A-5nj6A:
33.1		 3vw7A-5nj6A:
34.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 LEU A 573
LEU A 437
LEU A 433
ALA A 520
ALA A 522
 None
 1.11A 3vw7A-5oc9A:
undetectable		 3vw7A-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		5 TYR A 177
LEU A 170
PHE A  40
ALA A 150
TYR A 154
 None
 0.85A 3vw7A-5swnA:
undetectable		 3vw7A-5swnA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v13 AAEL008620-PA
ODORANT-BINDING
PROTEIN

(Aedes aegypti) 		no annotation 5 LEU B  74
PHE B 132
LEU B 102
LEU B 105
ALA B  97
 None
 1.17A 3vw7A-5v13B:
undetectable		 3vw7A-5v13B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v91 FOSFOMYCIN
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF00903
(Glyoxalase) 		5 TYR A  22
LEU A  47
PHE A  70
LEU A 105
LEU A 112
 None
 0.90A 3vw7A-5v91A:
undetectable		 3vw7A-5v91A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3

(Escherichia
coli) 		PF00903
(Glyoxalase) 		5 TYR A  22
LEU A  47
PHE A  70
LEU A 105
LEU A 112
 None
 0.89A 3vw7A-5vb0A:
undetectable		 3vw7A-5vb0A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x45 PROTEASE 2A

(Rhinovirus C) 		no annotation 5 TYR A 135
LEU A  28
LEU A  93
ALA A 121
ALA A 128
 None
 1.11A 3vw7A-5x45A:
undetectable		 3vw7A-5x45A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN
PEPTIDE FROM
POLYMERASE COFACTOR
VP35

(Marburg
marburgvirus) 		PF02097
(Filo_VP35)
PF05505
(Ebola_NP) 		5 LEU A 221
PHE B  25
LEU A 253
LEU A 250
ALA A 260
 None
 1.17A 3vw7A-5xsqA:
undetectable		 3vw7A-5xsqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 535
LEU A 595
PHE A 541
LEU A 550
ALA A 602
 None
 1.17A 3vw7A-5y3jA:
undetectable		 3vw7A-5y3jA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		4 PRO A 123
LEU A 121
HIS A 110
LEU A 108
 None
None
NAP  A 350 (-4.0A)
None
 1.29A 3vw7A-1c9wA:
undetectable		 3vw7A-1c9wA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cau CANAVALIN

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 PRO B 256
LEU B 265
HIS B 297
LEU B 379
 None
 1.40A 3vw7A-1cauB:
0.0		 3vw7A-1cauB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		no annotation 4 PRO X 256
LEU X 265
HIS X 297
LEU Y 379
 None
None
PO4  X1500 (-4.1A)
None
 1.38A 3vw7A-1dgrX:
undetectable		 3vw7A-1dgrX:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 PRO A  17
LEU A  19
HIS A1148
LEU A1147
 None
 1.25A 3vw7A-1e69A:
0.0		 3vw7A-1e69A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PRO A 310
LEU A 315
HIS A 258
LEU A 257
 None
 1.48A 3vw7A-1kijA:
0.0		 3vw7A-1kijA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 PRO A 531
LEU A  38
HIS A  75
LEU A 118
 None
 1.22A 3vw7A-1obhA:
0.0		 3vw7A-1obhA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 PRO A 686
LEU A 516
HIS A 242
LEU A 229
 None
 1.24A 3vw7A-2c11A:
0.0		 3vw7A-2c11A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 PRO A 467
LEU A 945
HIS A 897
LEU A 896
 None
None
EPE  A1151 (-4.2A)
None
 1.22A 3vw7A-2eyqA:
0.4		 3vw7A-2eyqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		4 PRO A 250
LEU A 252
HIS A 133
LEU A 132
 None
 1.28A 3vw7A-2fvmA:
0.0		 3vw7A-2fvmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02589
(LUD_dom) 		4 PRO A 104
LEU A 143
HIS A 134
LEU A 180
 None
 1.42A 3vw7A-2g40A:
undetectable		 3vw7A-2g40A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 PRO A 394
LEU A 450
HIS A 447
LEU B  48
 None
 1.47A 3vw7A-2incA:
0.9		 3vw7A-2incA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 PRO A 369
LEU A 361
HIS A 561
LEU A 560
 None
 1.38A 3vw7A-2ktqA:
undetectable		 3vw7A-2ktqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 PRO A 407
LEU A 402
HIS A 422
LEU A 425
 None
 0.82A 3vw7A-2yevA:
6.7		 3vw7A-2yevA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 PRO A 105
LEU A 212
HIS A 192
LEU A 193
 None
 1.50A 3vw7A-2z2bA:
undetectable		 3vw7A-2z2bA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 PRO A  98
LEU A  78
HIS A  54
LEU A  52
 None
 1.35A 3vw7A-3b7fA:
undetectable		 3vw7A-3b7fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdu PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Acinetobacter
baumannii) 		PF00378
(ECH_1) 		4 PRO A  94
LEU A  41
HIS A  10
LEU A   9
 GOL  A   1 (-4.3A)
None
None
None
 1.30A 3vw7A-3fduA:
undetectable		 3vw7A-3fduA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN

(Ruegeria
pomeroyi) 		PF13462
(Thioredoxin_4) 		4 PRO A  17
LEU A  53
HIS A  85
LEU A  88
 None
 1.16A 3vw7A-3gykA:
undetectable		 3vw7A-3gykA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 4 PRO A 348
LEU A 194
HIS A 191
LEU A  62
 None
 1.47A 3vw7A-3hr6A:
undetectable		 3vw7A-3hr6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 PRO A  33
LEU A 241
HIS A 244
LEU A 117
 None
 1.42A 3vw7A-3oepA:
undetectable		 3vw7A-3oepA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 PRO A  96
LEU A 122
HIS A 256
LEU A 257
 None
 1.30A 3vw7A-3vocA:
undetectable		 3vw7A-3vocA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7w HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 PRO A  67
LEU A 358
HIS A  34
LEU A  35
 None
 1.45A 3vw7A-4c7wA:
undetectable		 3vw7A-4c7wA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlo HOMOSERINE
O-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 PRO A  59
LEU A  51
HIS A  44
LEU A 132
 None
 1.27A 3vw7A-4qloA:
undetectable		 3vw7A-4qloA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 PRO A 304
LEU A  62
HIS A 342
LEU A  83
 None
None
HEM  A 403 (-3.9A)
HEM  A 403 (-3.8A)
 1.50A 3vw7A-5cweA:
0.0		 3vw7A-5cweA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 PRO A 364
LEU A 138
HIS A 149
LEU A 152
 None
 1.39A 3vw7A-5hssA:
undetectable		 3vw7A-5hssA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A 172
LEU A 220
HIS A 130
LEU A 133
 None
 1.37A 3vw7A-5jw6A:
undetectable		 3vw7A-5jw6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		4 PRO A 440
LEU A 438
HIS A 327
LEU A 330
 None
None
9JE  A 601 (-4.3A)
9JE  A 601 ( 4.3A)
 1.21A 3vw7A-5o3mA:
undetectable		 3vw7A-5o3mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 PRO A 413
LEU A 338
HIS A 258
LEU A 257
 None
 1.28A 3vw7A-5vdkA:
1.6		 3vw7A-5vdkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 PRO A1247
LEU A1238
HIS A1079
LEU A1007
 None
 1.21A 3vw7A-6bq1A:
1.8		 3vw7A-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1
RNAP2

(Escherichia
virus N4) 		no annotation 4 PRO B 331
LEU B 255
HIS A 163
LEU A 164
 None
 1.40A 3vw7A-6c2jB:
0.9		 3vw7A-6c2jB:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ

(Pyrococcus
furiosus) 		no annotation 4 PRO L 373
LEU L  19
HIS J  29
LEU J  70
 None
 1.48A 3vw7A-6cfwL:
0.7		 3vw7A-6cfwL:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 PRO A 483
LEU A1005
HIS A 964
LEU A 963
 None
 1.39A 3vw7A-6f9nA:
undetectable		 3vw7A-6f9nA:
16.67