SIMILAR PATTERNS OF AMINO ACIDS FOR 3VW1_D_CVID301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 TYR A 358
MET A 313
LEU A 308
 None
 0.81A 3vw1D-1csjA:
0.3		 3vw1D-1csjA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		3 TYR A 258
MET A 293
LEU A  32
 None
 0.98A 3vw1D-1dmuA:
0.0		 3vw1D-1dmuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 TYR A 153
MET A 302
LEU A 294
 None
 0.85A 3vw1D-1ehiA:
0.0		 3vw1D-1ehiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)

(Homo sapiens;
Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		3 TYR B 283
MET P  17
LEU P  27
 None
 0.94A 3vw1D-1htrB:
undetectable		 3vw1D-1htrB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9m DD-TRANSPEPTIDASE

(Streptomyces
sp. K15) 		PF00768
(Peptidase_S11) 		3 TYR A  12
MET A  40
LEU A 132
 None
 0.83A 3vw1D-1j9mA:
0.0		 3vw1D-1j9mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		3 TYR A 175
MET A 147
LEU A 348
 None
 0.94A 3vw1D-1jctA:
0.0		 3vw1D-1jctA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		3 TYR A 257
MET A 316
LEU A 310
 None
 0.91A 3vw1D-1poiA:
0.0		 3vw1D-1poiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 TYR A 151
MET A 107
LEU A  60
 None
 0.85A 3vw1D-1qpoA:
0.0		 3vw1D-1qpoA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		3 TYR A 123
MET A 266
LEU A 211
 None
 0.99A 3vw1D-1rptA:
0.4		 3vw1D-1rptA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		3 TYR A 348
MET A 268
LEU A 278
 GOL  A1500 (-3.9A)
None
None
 0.87A 3vw1D-1v4vA:
0.0		 3vw1D-1v4vA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		3 TYR A  41
MET A   1
LEU A   6
 None
 0.77A 3vw1D-1y56A:
undetectable		 3vw1D-1y56A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		3 TYR A 119
MET A 106
LEU A 244
 None
 0.99A 3vw1D-2amcA:
undetectable		 3vw1D-2amcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		3 TYR A  97
MET A 109
LEU A  48
 None
 0.80A 3vw1D-2cycA:
undetectable		 3vw1D-2cycA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i39 PROTEIN N1

(Vaccinia virus) 		PF06227
(Poxvirus) 		3 TYR A  20
MET A   1
LEU A 113
 MPD  A 501 (-3.7A)
None
None
 0.94A 3vw1D-2i39A:
undetectable		 3vw1D-2i39A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		3 TYR A 326
MET A 341
LEU A 163
 None
 0.92A 3vw1D-2inrA:
undetectable		 3vw1D-2inrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 TYR A 548
MET A 591
LEU A 599
 None
 0.99A 3vw1D-2inyA:
undetectable		 3vw1D-2inyA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 405
MET A 343
LEU A 363
 None
 0.94A 3vw1D-2ix5A:
2.1		 3vw1D-2ix5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 TYR A 398
MET A 360
LEU A 324
 None
 0.95A 3vw1D-2jbrA:
1.5		 3vw1D-2jbrA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxu TERB

(Klebsiella
pneumoniae) 		PF05099
(TerB) 		3 TYR A  99
MET A  31
LEU A  11
 None
 1.01A 3vw1D-2jxuA:
undetectable		 3vw1D-2jxuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1m AUXIN-INDUCED
PROTEIN IAA4

(Pisum sativum) 		PF02309
(AUX_IAA) 		3 TYR A  49
MET A  92
LEU A 100
 None
 1.01A 3vw1D-2m1mA:
undetectable		 3vw1D-2m1mA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcs CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF06240
(COXG) 		3 TYR A 107
MET A  31
LEU A 131
 UNL  A 161 ( 4.8A)
None
None
 1.01A 3vw1D-2pcsA:
undetectable		 3vw1D-2pcsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw AVIRULENCE PROTEIN

(Pseudomonas
syringae) 		PF11592
(AvrPto) 		3 TYR A  69
MET A 109
LEU A  80
 None
 0.89A 3vw1D-2qkwA:
undetectable		 3vw1D-2qkwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		3 TYR A 410
MET A  66
LEU A 372
 None
 0.95A 3vw1D-2qs8A:
undetectable		 3vw1D-2qs8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 TYR A 141
MET A 307
LEU A 113
 None
 1.02A 3vw1D-2qygA:
undetectable		 3vw1D-2qygA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		3 TYR A  68
MET A 177
LEU A 342
 None
 0.84A 3vw1D-2r26A:
undetectable		 3vw1D-2r26A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		3 TYR A 339
MET A  85
LEU A  54
 None
 0.71A 3vw1D-2ragA:
0.7		 3vw1D-2ragA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxe HYPOTHETICAL PROTEIN

(Vaccinia virus) 		PF06227
(Poxvirus) 		3 TYR A  20
MET A   1
LEU A 113
 None
 0.96A 3vw1D-2uxeA:
undetectable		 3vw1D-2uxeA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 TYR A 485
MET A 701
LEU A 689
 None
 0.92A 3vw1D-2vsqA:
undetectable		 3vw1D-2vsqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		3 TYR A 454
MET A 392
LEU A 157
 None
 1.00A 3vw1D-2weuA:
undetectable		 3vw1D-2weuA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 TYR A 643
MET A 661
LEU A 362
 None
 0.79A 3vw1D-2ww2A:
undetectable		 3vw1D-2ww2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 TYR A  94
MET A 131
LEU A 175
 None
 0.91A 3vw1D-2xaxA:
undetectable		 3vw1D-2xaxA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 TYR A 222
MET A 267
LEU A 233
 None
 1.01A 3vw1D-2xydA:
undetectable		 3vw1D-2xydA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 TYR A 191
MET A  99
LEU A  92
 None
CHD  A   2 (-4.0A)
CHD  A   1 (-4.8A)
 0.70A 3vw1D-3aqiA:
undetectable		 3vw1D-3aqiA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		3 TYR A 330
MET A 656
LEU A 356
 HEM  A 801 (-4.6A)
HEM  A 801 (-4.0A)
HEM  A 801 (-4.8A)
 0.81A 3vw1D-3ayfA:
undetectable		 3vw1D-3ayfA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		3 TYR A 309
MET A 286
LEU A 367
 None
 0.99A 3vw1D-3bwnA:
undetectable		 3vw1D-3bwnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 TYR A  58
MET A 123
LEU A 311
 CI2  A 328 ( 4.5A)
None
None
 0.91A 3vw1D-3cavA:
undetectable		 3vw1D-3cavA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		3 TYR A 297
MET A 267
LEU A 208
 None
 0.91A 3vw1D-3cm5A:
undetectable		 3vw1D-3cm5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn6 CT0912, ORFAN
PROTEIN WITH A
FERREDOXIN-LIKE
DOMAIN REPEAT

(Chlorobaculum
tepidum) 		no annotation 3 TYR A 249
MET A 272
LEU A 221
 None
 0.92A 3vw1D-3gn6A:
undetectable		 3vw1D-3gn6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		3 TYR A 142
MET A  49
LEU A  90
 None
 0.56A 3vw1D-3hjcA:
undetectable		 3vw1D-3hjcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		3 TYR A 466
MET A 364
LEU A 336
 None
 1.01A 3vw1D-3iacA:
undetectable		 3vw1D-3iacA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 TYR A  21
MET A  45
LEU A 136
 None
 0.88A 3vw1D-3itaA:
undetectable		 3vw1D-3itaA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A  52
MET A 231
LEU A 198
 None
EDO  A   4 (-4.8A)
None
 0.94A 3vw1D-3iv0A:
0.2		 3vw1D-3iv0A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		3 TYR A 754
MET A 817
LEU A 763
 None
 0.74A 3vw1D-3j9dA:
undetectable		 3vw1D-3j9dA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kea K1L

(Vaccinia virus) 		PF12796
(Ank_2) 		3 TYR A 246
MET A 209
LEU A 180
 None
 0.96A 3vw1D-3keaA:
undetectable		 3vw1D-3keaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC

(Carboxydothermus
hydrogenoformans) 		PF01656
(CbiA) 		3 TYR A  92
MET A 102
LEU A 127
 None
 0.91A 3vw1D-3kjeA:
undetectable		 3vw1D-3kjeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		3 TYR B1318
MET B1293
LEU B1257
 None
 0.98A 3vw1D-3mzkB:
undetectable		 3vw1D-3mzkB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nio GUANIDINOBUTYRASE

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		3 TYR A 112
MET A  23
LEU A 306
 None
 0.98A 3vw1D-3nioA:
undetectable		 3vw1D-3nioA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		3 TYR A 223
MET A 311
LEU A 301
 None
 0.43A 3vw1D-3nwnA:
undetectable		 3vw1D-3nwnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph9 ANTERIOR GRADIENT
PROTEIN 3 HOMOLOG

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		3 TYR A 136
MET A 155
LEU A 148
 None
 0.93A 3vw1D-3ph9A:
undetectable		 3vw1D-3ph9A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pry HEAT SHOCK PROTEIN
HSP 90-BETA

(Homo sapiens) 		PF00183
(HSP90) 		3 TYR A 426
MET A 513
LEU A 469
 None
 1.01A 3vw1D-3pryA:
undetectable		 3vw1D-3pryA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 TYR A 358
MET A 313
LEU A 308
 None
 0.87A 3vw1D-3qghA:
undetectable		 3vw1D-3qghA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3raz THIOREDOXIN-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF08534
(Redoxin) 		3 TYR A 135
MET A  77
LEU A 148
 None
 0.89A 3vw1D-3razA:
undetectable		 3vw1D-3razA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		3 TYR A 119
MET A 106
LEU A 244
 None
 1.00A 3vw1D-3tehA:
undetectable		 3vw1D-3tehA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		3 TYR A 174
MET A 220
LEU A 191
 None
 0.67A 3vw1D-3tw8A:
undetectable		 3vw1D-3tw8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 TYR A 185
MET A 197
LEU A 588
 None
 1.01A 3vw1D-4ah6A:
undetectable		 3vw1D-4ah6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 TYR A  26
MET A  50
LEU A 141
 None
 0.98A 3vw1D-4drtA:
undetectable		 3vw1D-4drtA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		3 TYR A 163
MET A 187
LEU A 255
 None
 1.00A 3vw1D-4dwsA:
undetectable		 3vw1D-4dwsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7h FERMITIN FAMILY
HOMOLOG 2

(Homo sapiens) 		PF00169
(PH) 		3 TYR A 485
MET A 421
LEU A 456
 None
 0.99A 3vw1D-4f7hA:
undetectable		 3vw1D-4f7hA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8t GLUCARATE
DEHYDRATASE

(Actinobacillus
succinogenes) 		PF13378
(MR_MLE_C) 		3 TYR A 171
MET A 143
LEU A 344
 None
 0.93A 3vw1D-4g8tA:
undetectable		 3vw1D-4g8tA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		3 TYR A 199
MET A  50
LEU A 129
 None
 0.96A 3vw1D-4gpgA:
undetectable		 3vw1D-4gpgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 TYR A  51
MET A 336
LEU A 148
 None
 0.88A 3vw1D-4gqoA:
undetectable		 3vw1D-4gqoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo sapiens) 		PF00328
(His_Phos_2) 		3 TYR A 412
MET A 343
LEU A 289
 None
 1.01A 3vw1D-4jocA:
undetectable		 3vw1D-4jocA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 TYR A 195
MET A 206
LEU A 323
 None
1Q5  A 401 (-4.1A)
1Q5  A 401 ( 4.3A)
 0.85A 3vw1D-4k5yA:
2.4		 3vw1D-4k5yA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzy 40S RIBOSOMAL
PROTEIN S2

(Oryctolagus
cuniculus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		3 TYR C  67
MET C 201
LEU C  87
 None
 0.88A 3vw1D-4kzyC:
undetectable		 3vw1D-4kzyC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 TYR B 285
MET B 272
LEU B 201
 None
 0.93A 3vw1D-4mrmB:
undetectable		 3vw1D-4mrmB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		3 TYR A 199
MET A  50
LEU A 129
 None
 0.94A 3vw1D-4nsyA:
undetectable		 3vw1D-4nsyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		3 TYR A 451
MET A 466
LEU A 429
 None
 1.00A 3vw1D-4pb6A:
undetectable		 3vw1D-4pb6A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 TYR A 496
MET A 523
LEU A 509
 None
 0.94A 3vw1D-4ph9A:
undetectable		 3vw1D-4ph9A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 TYR A 401
MET A 372
LEU A 420
 None
 0.98A 3vw1D-4wzbA:
undetectable		 3vw1D-4wzbA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6t COAT PROTEIN

(Tobacco streak
virus) 		PF01787
(Ilar_coat) 		3 TYR A 178
MET A 153
LEU A 139
 None
 0.67A 3vw1D-4y6tA:
undetectable		 3vw1D-4y6tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 TYR D 331
MET D 296
LEU D 282
 None
 0.98A 3vw1D-4yg7D:
undetectable		 3vw1D-4yg7D:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zev PFHAD1

(Plasmodium
falciparum) 		PF08282
(Hydrolase_3) 		3 TYR A  88
MET A 236
LEU A  32
 None
 0.80A 3vw1D-4zevA:
undetectable		 3vw1D-4zevA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		3 TYR C 868
MET C 391
LEU C 365
 None
 0.88A 3vw1D-5a6fC:
undetectable		 3vw1D-5a6fC:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an1 GLUTATHIONE
S-TRANSFERASE

(Litopenaeus
vannamei) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 TYR A 119
MET A 107
LEU A 129
 None
 0.91A 3vw1D-5an1A:
undetectable		 3vw1D-5an1A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		3 TYR E 713
MET E 777
LEU E 647
 None
 0.97A 3vw1D-5c4gE:
2.7		 3vw1D-5c4gE:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		3 TYR A 385
MET A 276
LEU A 202
 None
 1.00A 3vw1D-5e9jA:
undetectable		 3vw1D-5e9jA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 TYR A  23
MET A  47
LEU A 138
 None
 0.86A 3vw1D-5fsrA:
undetectable		 3vw1D-5fsrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 3 TYR G 290
MET G 550
LEU G 363
 None
 0.83A 3vw1D-5h0rG:
undetectable		 3vw1D-5h0rG:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		3 TYR A 174
MET A 183
LEU A 351
 None
 0.99A 3vw1D-5h3oA:
1.4		 3vw1D-5h3oA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 3 TYR A 174
MET A  85
LEU A  94
 None
 0.83A 3vw1D-5ig9A:
undetectable		 3vw1D-5ig9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		3 TYR A 495
MET A 522
LEU A 508
 None
ID8  A 601 (-4.2A)
None
 0.99A 3vw1D-5ikrA:
undetectable		 3vw1D-5ikrA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		3 TYR A 417
MET A 388
LEU A 436
 None
 1.02A 3vw1D-5kojA:
undetectable		 3vw1D-5kojA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		3 TYR A 125
MET A 195
LEU A 155
 None
 1.00A 3vw1D-5m0tA:
undetectable		 3vw1D-5m0tA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 TYR A 173
MET A 453
LEU A 426
 None
 0.98A 3vw1D-5mfaA:
undetectable		 3vw1D-5mfaA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 TYR A 363
MET A 354
LEU A 419
 None
 0.93A 3vw1D-5n6uA:
undetectable		 3vw1D-5n6uA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		3 TYR B 388
MET B 242
LEU B 371
 None
 0.68A 3vw1D-5njfB:
undetectable		 3vw1D-5njfB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 TYR A  47
MET A  71
LEU A 159
 None
 0.94A 3vw1D-5tr7A:
undetectable		 3vw1D-5tr7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 3 TYR A 545
MET A 567
LEU A 888
 None
 1.01A 3vw1D-5u30A:
2.0		 3vw1D-5u30A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		3 TYR C 418
MET C 332
LEU C 379
 None
 0.97A 3vw1D-5uj7C:
2.5		 3vw1D-5uj7C:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		3 TYR A 121
MET A 205
LEU A 225
 None
 0.83A 3vw1D-5usdA:
undetectable		 3vw1D-5usdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		3 TYR A 411
MET A 404
LEU A 364
 None
 0.92A 3vw1D-5vc2A:
undetectable		 3vw1D-5vc2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		3 TYR A 375
MET A 243
LEU A 124
 None
 1.02A 3vw1D-5vwsA:
undetectable		 3vw1D-5vwsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		3 TYR G  61
MET G 103
LEU G 278
 None
 1.01A 3vw1D-5x5yG:
undetectable		 3vw1D-5x5yG:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 3 TYR A 173
MET A 453
LEU A 426
 None
 0.96A 3vw1D-6azpA:
undetectable		 3vw1D-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 3 TYR A 187
MET A 262
LEU A 288
 None
 0.84A 3vw1D-6bk6A:
undetectable		 3vw1D-6bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
GP120 OF ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1;
Human
immunodeficiency
virus 1) 		no annotation
no annotation 		3 TYR G  40
MET B 629
LEU B 523
 None
 0.99A 3vw1D-6ck9G:
undetectable		 3vw1D-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 TYR A2447
MET A2358
LEU A2322
 None
 0.88A 3vw1D-6ez8A:
undetectable		 3vw1D-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 508
MET A 694
LEU A 541
 None
 0.80A 3vw1D-6f42A:
undetectable		 3vw1D-6f42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 3 TYR A 632
MET A 650
LEU A 361
 None
 0.92A 3vw1D-6f8zA:
undetectable		 3vw1D-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 3 TYR A 728
MET A 792
LEU A 662
 None
 0.98A 3vw1D-6gl3A:
undetectable		 3vw1D-6gl3A:
undetectable