SIMILAR PATTERNS OF AMINO ACIDS FOR 3VW1_D_CVID301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a05 3-ISOPROPYLMALATE
DEHYDROGENASE

(Acidithiobacillus
ferrooxidans) 		PF00180
(Iso_dh) 		5 ILE A  69
SER A 298
ALA A  31
CYH A  37
ASP A  28
 None
 1.20A 3vw1D-1a05A:
0.4		 3vw1D-1a05A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		5 LEU A 182
ILE A 251
TYR A 212
ILE A 190
VAL A 228
 None
 1.28A 3vw1D-1awbA:
0.1		 3vw1D-1awbA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 206
SER A 153
ILE A 119
VAL A 229
PHE A 187
 None
PO4  A 906 (-3.0A)
None
None
None
 1.04A 3vw1D-1cqjA:
0.0		 3vw1D-1cqjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 LEU A 362
THR A   4
ILE A 361
ALA A  47
ASP A 351
 None
 1.15A 3vw1D-1d8cA:
2.0		 3vw1D-1d8cA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 THR A 307
ILE A 310
ILE A 376
ALA A 370
VAL A 337
 None
 1.24A 3vw1D-1ftsA:
0.0		 3vw1D-1ftsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 LEU A 199
THR A  14
ILE A 221
ILE A 167
ALA A  79
 None
 1.14A 3vw1D-1fuuA:
undetectable		 3vw1D-1fuuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 LEU A 286
CYH A 285
ILE A 105
VAL A 264
ASP A 193
 None
 1.18A 3vw1D-1g0dA:
0.0		 3vw1D-1g0dA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		5 THR A 246
SER A 192
TYR A 191
ASP A 115
PHE A 114
 None
None
SPL  A 284 ( 3.9A)
None
SPL  A 284 (-4.9A)
 1.24A 3vw1D-1mqtA:
undetectable		 3vw1D-1mqtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 206
SER A 153
ILE A 119
VAL A 229
PHE A 187
 None
 1.01A 3vw1D-1oi7A:
0.3		 3vw1D-1oi7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		5 LEU A 295
THR A  71
ILE A  74
SER A  77
ILE A 299
 None
 1.24A 3vw1D-1p0nA:
0.5		 3vw1D-1p0nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 LEU A 321
CYH A 325
ILE A 332
SER A 300
ASP A 317
 None
 1.27A 3vw1D-1pl0A:
undetectable		 3vw1D-1pl0A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 LEU A 199
THR A  14
ILE A 221
ILE A 167
ALA A  79
 None
 1.01A 3vw1D-1qvaA:
undetectable		 3vw1D-1qvaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 LEU A 136
CYH A 132
ILE A 107
ALA A 106
CYH A  16
 None
None
None
None
FMN  A 200 (-4.6A)
 1.12A 3vw1D-1t0iA:
undetectable		 3vw1D-1t0iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR

(Caenorhabditis
elegans) 		PF09287
(CEP1-DNA_bind) 		5 LEU A 366
CYH A 365
THR A 255
ILE A 399
PHE A 284
 None
ZN  A 201 (-2.4A)
None
None
None
 1.04A 3vw1D-1t4wA:
undetectable		 3vw1D-1t4wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE

(Salmonella
enterica) 		PF02525
(Flavodoxin_2) 		5 LEU A  21
ILE A 177
ILE A 195
ALA A 193
ASP A 190
 None
FMN  A 202 ( 4.1A)
None
None
None
 1.17A 3vw1D-1t5bA:
undetectable		 3vw1D-1t5bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A 385
THR A 350
ILE A  37
ALA A  39
VAL A 313
 None
 1.20A 3vw1D-1ud3A:
undetectable		 3vw1D-1ud3A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 LEU A 184
ILE A 189
TYR A 187
ALA A 485
VAL A 212
 None
 1.16A 3vw1D-1uikA:
undetectable		 3vw1D-1uikA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9c CRM1 PROTEIN

(Homo sapiens) 		PF08767
(CRM1_C) 		5 THR A 740
ILE A 745
SER A 747
ALA A 783
ASP A 787
 None
 1.13A 3vw1D-1w9cA:
2.5		 3vw1D-1w9cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		5 LEU A 239
ILE A 218
ILE A 277
ALA A 268
PHE A 376
 None
 1.20A 3vw1D-1wrbA:
undetectable		 3vw1D-1wrbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		5 LEU A 119
CYH A 118
ILE A 151
ILE A 167
PHE A 172
 None
 1.22A 3vw1D-1yd9A:
undetectable		 3vw1D-1yd9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 LEU A  81
THR A 128
ILE A 127
ILE A  84
VAL A 108
 None
 1.28A 3vw1D-1zg4A:
undetectable		 3vw1D-1zg4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		5 LEU A 239
THR A 283
ILE A 150
VAL A 183
ASP A 246
 None
 1.24A 3vw1D-2axcA:
undetectable		 3vw1D-2axcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be9 ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Sulfolobus
acidocaldarius) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		5 LEU B  36
ILE B  46
ILE B  78
ALA B  85
VAL B  12
 None
 1.25A 3vw1D-2be9B:
undetectable		 3vw1D-2be9B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 CYH M 337
ILE M 355
SER M 364
ILE M 324
ALA M 350
 None
 1.23A 3vw1D-2bp5M:
undetectable		 3vw1D-2bp5M:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bri URIDYLATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 LEU A 167
ILE A 192
ALA A 125
VAL A  11
ASP A   6
 None
 1.18A 3vw1D-2briA:
undetectable		 3vw1D-2briA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		5 LEU A 164
THR A 281
ILE A 280
ILE A  85
ALA A 184
 None
 1.05A 3vw1D-2d0jA:
undetectable		 3vw1D-2d0jA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		5 LEU A 285
ILE A 156
ILE A 400
ALA A 398
VAL A 205
 None
 1.23A 3vw1D-2dv6A:
undetectable		 3vw1D-2dv6A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 SER A 331
TYR A 333
ILE A 266
VAL A 360
ASP A 239
 None
 1.18A 3vw1D-2efjA:
undetectable		 3vw1D-2efjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 215
SER A 162
ILE A 128
VAL A 242
PHE A 196
 None
PO4  A 401 (-2.7A)
None
None
None
 1.23A 3vw1D-2fpgA:
undetectable		 3vw1D-2fpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 216
ILE A 195
ILE A 238
ALA A 234
VAL A 187
 None
None
None
NAD  A 501 (-3.8A)
None
 1.20A 3vw1D-2g76A:
undetectable		 3vw1D-2g76A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 LEU A  33
ILE A  28
ALA A 222
VAL A 122
PHE A 102
 None
 1.25A 3vw1D-2ggqA:
undetectable		 3vw1D-2ggqA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 ILE A  31
ALA A  27
VAL A 141
ASP A  23
PHE A 148
 None
 1.28A 3vw1D-2gt1A:
undetectable		 3vw1D-2gt1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A  90
ILE A 125
SER A  67
CYH A 153
PHE A 133
 None
 1.25A 3vw1D-2iukA:
undetectable		 3vw1D-2iukA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 759
THR A 579
ILE A 596
ILE A 763
ALA A 766
 None
 1.07A 3vw1D-2np0A:
0.9		 3vw1D-2np0A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 THR A 481
ILE A 482
ILE A 424
ALA A 412
PHE A 439
 None
 1.16A 3vw1D-2pkgA:
undetectable		 3vw1D-2pkgA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 208
TYR A 262
ALA A 183
ASP A 282
PHE A 281
 None
 1.15A 3vw1D-2yjqA:
undetectable		 3vw1D-2yjqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 213
SER A 160
ILE A 126
VAL A 237
PHE A 194
 None
 0.95A 3vw1D-2yv2A:
undetectable		 3vw1D-2yv2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 LEU A 425
CYH A 426
ILE A 455
ILE A 466
VAL A  84
 None
 1.14A 3vw1D-2ywgA:
undetectable		 3vw1D-2ywgA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		5 LEU A  21
ILE A 143
ILE A  18
ALA A  49
VAL A 109
 None
 1.07A 3vw1D-3eeaA:
undetectable		 3vw1D-3eeaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		5 LEU A  21
THR A 140
ILE A 143
ILE A  18
ALA A  49
 None
 1.07A 3vw1D-3eeaA:
undetectable		 3vw1D-3eeaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C 371
ILE C  36
ILE C 367
ALA C 327
VAL C  85
 None
 1.26A 3vw1D-3j9uC:
undetectable		 3vw1D-3j9uC:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 255
ILE A 236
SER A 407
ILE A 257
ASP A 327
 None
 1.24A 3vw1D-3k7nA:
undetectable		 3vw1D-3k7nA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqk DIPICOLINATE
SYNTHASE SUBUNIT B

(Bacillus
halodurans) 		PF02441
(Flavoprotein) 		5 THR A 117
ILE A 128
ALA A 169
CYH A  87
VAL A   8
 None
 1.21A 3vw1D-3lqkA:
undetectable		 3vw1D-3lqkA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ILE A  11
SER A  48
ILE A  80
VAL A   3
PHE A 130
 None
 1.21A 3vw1D-3mmwA:
undetectable		 3vw1D-3mmwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 THR A 311
ILE A  12
SER A  43
ILE A 192
ASP A 106
 None
 1.09A 3vw1D-3qgvA:
undetectable		 3vw1D-3qgvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		5 THR A 413
ILE A 416
SER A 419
ILE A  19
ASP A 428
 None
 1.22A 3vw1D-3rmtA:
undetectable		 3vw1D-3rmtA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 SER A 191
TYR A 193
ILE A 210
ALA A 235
VAL A 288
 None
 1.20A 3vw1D-3s5wA:
undetectable		 3vw1D-3s5wA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		5 LEU A  75
THR A 123
ILE A 122
TYR A 120
ILE A 115
 None
 1.18A 3vw1D-3tcqA:
undetectable		 3vw1D-3tcqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		5 LEU A  70
ILE A 297
SER A 299
ILE A   5
VAL A 355
 None
 1.20A 3vw1D-3u1hA:
undetectable		 3vw1D-3u1hA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vw1 PUTATIVE REGULATORY
PROTEIN

(Salmonella
enterica) 		PF00440
(TetR_N) 		10 LEU A  66
CYH A  67
THR A  85
ILE A  88
SER A  91
TYR A  92
ILE A 106
ALA A 110
CYH A 134
PHE A 155
 None
 0.78A 3vw1D-3vw1A:
29.8		 3vw1D-3vw1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vw1 PUTATIVE REGULATORY
PROTEIN

(Salmonella
enterica) 		PF00440
(TetR_N) 		11 LEU A  66
CYH A  67
THR A  85
SER A  91
TYR A  92
ILE A 106
ALA A 110
CYH A 134
VAL A 138
ASP A 152
PHE A 155
 None
 0.68A 3vw1D-3vw1A:
29.8		 3vw1D-3vw1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 ILE A 240
ALA A 190
VAL A 146
ASP A 222
PHE A 220
 None
 1.26A 3vw1D-3wzfA:
undetectable		 3vw1D-3wzfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 THR A  41
ILE A  45
SER A  48
ILE A  14
ALA A   5
 None
 1.22A 3vw1D-3zizA:
undetectable		 3vw1D-3zizA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 LEU A 795
THR A 615
ILE A 632
ILE A 799
ALA A 802
 None
 1.04A 3vw1D-3zuqA:
0.4		 3vw1D-3zuqA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		5 LEU A 182
ILE A 251
TYR A 212
ILE A 190
VAL A 228
 None
 1.26A 3vw1D-4as5A:
undetectable		 3vw1D-4as5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eah FORMIN-LIKE PROTEIN
3

(Mus musculus) 		PF02181
(FH2) 		5 LEU A 809
TYR A 925
ILE A 812
VAL A 757
PHE A 826
 None
 1.23A 3vw1D-4eahA:
undetectable		 3vw1D-4eahA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 LEU A 139
CYH A 159
ILE A 164
ILE A 119
VAL A 170
 None
 1.17A 3vw1D-4fs7A:
undetectable		 3vw1D-4fs7A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		5 THR A  37
ILE A 191
TYR A 208
ILE A 141
ALA A 139
 None
 1.26A 3vw1D-4gsoA:
undetectable		 3vw1D-4gsoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU C 350
ILE C 286
ILE C 353
ASP C 308
PHE C 311
 None
 1.28A 3vw1D-4hb4C:
3.1		 3vw1D-4hb4C:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME

(Escherichia
virus T4;
Aquifex
aeolicus) 		PF00902
(TatC) 		5 LEU A 170
TYR A 220
ILE A 179
VAL A 197
PHE A 191
 None
 1.25A 3vw1D-4httA:
2.7		 3vw1D-4httA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 ILE A 452
SER A 435
ILE A 385
ALA A 418
PHE A 411
 None
 1.15A 3vw1D-4hz8A:
undetectable		 3vw1D-4hz8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		5 LEU A 110
ILE A 452
ILE A 150
VAL A 455
ASP A 101
 None
 1.26A 3vw1D-4hz8A:
undetectable		 3vw1D-4hz8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9
ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00022
(Actin)
PF07529
(HSA) 		5 LEU B 143
ILE B 439
SER B 436
ALA B 178
PHE C 629
 None
 1.19A 3vw1D-4i6mB:
undetectable		 3vw1D-4i6mB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Synechococcus
elongatus) 		PF06745
(ATPase) 		5 LEU A 171
THR A 181
SER A  41
ILE A 134
ALA A 133
 None
 1.22A 3vw1D-4ijmA:
undetectable		 3vw1D-4ijmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 294
CYH A 299
ILE A 293
ALA A 278
VAL A 446
 None
None
SO4  A 614 ( 4.4A)
None
None
 1.15A 3vw1D-4ksiA:
undetectable		 3vw1D-4ksiA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		6 LEU A 265
THR A 220
ILE A 221
ILE A 266
ALA A 174
PHE A 124
 None
 1.40A 3vw1D-4l5iA:
2.1		 3vw1D-4l5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 THR A 481
ILE A 482
ILE A 424
ALA A 412
PHE A 439
 None
 1.26A 3vw1D-4lacA:
undetectable		 3vw1D-4lacA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 311
ILE A 290
ILE A 346
ALA A 337
PHE A 445
 None
 1.22A 3vw1D-4lk2A:
undetectable		 3vw1D-4lk2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		5 LEU A 194
ILE A 278
ALA A 263
VAL A 344
PHE A 175
 GDP  A 401 (-4.8A)
GDP  A 401 (-4.9A)
None
None
None
 1.14A 3vw1D-4n9wA:
undetectable		 3vw1D-4n9wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrd UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF16255
(Lipase_GDSL_lke) 		5 LEU A 198
THR A  65
SER A 217
ALA A 122
ASP A  31
 None
 1.27A 3vw1D-4nrdA:
undetectable		 3vw1D-4nrdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 277
THR A 109
ILE A 104
ALA A 357
VAL A  49
 None
 1.18A 3vw1D-4nzsA:
undetectable		 3vw1D-4nzsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 THR A  87
ILE A 238
TYR A 144
ASP A  41
PHE A  40
 None
 1.22A 3vw1D-4ovtA:
undetectable		 3vw1D-4ovtA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 235
ILE A 214
ILE A 282
ALA A 273
PHE A 381
 None
 1.21A 3vw1D-4px9A:
undetectable		 3vw1D-4px9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 127
SER A 197
TYR A 216
ILE A 325
ALA A  79
 None
 1.26A 3vw1D-4qorA:
undetectable		 3vw1D-4qorA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 LEU A 316
SER A 309
ILE A 276
ALA A 277
ASP A 337
 None
 1.25A 3vw1D-4rgkA:
undetectable		 3vw1D-4rgkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 CYH A 156
THR A  35
ILE A  34
ILE A  45
ASP A  22
 None
 1.27A 3vw1D-4rybA:
undetectable		 3vw1D-4rybA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU S  60
THR S  47
ILE S 101
ALA S 105
VAL S  24
 None
 1.26A 3vw1D-4u9iS:
undetectable		 3vw1D-4u9iS:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		5 LEU A 240
THR A 288
ILE A 291
ALA A 263
VAL A 346
 None
 1.15A 3vw1D-4uz1A:
undetectable		 3vw1D-4uz1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 LEU A 109
CYH A 110
ILE A  52
ILE A 144
ASP A  94
 None
 1.19A 3vw1D-4wseA:
undetectable		 3vw1D-4wseA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A 204
THR A 193
ILE A 212
VAL A 155
PHE A 176
 None
 1.06A 3vw1D-4x4wA:
undetectable		 3vw1D-4x4wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A 292
SER A 308
ILE A 110
ALA A 266
PHE A  87
 None
 1.27A 3vw1D-4xajA:
undetectable		 3vw1D-4xajA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 LEU A 211
THR A 258
ILE A 257
ILE A 214
VAL A 238
 None
 1.26A 3vw1D-5aqaA:
undetectable		 3vw1D-5aqaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 235
ILE A 214
ILE A 282
ALA A 273
PHE A 381
 None
 1.22A 3vw1D-5e7jA:
undetectable		 3vw1D-5e7jA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 LEU A 947
SER A 949
TYR A 951
VAL A 828
PHE A 783
 None
 1.13A 3vw1D-5ffjA:
2.1		 3vw1D-5ffjA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 LEU A 260
THR A   7
ILE A  11
ILE A 264
ALA A 267
 None
 1.12A 3vw1D-5ffnA:
undetectable		 3vw1D-5ffnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A

(Homo sapiens) 		PF06105
(Aph-1) 		5 ILE C 168
SER C 129
ILE C 137
ALA C 141
PHE C  14
 None
 1.26A 3vw1D-5fn4C:
3.8		 3vw1D-5fn4C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 LEU F 540
ILE F 529
TYR F 549
VAL F 563
PHE F 511
 None
 1.18A 3vw1D-5it5F:
undetectable		 3vw1D-5it5F:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		5 LEU A2130
TYR A2026
CYH A2029
VAL A2034
ASP A2067
 None
 1.13A 3vw1D-5mv9A:
1.1		 3vw1D-5mv9A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 5 LEU A 217
ILE A 196
ILE A 239
ALA A 235
VAL A 188
 None
None
None
NAD  A 402 (-3.6A)
None
 1.23A 3vw1D-5n6cA:
undetectable		 3vw1D-5n6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 LEU B 901
THR B 494
ILE B 498
TYR B 499
PHE B 824
 None
 1.16A 3vw1D-5nd1B:
undetectable		 3vw1D-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 LEU A 292
ILE A 320
SER A 318
ALA A 125
VAL A 334
 None
 1.11A 3vw1D-5o0sA:
undetectable		 3vw1D-5o0sA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 LEU A  19
CYH A  20
ILE A   7
ALA A 290
VAL A 137
 None
 1.12A 3vw1D-5tulA:
undetectable		 3vw1D-5tulA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkw ADENYLOSUCCINATE
LYASE

(Candida
albicans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 118
TYR A 233
ILE A 190
ALA A 186
ASP A 247
 None
 1.25A 3vw1D-5vkwA:
undetectable		 3vw1D-5vkwA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 5 CYH A 337
ILE A 355
SER A 364
ILE A 324
ALA A 350
 None
 1.23A 3vw1D-5wrkA:
undetectable		 3vw1D-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 ILE A 265
ILE A 122
ALA A 126
ASP A 274
PHE A 247
 None
 1.27A 3vw1D-5wyaA:
undetectable		 3vw1D-5wyaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 LEU A 211
ILE A 258
SER A 261
TYR A 262
ALA A 189
 None
 1.06A 3vw1D-5x7sA:
undetectable		 3vw1D-5x7sA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7v NUCLEOSOME ASSEMBLY
PROTEIN

(Plasmodium
falciparum) 		PF00956
(NAP) 		5 LEU A  84
ILE A 121
ILE A  93
VAL A 151
PHE A 189
 None
 0.96A 3vw1D-5x7vA:
undetectable		 3vw1D-5x7vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 THR A 226
SER A  55
ILE A  16
ALA A 351
VAL A  65
 None
GOL  A 403 (-2.7A)
None
None
None
 1.26A 3vw1D-5za2A:
undetectable		 3vw1D-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 LEU L 422
THR L 525
ILE L 265
ALA L 113
ASP L 115
 None
 1.26A 3vw1D-6ehsL:
undetectable		 3vw1D-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 LEU A 543
THR A 580
ILE A 541
ALA A 565
VAL A 629
 None
ADP  A1001 ( 3.9A)
None
None
None
 1.25A 3vw1D-6fa5A:
undetectable		 3vw1D-6fa5A:
undetectable